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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： khaled Alok Timothy g.White Chunyan Li department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSds)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSds,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSds,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIkV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

global parasite and Rattus rodent invasions: The consequences for rodent-borne diseases

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Integrative Zoology 2015年第5期10卷 409-423页

作者： Serge MORANd Frédéric bordES Hsuan-Wien CHEN Julien CLAUdE Jean-François COSSON Maxime gALAN g.boráczirják.alex d g.eenwood Alice LATINNE Johan MICHAUX alexis RIBAS Centre National de la Recherche Scientifique(CNRS)-Centre de coopération Internationale en Recherche Agronomique pour le développement(CIRAd)Animal et gestion Intégrée des Risques Centre d’Infectiologie Christophe Mérieux du LaosVientianeLao PDR department of Helminthology Faculty of Tropical MedicineMahidol UniversityBangkokThailand Institut des Sciences de l’Evolution Centre National de la Recherche Scientifique(CNRS)-Universitéde Montpellier-Institut de Recherche pour le Développement(IRD)MontpellierFrance department of Biological Resources National Chiayi UniversityChiayi CityTaiwanChina Institut National de la Recherche Agronomique(INRA) Centre de Biologie et de Gestion des PopulationsBaillarguetFrance Institut National de la Recherche Agronomique(INRA) UMR Biologie et Immunologie Parasitaire Agence Nationale de SécuritéSanitaire de l’Alimentationde l’Environnement et du Travail sesMaisons-AlfortFrance Leibniz Institute for Zoo and Wildlife Research.department of Wildlife diseases 10315 BerlinGermany Conservation genetics Unit.University of Liège 4000 Liège Belgium Biodiversity Research group Faculty of ScienceUdon Thani Rajabhat UniversityUdon ThaniThailand

We summarize the current knowledge on parasitism-related invasion processes of the globally invasive Rattus lineages,originating from Asia,and how these invasions have impacted the local epidemiology of rodent-borne *** play an important role in the invasion processes and successes of their hosts through multiple biological mechanisms such as“parasite release,”“immunocompetence advantage,”“biotic resistance”and“novel weapon.”Parasites may also greatly increase the impact of invasions by spillover of parasites and other pathogens,introduced with invasive hosts,into new hosts,potentially leading to novel emerging *** potential impact is the ability of the invader to amplify local parasites by *** both cases,local fauna and humans may be exposed to new health risks,which may decrease biodiversity and potentially cause increases in human morbidity and *** we review the current knowledge on these processes and propose some research priorities.

关键词： biological invasion immunocompetence parasite release spillback spillover

Lower bounds on the minimum distance in Hermitian one-point differential codes

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Science China Mathematics 2013年第7期56卷 1449-1455页

作者： kORCHMROS g.bor NAgY g.bor Pétery dipartimento di Matematica e Informatica Università della Basilicata Bolyai Institute University of Szeged

korchmaros and Nagy [Hermitian codes from higher degree places. J Pure Appl Algebra, doi： 10. 1016/***.2013.04.002, 2013] computed the Weierstrass gap sequence g（P） of the Hermitian function field Fq2 （H） at any place P of degree 3, and obtained an explicit formula of the Matthews-Michel lower bound on the minimum distance in the associated differential Hermitian code CΩ（d, mP） where the divisor d is, as usual, the sum of all but one 1-degree Fq2-rational places of Fq2 （H） and m is a positive integer. For plenty of values of m depending on q, this provided improvements on the designed minimum distance of CΩ（d, mP）. Further improvements from g（P） were obtained by korchmaros and Nagy relying on algebraic geometry. Here slightly weaker improvements are obtained from g（P） with the usual function-field method depending on linear series, Riemann-Roch theorem and Weierstrass semigroups. We also survey the known results on this subject.

关键词： Ag code Weierstrass gap Hermitian curve

Endangered lowland oak forest steppe remnants keep unique bird species richness in Central Hungary

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Journal of Forestry Research 2022年第1期33卷 343-355页

作者： g.borÓnodi Zoltán Botta‑dukát dániel Winkler Tamás Rédei Institute of Ecology and Botany Centre for Ecological ResearchVácrátótHungary department of Botany and Biodiversity Research University of ViennaViennaAustria Institute of Wildlife Management and Wildlife Biology University of SopronSopronHungary

The biodiversity of natural or semi-natural native,old oak woodlands have high conservation importance,especially in landscapes of monocultural forest plantations and arable *** a wider variety of microhabitats and foraging sources,such old oak forests can provide essential habitat for native forest bird *** conducted a study using bird point counts to compare the forest bird communities of old pedunculate oak(Quercus robur)remnants with native and non-native plantations in central Hungary in a landscape of mostly arable fields,settlements,and monocultural *** surveys were carried out in old oak forest remnants,middle-aged oak,white poplar(Populus alba),hybrid poplar(Populus×euramericana),black locust(Robinia pseudoacacia),and pine(Pinus spp.)*** has been carried out in nine study sites,where all six habitat types were represented(with a few exceptions),to determine total abundance,species richness,Shannon–Wiener diversity,species evenness,dominant and indicator species,and guild *** found that old oak forest remnants were the most diverse habitats among the studied forest types,while hybrid poplar and pine plantations exhibited the lowest avian *** avian guilds most sensitive to the loss of old oak forest remnants were ground foragers,bark foragers,cavity-nesters,residents,and Mediterranean migratory *** habitats were more diverse than non-native *** results suggest that it is important to conserve all remaining high biodiversity old oak stands and to avoid clear-cutting of monocultural plantations in favour of practices such as mixed-species plantations,longer rotation lengths,or retention forestry.

