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Enterprise stent-within-stent embolization of a basilar artery perforator aneurysm

World Journal of Neuroscience 2011年第3期1卷 45-48页

作者： Eric M. Deshaies Walter jacobsen Satish Krishnamurthy 不详

Objective and Importance—Vertebrobasilar artery aneurysms can be very challenging to treat and are preferentially dealt with using endovascular tech-niques, since they are associated with lower risk than surgical clipping. Small aneurysms located on perfo-rating arteries can pose problems though, as their dimensions may not be favorable for coiling and leave the endovascular surgeon without many options. We present a basilar perforating artery aneurysm that was successfully embolized using a stent-within-stent technique. Clinical Presentation—A 47 year old fe-male presented with a Hunt-Hess 3, Fisher grade-3 subarachnoid hemorrhage with blood in the pre-pontine cistern. Initial imaging (CT angiogram and digital subtraction angiography) did not reveal an aneurysm. Follow-up angiography on post-bleed day eight demonstrated a three-millimeter basilar perforating artery aneurysm. After an unsuccessful coiling attempt a closed-cell stent-within-stent tech-nique was used to divert flow away from the aneu-rysm neck to induce aneurysm thrombosis. Interven-tion (or Technique)—Multiple attempts were made to access and stabilize a microcatheter in the small basilar perforator artery aneurysm in order to de-liver coils for endovascular embolization;this could not be done safely. Therefore a closed-cell 4.5 × 22 mm Enterprise stent (Cordis Neurovascular, Inc., Miami Lakes, Florida) was deployed in the basilar artery across the origin of the perforator aneurysm in order for the stent tines to divert flow away from the aneurysm neck and induce thrombosis. Persistant brisk flow within the aneurysm continued however, and a second closedcell 4.5 × 22 mm Enterprise stent was placed within the first one to increase the stent metal surface area across the aneurysm neck to further reduce flow into the aneurysm. Subsequently, angiography demonstrated stagnant blood flow in the aneurysm dome and the aneurysm spontaneously thrombosed, sparing all associated vessels. Conclu-sion—Stent-within

关键词： Aneurysm Basilar Enterprise Stent Subara- chnoid Hemorrhage

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Paediatric Surgical Outreach to Papua New guinea: Initial Experience

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International Journal of Clinical Medicine 2018年第9期9卷 697-702页

作者： R. Rai Jack Mulu A. S. jacobsen Department of Paediatric Surgery K K Women’s & Children’s Hospital Singapore Paediatric Surgical Unit Port Moresby General Hospital Korobosea Papua New Guinea

This is a report of our early experience in establishing a Paediatric surgical outreach program to Papua New guinea (PNg) to build capacity and improve care. A Paediatric surgical outreach mission was initiated about 4 years ago in collaboration with Singhealth and PNg along with the multidisciplinary team of health care professionals from Cardiology, Cardiothoracic Surgery, Orthopaedics, Urology, Plastics and Anaesthesia. On each mission trip of 4 - 7 days duration, Singhealth doctors supervise or perform surgeries for complex cases, conduct patient consultations and give lectures to impart knowledge and transfer skills to the local health care community in PNg. In addition, a 6 - 12 months training program in Singapore for PNg doctors has been started. For complex cases which cannot be managed in PNg, there is provision for transfer of patients to Singapore under KKROK fund for further treatment. So far 4 mission trips have been conducted in past 4 years for paediatric surgical unit in Port Moresby general Hospital of PNg focussing on teaching and training of local Paediatric surgeons. Based on evaluation of the Singhealth medical team, there is severe shortage of medical manpower, surgical skill and specialised expertise. Due to lack of intensive care facility, adequate medications and proper medical equipment in the hospital, there are many conditions being left untreated causing high morbidity and mortality among infants and neonates. Such humanitarian work inspires Singhealth towards its global health mission of promoting health equity in responding to the medical needs of PNg through training and leveraging on strength through partnership. In addition, our doctors gain invaluable learning from the exposure, hone their skill as they treat a diversity of cases and are innovative in their treatment options by working in an environment with limited resources.

