检索结果-南通市图书馆

Heterogeneity of mature oligodendrocytes in the central nervous system

Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.r.wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NMr double resonance study of azide binding to cytochrome c

引用

Chinese Journal of Chemistry 1992年第1期10卷 40-44页

作者： CONCAr D. moore g.r. WILLIAMS r.J.P. Inorganic Chemistry Laboratory University of OxfordUK

Equilibrium constants for the binding of azide to ferri-cytochrome c at temperature range of 305—325 K were determined at pH=7 by using ~1H double resonance *** values(⊿H^o=-34.5 kJ/mol,⊿S^o=-100 J/mol)were obtained from van't Hoff's relation and were compared with those for azide binding to other ferric *** reason of lower affinity of cytochrome c for azide was discussed.

关键词： NMr double resonance study of azide binding to cytochrome c

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Issues in the Mining of Heart Failure Datasets

引用

International Journal of Automation and computing 2014年第2期11卷 162-179页

作者： Nongnuch Poolsawad Lisa moore Chandrasekhar Kambhampati John g.F.Cleland Intelligent Systems research group(IS Department of Computer Science) University of Hull Hull York Medical School Department of CardiologyUniversity of Hull

This paper investigates the characteristics of a clinical dataset using a combination of feature selection and classification methods to handle missing values and understand the underlying statistical characteristics of a typical clinical dataset. Typically, when a large clinical dataset is presented, it consists of challenges such as missing values, high dimensionality, and unbalanced classes. These pose an inherent problem when implementing feature selection and classification algorithms. With most clinical datasets, an initial exploration of the dataset is carried out, and those attributes with more than a certain percentage of missing values are eliminated from the dataset. Later, with the help of missing value imputation, feature selection and classification algorithms, prognostic and diagnostic models are developed. This paper has two main conclusions: 1) Despite the nature of clinical datasets, and their large size, methods for missing value imputation do not affect the final performance. What is crucial is that the dataset is an accurate representation of the clinical problem and those methods of imputing missing values are not critical for developing classifiers and prognostic/diagnostic models. 2) Supervised learning has proven to be more suitable for mining clinical data than unsupervised methods. It is also shown that non-parametric classifiers such as decision trees give better results when compared to parametric classifiers such as radial basis function networks(rBFNs).

关键词： Heart failure clinical dataset classification clustering missing values feature selection.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microbiological safety of spices and their interaction with antibiotics:implications for antimicrobial resistance and their role as potential antibiotic adjuncts

引用

Food Quality and Safety 2019年第2期3卷 93-97页

作者： rachel E.moore B.Cherie Millar Jayachandran r.Panickar John E.moore Department of Bacteriology Northern Ireland Public Health LaboratoryBelfast City HospitalLisburn RoadBelfastNorthern IrelandBT97ADUK School of Biomedical Sciences Ulster UniversityCromore RoadColeraineBT521SANorthern IrelandUK Centre for Experimental Medicine Queen’s University97 Lisburn RoadBelfast BT97BLNorthern IrelandUK Department of Paediatrics Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates

Objectives:A study was undertaken to:*** contaminating bacteria on a variety of spices purchased at retail market;*** if spice bacterial enrichments alter the phenotype of 13 bacterial foodborne and clinical pathogens and 1 probiotic organism;and *** if spices can alter antimicrobial activity of seven clinical antibiotics against 16 bacterial foodborne/clinical *** and Methods:Microbiological examination was undertaken employing 27 spice varieties with four antibiotics and 15 bacterial ***:Bacteriological contamination levels varied amongst spice varieties,ranging from Kasmin chilli powder(7.5×10^(6)cfu/g;log10^(6).88 cfu/g)to ginger(1.5×10^(4)cfu/g;log_(10)4.18 cfu/g);mean contamination was 1.38×10^(6)cfu/g(log_(10)6.14 cfu/g).Four species within the genus Bacillus were identified(Bacillus megaterium,Bacillus subtilis,Bacillus licheniformis,and Bacillus cereus).There was no phenotypic difference with the 14 bacteria,with bacterial colony growth/proliferation,pigment production,or with adhesin and mucoid *** of the spice cultures inhibited any of the 14 bacterial species *** the case of doxycycline,amoxicillin,colistin,erythromycin,and piperacillin/tazobactam,the zone of inhibition increased with the inclusion of the 26 spice varieties,suggesting that the spices were interacting synergistically with the antibiotic,thus making the antibiotic more potent against the bacteria ***:This study demonstrates a positive interaction between spices and conventional *** the burden of antimicrobial resistance(AMr)worldwide,but particularly in South Asian countries(India and Pakistan),any food-related innovation that can help maximize the potency of existing antibiotics is to be encouraged and *** specific mechanism as to how spices increase the potency of antibiotics needs to be elucidated,as well as novel food(spice)delivery modalities including novel medicinal foo

