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Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem Ⅰfrom Arabidopsis thaliana

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Molecular Plant 2022年第3期15卷 454-467页

作者： Xiaodong Su Duanfang Cao Xiaowei Pan Lifang Shi Zhenfeng Liu Luca Dall’Osto Roberto bassi Xinzheng Zhang Mei Li National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China College of Life Science Capital Normal UniversityBeijing 100101P.R.China Dipartimento di Biotecnologie Universitàdi Verona37134 VeronaItaly Center for Biological Imaging CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101P.R.China

Cyclic electron transport/flow(CET/CEF)in chloroplasts is a regulatory process essential for the optimization of plant photosynthetic efficiency.A crucial CEF pathway is catalyzed by a membrane-embedded NADH dehydrogenase-like(NDH)complex that contains at least 29 protein subunits and associates with photosystem I(PSI)to form the NDH-PSI ***,we report the 3.9Åresolution structure of the Arabidopsis thaliana NDH-PSI(AtNDH-PSI)*** constructed structural models for 26 AtNDH subunits,among which 11 are unique to chloroplasts and stabilize the core part of the NDH *** the supercomplex,one NDH can bind up to two PSI-light-harvesting complex I(PSI-LHCI)complexes at both sides of its membrane *** minor LHCIs,Lhca5 and Lhca6,each present in one PSI-LHCI,interact with NDH and contribute to supercomplex formation and ***,our study reveals the structural details of the AtNDH-PSI supercomplex assembly and provides a molecular basis for further investigation of the regulatory mechanism of CEF in plants.

关键词： cyclic electron transport/flow NADH dehydrogenase-like(NDH)complex photosystem I structure Arabidopsis thaliana

The indispensable role of urinalysis for patients undergoing treatment for nonmuscle invasive bladder cancer

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How to reduce bacillus Calmette-guerin discontinuation in patients with severe functional impairment

当代泌尿学（英文） 2022年第3期16卷 172-174页

作者： Luca Di gianfrancesco Mauro Ragonese giuseppe Palermo Emilio Sacco Foschi Nazario PierFrancesco bassi Marco Racioppi Clinica Urologica Fondazione Policlinico Universitario"Agostino Gemelli"IRCCS-Università Cattolica del Sacro Cuore di RomaRomeItaly

Despite several efforts in the search for noninvasive biomarkers to provide prognostic information for noninvasive muscle bladder can-cer,none have shown significant *** this context,standard urinalysis is still necessary to provide many *** method is an inexpensive,simple,and easy-to-repeat tool to follow-up patients over *** does not fall within study protocols and allows evaluation of the immune activation/response(even if indirectly).As such,this method can certainly provide useful information for prognosis.

关键词： Bacteriuria Immune system Inflammatory response Microbiome Prognosis Urinalysis

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Current Urology 2022年第3期16卷 160-167页

作者： Luca Di gianfrancesco Mauro Ragonese Massimiliano Foti giuseppe Palermo Emilio Sacco PierFrancesco bassi Marco Racioppi Clinica Urologica Fondazione Policlinico Universitario"Agostino Gemelli"IRCCS-Università Cattolica del Sacro Cuore di RomaRome800168Italy

Background:Severe functional impairment is often considered a contraindication to intravesical therapy for nonmuscle-invasive bladder cancer(NMIBC).A tailored intravesical bacillus Calmette-guérin(BCg)procedure was evaluated in high-risk(HR)-NMIBC patients with severe functional *** and methods:Patients with a Katz Index score of 2 or less and an initial diagnosis of HR-NMIBC with atraumatic insertion of a Foley-type indwelling catheter,bladder emptying,and BCg instillation were prospectively treated;after 2 hours,the bladder was emptied and the catheter was removed(group A).After propensity score matching,52 patients in group A were compared with that of 52 consecutive patients in group B using a retrospective database,with similar baseline/oncological characteristics and treated with standard intermittent ***,groups A and B were compared with that of 130 consecutive patients(group C)retrospectively evaluated,with similar oncological characteristics but with a Katz Index score of 3 or greater and treated with standard intermittent ***:The discontinuation rates were 11.5%,35%,and 9%in groups A,B,and C,respectively(A vs.B,log-rank score 42.52[po0.05]).The overall adverse event rates were 38.5%,57.7%,and 39.2%,respectively(A vs.B,p=0.04;B vs.C,0.03;A vs.C,0.92).The rates of severe adverse events were 1.9%,1.9%,and 1.5%,respectively,without statistically significant *** cumulative HR disease-free survival rates were 63.4%,48%,and 69.2%,respectively(A vs.B,log-rank score 154.9[pg discontinuation and adverse effects.

