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Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 27-33页

作者： gilbert Samuel jebakumar jeevanandham Muthiah Loganathan jayapal R.Santhosh Kumar Siddhesh Tasgaonkar K.S.Santhosh Anand j.K.A.jameel Sudeepta Kumar Swain K.j.Raghunath Prasanna Kumar reddy Tirupporur govindaswamy Balachandar Department of Surgical gastroenterology Apollo HospitalsChennai 600006India Department of general Surgery Apollo HospitalsChennai 600006India Department of Minimal Access Surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(january 2017 to December 2022)at Apollo Hospitals in South *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： Remnant gall bladder Stump cholecystitis Subtotal cholecystectomy Laparoscopic completion cholecystectomy

Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients

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World journal of Diabetes 2024年第1期15卷 24-33页

作者： Rupak Desai Nishanth Katukuri Sumaja reddy goguri Azra Kothawala Naga Ruthvika Alle Meena Kumari Bellamkonda Debankur Dey Sharmila ganesan Minakshi Biswas Kuheli Sarkar Pramoda Prattipati Shaylika Chauhan Independent Researcher Independent ResearcherAtlantaGA 30079United States Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Medicine Chalmeda Anand Rao Institute of Medical SciencesTelangana 505001India Department of Medicine Jawaharlal Nehru Medical CollegeBelgaum 590010India Department of Medicine Narayana Medical CollegeAndhra PradeshNellore 524003India Department of Medicine Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research FoundationVijaywada 521286India Department of Medicine Medical College KolkataKolkata 700073India Department of Medicine P.E.S.Institute of Medical Sciences and ResearchAndhra Pradesh 517425India Department of Medicine Shaheed Ziaur Rahman Medical CollegeBogra 5800Bangladesh Department of Medicine College of Medicine and J.N.M HospitalKalyani 741235India Department of Medicine Jawaharlal Nehru Medical College IndiaKarnatakaBelagavi 590010India Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States

BACKgROUND Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events(MACCE).However,the relationship between prediabetes and MACCE in atrial fibrillation(AF)patients has not been extensively ***,this study aimed to establish a link between prediabetes and MACCE in AF *** To investigate a link between prediabetes and MACCE in AF *** We used the National Inpatient Sample(2019)and relevant ICD-10 CM codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes,excluding *** primary outcome was MACCE(all-cause inpatient mortality,cardiac arrest including ventricular fibrillation,and stroke)in AF-related *** Of the 2965875 AF-related hospitalizations for MACCE,47505(1.6%)were among patients with *** prediabetes cohort was relatively younger(median 75 vs 78 years),and often consisted of males(56.3%vs 51.4%),blacks(9.8%vs 7.9%),Hispanics(7.3%vs 4.3%),and Asians(4.7%vs 1.6%)than the non-prediabetic cohort(Pgroup had significantly higher rates of hypertension,hyperlipidemia,smoking,obesity,drug abuse,prior myocardial infarction,peripheral vascular disease,and hyperthyroidism(all Pged routinely(51.1%vs 41.1%),but more frequently required home health care(23.6%vs 21.0%)and had higher *** adjusting for baseline characteristics or comorbidities,the prediabetes cohort with AF admissions showed a higher rate and significantly higher odds of MACCE compared to the non-prediabetic cohort[18.6%vs 14.7%,odds ratio(OR)1.34,95%confidence interval 1.26-1.42,Pgroup analyses,males had a stronger association(aOR 1.43)compared to females(aOR 1.22),whereas on the race-wise comparison,Hispanics(aOR 1.43)and Asians(aOR 1.36)had a stronger association with MACCE with prediabetes vs whites(aOR 1.33)and blacks(aOR 1.21).CONCLUSION This population-

关键词： Prediabetes Atrial fibrillation Cardiovascular disease risk Major adverse cardiovascular and cerebrovascular events Stroke Mortality

Solvent-free aerobic oxidation of ethylbenzene over supported Ni catalysts using molecular oxygen at atmospheric pressure

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journal of Natural gas Chemistry 2008年第3期17卷 293-297页

作者： g.Raju P.Shiva reddy j.Ashok B.Mahipal reddy A.Venugopal Catalysis & Physical Chemistry Division Indian Institute of Chemical Technology

We investigated the aerobic oxidation of ethylbenzene in the absence of solvent or any additive carried out over Ni on different types of supports namely SiO2, hydroxyapatite, SBA-15, and USY Zeolites. The oxidation of ethylbenzene activities was measured in a round bottom flask immersed in oil bath at known reaction temperature. The physicochemical characteristics of the catalysts were examined by BET surface area, XRD, FT-IR and the oxidation activities were correlated with the acidities of the catalysts obtained by TPD of NH3. It was observed that both hydroxyapatite and USY （13% Na2O） supported Ni catalysts displayed higher ethylbenzene conversion and 80% selectivity towards acetophenone.

