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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSds)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSds,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSds,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

The HIV’s Transmission from the Mother to the Child at the Community Hospital Center of Bangui (Central African Republic)

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Open Journal of Obstetrics and gynecology 2020年第6期10卷 802-808页

作者： N. R. Ngbale C. E. gaunefet A. koïrokpi g. d. kossa-ko-ouakoua S. Matoulou-Mbala-Wa-Ngogbe S. Ouapou A. Manirakiza L. kobangue A. Sepou gynaecology-Obstetrics Service of the Bangui Community Hospital Bangui Central African Republic department of Public Health of the University of Bangui Bangui Central African Republic dermatology-Venerology Service of the CNHU of Bangui Bangui Central African Republic

Objective: Assess the impact of B + option on mother-to-child HIV’s transmission at the community university hospital center after 4 years of use. Patients and methods: This was a retrospective and analytical study from January 1st 2015 to December 31st 2018 i.e. 4 years. The population’s study was on HIV-positive mothers and their infants care in the service. Results:dana;">dana;">dana;

关键词： Transmission HIV Community Hospital

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Childbirth in Teenagers at the Centre Hospitalier Universitaire Communautaire de Bangui

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Open Journal of Obstetrics and gynecology 2020年第8期10卷 1141-1146页

作者： N. R. Ngbale A. koirokpi g. R. d. L. kogboma-Wongo C. gaunefet S. Ouapou A. Touanga g. d. kossa ko ouakoua S. Matoulou-M’bala A. Sepou Obstetrics gynecology department Centre Hospitalier Universitaire Communautaire de Bangui Bangui Sango

Introduction: The teenager is the one whose chronological age is between 10 and 19 years according to the World Health Organization. Pregnancy dur-ing teenage age, whether desired or not, presents serious obstetric ri... 详细信息

g>Introductiong>: The teenager is the one whose chronological age is between 10 and 19 years according to the World Health Organization. Pregnancy dur-ing teenage age, whether desired or not, presents serious obstetric risks. The purpose of this study was to assess risk factors associated with childbirth in teenagers. g>Patients and Methodsg>: This was an analytical cross-sectional study (witness case) conducted over the period from April 1st to September 30th, 2019 (6 months) in the maternity ward of the Centre Hospitalier Uni-versitaire. It was included in the study all the parturients who were presented according to the place where the pregnancy was monitored. g>Resultsg>: A total of 510 childbirths were recorded during the study period, we identified 157 childbirth aged under 20 (teenager), and 353 controls. The frequency of childbirth for teenage girls was 30.7%. The average age of teenage girls was 15 years with extremes of 13-19 years old. Risk factors were represented by preeclampsia, episiotomy. The low birth weight and premature birth are the most significant fetal morbidity. Conclusion: The pregnancy in teenagers is a public health issue.

关键词： Teenagers Morbidity Central Africa Amenorrhea Week (AW)

Materno-Fetal Prognosis of Retro-Placental Hematoma at the Centre Hospitalier Universitaire Communautaire

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Open Journal of Obstetrics and gynecology 2020年第10期10卷 1351-1357页

作者： N. R. Ngbale g. R. d. L. kogboma-Wongo A. koirokpi C. E. gaunefet g. d. kossa ko ouakoua S. Ouapou d. M. Callot S. Matoulou-M’bala A. Sepou The Maternity of Centre Hospitalier Universitaire Communautaire Bangui Central African Republic

Introduction: The majority of pregnancies and births go off without incident even though they all present risks. Retro-placental hematoma (RPH) is an extreme obstetric emergency. The aim of our study was to assess the... 详细信息

g>Introduction:g> The majority of pregnancies and births go off without incident even though they all present risks. Retro-placental hematoma (RPH) is an extreme obstetric emergency. The aim of our study was to assess the maternal-fetal prognosis of this pathology in our patients. Patients and Methods: This is a retrospective descriptive and analytical study over 5 years ranging from the period from January 1st, 2015 to December 31st, 2019. The study’s population consisted of pregnant women, in the 3rd trimester, who were presented with the retro-placental hematoma during the pregnancy or childbirth and taken care of in the maternity ward of the Centre Hospitalier Universitaire Communautaire. Results: During our study period, we recorded 87 cases of retro-placental hematoma, and 40,763 deliveries. The frequency of retro-placental hematoma was 0.21% at delivery. The average maternal age was 26.4 years with extremes of 16 and 40 years. The parity’dana;">s average was 3.8 with extremes of 1 and 13. The

