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Using fracture-based continuum modeling of coupled geomechanical-hydrological processes for numerical simulation of hydraulic fracturing

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Journal of Rock Mechanics and geotechnical Engineering 2024年第5期16卷 1582-1599页

作者： goodluck i.Ofoegbu gNO Modeling Research LLc. San AntonioTX78253USA

This paper desc.ibes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBcM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fracture *** simulations are innovative because of modeling discrete fractures explicitly in continuum analysis.A key advantage of FBcM is that fracture initiation and propagation are modeled explicitly without changing the domain grid(*** re-meshing).Further,multiple realizations of a preexisting fracture distribution can be analyzed using the same domain *** simulated hydraulic fracturing technique consists of pressurizing multiple wells simultaneously:initially without permeating fluids into the rock,to seed fractures uniformly and at high density in the wall rock of the wells;followed by fluid injec.ion to propagate the seeded fracture density *** combines the ease of continuum modeling with the potential accuracy of modeling discrete fractures and fracturing *** are modeled as piecewise planar based on intersec.ions with domain elements;fracture geometry stored as continuum properties is used to calculate parameters needed to model individual fractures;and rock behavior is modeled through tensorial aggregation of the behavior of discrete fractures and unfractured *** are presented for previously unfractured rock and for rock with preexisting fractures of horizontal,shallow-dipping,steeply dipping,or vertical *** of a single-well model are used to determine the pattern and spacing for a multiple-well *** results illustrate high-density fracturing and fracture caging through simultaneous fluid injec.ion in multiple wells:for previously unfractured rock or rock with preexisting shallow-dipping or horizontal fractures,and in situ vertical compressive stress greater than *** preexisting fractures are steeply dipping or vertical,and considering the same in situ

关键词： Discrete fracture Fracture-based continuum modeling Fracture caging High-density fracturing Hydraulic fracturing Preexisting fracture

Effect of solidification cooling rate on microstructure and tribology characteristics of Zn-4Si alloy

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international Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 362-373页

作者： F.Akbari M.golkaram S.Beyrami g.Shirazi K.Mantashloo R.Taghiabadi M.Saghafi Yazdi i.Ansarian Department of Metallurgy and Material Science Imam Khomeini International University(IKIU)Qazvin ***Iran

The main objec.ive of this work was to modify the microstructure and enhance the tribological properties of a new Zn-4Si al-loy through a high solidification cooling rate(ScR).According to the results,by increasing the ScR from 2.0 to 59.5℃/s the average size of primary Si particles and that of the grains reduced from 76.1 and 3780μm to less than about 14.6 and 460μm,***-ing the ScR also enhanced the microstructural homogeneity,decreased the porosity content(by 50%),and increased the matrix hardness(by 36%).These microstructural changes enhanced the tribological *** instance,under the applied pressure of 0.5 MPa,an in-crease in the ScR from 2.0 to 59.5℃/s decreased the wear rate and the average fric.ion coefficient of the alloy by 57%and 23%,*** wear mechanism was also changed from the severe delamination,adhesion,and abrasion in the slowly-cooled alloy to the mild tribolayer delamination/abrasion in the high-cooling-rate-solidified sample.

关键词： zinc-silicon alloy primary silicon solidification cooling rate tribology sliding wear

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Electro-Optical Model of Soiling Effects on Photovoltaic Panels and Performance implications

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Energy Engineering 2024年第2期121卷 243-258页

作者： A.Asbayou g.P.Smestad i.ismail A.Soussi A.Elfanaoui L.Bouhouch A.ihlal Laboratory of Materials and Renewable Energies University Ibn ZohrAgadir80000Morocco Sol ideas Technology Development San José95150USA

in this paper,a detailed model of a photovoltaic(PV)panel is used to study the accumulation of dust on solar *** presence of dust diminishes the incident light intensity penetrating the panel’s cover glass,as it increases the reflec.ion of light by *** phenomenon,commonly known as the“soiling effect”,presents a significant challenge to PV systems on a global *** basic models of the equivalent circ.its of a solar cell can be found,namely the single-diode model and the two-diode *** limitation of efficiency data in manufacturers’datasheets has encouraged us to develop an equivalent electrical model that is efficient under dust conditions,integrated with optical transmittance considerations to investigate the soiling *** proposed approach is based on the use of experimental current-voltage(i-V)characteristics with simulated data using MATLAB/*** research outcomes underscores the feasibility of accurately quantifying the reduc.ion in energy produc.ion resulting from soiling by assessing the optical transmittance of accumulated dust on the surface of PV glass.

关键词： Photovoltaics solar energy optical transmittance soiling dust PV performance

New immune regulators of sciatic nerve regeneration?Lessons from the neighborhood

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Neural Regeneration Research 2024年第4期19卷 705-706页

作者： AndréL.Bombeiro Rodrigo g.Q.Fernandes Julie c.Ribot instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

For decades,the immune system has been associated with host protec.ion against infec.ious pathogens or tumors,while also contributing to ***,this paradigm is now changing,with recent studies highlighting novel roles for immune mediators in the maintenance of steady-state tissue *** this perspec.ive,we review some of the latest findings featuring immune modulators of the nervous system pathophysiology,with a special focus on interleukin(iL)-17.

