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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

multilayered plate elements with node-dependent kinematics for electro-mechanical problems

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International Journal of Smart and Nano materials 2018年第4期9卷 279-317,I0004页

作者： E.Carrera S.Valvano g.m Kulikov Department of mechanical and Aerospace Engineering Politecnico di TorinoTurinItaly Department of Applied mathematics and mechanics Tambov State Technical UniversityTambovRussia

In the present work,a new class of finite elements(FEs)for the analysis of composite and sandwich plates embedding piezoelectric skins and patches is *** making use of node-by-node variable plate theory assumptions,the new finite element allows for the simultaneous analysis of different subregions of the problem domain with different kinematics and accuracy,in a global/local *** a consequence,the computational costs can be reduced drastically by assuming refined theories only in those zones/nodes of the structural domain where the resulting strain and stress states,and their electro-mechanical coupling present a complex *** primary advantage is that no ad-hoc techniques and mathematical artifices are required to mix the fields coming from two different and kinematically incompatible adjacent elements,because the plate structural theory varies within the finite element *** other words,the structural theory of the plate element is a property of the FE node in this present approach,and the continuity between two adjacent elements is ensured by adopting the same kinematics at the interface *** finite element arrays of the generic plate element are formulated in terms of fundamental nuclei,which are invariants of the theory approximation order and the modeling technique(Equivalent-Single-Layer,Layer-Wise).In this work,the attention is focused on the use of Legendre polynomial expansions to describe the through-the-thickness unknowns to develop advanced plate *** numerical investigations,such as composite and sandwich multilayered plates embedding piezoelectric skins and patches with various load,boundary conditions,and piezoelectric material polarizations,are carried out to validate and demonstrate the accuracy and efficiency of the present plate element,including comparison with various closed-form and FE solutions from the literature.

关键词： multilayered plate elements piezoelectric global/local analysis carrera unified formulation node-dependent kinematics

INVESTIgATION OF LOW CYCLE FATIgUE BEHAVIOROF BUILDINg STRUCTURAL STEELS UNDEREARTHQUAKE LOADINg

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Acta metallurgica Sinica(English Letters) 1997年第1期10卷 51-55页

作者： g.m Sheng and S.H gong(Department of metallurgy and materials Engineering, Chongqing University Chongqing 630044, China) Chongqing Univ Chongqing China

Based on the failure model of building structural steels under earthquake loading, the low cycle fatigue test at constant strain, the stochastical fatigue test under real earthquake load spectrum and the structural fatigue test are carried out. The experimental results show that microalloying of V Ti and Nb can improve the anti-seismic propersties of steel bars. In the high strain and shori life range, both the static strength and ductility of steels are very important to increasing the low cycle fatigue resistance of steels.

关键词： low cycle fatigue earthquake building structural steel microalloying

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乔治·莫兰迪版画收藏

美术 2022年第1期649卷 130-131页

作者： g.m 不详

多年前,笔者在罗马的Via del Babuino街上散步,这条街在当时是古董街。笔者带着好奇心偶然在Valdese教堂旁边发现了Querzola古董书店橱窗里的一幅版画。一张小卡片上写着这幅画的创作者是一位名叫乔治·莫兰迪(giorgio morandi)的艺术家... 详细信息

多年前,笔者在罗马的Via del Babuino街上散步,这条街在当时是古董街。笔者带着好奇心偶然在Valdese教堂旁边发现了Querzola古董书店橱窗里的一幅版画。一张小卡片上写着这幅画的创作者是一位名叫乔治·莫兰迪(giorgio morandi)的艺术家,当时笔者对这个名字还很陌生。那是一幅静物版画,画中的各个物体都通过黑白色调和半色调的平面产生模糊而强烈的对比。

关键词：半色调版画古董黑白色调好奇心小卡片

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a g.mut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying.myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying.mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Nonlinear forced vibration in a subcritical reg.me of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.gHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(Fgm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the Fgm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of Fgm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in Fgm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cgAS–STINg axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

通过农杆菌介导法将哈兹木霉几丁质酶ThEn-42基因导入核桃

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园艺学报 2001年第1期28卷 12-18页

作者：汤浩茹 Wallbraun m 任正隆 Reustle g.m Krczal g 四川农业大学林学园艺学院雅安625014 德国莱茵兰-法尔兹植物生物技术中心 neustadtw67435

通过根癌农杆菌C58C1ATHVRifR 介导法 ,利用烟草花叶病毒 35S双启动子和苜蓿花叶病毒引导序列控制下的含抗新霉素磷酸转移酶基因 (nptⅡ )和哈兹木霉几丁质酶基因(ThEn 4 2 )的质粒pBin19ESR为载体 ,对 3个核桃体细胞胚系进行遗传转化 ... 详细信息

通过根癌农杆菌C58C1ATHVRifR 介导法 ,利用烟草花叶病毒 35S双启动子和苜蓿花叶病毒引导序列控制下的含抗新霉素磷酸转移酶基因 (nptⅡ )和哈兹木霉几丁质酶基因(ThEn 4 2 )的质粒pBin19ESR为载体 ,对 3个核桃体细胞胚系进行遗传转化 ,结果获得 4 1个抗卡那霉素的体细胞胚系。经PCR和复式PCR检测 ,4 1个转化系均含有nptⅡ基因 ,其中 38个转化系含有ThEn 4 2基因。Southern杂交分析表明 ,ThEn 4 2基因已被整合到核桃体的基因组中。几丁质酶活性检测结果表明 ,转化的体细胞胚系的几丁质酶活性比对照高几十至几千倍。

关键词：核桃几丁质酶转基因体细胞胚农杆菌介导