关键词： Prognosis Retro-Placental Hematoma (RPH) Bangui

Modeling net-charge fluctuations in heavy-ion collisions at the LHC

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Chinese Physics C 2025年第1期49卷 281-289页

作者： g.O.Ambaryan A.S.Chernyshov g.Kh.Eyyubova V.L.korotkikh I.P.Lokhtin S.V.Petrushanko A.M.Snigirev E.E.Zabrodin Physics department Lomonosov Moscow State UniversityRU-119991 MoscowRussia Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityRU-119991 MoscowRussia Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchRU-141980 DubnaRussia department of Physics University of OsloN-0316 OsloNorway

Analysis of Pb+Pb data for net-charge fluctuations at LHC energies using the HYdJET++model is *** strongly intensive quantities d and Σ were used to remove the effects related to system volume *** employed two versions of HYdJET++for the *** first one is the standard or default version,whereas the second one is a modification that takes into account explicit event-by-event conservation of the electric net-charge of produced *** inclusion of the canonical net-charge conservation in the model allows for better description of the experimental data obtained by the ALICE and CMS Collaborations.A comparison with calculations from other models is also presented.

关键词： relativistic heavy-ion collisions net-charge fluctuations strongly intensive variables canonical charge conservation

Abdominal Pregnancy: About a Case Observed at the Maternity of the Community University Hospital Center, Bangui, Central African Republic

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Open Journal of Obstetrics and gynecology 2021年第3期11卷 296-302页

作者： g. d. kossa-ko-ouakoua A. koirokpi S. Matoulou-Mbala Wa-Ngogbe R. M’Betid-degana E. Serdouma F. kouandongui Bangue Songrou g. R. dotte N. R. Ngbale A. Sepou department of gynecology and Obstetrics Community University Hospital Center Bangui Central African Republic department of gynecology and Obstetrics Sino-Central African Friendship University Hospital Center Bangui Central African Republic Medical Imaging department Community University Hospital Center Bangui Central African Republic Medical Oncology department Community University Hospital Center Bangui Central African Republic

Abdominal pregnancy is a life threat to both mother and fetus requiring surgery regardless of the age of pregnancy. We report a case of abdominal pregnancy, delivered by laparotomy with a live newborn. This is a 31-year-old woman with 34 weeks and 2 days of amenorrhea whose ultrasound showed an abdominal pregnancy. Laparotomy extracted a newborn female weighing 3000 grams with APgAR at birth rated at 7/10 at one minute. The postoperatives were simple. The patient was discharged on the 14th postoperative day on 20 mg methrotrexate injection once a week for four weeks.

关键词： Abdominal Pregnancy Laparotomy Live Newborn Central African Republic

dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria d'Amato gennaro Iengo Nicola Massa Chiara Carlomagno department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKgROUNd Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(dPd),encoded by the dPYd *** 7%of the European population is a carrier of dPYd gene polymorphisms associated with reduced dPd enzyme *** To assess the prevalence of dPYd polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a diagnosis of gastrointestinal malignancy and treated with a fluoropyrimidine-based regimen were included in the analysis and divided into two cohorts:(1)149 patients who started fluoropyrimidines after dPYd testing;and(2)151 patients treated without dPYd *** the patients in cohort A,15%tested only the dPYd2A polymorphism,19%tested four polymorphisms(dPYd2A,HapB3,c.2846A>T,and dPYd13),and 66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a dPYd variant,the most common being dPYd6(12.1%).Patients in cohort A reported≥g3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides additional information on the prevalence of dPYd polymorphisms in the Italian population and highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： dihydropyrimidine dehydrogenase dPYd polymorphisms Fluoropyrimidine Caucasian population gastrointestinal cancers