检索结果-南通市图书馆

Revisiting cerebral endothelial cells in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

经导管动脉栓塞治疗40例植入性胎盘伴有相关的产后出血

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2013年第3期 290-290页

作者： s.M.Hwang g.s.jeon M.D.Kim s.H.Kim J.T.Lee M.J.Choi 尹学青 Department of Radiology CHA Bundang Medical CenterCHA University

目的评价盆腔动脉栓塞术(PAE)治疗急性难治性植入性胎盘(PA)伴有相关的产后出血(PPH)的价值。方法对植入性胎盘产后出血行动脉栓塞的40例病人进行回顾性研究。回顾了分娩和盆腔动脉栓塞的治疗过程。通过电话方式随访髂动脉栓塞术后的效... 详细信息

目的评价盆腔动脉栓塞术(PAE)治疗急性难治性植入性胎盘(PA)伴有相关的产后出血(PPH)的价值。方法对植入性胎盘产后出血行动脉栓塞的40例病人进行回顾性研究。回顾了分娩和盆腔动脉栓塞的治疗过程。通过电话方式随访髂动脉栓塞术后的效果。结果所有病人栓塞术均成功(100%)。最初的临床治愈率为82.5%(33/40)。3例病人在栓塞术后未能成功止血,于栓塞术后24h内进行了子宫切除,3例病人进行了再次栓塞术(2例在栓塞术后2d行再次栓塞,1例在首次栓塞术后6h行再栓塞),病人出血最终得以控制。临床成功率为92.5%。有4例病人术后立即出现了并发症,例如骨盆疼痛、恶心、荨麻疹。有3例出现较轻的远期并发症,即短时期的停经。病人均未出现较严重的远期并发症。有35例栓塞术后恢复了正常月经,包括2例单纯妊娠。1例病人尽管栓塞术成功止血,但因出现弥漫性血管内出血及脑内出血而死亡。结论 PAE可以安全有效地治疗很多PA伴有相关的PPH,许多病人可以避免切除子宫。PAE很少有严重并发症。要点①PAE是治疗产后出血的一种重要治疗方法。②PAE治疗PA伴PPH可能是安全和有效的。③PAE治疗保留子宫功能,不影响月经。④PAE很少有严重的并发症。

关键词：产后出血经血管栓塞术植入性胎盘保留生育能力并发症

A systematic review of progenitor survival and maturation in Parkinsonian models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： giulia Comini Eilís Dowd Pharmacology&Therapeutics and galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain gabriele Univ.grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNs),have attracted considerable attention in conditions where cortical spreading depolarizations(CsDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CsDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CsDs,particularly emphasizing TNs,and to underscore TNs’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

A Novel Framework to Construct s-Box Quantum Circuits Using system Modeling: Application to 4-Bit s-Boxes

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & sciences 2024年第10期141卷 545-561页

作者： Yongjin jeon seungjun Baek Jongsung Kim Department of Financial Information security Kookmin UniversitySeoul02707Republic of Korea

Quantum computers accelerate many algorithms based on the superposition principle of quantum *** grover algorithm provides significant performance to malicious users attacking symmetric key *** the performance of attacks using quantum computers depends on the efficiency of the quantum circuit of the encryption algorithms,research research on the implementation of quantum circuits is *** paper presents a new framework to construct quantum circuits of substitution boxes(s-boxes)using system *** model the quantum circuits of s-boxes using two layers:Toffoli and linear *** generate vector spaces based on the values of qubits used in the linear layers and apply them to find quantum *** framework finds the circuit bymatching elements of vector spaces generated fromthe input and output of a given s-box,using the forward search or themeet-in-the-middle *** developed a tool to apply this framework to 4-bit *** the 4-bit s-box quantum circuit construction tool LIgHTER-R only finds circuits that can be implemented with four qubits,the proposed tool achieves the circuits with five *** proposed tool can find quantum circuits of 4-bit odd permutations based on the controlled NOT,NOT,and Toffoli gates,whereas LIgHTER-R is unable to perform this task in the same *** expect this technique to become a critical step toward optimizing s-box quantum circuits.

关键词： system modeling quantum circuit s-box circuit quantum computer

Understanding activity of butyrate at a cellular level

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber