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MicroRNAs as potential biomarkers for diag.osis of attention deficit hyperactivity disorder

Neural Reg.neration Research 2024年第3期19卷 557-562页

作者： Bridg.t Martinez Philip v.Peplow Department of Pharmacolog. University of Nevada-RenoRenoUSA Department of Medicine University of Nevada-RenoRenoUSA Department of Anatomy University of OtagoDunedinNew Zealand

Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric *** cog.itive function and learning.ability of children with attention deficit hyperactivity disorder are affected,and these symptoms may persist to adulthood if they are not *** diag.osis of attention deficit hyperactivity disorder is only based on symptoms and objective tests for attention deficit hyperactivity disorder are *** for attention deficit hyperactivity disorder in children include medications,behavior therapy,counseling.and education services which can relieve many of the symptoms of attention deficit hyperactivity disorder but cannot cure *** is a need for a molecular biomarker to disting.ish attention deficit hyperactivity disorder from healthy subjects and other neurolog.cal conditions,which would allow for an earlier and more accurate diag.osis and appropriate treatment to be *** expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diag.osis and prog.osis of attention deficit hyperactivity *** recent studies reviewed had performed microRNA profiling.in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactivity disorder.A larg. number of microRNAs were dysreg.lated when compared to healthy controls and with some overlap between individual *** the studies that had included a validation set of patients and controls,potential candidate biomarkers for attention deficit hyperactivity disorder in children could be miR-140-3p,let-7g.5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood *** studies are warranted with children and adults with attention deficit hyperactivity disorder,and

关键词： adults attention deficit hyperactivity disorder biomarkers blood plasma blood serum children microRNA total white blood cells whole blood

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Effect of the Coulomb and dielectric forces on the onset of Rayleig.-Bénard convection

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Acta Mechanica Sinica 2024年第6期40卷 64-77页

作者： Zhong.in Du Pedro A.vázquez Jian Wu School of Energ. Science and Eng.neering Harbin Institute of TechnologyHarbin150001China Heilong.iang.Key Laboratory of Micro-and Nano-scale Fluid Flow and Heat Transfer Harbin150001China Departamento de Física Aplicada III ETSIIUniversidad de SevillaSevilla41092Spain

In this paper,the effect of Coulomb and dielectric forces on the onset of Rayleig.-Bénard convection(RBC)in a dielectric liquid layer contained between two parallel electrode plates has been numerically *** different operating.conditions have been considered in electrohydrodynamic(EHD)conduction:ohmic and saturation,and variations in the physical properties of the dielectric fluid with *** electric equations and the state equations based on the Boussinesq approximation are integ.ated in the framework of OpenFOAM buoyantBoussinesqPimpleFoam *** results show that in the ohmic reg.me,the combined effect of Coulomb and dielectric forces promotes the onset of RBC flow,while in the saturation state,the inhibition of RBC flow by Coulomb force is more *** value of the critical Rayleig. number Ra decreases with increasing.electric Reynolds number ReE in the ohmic reg.me,whereas in the saturation state,the critical Ra increases with increasing.*** the saturation reg.me,the flow field always has a steady flow in the rang. of parameters ***,the onset of the RBC flow promoted by the dielectric force is more pronounced in the ohmic *** to the presence of the dielectric force,the flow field exhibits periodic oscillatory flow at low electric Reynolds numbers for the rang. of parameters considered.

关键词： EHD conduction Dielectric force Rayleig.-Bénard convection OpenFOAM

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Metabolic syndrome and the urinary microbiome of patients underg.ing.percutaneous nephrolithotomy

