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Cellular & Molecular Immunology 2024年第1期21卷 19-32页

作者： Ying Fu Baichao Yu Qi Wang Zhou Lu Hushan zhang Dan zhang Feifei Luo Ronghua Liu Luman Wang Yiwei Chu Department of Immunology School of Basic Medical SciencesShanghai Key Laboratory of Medical Epigenetics and MetabolismInstitutes of Biomedical SciencesFudan UniversityShanghaiChina Zhongshan Hospital Institute of Clinical Science Zhongshan HospitalShanghaiChina Zhaotong Health Vocational College ZhaotongYunnanChina Department of Digestive Diseases Huashan HospitalFudan UniversityShanghaiChina Shanghai Fifth People’s Hospital Fudan UniversityShanghaiChina

The metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains *** a Pseudomonas aeruginosa-induced pneumonia model,we reported that IL-10-producing B cells(IL-10+B cells)play a key role in spontaneously resolving infection-mediated *** cytosolic reactive oxygen species(ROS)during inflammation were shown to drive IL-10+B-cell generation by remodeling one-carbon *** of the enzyme serine hydroxymethyltransferase 1(Shmt1)led to inadequate one-carbon metabolism and decreased IL-10+B-cell ***,increased one-carbon flux elevated the levels of the methyl donor S-adenosylmethionine(SAM),altering histone H3 lysine 4 methylation(H3K4me)at the Il10 gene to promote chromatin accessibility and upregulate Il10 expression in B ***,the one-carbon metabolism-associated compound ethacrynic acid(EA)was screened and found to potentially treat infectious pneumonia by boosting IL-10+B-cell ***,these findings reveal that ROS serve as modulators to resolve inflammation by reprogramming one-carbon metabolism pathways in B cells.

关键词： IL-10-producing B cell Reactive oxygen species One-carbon metabolism H3K4me Pneumonia

Spatiotemporal characteristics of water exchange between the Andaman Sea and the Bay of Bengal

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Acta Oceanologica Sinica 2024年第5期43卷 1-15页

作者： Yihao Wang feng Zhou Xueming Zhu Ruijie Ye Yingyu Peng Zhentao Hu Haoran Tian Na Li Ocean College Zhejiang UniversityZhoushan 316021China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Observation and Research Station of Yangtze River Delta Marine Ecosystems Ministry of Natural ResourcesZhoushan 316022China Southern Marine Science and Engineering guangdong Laboratory(Zhuhai) Zhuhai 519080China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China School of Marine Sciences Sun Yat-sen UniversityZhuhai 519080China

A high-resolution customized numerical model is used to analyze the water transport in the three major water passages between the Andaman Sea(AS)and the Bay of Bengal,i.e.,the Preparis Channel(PC),the Ten Degree Channel(TDC),and the great Channel(gC),based on the daily averaged simulation results ranging from 2010 to *** analysis and Empirical Orthogonal Function(EOF)methods are employed to investigate the spatiotemporal variability of the water exchange and controlling *** results of model simulation indicate that the net average transports of the PC and gC,as well as their linear trend,are opposite to that of the *** indicates that the PC and the gC are the main inflow channels of the AS,while the TDC is the main outflow channel of the *** transport variability is most pronounced at surface levels and between 100 m and 200 m depth,likely affected by monsoons and circulation.A 182.4-d semiannual variability is consistently seen in all three channels,which is also evident in their second principal *** on sea level anomalies and EOF analysis results,this is primarily due to equatorial winds during the monsoon transition period,causing eastward movement of Kelvin waves along the AS coast,thereby affecting the spatiotemporal characteristics of the flow in the *** first EOF of the PC flow field section shows a split at 100 m deep,likely due to *** first EOF of the TDC flow field section is steady but has potent seasonal oscillations in its time ***,the first EOF of the gC flow field section indicates a stable surface inflow,probably influenced by the equatorial Indian Ocean’s eastward current.

