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Existing Case of Transportation System in Turkey and Transportation Trends in Istanbul

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Journal of Traffic and Transportation Engineering 2024年第5期12卷 248-253页

作者： Mehmet Çağrı Kızıltaş Vail Karakale Istanbul Ticaret University Istanbul 34445Turkey Istanbul Medeniyet University Istanbul 34720Turkey

Transportation sector is one of the most important elements of a country’s economy with its highway,railway,airway and seaway modes,besides the information and communication *** sector has a pattern that affects the society continuously with its economic and social inputs that has a significant role in economies of countries in terms of being an important part of manufacturing process and effects of sizable investments on *** of more comfortable,more reliable,more safe and more punctual transport in developing economy is an arising trend worldwide and this shows an increase the importance of the transportation *** of an efficient and functional transportation system is closely related with traffic safety,intermodal integration and balanced modal *** Turkey,an important improvement has been achieved in these issues,but also some basic constitutive problems are still *** constitutional problems can be summarized as providing traffic safety,integration of innovative implementations to transportation system,enhancing of infrastructure and an effective usage of existing infrastructure.

关键词： Traffic safety modal share railways transportation system transportation policies

Clindamycin-induced acute cholestatic hepatitis

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World Journal of gastroenterology 2007年第40期13卷 5408-5410页

作者： Cem Aygün Orhan Kocaman Yesim g.rbüz mer Sentürk Sadettin Hülagü Department of gastroenterology Pathology Kocaeli University Medical FacultyKocaeli 41380Turkey

We report a case of acute hepatotoxicity in a 42-yearold woman after administration of clindamycin for a dental infection. After 6 d of treatment, she had fatigue, nausea, vomiting, anorexia, pruritus and jaundice. Her laboratory analysis showed alanine aminotransferase （ALT）, 1795 IU/L （normal range 0-40）; aspartate aminotransferase （AST）, 1337 IU/L （normal range 5-34）; alkaline phosphatase （ALP）, 339 IU/L （normal range 40-150）; 7-glutamyl transpeptidase （ggT）, 148 IU/L （normal range 9-64 IU/L）; total bilirubin, 4.1 mg/dL; direct bilirubin, 2.9 mg/dL and prothrombin time （PT）, 13.5 s, with international normalized ratio （INR）, 1.04. She was hospitalized, with immediate drug discontinuation. Her liver biopsy specimen showed mixed-type （both hepatocellular and cholestatic） hepatic injury, compatible with a diagnosis of drug-induced hepatitis. An objective causality assessment using the Naranjo probability scale suggested that clindamycin was the probable cause of the acute hepatitis. In susceptible individuals, clindamycin use may lead to acute mixedtype liver toxicity. Complete recovery may be possible if the drug is discontinued before severe liver injury is established.

关键词： Clindamycin Hepatic injury Hepatitis

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKgROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),gross Motor Function Classification System(gMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).gMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Periodontitis:An often-neglected complication of diabetes

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World Journal of Diabetes 2024年第3期15卷 318-325页

作者： Marina g Kudiyirickal Joseph M Pappachan Primary Care Dental Practice The Smile ClinicPreston PR16PZUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

The bidirectional association between type 2 diabetes mellitus(T2DM)and periodontitis is now well established,resulting in periodontal disease being considered as the 6th major complication of diabetes mellitus(DM)after cardiovascular disease,eye disease,neuropathy,nephropathy,and peripheral vascular *** can worsen the virulence and invasiveness of pathogenic oral microbial flora aggravating the local inflammation and infection in those with periodontal *** the other hand,the chemical and immunological mediators released into the circulation as part of periodontal inflammation worsen the systemic insulin resistance with worsening of *** if undiagnosed or left untreated can also result in eventual tooth loss.A study by Xu et al in the World Journal of Diabetes examined the predictive factors associated with periodontitis in Chinese patients with *** prevalence of periodontitis was found to be 75.7%in this *** on logistic regression analysis,the predictive factors for higher risk were low tooth brushing frequency[odds ratio(OR)=4.3],high triglycerides(Tg;OR=3.31),high total cholesterol(TC;OR=2.87),higher glycated hemoglobin(HbA1c;OR=2.55),and higher age(OR=1.05)while higher education level was protective(OR=0.53).However,the most influential variables were HbA1c followed by age,TC,Tg,low education level,brushing frequency,and sex on the random forest model(this model showed higher sensitivity for predicting the risk).A good understanding of the predictors for periodontitis in T2DM patients is important in prevention,early detection of susceptible patients,and intervention to improve periodontal health and enable long-term glycaemic control as observed by Xu et al.

关键词： Diabetes mellitus Periodontitis Predictive factors Cardiovascular disease glycaemic control

Nonlinear corrections for the nuclear gluon distribution in eA processes

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Chinese Physics C 2024年第3期48卷 52-64页

作者： g.R.Boroun B.Rezaei F.Abdi Department of Physics Razi UniversityKermanshah 67149Iran.

An analytical study with respect to the nonlinear corrections for the nuclear gluon distribution function in the next-to-leading order approximation at small x is *** consider the nonlinear corrections to the nuclear gluon distribution functions at low values of x and Q^(2) using the parametrization F_(2)(x,Q^(2))and the nuclear modification factors obtained from the Khanpour-Soleymaninia-Atashbar-Spiesberger-guzey *** CT18 gluon distribution is used for the baseline proton gluon density at Q^(2)_(0)=*** discuss the behavior of the gluon densities in the next-to-leading order and the next-to-next-to-leading order approximations at the initial scale Q^(2)_(0),as well as the modifications due to the nonlinear *** find that the QCD nonlinear corrections are more significant for the next-to-leading order accuracy than the next-to-next-to-leading order for light and heavy *** results of the nonlinear gLR-MQ evolution equation are similar to those obtained with the Rausch-guzey-Klasen gluon upward and downward evolutions within the *** magnitude of the gluon distribution with the nonlinear corrections increases with a decrease in x and an increase in atomic number A.