关键词： nickel SBA-15 zeolites hydroxyapatite ethylbenzene oxidation TPD of NH3

Near-Net-Shaped Objects of RE123 Superconductors byInfiltration Processing

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Tsinghua Science and Technology 2003年第3期8卷 292-306页

作者： E.S.reddy g.j.Schmitz ACCESS Materials and Processes D-52056 AachenGermanyACCESS Materials and ProcessesD-52056 AachenGermany

The fabrication of near-net-shaped objects of RE123 superconductors by 'infiltration processing' is discussed. Near-net-shape processing involves the infiltration of preshaped porous green bodies of either 211 or yttria phases by liquids containing barium cuprates and copper oxides followed by a controlled peritectic solidification. The process yields poly- and also single-crystalline superconducting objects with a shrinkage of less than half of one percent of the green bodies. The preservation of the initial structure of the green bodies results in fabrication of RE 123 in a wide variety of dimensions and complex shapes. The demonstrated products include bulk components like cylinders, single domain thick films on a variety of substrates, freestanding fabrics and open porous superconducting foams. This paper presents a comprehensive description of the infiltration processing technique and the resulting microstructures of the superconducting bodies. The advantages of this technique and practical applications of the processed superconducting structures are highlighted.

关键词： infiltration processing near-net shape shaping joining single domain crystal growth thick films foams applications

Metathesis synthesis, characterization, spectral and photoactivity studies of Ln_(2/3)MoO_4(Ln=La, Pr, Nd, Sm, Eu, gd, Tb, Dy, Er and Y)

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journal of Rare Earths 2015年第8期33卷 837-845页

作者： Radha Velchuri Suresh Palla g.Ravi Naveen Kumar Veldurthi j.R.reddy M.Vithal Department of Chemistry Osmania University

Rare earth ortho-oxomolybdates of composition Ln2/aMoO4 （Ln=La, Pr, Nd, Sm, Eu, gd, Tb, Dy, Er and Y） were prepared by metathesis reaction. All these materials were characterized by powder X-ray diffraction, Fourier transform-infrared spectroscopy （FT-IR） and UV-Vis diffuse reflectance spectra. The Rietveld analysis of all the samples was carried out to obtain the unit cell parameters and reliability factors. All the materials were crystallized in tetragonal lattice with I41/a space group. The infrared spectra of all the samples were characterized by bands due to MoO42 units. The bandgap energies of all the samples were obtained from UV-Vis DRS spectra. The luminescence spectra of Ln2/3MoO4 （Ln=Pr, Eu and Dy） showed characteristic transitions of the rare earth ions. The visible light photocatalytic activity of all the samples was studied against degradation of methylene blue.

关键词： metathesis X-ray diffxaction IR spectroscopy UV-Vis spectroscopy photodegradation rare earths

Dietary green Tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis

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Open journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： galande Sheethal Ranjeet K. Tokala Pavan Pondugala Krishna Vemula Vijayalakshmi Venkatesan Pothani Suresh Surya Satyanarayana Singh guduru Venkat Rao Duvvur Nageshwar reddy Mitnala Sasikala Basic Science and Translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biology National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surgical gastroenterology Asian Institute of Gastroenterology Hyderabad India Department of gastroenterology Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EgCg) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EgCg dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EgCg. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EgCg) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/j Mice Epigallocatechin-3-gallate N-Acetyl Cysteine Curcumin Chronic Pancreatitis Islets glucose Stimulated Insulin Secretion

The role of cysteine-rich secretory proteins in male fertility

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Asian journal of Andrology 2011年第1期13卷 111-117页

