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The First Pilot Epigenetic Type Improvement of Neuropsychiatric symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/g), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAs/CANs: Positive Clinical Outcome with Precision-guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron Ashim gupta shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino Drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy sunder Kevin Murphy Nicole jafari Foojan Zeine Paul R. Carney Mark s. gold Kai-Uwe Lewandowski Alireza sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management science and statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAs/CANs) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency syndrome (RDs) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYgEN®) to help induce “dopamine homeostasis” in patients with PANDAs, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (gARs) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/g), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYgEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAs CANs genetic Addiction Risk Testing (gARs) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

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复合圆柱形壳在径向冲击荷载和轴压荷载作用下的瞬时动力响应

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钢结构 2008年第7期23卷 76-76页

作者： A.A. jafari s.M.R. Khalili R. Azarafza

基于首次逼近理论,利用第一阶剪切变形理论对圆柱形壳的自由和强迫振动进行分析。边界条件(BCs)考虑为悬臂状态。分析复合壳体在横向冲击和轴向压力作用下的动力响应(轴压荷载小于临界屈曲荷载),同时对复合柱形壳进行了建模分析。利用... 详细信息

基于首次逼近理论,利用第一阶剪切变形理论对圆柱形壳的自由和强迫振动进行分析。边界条件(BCs)考虑为悬臂状态。分析复合壳体在横向冲击和轴向压力作用下的动力响应(轴压荷载小于临界屈曲荷载),同时对复合柱形壳进行了建模分析。利用卷积积分对给定荷载状况下的壳体进行分析。揭示纤维方向、轴向荷载及一些几何参数对壳体时间响应的影响。结果表明:动力响应主要由结构的自振周期所控制。

关键词：强迫振动复合柱形壳轴向荷载动力响应

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一项随机、前瞻性、双盲试验：比较3％氯普鲁卡因随即0．5％布比卡因与2％利多卡因随即0．5％布比卡因用于肌间沟臂丛阻滞

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麻醉与镇痛 2011年第5期7卷 30-33页

作者： soheila jafari, MD Allison I. Kalstein, DO Habib M. Nasrullah, MD Mehrdad Hedayamia, MD Joel M. Yarmush, MD Joseph schianodiCola, MD 闫红林（译） Department of Anesthesiology New York Methodist Hospital Brooldyn New York. 不详

背景早前曾将2-氯普鲁卡因和布比卡因（C／B）联合用于区域麻醉，但因效果不确定而放弃。在这项前瞻性、双盲、随机研究中，我们比较了C／B联合-9利多卡因／布比卡因（L／B）联合的肌间沟阻滞的起效。方法30例拟在肌间沟阻滞下行肩关节... 详细信息

背景早前曾将2-氯普鲁卡因和布比卡因（C／B）联合用于区域麻醉，但因效果不确定而放弃。在这项前瞻性、双盲、随机研究中，我们比较了C／B联合-9利多卡因／布比卡因（L／B）联合的肌间沟阻滞的起效。方法30例拟在肌间沟阻滞下行肩关节镜术患者被分为2组，每组15例。一组（C／B）接受含有碳酸氢钠和肾上腺素的3％2．氯普鲁卡因，随即接受含肾上腺素的0．5％布比卡因；另一组（L／B）接受2％利多卡因而不用3％2．氯普鲁卡因。每15秒评估一次运动和感觉阻滞。主要的观察终点是完全运动阻滞的起效时间。使用时间-事件（生存率）统计分析检验。结果L／B组1例阻滞失败，被排除。C／B和L／B运动阻滞的中位数时间分别为90秒（15—575秒）和180秒（15．3720秒）（P=0．0325），C／B和L／B的感觉阻滞中位数时间分别为90秒（30～600秒）和210秒（30—3900秒）（P=0．0185）。生存分析显示，在第5分钟，C／B组15例患者中13例产生了成功的运动阻滞，而L／B组14例患者中只有7例。在第10分钟，C／B组15例患者全部产生了成功的运动阻滞，而L／B组14例中只有10例。对L／B组阻滞成功或失败的评价需时60分钟。结论本研究证明，肌间沟阻滞C／B比L／B较快达到成功阻滞。

关键词：肌间沟臂丛阻滞氯普鲁卡因布比卡因利多卡因双盲试验随机研究肌间沟阻滞运动阻滞

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