关键词： antibiotic resistance antimicrobial resistance Bacillus foodborne pathogen microbiology Pseudomonas aeruginosa spice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bedrock aquifers and population growth in the Denver Basin, Colorado, USA

引用

Episodes 2007年第2期30卷 115-118页

作者： John E. moore robert g. raynoldse Marieke Dechesne U.S. geological Survey Denver Colorado USA. Denver Museum of Nature ＆ Science Denver Colorado USA.

The Denver Basin bedrock aquifer system consists of Tertiary and Cretaceous age sedimentary rocks known as the Dawson, Denver, Arapahoe and Laramie-Fox Hills aquifers. The number of bedrock wells has increased from 12,000 in 1985 to over 33,700 in 2001 and the withdrawal of groundwater has caused water level declines in excess of 75 meters. Water level declines now range from 3 to 12 meters per year in the critical Arapahoe Aquifer. The groundwater supplies were once thought to be sufficient for 100 years but there is concern that they may be depleted in 10 to 15 years in areas on the west side of the basin. groundwater is being mined from the aquifer system because the withdrawal through wells exceeds the rate of recharge. Increased groundwater withdrawal will cause further water level declines, increased costs to pump groundwater, and reduced yield from existing wells. In the Denver Basin, hydrologists have some capability to monitor declines in water levels for the Arapaho Aquifer, but generally have a limited ability to monitor water use. More complete and accurate water use data are needed to predict groundwater longevity for the Arapahoe Aquifer. The life of the Arapahoe Aquifer can be extended with artificial recharge using imported surface water, water reuse, restrictions on lawn watering, well permit restrictions and other conservation measures. Availability of groundwater may limit growth in the Denver Basin over the next 20 years unless residents are willing to pay for additional new sources of supply.

关键词：基岩含水层丹佛盆地美国

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sperm speed is associated with sex bias of siblings in a human population

引用

Asian Journal of Andrology 2013年第1期15卷 152-154页

作者： Jim A Mossman Jon Slate Tim r Birkhead Harry D moore Allan A Pacey Department of Ecology and Evolutionary Biology Box G Brown University Providence Rhode Island 02912 USA Department of Animal and Plant Sciences University of Sheffield Western Bank Sheffield S10 2TN UK Centre for Stem Cell Biology Department of Biomedical Sciences University of Sheffield Western Bank Sheffield $10 2TN UK Academic Unit of reproductive and Developmental Medicine Department of Human Metabolism School of Medicine and Biomedical Sciences Sheffield $10 2SF UK

recent studies investigating possible causes of male subfertility have largely focused on how lifestyle or environmental factors impact on the process of spermatogenesis, Markedly, fewer studies have investigated those risk factors that result in reduced sperm quality, such as poor sperm motility. The speed at which sperm swim is a major predictor of fertility and is extremely variable in human populations. It has been hypothesized that offspring sex may be adaptively manipulated to maximize the offspring＇s reproductive fitness （e.g., parents with genes for good male fertility traits, such as high sperm speed, would produce primarily sons and fewer daughters because the offspring will inherit advantageous male fertility genes）. Conversely, parents with poor male fertility genes would produce primarily daughters, We tested whether there was an association between how fast a man＇s sperm swam and the sex bias of his siblings in a sample of men attending clinic for fertility investigations with their partner and with a wide range of semen characteristics, including sperm speed. We found that the sex bias of a man＇s siblings is associated with his sperm speed; men with female-biased siblings had significantly slower sperm （judged using computer-assisted sperm analysis （CASA）） than men from male-biased sibships. This observation suggests family composition is an important factor that needs to be considered in future eDidemiological and clinical studies of human fertility,

关键词： computer-assisted sperm analysis (CASA) fertility intralocus sexual conflict male offspring sex ratio sexual antagonism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathophysiology and treatment of diabetic erectile dysfunction

引用

Asian Journal of Andrology 2006年第6期8卷 675-684页

作者： Charles r.moore Department of Urology University of Texas Health Science Center and MD Anderson Cancer CenterHoustonTexas 77030USA