关键词： Andaman Sea water exchange Regional Ocean Modeling Systems(ROMS) Kelvin waves spatiotemporal characteristics

Epigenetics:Mechanisms,potential roles,and therapeutic strategies in cancer progression

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genes & Diseases 2024年第5期11卷 300-314页

作者： Dong Wang Yan zhang Qingbo Li Yu Li Wen Li Ao zhang Jingxuan Xu Jingyan Meng Lin Tang Shuhua Lyu graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pathology Tianjin Union Medical CenterTianjin 300121China

Mutations or abnormal expression of oncogenes and tumor suppressor genes are known to cause *** studies have shown that epigenetic modifications are key drivers of cancer development and ***,the mechanistic role of epigenetic dysregulation in the tumor microenvironment is not fully ***,we reviewed the role of epigenetic modifications of cancer cells and non-cancer cells in the tumor microenvironment and recent research advances in cancer epigenetic *** addition,we discussed the great potential of epigenetic combination therapies in the clinical treatment of ***,there are still some challenges in the field of cancer epigenetics,such as epigenetic tumor heterogeneity,epigenetic drug heterogeneity,and crosstalk between epigenetics,proteomics,metabolomics,and other omics,which may be the focus and difficulty of cancer treatment in the *** conclusion,epigenetic modifications in the tumor microenvironment are essential for future epigenetic drug development and the comprehensive treatment of *** combination therapy may be a novel strategy for the future clinical treatment of cancer.

关键词： Cancer Epigenetics gene expression Heterogeneity Tumor microenvironment

基于遗传算法的宽带渐变电阻膜超材料吸波器设计

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物理学报 2024年第7期73卷 152-162页

作者：王超李绣峰张生俊王如志北京工业大学材料科学与工程学院新能源材料与技术研究所新型功能材料教育部重点实验室北京100124 北京航天长征飞行器研究所试验物理与计算数学国家重点实验室北京100076

近年来,基于超材料的电磁吸波器件由于其宽带、易制备等优势而备受各国研究者的广泛关注.本文为实现宽带电磁低可探测,提出一种渐变电阻膜-介质复合结构的超材料吸波器.基于传输线理论和阻抗匹配原理,对强吸波条件进行了分析.在单元结... 详细信息

近年来,基于超材料的电磁吸波器件由于其宽带、易制备等优势而备受各国研究者的广泛关注.本文为实现宽带电磁低可探测,提出一种渐变电阻膜-介质复合结构的超材料吸波器.基于传输线理论和阻抗匹配原理,对强吸波条件进行了分析.在单元结构设计方面,采用遗传算法在多变量域内全局搜索最优解,快速地确定出能够兼顾低频与宽带吸波性能的超材料单元结构与电阻参数,并对器件吸波性能与吸波机理进行了深入的探讨.仿真结果表明,在垂直入射下,所设计的超材料吸波器对1.62—19.16 gHz(相对带宽168.8%)之间的入射波吸收率均大于90%,有效地向L和K波段拓展了吸收带宽.虽然在部分频段测试和仿真结果之间存在一定偏差,但两种类型的曲线随频率的变化趋势基本一致,这充分证明了所设计的超材料吸波器在低频宽带吸波领域具有潜在应用价值.

关键词：超材料吸波体渐变电阻膜遗传算法

Sn-fused perylene diimides: Synthesis, mechanism, and properties

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Chinese Chemical Letters 2024年第10期35卷 244-248页

作者： Wenzhong zhang Zirui Yan Lingcheng Chen Yi Xiao State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

The first example of metal Sn-fused perylene diimides(PDI)derivative(Sn-PDI)was designed,synthesized,and *** obtain this type compound,a simple one-pot synthesis,named stannylative cycloaddition reaction,has been successfully developed via a palladium-based catalyst *** novel mechanism exhibits that the reaction experiences oxidative addition,Pd-cyclization,stannylation,Pd-Sn-cyclization,and reductive elimination processes *** stannylative cycloaddition does realize uniqueσ-πhyperconjugation effect and therefore significantly influencing on the photophysical,electrochemical and excited state *** with those of PDI,both of the absorption and fluorescence spectra of Sn-PDI display large red-shifts over 20 *** electron energy levels of Sn-PDI have changed with an uncommon *** Sn-PDI gives a considerably raised highest occupied molecular orbital(HOMO)level of-6.00 eV More importantly,the singlet excitons of Sn-PDI could efficiently intersystem cross(ISC)into triplet state with a long lifetime of 17.8μs,which is far longer than that(4.4 ns)of PDI.