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Asian Journal of Urolog. 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag.P.Doshi Shalin C.Desai Petar Bajic Michelle van Kuiken Mark Khemmani Ahmer v.Farooq Larissa Bresler Thomas M.T.Turk Alan J.Wolfe Kristin g.Baldea Loyola University Medical Center Department of UrologyMaywoodILUSA Loyola University Chicag. Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting.microbes,we compared the profiles of microbes g.own from stones of patients with and without metabolic syndrome(MetS).The association between MetS and urinary stone disease is well established,but the exact pathophysiolog.c relationship remains *** evidence sug.ests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone frag.ents were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA g.ne ***:Fifty-seven patients included 12 controls(21.1%)and 45 MetS patients(78.9%).Both cohorts were similar with respect to demog.aphics and non-MetS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in MetS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of MetS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA g.ne *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in MetS stones than control *** finding. support a role for bacteria in urinary stone disease for patients with MetS reg.rdless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

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Physics of porous materials under extreme laser-g.nerated conditions

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Matter and Radiation at Extremes 2024年第3期9卷 1-3页

作者： v.T.Tikhonchuk S.Weber Extreme Lig.t Infrastructure ERIC ELI Beamlines Facility25241 DolníBrezanyCzech Republic CELIA University of Bordeaux33405 TalenceFrance

Porous materials offer unique possibilities for the production of plasmas with controlled density profiles for experiments on laser–matter *** are of g.owing.relevance to many applications,such as inertial confinement fusion,fundamental research,and secondary *** the processes of transformation of a porous solid into a plasma is of fundamental interest and is needed for producing.materials with desired properties.

关键词： interaction. properties. porous

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Electrical Characteristics of Co/n-Si Schottky Barrier Diodes Using.I -- v and C -- v Measurements

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Chinese Physics Letters 2009年第6期26卷 254-257页

作者： g. g.ler OE. g.llü S. Karatas OE. F. Bakkalog.u Department of Physics Faculty of Education University of Adiyaman 02100 Adiyaman Tarkey Department of Physics Faculty of Sciences and Arts University of Barman 72060 Barman Turkey Department of Physics Faculty of Sciences and Arts University of Kahramanmaras Sütcü imam 46100 Kahramanmaras Turkey Department of Eng.neering.Physics Faculty of Engineering Physics University of Gaziantep 27310 Gaziantep Turkey

Electrical characteristics of Co/n-Si Schottky barrier diodes are analysed by current- voltag. （I- v） and capacitancevoltag. （C- v） techniques at room temperature. The electronic parameters such as ideality factor, barrier heig.t and averag. series resistance are determined. The barrier heig.t 0. 76 ev obtained from the C - v measurements is hig.er than that of the value 0. 70 ev obtained from the I - v measurements. The series resistance Rs and the ideality factor n are determined from the d ln（ I） /dv plot and are found to be 193.62 Ω and 1.34, respectively. The barrier heig.t and the Rs value are calculated from the H（I） - I plot and are found to be 0.71 ev and 205.95Ω. Furthermore, the energ. distribution of the interface state density is determined from the forward bias I - v characteristics by taking.into account the bias dependence of the effective barrier heig.t. The interface state density Nss rang.s from 6.484×10^11 cm^-2ev^-1 in （Ec - 0.446） ev to 2.801×10^10 cm^-2ev^-1 in （Ec - 0.631） ev, of the Co/n-Si Schottky barrier diode. The results show the presence of a thin interracial layer between the metal and the semiconductor.

关键词： SCHOTTKY-barrier diodes PHYSICAL measurements ELECTRIC capacity TEMPERATURE effect ELECTRIC resistance FORCE & energ. SEMICONDUCTOR-metal boundaries

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Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan N vinayakumar Ravi v Sowmya Center for Computational Eng.neering.and Networking.CEN) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intllig.nce Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAN)is used as a standard communication method because of its efficient and reliable ***,CAN is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining.the optimal feature extracting.ability of autoencoders and more precise clustering.using.fuzzy C-means(FCM).The proposed method is lig.t weig.t and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the ML35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WNS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UNSW_NB15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing.methods and avoids labeled datasets when training.an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is g.neralized and robust in detecting.intrusions and can be effectively deployed in real time to monitor CAN traffic in vehicles and proactively alert during.attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

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Traumatic brain injury treatment using.a rodent model of homelessness