关键词： gluon distribution nonlinear corrections light and heavy nuclei low x physics

Numerical study on waste polyethylene pyrolysis driven by self-sustaining smoldering

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Science China(Technological Sciences) 2024年第2期67卷 627-638页

作者： PAN RuMing WU YiBo gUENE LOUgOU Bachirou SHUAI Yong DEBENEST gérald School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institut de Mecanique des Fluides de Toulouse(IMFT)-Universite de Toulouse CNRS-INPT-UPSToulouse 31400France

Polyethylene is the type of waste plastic that accounts for the most significant proportion of municipal solid *** polyethylene can be valorized via pyrolysis and produce value-added oil,gas,and *** the other hand,self-sustaining smoldering is an emerging technical means to deal with sand/soil contaminated by organic *** high-temperature heat generated by smoldering can be used as a heat source for pyrolyzing waste ***,this study investigates numerically the pyrolysis of waste polyethylene driven by self-sustaining smoldering.A novel 4-step lumped kinetic model is proposed for simulating the pyrolysis of waste *** results indicate that the operating parameters can determine the pyrolysis product yields by regulating the pyrolysis temperature and the volatile residence *** that higher temperatures and longer residence times favor the generation of shorter-chain pyrolysis products because of the intensified volatiles’secondary *** can be concluded that a high interface-wall heat transfer coefficient(400 W m^(-2)K^(-1)),a low PE content(0.20),a high char concentration(2.4%),and a moderate air velocity(0.040 m s^(-1))are beneficial to oil *** some extent,this study may broaden the boundaries for the application of self-sustained smoldering-driven pyrolysis.

关键词： self-sustained smoldering waste polyethylene thermal decomposition oil production waste valorization

High CO_(2)permeation using a new Ce_(0.85)gd_(0.15)O_(2-δ)-LaNiO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： Daniela gonzález-Varela JFrancisco gómez-garcía gustavo Tavizon Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico Departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)gd_(0.15)O_(2-δ)-LaNiO_(3)(Cg-LN)composites,where the fluorite-perovskite ratio(Cg:LN)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRD,SEM and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity ***,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were ***,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane ***,the gC80-LN20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation Doped CeO_(2) LaNiO_(3) Impedance Ceramic carbonate membrane

An integrated microfluidic platform for nucleic acid testing

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Microsystems & Nanoengineering 2024年第3期10卷 181-194页

作者： Antao Sun Petra Vopařilová Xiaocheng Liu Bingqian Kou TomášŘezníček TomášLednický Sheng Ni JiříKudr Ondřej zítka zdenka Fohlerová Petr Pajer Haoqing zhang Pavel Neužil Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072P.R.China Department of Chemistry and Biochemistry Mendel University in BrnoZemědělská161300 BrnoCzech Republic ITD Tech s.r.o Osvoboditelů100573581 BohumínCzech Republic Central European Institute of Technology Brno University of TechnologyPurkyňova 123Brno 61200Czech Republic Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Department of Microelectronics Faculty of Electrical Engineering and CommunicationBrno University of TechnologyTechnická3058/10Brno 61600Czech Republic Military Health Institute U Vojenskénemocnice 120016200 Praha 6Czech Republic The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049P.R.China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049P.R.China

This study presents a rapid and versatile low-cost sample-to-answer system for SARS-CoV-2 *** system integrates the extraction and purification of nucleic acids,followed by amplification via either reverse transcriptionquantitative polymerase chain reaction(RT–qPCR)or reverse transcription loop-mediated isothermal amplification(RT–LAMP).By meeting diverse diagnostic and reagent needs,the platform yields testing results that closely align with those of commercial RT-LAMP and RT‒qPCR *** advantages of our system include its speed and *** assay is completed within 28 min,including sample loading(5 min),ribonucleic acid(RNA)extraction(3 min),and RT-LAMP(20 min).The cost of each assay is≈$9.5,and this pricing is competitive against that of Food and Drug Administration(FDA)-approved commercial *** some RNA loss during on-chip extraction is observed,the platform maintains a potential limit of detection lower than 297 *** makes the system particularly useful in environments where centralized laboratories are either unavailable or inconveniently *** key feature is the platform’s versatility,allowing users to choose between RT‒qPCR or RT‒LAMP tests based on specific requirements.

关键词： testing maintain versatile

Use of an immunocapture device to detect cytokine release in discrete brain regions

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Neural Regeneration Research 2024年第4期19卷 703-704页

作者： Matthew g.Frank Michael V.Baratta Department of Integrative Physiology University of Colorado BoulderBoulderCOUSA(Frank MG)Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderCOUSA(Baratta MV)

Production of proinflammatory cytokines in the central nervous system is a key process in the neuroinflammatory response to trauma,infection,and neurodegenerative diseases(Kumar,2019).These intercellular signaling molecules play multiple roles in the immune response in the central nervous system including the orchestration of the sickness response to innate immune perturbations in the brain(Dantzer et al.,2008).

关键词： system release innate