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Role of symptoms in diagnosis and outcome of gastric cancer

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World Journal of gastroenterology 2008年第8期14卷 1149-1155页

作者： giovanni Maconi gianpiero Manes gabriele bianchi Porro Department of Clinical Sciences Chair of Gastroenterology L. Sacco University Hospital Via G.B. Grassi 74 Milan 20157 Italy

gastric cancer is one of the most common cancers and the second most common cause of cancer deaths worldwide. Apart from Japan, where screening programmes have resulted in early diagnosis in asymptomatic patients, in most countries the diagnosis of gastric cancers is invariably made on account on dyspeptic and alarm symptoms, which may also be of prognostic significance when reported by the patient at diagnosis. However, their use as selection criteria for endoscopy seems to be inconsistent since alarm symptoms are not sufficiently sensitive to detect malignancies. In fact, the overall prevalence of these symptoms in dyspeptic patients is high, while the prevalence of gastro-intestinal cancer is very low. Moreover, symptoms of early stage cancer may be indistinguishable from those of benign dyspepsia, while the presence of alarm symptoms may imply an advanced and often inoperable disease. The features of dyspeptic and alarm symptoms may reflect the pathology of the tumour and be of prognostic value in suggesting site, stage and aggressiveness of cancer. Alarm symptoms in gastric cancer are independently related to survival and an increased number, as well as specific alarm symptoms, are closely correlated to the risk of ***, weight loss and a palpable abdominal mass appear to be major independent prognostic factors in gastric cancer, while gastro-intestinal bleeding, vomiting and also duration of symptoms, do not seem to have a relevant prognostic impact on survival in gastric cancer.

关键词： gastric cancer Symptoms Diagnosis Survival Cancer stage Alarm symptoms Dyspepsia

A New Hypothesis on the Dark Matter

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Journal of High Energy Physics, gravitation and Cosmology 2021年第2期7卷 572-594页

作者： A. bianchi g. guido The Extreme Energy Events (EEE) Project at the High Scholls “Gandini” Lodi Milano Italy The EEE Project at the High Scholl “C. Cavalleri” Parabiago Milano Italy

In this paper, using the AgM model (Aureum geometric Model), where geometric structures of coupled quantum oscillators represent particles, we formulate a new hypothesis about the origin of the Dark Matter (DM). Highlighting its hadronic nature, we identify the representative particle’s particular geometric structure, the “dark pion”, and calculate its mass. Finally, we propose an experiment for the detection of this particle.

关键词： Quark Dark Matter Structure Equation geometric Structure golden Number Interpenetration IQuO gluon Pion Dark Pion Dark Proton

Exploring the Potentialities of Automatic Extraction of University Webometric Information

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Journal of Data and Information Science 2020年第4期5卷 43-55页

作者： gianpiero bianchi Renato Bruni Cinzia Daraio Antonio Laureti Palma giulio Perani Francesco Scalfati ISTAT Italian National Institute of StatisticsVia Cesare Balbo 16Rome 00184Italy DIAg Sapienza University of RomeVia Ariosto 25Rome 00185Italy

Purpose:The main objective of this work is to show the potentialities of recently developed approaches for automatic knowledge extraction directly from the universities’*** information automatically extracted can be potentially updated with a frequency higher than once per year,and be safe from manipulations or ***,this approach allows us flexibility in collecting indicators about the efficiency of universities’websites and their effectiveness in disseminating key *** new indicators can complement traditional indicators of scientific research(*** of articles and number of citations)and teaching(*** of students and graduates)by introducing further dimensions to allow new insights for“profiling”the analyzed ***/methodology/approach:Webometrics relies on web mining methods and techniques to perform quantitative analyses of the *** study implements an advanced application of the webometric approach,exploiting all the three categories of web mining:web content mining;web structure mining;web usage *** information to compute our indicators has been extracted from the universities’websites by using web scraping and text mining *** scraped information has been stored in a NoSQL DB according to a semistructured form to allow for retrieving information efficiently by text mining *** provides increased flexibility in the design of new indicators,opening the door to new types of *** data have also been collected by means of batch interrogations of search engines(Bing,***)or from a leading provider of Web analytics(SimilarWeb,http://***).The information extracted from the Web has been combined with the University structural information taken from the European Tertiary Education Register(https://***/#/home),a database collecting information on Higher Education Institutions(HEIs)at European *** the above was used to perfo

关键词： Development of data and information services Webometrics indicators Higher education institutions Automatic extraction Machine learning Optimization

Diurnal variation of precipitable water vapor over Central and South America

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geodesy and geodynamics 2020年第6期11卷 426-441页

作者： Amalia Meza Luciano Mendoza María Paula Natali Clara bianchi Laura Fernández Laboratorio de Meteorología espacial Atmosfera terrestreGeodesiaGeodinamicadiseno de Instrumentaly Astrometría(MAGGIA)Facultad de Ciencias Astronomicasy Geofísicas(FCAG)Universidad Nacional de La Plata(UNLP)Paseo del Bosque s/nB1900FWALa Plata(UNLP)Paseo del Bosque s/nB1900FWALa PlataArgentina Consejo Nacional de Investigacion Científicay Tecnica Godoy Cruz 2290C1425FQBBuenos AiresArgentina