关键词： Functional dyes Perylene diimides Organometallic heterocyclics Hyperconjugation Triplet state

Vitamin D,selenium,and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis

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World Journal of Diabetes 2024年第2期15卷 209-219页

作者： Fen feng Bin Zhou Ci-La Zhou Ping Huang gang Wang Kuang Yao School of Pharmacy Shaoyang UniversityShaoyang 422099Hunan ProvinceChina Department of Endocrinology The Central Hospital of ShaoyangShaoyang 422099Hunan ProvinceChina

BACKgROUND Diabetes and thyroiditis are closely *** occur in combination and cause significant damage to the *** is no clear treatment for type-2 diabetes mellitus(T2DM)with Hashimoto's thyroiditis(HT).While single symptomatic drug treatment of the two diseases is less effective,combined drug treatment may improve *** To investigate the effect of a combination of vitamin D,selenium,and hypoglycemic agents in T2DM with *** This retrospective study included 150 patients with T2DM and HT treated at The Central Hospital of Shaoyang from March 2020 to February *** patients were assigned to the control group,test group A,and test group B according to different treatment *** control group received low-iodine diet guidance and hypoglycemic drug *** group A received the control treatment plus vitamin D *** group B received the group A treatment plus *** levels of markers of thyroid function[free T3(FT3),thyroid stimulating hormone(TSH),free T4(FT4)],autoantibodies[thyroid peroxidase antibody(TPOAB)and thyroid globulin antibody(TgAB)],blood lipid index[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(Tg)],blood glucose index[fasting blood glucose(FBg),and hemoglobin A1c(HbA1c)]were measured pre-treatment and 3 and 6 months after *** relationships between serum 25-hydroxyvitamin D3[25(OH)D3]level and each of these indices were *** The levels of 25(OH)D3,FT3,FT4,and LDL-C increased in the order of the control group,test group A,and test group B(all PgAB,TC,Tg,FBg,HbA1c,and TSH levels increased in the order of test groups B,A,and the control group(all Pgence in serum 25(OH)D3 level,thyroid function-related indexes,autoantibodies level,blood glucose,and blood lipid index between the control group,test groups A and B(all P>

关键词： Type-2 diabetes mellitus Hashimoto's thyroiditis Vitamin D Selenium agent Hypoglycemic drugs Curative effect

多网络控制器FC-AE-1553动态带宽调度机制

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北京航空航天大学学报 2024年第9期50卷 2963-2974页

作者：李心茹张馨月李铮何锋北京航空航天大学电子信息工程学院北京100191 中国科学院空天信息创新研究院北京100190 中国科学院空间信息处理与应用系统技术重点实验室北京100190

由于航电系统通信需求的日趋复杂化,对基于FC-AE-1553组网的通信系统需要采用多网络控制器(NC)构建分布式网络环境,如何实施多个控制器之间的控制权分配,并解决跨域业务冲突的问题是其中的关键。为实现多NC协同调度,提出了一种主从NC协... 详细信息

由于航电系统通信需求的日趋复杂化,对基于FC-AE-1553组网的通信系统需要采用多网络控制器(NC)构建分布式网络环境,如何实施多个控制器之间的控制权分配,并解决跨域业务冲突的问题是其中的关键。为实现多NC协同调度,提出了一种主从NC协作的多NC动态带宽调度机制,采用并发通信方式提高网络带宽利用率,同时提升各类业务的传输保障能力。对于周期性业务采用固定时隙进行传输,对于强时效性突发业务采用抢占式带宽分配,对于一般突发业务按照“先跨域后域内”分别进行带宽分配。通过OMNeT++搭建FC-AE-1553网络仿真平台,结果表明:该调度机制可以满足多NC条件下不同类型通信业务的协同带宽分配和调度,对于周期性业务和强时效性突发业务,可以保障其实时性通信要求;对于一般突发业务,在网络负载不超过57%时也能为其提供合适的带宽进行传输。与单NC集中式相比,当网络负载大于0.5或跨域/域内业务比值大于0.8时,多NC控制具有较明显的时延优势。

关键词： FC-AE-1553 多网络控制系统动态调度控制权分配跨域传输

Enhanced piezoelectricity of Cu-doped K(Ta,Nb)O_(3) single crystals

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Journal of Materiomics 2024年第5期10卷 1017-1025页

作者： Fulin zhang Songtao Fan Yingxu Zhu Wendie Chen Bing Liu Yuguo Yang Limei Zheng Yuanyuan zhang Xianshun Lv Xuping Wang Advanced Materials Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan250014China Qilu University of Technology(Shandong Academy of Sciences) Advanced Materials InstituteKey Laboratory of Light Conversion Materials and Technology of Shandong Academy of SciencesJinan250014China School of Physics Shandong UniversityJinan250100China