关键词： Forest bird community Bird conservation Old oak forest-steppe remnant Plantation forestry Forest conservation Non-native plantation

Sex-specific life-history strategies among immature jumping spiders:differences in body parameters and behavior

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Current Zoology 2023年第5期69卷 535-551页

作者： LászlóMezőfi Viktor Markó dóraÁgnes Taranyi g.bor Markó Institute of Plant Protection Hungarian University of Agriculture and Life SciencesBudapest 1118Hungary Institute of Viticulture and Enology Hungarian University of Agriculture and Life SciencesBudapest 1118Hungary

Selection forces often generate sex-specific differences in various traits closely related to *** in adult spiders(Araneae),sexes often differ in coloration,body size,antipredator,or foraging behavior,such sex-related differences are less pronounced among ***,sex-specific life-history strategies may also be adaptive for ***,we hypothesized that among spiders,immature individuals show different life-history strategies that are expressed as sex-specific differences in body parameters and behavioral features,and also in their *** used immature individuals of a protandrous jumping spider,Carrhotus xanthogramma,and examined sex-related *** results showed that males have higher mass and larger prosoma than *** were more active and more risk tolerant than *** activity increased with time,and larger males tended to capture the prey faster than small ones,while females showed no such ***,females reacted to the threatening abiotic stimuli more with the increasing number of test *** both males and females,individuals with better body conditions tended to be more risk *** showed no sex-specific differences in interindividual behavioral consistency and in intraindividual behavioral variation in the measured behavioral ***,we also found evidence for behavioral syndromes(i.e.,correlation between different behaviors),where in males,only the activity correlated with the risk-taking behavior,but in females,all the measured behavioral traits were *** present study demonstrates that *** sexes follow different life-history strategies even before attaining maturity.

关键词： activity behavioral syndrome boldness intraindividual variability repeatability sexual dimorphism

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

A different cardiac resynchronization therapy technique might be needed in some patients with nonspecific intraventricular conduction disturbance pattern

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Journal of geriatric Cardiology 2021年第12期18卷 975-985页

作者： g.bor katona Zsuzsanna Szelényi g.bor Szénási Bálint kozman Zsolt Rekvényi Luca kópházi Zsolt dobos Szilvia Vereckei András Vereckei department of Medicine and Hematology Semmelweis UniversityBudapestHungary Heart and Vascular Center Semmelweis UniversityBudapestHungary Institute of Translational Medicine Semmelweis UniversityBudapestHungary Ardinsys Ltd. BudapestHungary Budapest University of Technology and Economics Faculty of ArchitectureBudapestHungary

BACkgROUNd Current cardiac resynchronization therapy(CRT),devised to eliminate dyssynchrony in left bundle branch block(LBBB),works by pacing the latest activated left ventricular site(LALVS).We hypothesized that patients with nonspecific intraventricular conduction disturbance(NICd)pattern respond less favorably to CRT,because their LALVS is far away from that in *** By measuring the amplitude and polarity of secondary ST-segment alterations in two optional frontal and hori-zontal surface electrocardiogram(ECg)leads and using a software,we determined the resultant 3d spatial secondary ST vector,which is directed 180o away from the LALVS,in 110 patients with LBBB pattern and 77 patients with NICd pattern and heart *** validate the ECg method,we also estimated the LALVS by echocardiography using 3d parametric imaging and 2d speckle tracking in 22 LBBB patients and 20 NICd *** with NICd pattern were subdivided according to their non-overlapping frontal plane resultant secondary ST vector ranges to the NICd-1 subgroup(n=44)and the NICd-2 subgroup(n=33).RESULTS Based on the software determined coordinates of the resultant 3d spatial secondary ST vector directed 180o away from the LALVS,the LALVSs were located leftward,posterosuperior in the LBBB group,slightly left,superior in the NICd-1 sub-group,and slightly left,posteroinferior in the NICd-2 *** LALVS determined by ECg and echocardiography matched in all patients,except *** In the NICd-2 subgroup,a remote LALVS was found from that in LBBB pattern,which might explain the high non-response rate of the NICd pattern to the current CRT technique.

关键词： patients pattern ventricular

de novo exploration and self-guided learning of potentialenergy surfaces

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npj Computational Materials 2019年第1期5卷 262-270页

作者： Noam Bernstein g.bor Csányi Volker L.deringer Center for Materials Physics and Technology U.S.Naval Research LaboratoryWashingtonDC 20375USA department of Engineering University of CambridgeCambridge CB21PZUK department of Chemistry University of OxfordOxford OX13QRUK

Interatomic potential models based on machine learning(ML)are rapidly developing as tools for material ***,because of their flexibility,they require large fitting databases that are normally created with substantial manual selection and tuning of reference ***,we show that ML potentials can be built in a largely automated fashion,exploring and fitting potential-energy surfaces from the beginning(de novo)within one and the same *** key enabling step is the use of a configuration-averaged kernel metric that allows one to select the few most relevant and diverse structures at each *** resulting potentials are accurate and robust for the wide range of configurations that occur during structure searching,despite only requiring a relatively small number of single-point dFT calculations on small unit *** apply the method to materials with diverse chemical nature and coordination environments,marking an important step toward the more routine application of ML potentials in physics,chemistry,and materials science.

关键词： apply routine searching