Annual and seasonal diurnal precipitable water vapor(PWV)variations over Central and South America are analyzed for the period *** values were obtained from global Navigation Satellite Systems(gNSS)observations of sixty-nine gNSS tracking *** by climate categories show that PWV values for temperate,polar and cold dry climate have a positive skewed distribution and for tropical climates(except for monsoon subtype)show a negative skewed *** diurnal PWV and surface temperatures(T)anomaly datasets are analyzed by using principal components analysis(PCA).The first two modes represent more than 90%of the PWV *** first PCA mode of PWV variability shows a maximum amplitude value in the late afternoon few hours later than the respective values for surface temperature(T),therefore the temperature and the surface conditions(to yield evaporation)could be the main agents producing this variability;PWV variability in inland stations are mainly represented by this *** second mode of PWV variability shows a maximum amplitude at midnight,a possible explanation of this behavior is the effect of the sea/valley *** coastal and valley stations are affected by this mode in most ***,the"undefined"stations,surrounded by several water bodies,are mainly affected by the second mode with negative *** the seasonal analysis,both the undefined and valley stations constitute the main cases that show a sea or valley breeze only during some seasons,while the rest of the year they present a behavior according to their temperature and the surface *** a result,the PCA proves to be a useful numerical tool to represent the main sub-daily PWV variabilities.

关键词： Precipitable water vapor(PWV) global navigation satellite systems(gNSS) Koppen and geiger climate type classification(K-g) Surface temperature Principal component analysis(PCA)

Procoagulant activity of circulating microparticles is associated with the presence of moderate calcified plaque burden detected by multislice computed tomography

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Journal of geriatric Cardiology 2014年第1期11卷 13-19页

作者： Serena Del Turco giuseppina Basta Alessandro Mazzarisi Debora Battaglia Teresa Navarra Michele Coceani Massimiliano bianchi Mathis Schlueter Paolo Marraccini Institute of Clinical Physiology CNR San Cataldo Research Area Via Moruzzi 1 56124 Pisa Italy Fondazione g. Monasterio CNR-Regione Toscana Via Moruzzi 1 56124 Pisa Italy

Background Circulating microparticles （MPs） have been reported to be associated with coronary artery disease （CAD）. In this study, we explored the relationship between MPs procoagulant activity and characteristics of atherosclerotic plaque detected by 64-slice computed tomography angiography （CTA）. Methods In 127 consecutive patients with CAD but without acute coronary syndrome and who under went 64-slice CTA, MPs procoagulant activity in plasma Coy a thrombin generation test）, soluble form of lectin-like oxidized low-density lipoprotein receptor-1 （sLOX-1） and N（epsilon）-（carboxymethyl） lysine （CML） circulating levels （by ELISA） were measured. A quantitative volumetric analysis of the lumen and plaque burden of the vessel wall （soft and calcific components）, for the three major coronary vessels, was performed. The patients were classified in three groups according to the presence of calcium volume： non-calcified plaque （NCP） group （calcium volume （%） = 0）, moderate calcified plaque （MCP） group （0 〈 calcium volume （%）〈 1）, and calcified plaque （CP） group （calcium volume （%）〉 1）. Results MPs procoagulant activity and CML levels were higher in MCP group than in CP or NCP group （P = 0.009 and P = 0.027, respectively）. MPs procoagulant activity was positively associated with CML （r = 0.317, P 〈 0.0001） and sLOX-1 levels （r = 0.216, P = 0.0025）. Conclusions MPs procoagulant activity was higher in the MCP patient group and correlated positively with sLOX-1 and CML levels, suggesting that it may characterize a state of blood vulnerability that may locally precipitate plaque instability and increase the risk of subsequent major cardiovascular events.

关键词： Computed tomograpby Micropanicles Low density lipoprotein Lysine Coronary artery disease

Scaling Notebooks as Re-configurable Cloud Workflows

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Data Intelligence 2022年第2期4卷 409-425页

作者： Yuandou Wang Spiros Koulouzis Riccardo bianchi Na Li Yifang Shi Joris Timmermans W.Daniel Kissling Zhiming Zhao Multiscale Networked Systems Informatics InstituteUniversity of Amsterdam1098XH AmsterdamThe Netherlands Life Watch ERIC Virtual Lab&InnovationCenter(VLIC)Science Park 9041098XH AmsterdamThe Netherlands Institute for Biodiversity and Ecosystem Dynamics(IBED) 1098xH AmsterdamThe Netherlands