The pathophysiology of diabetes is multifactorial and no single etiology is at the forefront. The proposed mechanisms of erectile dysfunction （ED） in diabetic patients includes elevated advanced glycation end-products （AgEs） and increased levels of oxygen free radicals, impaired nitric oxide （NO） synthesis, increased endothelin B receptor binding sites and ultrastructural changes, upregulated rhoA/rho-kinase pathway, NO-dependent selective nitrergic nerve degeneration and impaired cyclic guanosine monophosphate （cgMP）-dependent kinase-1 （PKg-1）. The treatment of diabetic ED is multimodal. Treatment of the underlying hyperglycemia and comorbidities is of utmost importance to prevent or halt the progression of the disease. The peripherally acting oral phosphodiesterase type 5 （PDE5） inhibitors are the mainstay of oral medical treatment of ED in diabetics. Vacuum erection devices are an additional treatment as a non-invasive treatment option. Local administration of vasoactive medication via urethral suppository or intracorpora! injection can be effective with minimal side-effects. Patients with irreversible damage of the erectile mechanism are candidates for penile implantation. Future strategies in the evolution of the treatment of ED are aimed at correcting or treating the underlying mechanisms of ED. With an appropriate vector, researchers have been able to transfect diabetic animals with agents such as neurotrophic factors and nitric oxide synthase （NOS）. Further studies in gene therapy are needed to fully ascertain its safety and utility in humans.

关键词： erectile dysfunction diabetes mechanism treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

goal-directed therapy in intraoperative fluid and hemodynamic management

引用

The Journal of Biomedical research 2013年第5期27卷 357-365页

作者： Maria Cristina gutierrez Peter g.moore Hong Liu Department of Anesthesiology and Pain Medicine University of California Davis Health System

Intraoperative fluid management is pivotal to the outcome and success of surgery, especially in high-risk proce- dures. Empirical formula and invasive static monitoring have been traditionally used to guide intraoperative fluid management and assess volume status. With the awareness of the potential complications of invasive procedures and the poor reliability of these methods as indicators of volume status, we present a case scenario of a patient who underwent major abdominal surgery as an example to discuss how the use of minimally invasive dynamic monitoring may guide intraoperative fluid therapy.

关键词： high-risk surgery hemodynamic fluid monitoring goal-directed therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

平板边界层转捩的数值模拟

引用

航空动力学报 1991年第2期6卷 157-161页

作者：蒋洪德 J.g.moore J.moore 中国科学院工程热物理研究所美国弗吉尼亚理工学院机械系

对于自由湍流引起的压力梯度为零的平板边界层转捩过程的数值模拟 ,本文提出了一个单方程湍流模型 ( VL M模型 ) ,对湍流粘性系数和湍流长度尺度都进行了修正以正确引入低雷诺数效应。数值计算表明 ,该模型在自由来流湍流度为 0 .0 3～... 详细信息

对于自由湍流引起的压力梯度为零的平板边界层转捩过程的数值模拟 ,本文提出了一个单方程湍流模型 ( VL M模型 ) ,对湍流粘性系数和湍流长度尺度都进行了修正以正确引入低雷诺数效应。数值计算表明 ,该模型在自由来流湍流度为 0 .0 3～ 8%的大范围内能正确模拟边界层转捩全过程 ,包括转捩区起点位置和转捩区长度、边界层内的平均及脉动参数分布等。本文还提出了上述转捩过程的时均化五阶段模型。

关键词：边界层转捩数值模拟湍流

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation on the Two Filling Functions for the recovery of Forest Information in Mountainous Shadows on Landsat ETM + Image

引用

Journal of Mountain Science 2011年第3期8卷 414-426页

作者： SHAHTAHMASSEBI Amir reza moore Nathan Institute of Agriculture remote Sensing and Information Technology Zhejiang University Key Laboratory of Agricultural remote Sensing and Information System of Zhejiang Province Department of geography Michigan State University

In general,topographic shadow may reduce performance of forest mapping over mountainous regions in remotely sensed *** this paper,information in shadow was synthesized by using two filling techniques,namely,roifill and imfill,in order to improve the accuracy of forest mapping over mountainous *** two methods were applied to Landsat Enhanced Thematic Mapper (ETM +) multispectral image from Dong Yang County,Zhejiang Province,*** performance of these methods was compared with two conventional techniques,including cosine correction and multisource *** results showed that by applying filling approaches,average overall accuracy of classification was improved by 14 ***,through conventional methods this value increased only by 9 *** results also revealed that estimated forest area on the basis of shadow-corrected images by 'roifill' technique was much closer to the survey data compared to traditional *** from this finding,our finding indicated that topographic shadow was an accentuated problem in medium resolution images such as Landsat ETM+ over mountainous regions.

关键词： Shadow Imfill: roifill: Landsat ETM+

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：