关键词： Paediatric Surgery Outreach Papua New guinae

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Transport in graphene nanostructures

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Frontiers of physics 2011年第3期6卷 271-293页

作者： Christoph Stampfer Stefan Fringes Johannes gfittinger Francoise Molitor Christian Yolk Bernat Terrds Jan Dauber Stephan Engels Stefan Schnez Arnhild jacobsen Susanne Droscher Thomas Ihn Klaus Ensslin JARA-FIT and II. Institute of Physics B RWTH Aachen University 52074 Aachen and Peter Griinberg Institute （PCI-9） Forschungszentrum Jiilich 52425 Jiilich Germany Solid State Physics Laboratory ETH Zurich 8093 Zurich Switzerland

graphene nanostructures are promising candidates for future nanoelectronics and solid-state quan- tum information technology. In this review we provide an overview of a number of electron transport experiments on etched graphene nanostructures. We briefly revisit the electronic properties and the transport characteristics of bulk, i.e., two-dimensional graphene. The fabrication techniques for making graphene nanostructures such as nanoribbons, single electron transistors and quantum dots, mainly based on a dry etching ＂paper-cutting＂ technique are discussed in detail. The limitations of the current fabrication technology are discussed when we outline the quantum transport properties of the nanostructured devices. In particular we focus here on transport through graphene nanoribbons and constrictions, single electron transistors as well as on graphene quantum dots including dou- ble quantum dots. These quasi-one-dimensional （nanoribbons） and quasi-zero-dimensional （quantum dots） graphene nanostructures show a clear route of how to overcome the gapless nature of graphene allowing the confinement of individual carriers and their control by lateral graphene gates and charge detectors. In particular, wo emphasize that graphene quantum dots and double quantum dots are very promising systems for spin-based solid state quantum computation, since they are believed to have exceptionally long spin coherence times due to weak spin-orbit coupling and weak hyperflne interaction in graphene.

关键词： graphene nanostructures electron transport quantum dots

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Characteristics and processing of Pol Ⅳ-dependent transcripts in Arabidopsis

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Journal of genetics and genomics 2017年第1期44卷 3-6页

作者： Hsuan Yu Kuo Elise L.jacobsen Yanping Long Xinyuan Chen Jixian Zhai Department of Molecular Cell and Developmental BiologyUniversity of California at Los Angeles Department of Biology Southern University of Science and Technology

In plants, RNA-directed DNA methylation （RdDM） plays an essential role in silencing transposable elements that would otherwise have a deleterious effect on genome integrity. RdDM is an important pathway that establishes and maintains de novo DNA methylation in all three sequence contexts： Cg, CHg, and CHH （where H is A, C, or T）, and the methylation is targeted by 24-nt small interfering RNAs （siRNAs）（Law and jacobsen, 2010）.

关键词： DCL Characteristics and processing of Pol siRNAs

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美国明尼苏达州罗切斯特地区供氟化水前后髋部骨折发病率

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地方病译丛 1993年第6期14卷 31-32页

作者： J.jacobsen 徐训凤

自1945年起,为了预防龋齿,给居民饮用加氟水。有人假设增加的这些氟化物也加强了骨骼,可是多数生态学研究没有证实对骨折有预防作用。相反,Bernstein 等氏发现在自然高氟地区椎骨骨折普遍减少,

关键词：髋骨折发病率饮用水氟明尼苏达州

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Can regadenoson pharmacologic SPECT be performed effectively in patients with left bundle branch block or paced rhythm patients? A retrospective comparison to adenosine SPECT

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World Journal of Cardiovascular Diseases 2013年第2期3卷 222-227页

作者： gurunanthan Palani Aarthee S. Karthikeyan jacobsen gordon Karthik Ananthasubramaniam Department of Internal Medicine McLaren/Michigan State University Flint USA Heart and Vascular Institute Henry Ford Hospital Detroit USA

