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Identification of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Optimizing VO_(2)film properties for use in SAW devices

畜牧与生物技术杂志(英文版) 2024年第1期

作者： Quinn A.Hoorn gabriel A.Zayas Eduardo E.Rodriguez Laura M.Jensen Raluca g.Mateescu Peter J.Hansen

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Journal of Advanced Dielectrics 2021年第5期11卷 44-47页

作者： M.E.Kutepov g.Ya.Karapetyan I.V.Lisnevskaya K.g.Abdulvakhidov A.A.Kozmin E.M.Kaidashev Laboratory of Nanomaterials Southern Federal University Stachki200/1344090 Rostov-on-DonRussia Department of Chemistry Southern Federal University Zorge7344090Rostov-on-DonRussia Smart Materials Research Institute Southern Federal University Sladkova178/24344090Rostov-on-DonRussia

The aim of this study is to optimize the conditions for producing thin VO_(2)films for their use in SAW *** used the pulsed laser deposition(PLD)method to produce VO_(2)*** used a metallic vanadium *** dependence of the oxygen pressure during PLD on the resistive metal-insulator transition(MIT)on substrates of c-sapphire and LiNbO_(3)YX/128°was *** resulting films had sharp metal-insulator temperature transitions on c-Al_(2)O_(3).The most high-quality films showed resistance change by four orders of *** the lower point of the hysteresis,the resistance of these samples was in the range of 50-100Ω.The synthesized VO_(2)films had a sharp temperature transition and a relatively small width of thermal *** SAW damping during its passage through a VO_(2)/ZnO/LiNbO_(3)YX/128°film at the metal-insulator phase transition temperature was *** SAW decreases with increasing temperature from 52 dB/cm to 0 dB/cm.

关键词： Surface acoustic wave VO_(2)film laser pulsed deposition parameter S21 metal-insulator transition

Efficacy of anti-microbial agents on vaginal microorganisms and reproductive performance of synchronized estrus ewes

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Asian pacific Journal of Reproduction 2017年第3期6卷 121-127页

作者： K.M.Mohammed A.M.Nabih g.M.Darwish Animal Reproduction Research Institute(ARRI) GizaAL-HaramEgypt ARTICLE INFO

Objective:To isolate and identify microflora and fungal species at different phases during estrus synchronization of ewes and estimate their prevalence;compare the effectiveness of antimicrobial administration to intravaginal sponge on the changes in the vaginal micro-organisms and reproductive ***: Sixty Egyptian ewes were allocated into three equal groups (g: 1, 2 and 3). g1 was inserted with vaginal sponge containing medroxy-progesterone acetate and served as control;without antimicrobial additive. The other two groups were treated as g1, but sponges were previously injected with ciprofloxacin (g2), while sponges of g3 were injected with ciprofloxacin and clotrimazole. Vaginal swabs were collected from each treated ewe, prior sponge insertion, at sponge withdrawal and 48 h later for microbiological investigation and bacterial count. On the day of sponge removal, 300 IU/eCg was administered for each treated ewe. The identified bacterial strains before sponge insertion were tested for sensitivity with antimicrobial ***:Bacterial isolates before sponge insertion were more sensitive to ciprofloxacin. Frequencies of ewes in estrus;the interval from sponge withdrawal to onset estrus and the duration of estrus were statistically similar among treated groups. The pregnancy rate in g2 (100%) was higher than g1 (66.7%) and g3 (82.4%). The total bacterial count before sponge insertion was similar between all treatments and increased significantly in all groups on the day of sponge withdraw. The prevailing bacteria on D0, D14 and 48 h after sponge removal for all treated groups wereStaphylococcus spp. followed byEscherichia coli. Regarding to fungus species, percentages of isolation increased from 5% (before sponge insertion) to 100.00% and 88.89% at sponge withdraw for g1 and g2, respectively. In g3, the fungus was declined from 10% (before sponge insertion) to 5% (at sponge removal).Conclusions:The concomitant treatments by antimicrobial to the va

关键词： Sheep Estrus synchronization Reproductive performance Antimicrobial Fungus

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TiAl基合金中γ/γ界面关系的定量分析

材料工程 2004年第5期32卷 3-6,11页

作者：陈善华 g.舒马赫成都理工大学材料与生物工程学院成都610059 Hahn-Meitner研究院固体结构与动力学所柏林14109

γ/γ界面对于(γ+α2)双相TiAl基合金的力学性能具有重要影响。本工作利用汇聚束电子衍射技术对一种含有Mn,Nb合金元素的(γ+α2)TiAl基合金中具有六种不同晶体学取向的γ相及γ/γ界面关系进行了实验唯一测定。结果表明,仅利用一套〈... 详细信息