As a class of solid solution material,K(Ta,Nb)O3(KTN)single crystals have attracted significant interest due to their excellent piezoelectric and electro-optic *** this study,the piezoelectric properties of KTN were improved through Cu *** the advantages of composition-regulating phase transition,a large,high-quality Cu:KTN crystal measuring 30 mm×25 mm×20 mm in size was grown using the improved top seeded solution growth ***-doped KTN exhibited better piezoelectric properties than pure KTN,and the full matrix parameters were *** dielectric,piezoelectric,and electromechanical coupling responses(ε^(T)_(11)-2,136,d_(33)∼303 pC/N,k_(t)∼0.515,and k33∼0.672)were successfully *** realize the optimized orientation of the piezoelectric properties,the orientation dependence of the single domain properties was investigated,and the mechanism of Cu doping to improve piezoelectric properties was *** found that 0.36%(in mass)Cu doped crystal consisted of A-site substitution,following ferroelectric and domain *** small ferroelectric domain sizes led to a large domain wall mobility rate and high domain wall density,which contributed to high piezoelectric *** work revealed the effect of A-position doping on piezoelectric properties and provided a theoretical and experimental foundation for the performance optimization of KTN-based materials.

关键词： Solid solution material Lead-free piezoelectric Enhanced piezoelectricity

X-Ray Source Classification Using Machine Learning:A Study with EP-WXT Pathfinder LEIA

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Research in Astronomy and Astrophysics 2024年第8期24卷 175-195页

作者： Xiaoxiong Zuo Yihan Tao Yuan Liu Yunfei Xu Wenda zhang Haiwu Pan Hui Sun Zhen zhang Chenzhou Cui Weimin Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Data Center Beijing 100101China

X-ray observations play a crucial role in time-domain *** Einstein Probe(EP),a recently launched X-ray astronomical satellite,emerges as a forefront player in the field of time-domain astronomy and high-energy *** a focus on systematic surveys in the soft X-ray band,EP aims to discover high-energy transients and monitor variable sources in the *** achieve these objectives,a quick and reliable classification of observed sources is *** this study,we developed a machine learning classifier for autonomous source classification using data from the EP-WXT Pathfinder—Lobster Eye Imager for Astronomy(LEIA)and EP-WXT *** proposed Random Forest classifier,built on selected features derived from light curves,energy spectra,and location information,achieves an accuracy of approximately 95%on EP simulation data and 98%on LEIA observational *** classifier is integrated into the LEIA data processing pipeline,serving as a tool for manual validation and rapid classification during *** paper presents an efficient method for the classification of X-ray sources based on single observations,along with implications of most effective features for the *** work facilitates rapid source classification for the EP mission and also provides valuable insights into feature selection and classification techniques for enhancing the efficiency and accuracy of X-ray source classification that can be adapted to other X-ray telescope data.

关键词： methods data analysis-X-rays binaries-stars variables general-X-rays bursts

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星载电子器件温控的系统多尺度分析

物理学报 2024年第18期73卷 185-194页

作者：李心泽唐桂华汪子涵冯建朝张晓峰西安交通大学能源与动力工程学院热流科学与工程教育部重点实验室西安710049 中国科学院微小卫星创新研究院上海201304

为提高星载电子器件热分析的模拟分辨率和精度以及被动热控装置的控温效果,本文建立系统多尺度模型获得不同尺度下卫星内部电子器件的温度场和热流信息.结果表明:系统多尺度模型在系统级尺度模拟精度与实际模型相对误差小于9%,并且可消... 详细信息

为提高星载电子器件热分析的模拟分辨率和精度以及被动热控装置的控温效果,本文建立系统多尺度模型获得不同尺度下卫星内部电子器件的温度场和热流信息.结果表明:系统多尺度模型在系统级尺度模拟精度与实际模型相对误差小于9%,并且可消耗较少的计算资源获得器件级尺度芯片微小结构的热信息.系统级模型可从宏观尺度评估星载被动热控材料的控温隔热性能,采用复合相变隔热材料可将载荷舱室温度波动幅值降至2.43 K,相比平台舱室温度波动幅值降低约69.43%,通过复合相变隔热材料隔热后的温度波动信号呈现向高频域部分转移的特征.基于多元回归分析选定需要进行重点隔热控温的舱室后,采用器件级简化模型得到不同热控装置布局下的温度场信息形成训练数据集,采用神经网络遗传算法在器件尺度预测被动热控装置的最佳安装位置,并得到减小器件最大温度波动的热控布局方案,最大温度波动降低2.74 K.

关键词：星载电子器件系统多尺度温度控制神经网络遗传算法