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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping.over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping.over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of g.otechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of g.otechnical structures *** understanding.of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of g.otechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level g.ound site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading.on field-scale g.otechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake g.otechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

EVALuaTIoN oF SMART BooSTER FANS AND DAMPERS FoR ADVANCED HVAC SYSTEMS

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Journal of green Building 2021年第2期16卷 115-127页

作者： Behdad Rezanejadzanjani Paul g.o’Brien Department of Mechanical Engineering Lassonde School of EngineeringYork University 4700 Keele St.TorontoONM3J 1P3Canada

There is potential to significantly reduce Co_(2) emissions by increasing the efficiency and reducing the duty cycle of HVAC systems by using smart booster fans and *** booster fans fit in the vents within a home,operating quietly on low power(2W)to augment HVAC systems and improve their *** this study,a prototype duct system is used to measure and evaluate the ability for smart booster fans and dampers to control airflow to different vents for the purpose of increasing the efficiency of HVAC *** case studies were evaluated:an HVAC system(1)without any fans or dampers,(2)with a fan installed in one vent,but without any dampers,(3)with dampers installed at the vents,but without any fans,and(4)with both fan and dampers *** results from both the experi-mental and numerical evaluation show that the smart booster fan and dampers can significantly improve the airflow at a vent that is *** example,the airflow at the last vent in a ducting branch was increased from 17 to 37 CFM when a smart booster fan was installed at this *** from the numerical analysis show that for the case of an underperforming vent during the winter season the HVAC running time may be reduced from 24 hr/day to 5.6 hr/***,results from the numerical analysis show the HVAC running time is further reduced to 4.5 hr/day for cases 3 and 4.

关键词： HVAC efficiency smart booster fans smart dampers airflow at HVAC vents HVAC duty cycles computational fluid dynamics(CFD)

Projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： Lawrence g.Brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semig.oup,we show that the Cuntz semig.oup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Interpretation of pipe-jacking and lubrication records for drives in silty soil

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Underg.ound Space 2020年第3期5卷 199-209页

作者： Kevin g.o’Dwyer Bryan A.McCabe Brian B.Sheil Civil Engineering College of Engineering and InformaticsNational University of IrelandGalwayIreland Department of Engineering Science University of OxfordUnited Kingdom

In recent years,there has been an increased resort to microtunnelling/pipe-jacking as a means of constructing underg.ound conduits(for water,sewage,gas,and other utilities)to avoid on-street disruption in urban *** this paper,technical details of two 1200 mm internal diameter microtunnels in silty sand totalling.over 550 m in length are *** average skin friction values are extremely low for both drives suggesting effective lubrication practice,differences in normalised bentonite volumes appear to be responsible for differences in skin *** or near full buoyancy of the pipeline has been demonstrated for the majority of the *** frictional stress increase after a stoppage is shown to depend on not only the stoppage duration but also on the normalised lubrication *** of data in the manner presented in the paper is an important means of assimilating experience of microtunnelling in different g.ound conditions.

关键词： Microtunnelling Pipe-jacking Skin friction Lubrication Pipe buoyancy Stoppages

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diag.osis of *** evolution of AD diag.ostic criteria to include biological characterization(Alzheimer’s Association Working g.oup,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diag.ostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diag.oses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diag.osis

Dominant species of mid-elevation grasslands of the uKhahlamba-Drakensberg Park are predicted to be largely immune to climate change

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Journal of Mountain Science 2023年第9期20卷 2468-2486页

作者： Debbie JEWITT Craig D.MoRRIS Tim g.o’CoNNoR Michelle J.TEDDER Ezemvelo KZN Wildlife Scientific ServicesPO Box 13053Cascades 3202South Africa School of Animal Plant and Environmental SciencesUniversity of the WitwatersrandJohannesburgPrivate Bag X3WITS 2050South Africa Agricultural Research Council-Animal Production(ARC-AP) ℅School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa

Anticipating g.obal change impact on natural vegetation,especially in poorly researched systems,requires an understanding.of the environmental factors that most strongly influence the organisation of plant communities at different *** environmental relations of plant communities in the Drakensberg mountains of South Africa remain poorly *** study investigated the influence of selected environmental determinants on the dominant species of plant community organisation in this *** order to provide an overview of the influence of the environment on botanical composition and plant diversity,this study,conducted as four discrete exercises,investigated the interplay of altitude,aspect and slope on the abundance of selected species,and to examine the influence of latitude,g.ological substrate and local topography on species *** diversity showed no pattern of response to investigated environmental *** composition was related to temperature and solarradiation *** altitude sites facing east were distinct for non-graminoid *** and latitude exerted a pronounced effect on species composition,confounded by longitude and precipitation *** substrate,in concert with slope steepness and orientation,influenced composition,restricting the abundance but not distribution of some *** individualistic responses were found for C_3,C_4,and non-graminoid species in relation to altitude,slope and *** and aspect mediate the effects of altitude and hence temperature for some *** study has demonstrated the complexity of drivers influencing species and compositional distribution in the Drakensberg and permits a preliminary consideration of potential changes in the composition and dominance structure of mid-elevation grasslands in response to climate *** dominant grass species were widespread across environmental gradients,occupying currently warm,cool,moist and dry habitats

关键词： Drakensberg Environmental gradients grasslands Mountain biodiversity Vegetation