作者： Adam j Koppers Thulasimala reddy Moira K O＇Bryan Department of Anatomy and Developmental Biology School of Biomedical Sciences Monash University Clayton Vic. 3800 Australia

The cysteine-rich secretory proteins （CRISPs） are a subgroup of the CRISP, antigen 5 and Pr-1 （CAP） protein superfamily, and are found only in vertebrates. They show a strong expression bias to the mammalian male reproductive tract and the venom of poisonous reptiles. Within the male reproductive tract CRISPs have been implicated in many aspects of male germ cell biology spanning haploid germ cell development, epididymal maturation, capacitation, motility and the actual processes of fertilization. At a structural level, CRISPs are composed of two domains, a CAP domain, which has been implicated in cell-cell adhesion, and a CRISP domain, which has been shown to regulate several classes of ion channels across multiple species. Herein, we will review the current literature on the role of CRISPs in male fertility, and by inference to related non-mammalian protein, infer potential biochemical functions.

关键词： CRISPs epididymis fertility spermatozoa testis

Investigation of strong shock wave interactions with CeO2 ceramic

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journal of Advanced Ceramics 2014年第4期3卷 297-305页

作者： Vishakantaiah jAYARAM Asha gUPTA K.P.j.reddy Shock Induced Materials Chemistry Lab SSCUIndian Institute of ScienceBangalore-560012India Texas Materials Institute the University of Texas at AustinAustinTexas 78712USA Department of Aerospace Engineering Indian Institute of ScienceBangalore-560012India

Strong shock wave interactions with ceramic material ceria(CeO_(2))in presence of O_(2)and N2 gases were investigated using free piston driven shock tube(FPST).FPST is used to heat the test gas to very high temperature of about 6800-7700 K(estimated)at pressure of about 6.8-7.2 MPa for short duration(2-4 ms)behind the reflected shock *** is subjected to super heating and cooling at the rate of about 106 K/*** of CeO_(2)sample was done before and after exposure to shock heated test gases(O_(2)and N2).The surface composition,crystal structure,electronic structure and surface morphology of CeO_(2)ceramic were examined using X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectrometry,scanning electron microscopy(SEM)and high resolution transmission electron microscopy(HRTEM).Results obtained from the experimental investigations show that CeO_(2)can withstand high pressure accompanied by thermal shock without changing its crystal *** CeO_(2)releases lattice oxygen making it possible to shift between reduced and oxidized states upon the interaction with shock heated *** to such reaction mechanism,CeO_(2)ceramic undergoes nitrogen doping with decrease in lattice *** reveal that CeO_(2)retains its crystal structure during strong shock interaction,even at elevated pressure.

关键词： shock tube shock interaction high enthalpy gas ceria nitrogen-doped surface reaction

Non-classical continuum theories for solid and fluent continua and some applications

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International journal of Smart and Nano Materials 2019年第1期10卷 28-89,I0003页

作者： K.S.Surana D.Mysore j.N.reddy Mechanical Engineering University of KansasLawrenceKSUSA Mechanical Engineering Texas A&M UniversityCollege StationTXUSA

This paper presents two specific thermodynamically consistent nonclassical continuum theories for solid and fluent *** first non-classical continuum theory for solid continua incorporates jacobian of deformation in its entirety in the conservation and the balance laws and the derivation of the constitutive *** second non-classical continuum theory for solid continua considers jacobian of deformation in its entirety as well as the Cosserat rotations in the conservation and balance laws as well as the constitutive *** first non-classical continuum theory for fluent continua presented here considers velocity gradient tensor in its *** second non-classical continuum theory for fluent continua considers velocity gradient tensor in its entirety as well as Cosserat rotation rates in the derivation of the conservation and balance laws and the constitutive *** the non-classical continuum theories for solid and fluent continua considered here incorporate additional physics of deformation due to rotations and rotation rates compared to classical continuum mechanics,the conservation and balance laws of classical continuum mechanics are shown to require modification as well as a new balance law balance of moment of moments is required to accommodate the new physics due to rotations and rotation ***’s micropolar,micromorphic and microstretch theories,couple stress theories and nonlocal theories are also discussed within the context of the non-classical theories presented here for solid and fluent *** applications of these theories are also discussed.

关键词： Non-classical continuum theories micropolar jacobian of deformation internal rotations Cosserat rotations Cosserat rotation rates