γ/γ界面对于(γ+α2)双相TiAl基合金的力学性能具有重要影响。本工作利用汇聚束电子衍射技术对一种含有Mn,Nb合金元素的(γ+α2)TiAl基合金中具有六种不同晶体学取向的γ相及γ/γ界面关系进行了实验唯一测定。结果表明,仅利用一套〈334〉高阶劳厄带花样就可以完全决定该合金中γ层片的晶体学取向。该合金中γ/γ界面有四种,即绕〈111〉旋转120°、旋转180°呈镜面对称真孪晶、旋转60°呈镜面对称的伪孪晶和反相畴界面。统计分析表明,真孪晶γ/γ界面的比例最高,伪孪晶γ/γ界面和旋转120°γ/γ界面较少。TiAl合金中偶尔也会出现γ/γ反相畴界。

关键词： γ-TiAl基合金汇聚束电子衍射 γ/γ界面

Automated decision support for Hallux Valgus treatment options using anteroposterior foot radiographs

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World Journal of Orthopedics 2023年第11期14卷 800-812页

作者： Konrad Kwolek Artur gądek Kamil Kwolek Radek Kolecki Henryk Liszka Department of Orthopedics and Traumatology University HospitalKraków 30-688MałopolskaPoland Department of Orthopedics and Physiotherapy Jagiellonian University Collegium MedicumKraków 30-688MałopolskaPoland Department of Spine Disorders and Orthopedics Gruca Orthopedic and Trauma Teaching HospitalOtwock 05-400Poland

BACKgROUND Assessment of the potential utility of deep learning with subsequent image analysis to automate the measurement of hallux valgus and intermetatarsal angles from radiographs to serve as a preoperative aid in establishing hallux valgus severity for clinical *** To investigate the accuracy of automated measurements of angles of hallux valgus from radiographs for further integration with the preoperative planning *** The data comprises 265 consecutive digital anteroposterior weightbearing foot radiographs.181 radiographs were utilized for training(161)and validating(20)a U-Net neural network to achieve a mean Sørensen–Dice index>97%on bone segmentation.84 test radiographs were used for manual(computer assisted)and automated measurements of hallux valgus severity determined by hallux valgus(HVA)and intermetatarsal angles(IMA).The reliability of manual and computerbased measurements was calculated using the interclass correlation coefficient(ICC)and standard error of measurement(SEM).Inter-and intraobserver reliability coefficients were also *** operative treatment recommendation was then applied to compare results between automated and manual angle *** Very high reliability was achieved for HVA and IMA between the manual measurements of three independent *** HVA,the ICC between manual measurements was *** IMA,ICC was *** manual against automated computer measurement,the reliability was high as *** HVA,absolute agreement ICC and consistency ICC were 0.97,and SEM was *** IMA,absolute agreement ICC was 0.75,consistency ICC was 0.89,and SEM was ***,a strong correlation(0.80)was observed between our approach and traditional clinical adjudication for preoperative planning of hallux valgus,according to an operative treatment algorithm proposed by *** The proposed automated,artificial intelligence assisted determination of hallux valgus angles

关键词： Computer-aided diagnosis Artificial intelligence in orthopedics Automated preoperative decision support Deep learning Medical imaging

Unraveling the molecular genetics of head and neck cancer through genome-wide approaches

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genes & Diseases 2014年第1期1卷 75-86页

作者： Nadeem Riaz Luc g.Morris William Lee Timothy A.Chan Department of Radiation Oncology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Human Oncology and Pathogenesis Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

The past decade has seen an unprecedented increase in our understanding of the biology and etiology of head and neck squamous cell carcinomas(HNSCC).genome-wide sequencing projects have identified a number of recurrently mutated genes,including unexpected alterations in the NOTCH pathway and chromatin related ***-expression profiling has identified 4 distinct genetic subtypes which show some parallels to lung squamous cell carcinoma *** identification of the human papilloma virus as one causative agent in a subset of oropharyngeal cancers and their association with a favorable prognosis has opened up avenues for new therapeutic *** expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.