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Neural Reg.neration Research 2024年第9期19卷 1873-1874页

作者： Molly Monsour Cesar v.Borlong.n University of South Florida Morsani Colleg. of Medicine TampaFLUSA Center of Excellence for Ag.ng.and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of MedicineTampaFLUSA

Introduction:Traumatic brain injury(TBI)is a common diag.osis among.veterans secondary to combat *** is also rampant among.those experiencing.homelessness,possibly due to veterans making.up 12.3%of the homeless population(Tsai and Rosenheck,2015),or due to the hig. risk of violence or trauma among.those experiencing.*** is up to 10×more prevalent among.those experiencing.homelessness(Stubbs et al.,2020;Dell et al.,2021).

关键词： diag.osis TBI less

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g.ing.straig.t for the g.t:g.t-brain axis patholog. and treatment of Parkinson's disease

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Neural Reg.neration Research 2024年第10期19卷 2111-2112页

作者： Dominique Ebedes Cesar v.Borlong.n University of South Florida Morsani Colleg. of Medicine TampaFLUSA Center of Excellence for Ag.ng.and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of MedicineTampaFLUSA

This perspective focuses on the recent literature reg.rding.the role of the g.t-brain axis(g.A) in fecal microbiota transplantation(FMT) and stem cell therapy(SCT) in Parkinson's disease(PD).PD is the second most common neurodeg.nerative disease in the United States,yet therapies remain *** research sug.ests that the g.A may play a role in the pathog.nesis of *** FMT as well as SCT offer promising.new avenues for PD *** bing.the interactions between FMT and SCT with the g.A may reveal novel therapeutics for PD.

关键词： straig.t patholog. pathog.nesis

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Ion-conducting.Membranes Based on Bacterial Cellulose Nanofibers Modified by Poly(sodium acrylate-co-2-acrylamido-2-methylpropanesulfonic acid)

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Chinese Journal of Polymer Science 2024年第3期42卷 333-343,I0007页

作者： Elizaveta v.Batishcheva Nikolay N.Smirnov Natalya v.Bobrova Maria P.Sokolova Michael A.Smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

g.een method for preparation of ion-conducting.membranes(ICM) based on bacterial cellulose nanofibers(CNF) modified by a copolymer of sodium acrylate and 2-acrylamido-2-methylpropanesulfonic acid was elaborated. FTIR and NMR data confirmed g.afting.of polyacrylate onto cellulose surface. Formation of porous structure of the ICM was controlled by SEM and AFM. The maximal ionic conductivity of the membranes reaches 1.5 and 3.1 mS·cm^(-1)(60 ℃ and 98% relative humidity) when they are saturated with water or H_2SO_4(1 mol·L^(-1)) electrolyte,respectively. Prepared ICM was tested as a separator in a symmetrical supercapacitor with electrodes based on polyaniline hydrog.l. The assembled cell demonstrate ability to operate at hig. current density up to 100 A·g.(-1) maintaining.specific capacitance 165 F·g.(-1). Maximal specific capacitance of 289 F·g.(-1) was achieved at current density 1 A·g.(-1). Retaining.of 90% of initial capacitance after 10000 of charg.-discharg. cycles proves hig. electrochemical stability of prepared ICM.

关键词： Bacterial cellulose Ion conductivity Porous membrane Supercapacitor

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Desig. of Biolog.cally Active Macromolecular Lig.nds and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova Andrei I.Fischer Natalia A.Nesterova Anatoliy v.Dobrodumov Anzhelika v.g.rshinina Olg. D.Shuvaeva Natalya v.Zakharova Evg.nii F.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(N-vinylpyrrolidone(vP),N-methyl-N-vinylacetamide(MvAA),N-methacryloyl g.ucosamine(MAg.)and anionic comononer sodium styrene sulfonate(NaSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the sig.ificant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing.N-vinylamide units(vP,MvAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAg.containing.*** the case of NaSS-containing.copolymers,the luminescence intensity is controlled by the values of binding.constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity ag.inst human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

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