关键词： Intravesical bacillus Calmette-guérin Discontinuation rate Adverse event Tailored procedure Severe functional impairment

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

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中国物理C:英文版 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels g.bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev g.Benane g.Bencivenni E.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc J.E.Blank S.Blusk D.Bobulska J.A.Boelhauve O.Boente garcia T.Boettcher A.Boldyrev C.S.Bolognani R.Bolzonella N.Bondar F.Borgato S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone g.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary g.Casse M.Cattaneo g.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.g.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal g.Ciezarek g.Ciullo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cognera Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AgH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

Enhanced Photoprotection by Protein-Bound vs Free Xanthophyll Pools： A Comparative Analysis of Chlorophyll b and Xanthophyll Biosynthesis Mutants

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Molecular Plant 2010年第3期3卷 576-593页

作者： Luca Dall'Osto Stefano Cazzaniga Michel Havaux Roberto bassi Dipartimento di Biotecnologie Universita di Verona Strada Le Grazie 15 37134 Verona Italy CEA IBEB SBVME Laboratoire d'Ecophysiologie Moldculaire des Plantes 13108 Saint-Paul-lez-Durance France CNRS UMR Biologie Vegetale et Microbiologie Environnementales 13108 Saint-Paul-lez-Durance France Universite Aix-Marseille 13108 Saint-Paul-lez-Durance France

When light absorbed by plants exceeds the capacity of photosynthesis, the xanthophyll violaxanthin is reversibly de-epoxidized to zeaxanthin in the so-called xanthophyll cycle. Zeaxanthin plays a key role in the protection of photosynthetic organisms against excess light, by promoting rapidly reversible （qE） and long-term （ql） quenching of excited chlorophylls, and preventing lipid oxidation. The photoprotective role of zeaxanthin, either free or bound to light-harvesting complexes （Lhcs）, has been investigated by using mutants lacking Chl b （chl） and/or specific xanthophyll species （npq, lut2）. The chl mutation causes （1） the absence of Lhcb proteins; （2） strong reduction of the feedback deexcitation （qE）; and （3） accumulation of xanthophylls as free pigments into thylakoids. Chl mutants showed extreme sensitivity to photo-oxidative stress in high light, due to higher singlet oxygen （102） release. The double mutant chlnpql was more sensitive to photo-oxidation than chl, showing that zeaxanthin does protect lipids even when free in the membrane. Nevertheless, lack of zeaxanthin had a much stronger impact on the level of lipid peroxidation in Lhcs-containing plants （WTvs npql） with respect to Lhc-less plants （chl vs chlnpql）, implying that its protective effect is enhanced by interaction with antenna proteins. It is proposed that the antioxidant capacity of zeaxanthin is empowered in the presence of PSII- LHCs-Zea complexes, while its effect on enhancement of qE only provides a minor contribution. Comparison of the sensitivity of WT vs npql plants to exogenous 102 suggests that besides the scavenging of 102, at least one additional mechanism is involved in chloroplast photoprotection.

关键词： Zeaxanthin singlet oxygen photoprotection chloroplast light-harvesting complexes.

Consumer attitudes towards the mountain product label: Implications for mountain development

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Journal of Mountain Science 2021年第9期18卷 2255-2272页

作者： bassi Ivana CARZEDDA Matteo gRASSETTI Luca ISEPPI Luca NASSIVERA Federico Department of Agricultural FoodEnvironmental and Animal SciencesUniversity of Udinevia delle Scienze 206UdineItaly Department of Economics BusinessMathematics and StatisticsUniversity of Triestevia Tigor 22TriesteItaly Department of Economics and Statistics University of Udinevia Tomadini 30/AUdineItaly

To protect and promote the originality and authenticity of mountain foodstuffs, the European Union set Regulation No 1151/2012 to create the optional quality term "mountain product". Our research aimed at exploring the attractiveness of the mountain product label for consumers, considering both attitude towards the label itself and purchase intentions. We propose a model to investigate relationships between four latent constructs-mountain attractiveness, mountain food attractiveness, attitude towards the mountain product label, and purchase intention-which have been tested, thus confirming the statistical relevance of the relationships. All 47 items selected for describing the latent constructs are suitable for this purpose. Ridge and LASSO results also show that 17 items of the first three constructs are relevant in explaining purchase intentions. Some contextual variables, such as age, income, geographical origin of consumers, and knowledge of mountain products and mountains for tourism purposes, can positively influence consumers’ behavior. These findings could support the design of mountain development strategies, in particular marketing actions for both the product and the territory.