Purpose: Regadenoson (REg) is currently becoming the stress agent of choice in patients undergoing pharmacologic single photon emission computed tomography (SPECT). However, in patients with left bundle branch block (LBBB) and ventricular paced rhythm (VPR), hesitation exists amongst clinicians to use REg-SPECT due to the concern that the increased heart rate could cause false positive SPECT results. We sought to evaluate the comparability of A-SPECT and REg-SPECT in patients with LBBB and VPR. Methods: Retrospective study of 30 patients who served as their own controls. All 30 patients who underwent REg-SPECT (grp 1) were compared to their prior A-SPECT (grp 2) done within two years prior to REg-SPECT. Heart rate (HR) and blood pressure (BP) parameters, ECg, stress perfusion and gated variables, SPECT ischemia, and side-effects were evaluated. Statistical significance was set at P grp 1 and grp 2 were comparable in hemodynamic parameters with increase in HR and decrease in systolic and diastolic BP with administration of adenosine and REg stress agents. However, there were no significant differences found in hemodynamic parameters and II degree AV block between the groups. All normal A-SPECT were found to be normal with REg-SPECT. No differences could be found between the two groups among SPECT parameters. Muscle pain was significantly higher in REg (10.0% vs. 0.0%, P = 0.083) and so was the use of aminophylline (16.7% vs. 0.0%, P = 0.025) to relieve the side-effect. Conclusion: REg-SPECT can be administered in patients with LBBB and VPR patients based on favorable and comparable hemodynamic responses and arrhythmia occurrences to A-SPECT. REg-SPECT can also be used for adequate interpretation of presence or absence of SPECT ischemia particularly in the LAD territory without any concern for false positive perfusion defects.

关键词： Regadenoson Single Photon Emission Computed Tomography Left Bundle Branch Block Ventricular Paced Rhythm Adenosine False Positive SPECT

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同源转基因将成为利用野生资源进行作物育种的一种有效手段

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园艺学报 2006年第6期33卷 1397-1400页

作者：黄三文杜永臣屈冬玉 Evert jacobsen 中国农业科学院蔬菜花卉研究所北京100081 荷兰瓦赫宁根大学及研究中心植物育种系

作物育种的一个主要限制因素是各栽培种的遗传基础日趋狭窄,迫切需要从野生种质资源中导入优异等位基因。杂交障碍和连锁累赘降低了常规育种利用这些等位基因的效率。基因组研究的发展使得越来越多的植物基因的克隆成为可能。同源转基... 详细信息

作物育种的一个主要限制因素是各栽培种的遗传基础日趋狭窄,迫切需要从野生种质资源中导入优异等位基因。杂交障碍和连锁累赘降低了常规育种利用这些等位基因的效率。基因组研究的发展使得越来越多的植物基因的克隆成为可能。同源转基因就是将本物种或其近缘野生种克隆的优异等位基因导入到要改良的育种材料中。这不仅可以缩短育种的周期,而且不会有不良性状的连锁累赘。同源转基因和常规育种所要导入的目标基因的来源是相同的,因此育成的品种同样是安全的。如果转基因条例能够将同源转基因品种视同为常规育种品种,同源转基因将会成为人们利用野生资源进行作物改良的一种有效手段。

关键词：作物育种同源转基因安全评价

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Risk Perception of Seasonal and Swine Influenza Among University College Students： Does Study Direction Influence Attitudes？

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Journal of Health Science 2014年第2期2卷 89-93页

作者： John E. Berg Jorid grimeland Ida Wulff jacobsen Faculty of Health Sciences Oslo and Akershus University College Oslo 0130 Norway

In 2009, Norway faced the global challenge of the influenza pandemic. Risk communication is an important tool within healthy promoting work. In this study the main aim was to explore reflections of students on the risk assessment of season flu and the swine flu in 2009 according to field of study. A cross-sectional questionnaire survey based on 505 students is presented. 42.4% were health subject students, and 57.6% were non-health subject related students. The majority of the students were 20-24 years old. Most of the respondents were not concerned at being infected with the swine flu, and did underestimate the death toll of the common flu. Students were more concerned about the swine flu than the regular season flu. By logistic regression, the odds ratio for taking the swine flu vaccine was greater among students who were concerned （O.R. = 2.5）. During the swine flu pandemic, student trust towards the health authorities was low. Among the students, 74% stated they would consider advice from the health authorities, 37% from their parents and 20% from mass media. Stating risk of getting the common flu was at the medium or great risk level for far less non-health students than for health students, 38.2% versus 55.6%, P = 0.001. The perceived infection risk was likewise higher in the health student group, 52.4% versus 36.2%, P = 0.001. The respondents had little faith in general public vaccination as well as being critical concerning side effects of vaccination. The results from the study indicated that the students would rather follow advice about their personal hygiene than advice to take the swine flu-vaccine.