关键词： homeostasis neighborhood finding

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Polio eradication surveillance in Sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando N.S.Madarasinghe c.Rangana N.Weerasinghe D.c.U.D.Weligamage J.i.Abeynayake Department of Medical Microbiology and immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research institute Colombo 08Sri Lanka

Objec.ive:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,Sri ***:This retrospec.ive study analyzed all stool samples rec.ived under the acute flac.id paralysis(AFP)and immunodeficient vac.ine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,Sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transc.iptase polymerase chain reac.ion(iTD/VDPV rRTPcR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using desc.iptive ***:A total of 2141 stool samples from 1644 cases were rec.ived for AFP surveillance from Sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detec.ion rate was>1/100000 in c.ildren aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of rec.ipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,Sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detec.ion of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

Optimization of a photovoltaic-battery system using deep reinforcement learning and load forecasting

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Energy and Ai 2024年第2期16卷 168-183页

作者： António corte Real g.Pontes Luz J.M.c.Sousa M.c.Brito S.M.Vieira iDMEc Instituto Superior TécnicoUniversidade de LisboaLisboa1049-001Portugal instituto Dom Luiz Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Home Energy Management Systems(HEMS)are increasingly relevant for demand-side management at the residential level by collec.ing data(energy,weather,electricity prices)and controlling home appliances or storage *** control can be performed with classical models that find optimal solutions,with high real-time computational cost,or data-driven approaches,like Reinforcement Learning,that find good and flexible solutions,but depend on the availability of load and generation data and demand high computational resources for *** this work,a novel HEMS is proposed for the optimization of an electric battery operation in a real,online and data-driven environment that integrates state-of-the-art load forecasting combining cNN and LSTM neural networks to increase the robustness of *** Reinforcement Learning agents are trained with different algorithms(Double DQN,Dueling DQN,Rainbow and Proximal Policy Optimization)in order to minimize the cost of electricity purchase and to maximize photovoltaic self-consumption for a PV-Battery residential *** show that the best Reinforcement Learning agent ac.ieves a 35%reduc.ion in total cost when compared with an optimization-based agent.

关键词： Energy management system Deep reinforcement learning Demand-side management Load forecasting Deep learning Energy storage systems

Exploring one material for dual applications:A red-emitting Mg2geO4:Eu3+ nanophosphor for future generation energy efficient WLEDs and dosimetric applications

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Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Akshay Arjun g.P.Darshan S.c.Sharma H.Nagabhushana D.V.Sunitha H.B.Premkumar Department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied Sciences Jain University c.N.R.Rao centre for Advanced Materials Tumkur University School of Applied Sciences (Physics) REVA University

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg2geO4:Eu3+（1 mol%-9 mol%） nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffrac.ion patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg2geO4:Eu3+（1 mol%-9 mol%） nanophosphors was estimated and obtained to be～4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at ～579,589,610,661,and 707 nm,which are due to characteristic5D0→7F0,5D0→7F1,5Do→7F2,5D0→7F3and5D0→7F4transitions of Eu3+ions,*** commission international de L'Eclairage color coordinates are gradually tuned from pale red（0.5980,0.4012） to a pure red（0.6385,0.3611） *** glow peaks showcase excellent super-linear response at low doses of γ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared Mg2geO4:Eu3+（1 mol%-9 mol%） nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes（WLEDs） and personal dosimetric applications.

关键词： Dosimetry Nanophosphors Photoluminescence Photometric properties Rare earths Thermoluminescence

Overview on signal transduc.ion cascades regulation roles of garlic and its bioac.ive constituents

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Food Science and Human Wellness 2024年第5期13卷 2353-2362页

作者： Ammad Ahmad Farooqi iqra Mobeen Rukset Attar Khalida i.Noel Baojun Xu William c.cho institute of Biomedical and genetic Engineering(iBgE) Islamabad 44000Pakistan Khursheed Rasheed Hospital Lahore Lahore 53720Pakistan Department of Obstetrics and gynecology Yeditepe UniversityAtaşehir 34755Turkey Human Anatomy Department College of MedicineAl-Mustansiriyah UniversityBaghdad 10036Iraq Food Science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519087China Department of c.inical Oncology Queen Elizabeth HospitalHong Kong G514TFChina

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioac.ive molecules at unprecedented dimensionality and ***-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of *** researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).importantly,garlic and its biologically ac.ive chemicals targeted oncogenic signaling *** this mini-review we have attempted to summarize how garlic and its bioac.ive constituents regulated signal transduc.ion cascades in cell culture studies and tumor-bearing mice.

关键词： cancer Nutrigenomics Signaling Apoptosis Allium sativum

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Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses

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World Journal of gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna Mitchell Richard c Turkington Helen g coleman centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick g Johnston centre for cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BAcKgROUND The incidence of oesophageal adenocarcinoma(OAc)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAc,defined as OAc.in adults aged under 50 years,has been *** is unclear whether survival outcomes for early-onset OAc patients differ from older age *** To investigate survival outcomes in early-onset OAc *** Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAc and survival *** regarding the overall five-year survival and risk of death of younger and older patients with OAc were extracted and pooled using meta-analyses to produce pooled estimates and 95%cis where *** Eleven studies which compared survival of early-onset OAc,defined as age at diagnosis ofith older patients were included.A narrative review of median and mean survival demonstrated conflic.ing results,with studies showing early-onset OAc patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAc patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%ci:0.85-1.47).iNTRODUc.iON There is concern that the incidence of oesophageal adenocarcinoma(OAc.in patients under 50,desc.ibed as early-onset OAc.is ***,data regarding survival of younger patients with OAc.is ***,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival cancer epidemiology Systematic review Meta-analysis