关键词： genomics Head and neck cancer Mutation gene expression Copy number

Yeast knockout library allows for efficient testing of genomic mutations for cell-free protein synthesis

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Synthetic and Systems Biotechnology 2016年第1期1卷 2-6页

作者： Jennifer *** Lauren g.Clark Alaksh Choudhury C.Eric Hodgman Michael C.Jewett Department of Chemical and Biological Engineering Northwestern University2145 Sheridan RoadEvanstonIL 60208-3120USA Chemistry of Life Processes Institute 2170 Campus DriveEvanstonIL 60208-3120USA Masters in Biotechnology Program Northwestern University2145 Sheridan RoadEvanstonIL 60208-3120USA Robert H.Lurie Comprehensive Cancer Center Northwestern University676 N.St Clair StSuite 1200ChicagoIL 60611-3068USA Simpson Querrey Institute Northwestern University303 E.Superior StSuite 11-131ChicagoIL 60611-2875USA

Cell-free protein synthesis(CFPS)systems from crude lysates have benefitted from modifications to their enzyme *** example,functionally deleting enzymes in the source strain that are deleterious to CFPS can improve protein synthesis ***,making such modifications can take substantial *** a proof-of-concept to accelerate prototyping capabilities,we assessed the feasibility of using the yeast knockout collection to identify negative effectors in a Saccharomyces cerevisiae CFPS *** analyzed extracts made from six deletion strains that targeted the single deletion of potentially negative effectors(e.g.,nucleases).We found a statistically significant increase in luciferase yields upon loss of function of gCN3,PEP4,PPT1,NgL3,and XRN1 with a maximum increase of over 6-fold as compared to the wild *** work has implications for yeast CFPS and for rapidly prototyping strains to enable cell-free synthetic biology applications.

关键词： Cell-free protein synthesis Saccharomyces cerevisiae Synthetic biology In vitro translation Cell-free biology Protein expression

Ultrastructural effect of sildenafil citrate on corpus cavernosum and other genital organs in female rats

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Asian Journal of Andrology 2003年第1期5卷 37-41页

作者： K.Kilinc M.I.gündüz B.H.gümüs S.Vatansever F.Kaymaz Department of Urology University of Celal Bayar 45010 Manisa TurkeyDepartment of Urology University of Celal Bayar 45010 Manisa TurkeyDepartment of Urology University of Celal Bayar 45010 Manisa TurkeyDepartment of Histology University of Celal Bayar 45010 Manisa TurkeyDepartment of Histology University of Hacettepe Turkey

Aim: To determine the ultrastructural effects of sildenafil on the female genital organs. Methods: Twenty female cycling Wistar albino rats weighing 250±20 g were randomly divided into two groups of 10 each. Rats of one group were gavaged with 0.5 mg·kg-1·d-1 of sildenafil 3 days in a week for 4 weeks and the other served as the controls. After cessation of treatment animals were sacrificed by cervical dislocation under methoxyflurane anaesthesia. The clitoris, vagina, uterus and bartholin glands were taken at the estrous and were fixed with 10 % formalin solution for light microscopy and 2.5 % glutaraldehyde and osmic acid for electron microscopy. Results: Under the light microscope, the fibrocollageous tissue was found increased, the capillaries enlarged and the connecting tissue elements increased in the corpus cavernosum in the treated group. On electron microscopy, increased connective tissue, fibroblasts with notched nucleus, shorten immature collagen fibers without striation were seen. Abundant foldings and penetration with collagen bundles were observed in the basal membrane. Large connection complexes, especially gap junctions among the wide capillary endothelial cells were observed. Conclusion: There are evident histological changes due to sildenafil citrate in female rat corpus cavernosum. The clitoris and bartholin glands were the most effected organs. While the histopathological changes of clitoral tissue could be expected, an increase in the mass of bartholin gland was surprised.

关键词： sildenafil female clitoris histopathologic effects

Hybrid approach for loss recovery mechanism in OBS networks

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Chinese Optics Letters 2014年第4期12卷 21-25页

作者： Ramesh P.g.V. Prita Nair Anna University Department of Electronics and Communication St. Joseph's College of Engineering Optical Research and Networks Lab Department of Physics SSN College of Engineering

This letter reports a study of a hybrid burst assembly and a hybrid burst loss recovery scheme （delay-based burst assembly and hybrid loss recovery （DBAHLR）） which selectively employs proactive or reactive loss recovery techniques depending on the classification of traffic into short term and long term, respectively. Traffic prediction and segregation of optical burst switching network flows into the long term and short term are conducted based on predicted link holding times using the hidden Markov model （HMM）. The hybrid burst assembly implemented in DBAHLR uses a consecutive average-based burst assembly to handle jitter reduction necessary in real-time applications, with variations in burst sizes due to the non-monotonic nature of the average delay handled by additional burst length thresholding. This dynamic hybrid approach based on HMM prediction provides overall a lower blocking probability and delay and more throughput when compared with forward segment redundancy mechanism or purely HMM prediction-based adaptive burst sizing and wavelength allocation （HMM-TP）.

关键词： OBS over Hybrid approach for loss recovery mechanism in OBS networks HMM FSR