关键词： Swine flu seasonal flu pandemic influenza and risk perception.

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不同微生境两种滨藜属灌丛木质部的结构与功能

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Journal of Plant Ecology 2023年第6期16卷 92-107页

作者： Mustapha Ennajeh Mitchell Coleman Jaycie C.Fickle Viridiana Castro Robert Brandon Pratt Anna L.jacobsen Department of Biology California State UniversityBakersfieldCA 93311USA Laboratory of Biodiversity and Valorization of Bioresources in Arid Zones Faculty of Sciences of GabesUniversity of Gabes6072 GabesTunisia Tejon Ranch Conservancy Frazier ParkCA 93225USA

两种以前广泛分布的滨藜属(Atriplex)物种如今在南加州圣华金河谷沙漠的一系列微栖息地中以碎片化的种群出现。我们推测,由于土壤盐度和干旱程度的不同,大滨藜(***)和多果滨藜(***)在叶片和茎的结构和功能性状上存在种间和种内差异。我... 详细信息

两种以前广泛分布的滨藜属(Atriplex)物种如今在南加州圣华金河谷沙漠的一系列微栖息地中以碎片化的种群出现。我们推测,由于土壤盐度和干旱程度的不同,大滨藜(***)和多果滨藜(***)在叶片和茎的结构和功能性状上存在种间和种内差异。我们比较了3个大滨藜种群和4个多果滨藜种群的水势、木质部结构功能和叶片性状。两个物种的木质部性状差异显著,其中大滨藜的木质部密度较低,导管平均直径和最大直径较宽,导水率较高。这两个物种的叶片性状也具有显著差异,其中大滨藜与多果滨藜相比,具有更大的叶片和更高的比叶面积。叶片性状在大滨藜不同种群间存在显著差异。相反,茎木质部结构特征(平均管壁厚度、平均管径和最大管长)在多果滨藜不同种群间存在差异。这些差异在很大程度上与大滨藜的土壤盐度有关,而与多果滨藜的季节性水势关系不大。总体而言,两种滨藜属灌木均表现出较高的种内和种间性状变异。这可能是理解这些本地物种进化的关键考虑因素,对它们的保护和恢复具有重要意义。

关键词：干旱叶面积比水导电率圣华金河谷沙漠水势木质部解剖

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Numerical quality control for DFT-based materials databases

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npj Computational Materials 2022年第1期8卷 661-668页

作者： Christian Carbogno Kristian Sommer Thygesen Björn Bieniek Claudia Draxl Luca M.ghiringhelli Andris gulans Oliver T.Hofmann Karsten W.jacobsen Sven Lubeck Jens Jørgen Mortensen Mikkel Strange Elisabeth Wruss Matthias Scheffler Fritz-Haber-Institut der Max-Planck-gesellschaft Faradayweg 4-614195BerlinGermany Center for Atomic-scale Materials Design(CAMD) Department of PhysicsTechnical University of DenmarkFysikvej 12800Kongens LyngbyDenmark Physics Department and IRIS Adlershof Humboldt-Universität zu BerlinZum Großen Windkanal 612489BerlinGermany Institute of Solid State Physics Graz University of TechnologyNAWI GrazPetergasse 168010GrazAustria

Electronic-structure theory is a strong pillar of materials *** different computer codes that employ different approaches are used by the community to solve various scientific ***,the precision of different packages has only been scrutinized thoroughly not long ago,focusing on a specific task,namely selecting a popular density functional,and using unusually high,extremely precise numerical settings for investigating 71 monoatomic crystals^(1).Little is known,however,about method- and code-specific uncertainties that arise under numerical settings that are commonly used in *** shed light on this issue by investigating the deviations in total and relative energies as a function of computational *** typical settings for basis sets and k-grids,we compare results for 71 elemental^(1) and 63 binary solids obtained by three different electronic-structure codes that employ fundamentally different *** the basis of the observed trends,we propose a simple,analytical model for the estimation of the errors associated with the basis-set *** cross-validate this model using ternary systems obtained from the Novel Materials Discovery (NOMAD) Repository and discuss how our approach enables the comparison of the heterogeneous data present in computational materials databases.

关键词： structure precise selecting

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