关键词： Mountain product label Consumer attitudes Purchase intentions Structural Equation Model(SEM) LASSO regression

Computed tomography-based radiomic to predict resectability in locally advanced pancreatic cancer treated with chemotherapy and radiotherapy

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World Journal of gastrointestinal Oncology 2022年第3期14卷 703-715页

作者： gabriella Rossi Luisa Altabella Nicola Simoni giulio Benetti Roberto Rossi Martina Venezia Salvatore Paiella giuseppe Malleo Roberto Salvia Stefania guariglia Claudio bassi Carlo Cavedon Renzo Mazzarotto Department of Radiation Oncology University of Verona Hospital TrustVerona 37126Italy Department of Medical Physics University of Verona Hospital TrustVerona 37126Italy Department of general and Pancreatic Surgery Pancreas InstituteUniversity of Verona Hospital TrustVerona 37126Italy

BACKgROUND Surgical resection after neoadjuvant treatment is the main driver for improved survival in locally advanced pancreatic cancer(LAPC).However,the diagnostic performance of computed tomography(CT)imaging to evaluate the residual tumour burden at restaging after neoadjuvant therapy is low due to the difficulty in distinguishing neoplastic tissue from fibrous scar or *** this context,radiomics has gained popularity over conventional imaging as a complementary clinical tool capable of providing additional,unprecedented information regarding the intratumor heterogeneity and the residual neoplastic tissue,potentially serving in the therapeutic decision-making *** To assess the capability of radiomic features to predict surgical resection in LAPC treated with neoadjuvant chemotherapy and *** Patients with LAPC treated with intensive chemotherapy followed by ablative radiation therapy were retrospectively *** thousand six hundred and fifty-five radiomic features were extracted from planning CT inside the gross tumour *** extracted features and clinical data contribute to create and validate the predictive model of resectability *** were repeatedly divided into training and validation *** discriminating performance of each model,obtained applying a LASSO regression analysis,was assessed with the area under the receiver operating characteristic curve(AUC).The validated model was applied to the entire dataset to obtain the most significant *** Seventy-one patients were included in the *** age was 65 years and 57.8%of patients were *** patients underwent induction chemotherapy followed by ablative radiotherapy,and 19(26.8%)ultimately received surgical *** the first step of variable selections,a predictive model of resectability was developed with a median AUC for training and validation sets of 0.862(95%CI:0.792-0.921)and 0.853(95%CI:0.706-0.960),respectivel

关键词： Computed tomography Radiomics Predictive model Resectability Locally advanced pancreatic cancer Radiation oncology

Python for bioinformatics

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Retrograde Signaling and Photoprotection in a gun4 Mutant of Chlamydomonas reinhardtii

2010年

作者： Sebastian bassi.

Includes bibliographical references and index.

ISBN: (纸本)9781584889298;1584889292

Includes bibliographical references and index.

关键词： Bioinformatics Python (Computer program language

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Molecular Plant 2012年第6期5卷 1242-1262页

作者： Cinzia Formighieri Mauro Ceol giulia Bonente Jean-David Rochaix Roberto bassi Dipartimento di Biotecnologie Universita di Verona Strada Le Grazie 15 1-37134 Verona Italy Departments of Molecular Biology and Plant Biology University of Geneva Sciences Ⅲ 30 Quai Ernest-Ansermet CH-1211 Geneva 4 Switzerland

gUN4 is a regulatory subunit of Mg-chelatase involved in the control of tetrapyrrole synthesis in plants and cyanobacteria. Here, we report the first characterization of a gun4 insertion mutant of the unicellular green alga Chlamydomonas reinhardtii. The mutant contains 50% of chlorophyll as compared to wild-type and accumulates ProtolX. In contrast to the increase in LHCtranscription, the accumulation of most LHC proteins is drastically diminished, implying posttranscriptional down-regulation in the absence of transcriptional coordination. We found that 803 genes change their expression level in gun4 as compared to wild-type, by RNA-Seq, and this wide-ranging effect on transcription is apparent under physiological conditions. Besides LHCs, we identified transcripts encoding enzymes of the tetrapyrrole pathway and factors involved in signal transduction, transcription, and chromatin remodeling. Moreover, we observe perturbations in electron transport with a strongly decreased PSI-to-PSII ratio. This is accompanied by an enhanced activ- ity of the plastid terminal oxidase （PTOX） that could have a physiological role in decreasing photosystem II excitation pressure.

关键词： green algae Chlamydomonas genome uncoupled (gun) mutants gun4 retrograde signaling PTOX.