Literate computing environments,such as the Jupyter(i.e.,Jupyter Notebooks,JupyterLab,and JupyterHub),have been widely used in scientific studies;they allow users to interactively develop scientific code,test algorithms,and describe the scientific narratives of the experiments in an integrated *** scale up scientific analyses,many implemented Jupyter environment architectures encapsulate the whole Jupyter notebooks as reproducible units and autoscale them on dedicated remote infrastructures(e.g.,highperformance computing and cloud computing environments).The existing solutions are stl limited in many ways,e.g.,1)the workflow(or pipeline)is implicit in a notebook,and some steps can be generically used by different code and executed in parallel,but because of the tight cell structure,all steps in the Jupyter notebook have to be executed sequentially and lack of the flexibility of reusing the core code fragments,and 2)there are performance bottlenecks that need to improve the parallelism and scalability when handling extensive input data and complex *** this work,we focus on how to manage the workflow in a notebook *** 1)encapsulate the reusable cells as RESTful services and containerize them as portal components,2)provide a composition tool for describing workflow logic of those reusable components,and 3)automate the execution on remote cloud ***,we validate the solution's usability via a use case from the Ecology and Earth Science domain,illustrating the processing of massive Light Detection and Ranging(LiDAR)*** demonstration and analysis show that our method is feasible,but that it needs further improvement,especially on integrating distributed workflow scheduling,automatic deployment,and execution to develop as a mature approach.

关键词： Scientific experiments Jupyter Notebooks Workflow management Ecosystem structure data products Cloud Scalability

Functionalized liposomes for targeted breast cancer drug delivery

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Bioactive Materials 2023年第6期24卷 401-437页

作者： Janske Nel Kamil Elkhoury Émilie Velot Arnaud bianchi Samir Acherar grégory Francius Ali Tamayol Stéphanie grandemange Elmira Arab-Tehrany Universitéde Lorraine LIBioF-54000NancyFrance LAAS-CNRS F-31400ToulouseFrance Universitéde Lorraine CNRSIMoPAF-54000NancyFrance Universitéde Lorraine CNRSLCPMF-54000NancyFrance Universitéde Lorraine CNRSLCPMEF-54000NancyFrance Department of Biomedical Engineering University of Connecticut Health CenterFarmingtonCT06030USA Universitéde Lorraine CNRSCRANF-54000NancyFrance

Despite the exceptional progress in breast cancer pathogenesis,prognosis,diagnosis,and treatment strategies,it remains a prominent cause of female mortality ***,although chemotherapies are effective,they are associated with critical limitations,most notably their lack of specificity resulting in systemic toxicity and the eventual development of multi-drug resistance(MDR)cancer *** have proven to be an invaluable drug delivery system but of the multitudes of liposomal systems developed every year only a few have been approved for clinical use,none of which employ active *** this review,we summarize the most recent strategies in development for actively targeted liposomal drug delivery systems for surface,transmembrane and internal cell receptors,enzymes,direct cell targeting and dual-targeting of breast cancer and breast cancer-associated cells,e.g.,cancer stem cells,cells associated with the tumor microenvironment,etc.

关键词： Liposomes Breast cancer Anti-cancer agents Targeted drug delivery Surface functionalization Receptor-targeted drug delivery

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精练自动化技术方面的进展

丝绸 1989年第1期26卷 46-47页

作者： A.Svilokos bianchi g.M.Colonna 朱克敏意大利丝绸实验站

在丝绸精练中引入粉状或液状洗涤剂以取代传统的肥皂,导致精练浴使用时间的延长和连续精练法的推广。依靠测定pH来控制练浴,通常被认为是有效的,但在新的处理条件下则是无能为力的。应一家工业集团的请求,我们在丝绸实验站内进行研究,... 详细信息

在丝绸精练中引入粉状或液状洗涤剂以取代传统的肥皂,导致精练浴使用时间的延长和连续精练法的推广。依靠测定pH来控制练浴,通常被认为是有效的,但在新的处理条件下则是无能为力的。应一家工业集团的请求,我们在丝绸实验站内进行研究,寻找一种易于测定的、可替代pH的参数,它适用于工业生产和过程自动化。在研究的第一阶段。

关键词：精练自动化丝绸

bianchi type I in f(T) gravitational theories

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Chinese Physics B 2016年第5期25卷 58-64页

作者： M I Wanas g g L Nashed O A Ibrahim Astronomy Department Faculty of Science Cairo University Cairo Egypt Centre for Theoretical Physics The British University in Egypt El-Sherouk City Egypt Mathematics Department Faculty of Science Ain Shams University Cairo Egypt Egyptian Relativity group (ERg) Giza Egypt

A tetrad field that is homogeneous and anisotropic which contains two unknown functions A（t） and B（t） of cosmic time is applied to the field equations of f（T）, where T is the torsion scalar, T = T~μ_（νρ）S_μ^（νρ）. We calculate the equation of continuity and rewrite it as a product of two brackets, the first is a function of f（T） and the second is a function of the two unknowns A（t） and B（t）. We use two different relations between the two unknown functions A（t） and B（t） in the second bracket to solve it. Both of these relations give constant scalar torsion and solutions coincide with the de Sitter one. So,another assumption related to the contents of the matter fields is postulated. This assumption enables us to drive a solution with a non-constant value of the scalar torsion and a form of f（T） which represents ΛCDM.

关键词： f(T) gravitational theory bianchi type I special solutions