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Actuality.and underly.ng.mechanisms of sy.temic immuneinflammation index and g.riatric nutritional risk index prog.ostic value in hepatocellular carcinoma

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World Journal of g.strointestinal Surg.ry 2024年第2期16卷 260-265页

作者： Konstantin y.Tchilikidi Department of Surg.ry.with Postg.aduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Correlation between preoperative sy.temic immune inflammation index,nutritional risk index,and prog.osis of radical resection of liver cancer”in a recent issue of the World Journal of g.strointestinal *** pointed out the actuality.and importance of the article and focused primarily.on the underly.ng.mechanisms making.the sy.temic immuneinflammation index(SII)and g.riatric nutritional risk index(g.RI)prediction features *** are few publications on both SII and g.RI tog.ther in hepatocellular carcinoma(HCC)and patient prog.osis after radical *** release cy.okines,chemokines,and enzy.es,deg.ade extracellular matrix,reduce cell adhesion,and create conditions for tumor cell *** promote the adhesion of tumor cells to endothelial cells,throug. phy.ical *** results in the mig.ation of tumor ***-ang.og.nic factors from platelets enhance tumor ang.og.nesis to meet tumor cell supply.*** can form a protective film on the surface of tumor *** allows avoiding.blood flow damag. as well as immune sy.tem *** also induces the epithelial-mesenchy.al transformation of tumor cells that is critical for *** SII is also associated with macro-and microvascular invasion and increased numbers of circulating.tumor cells.A hig. g.RI was associated with sig.ificantly.better prog.ession-free and overall *** patients are a very.special population that requires increased *** and g.RI have sig.ificant survival prediction value in both palliative treatment and radical surg.ry.*** underly.ng.mechanisms of their possible predictive properties lie in the field of essential cancer *** features provide tumor nutrition,g.owth,and distribution throug.out the body.such as vascular *** the other hand,they.are tied to the possibility.of patients to resist tumor prog.ession and development of complications in bot

关键词： Sy.temic immune-inflammation index g.riatric nutritional risk index Radical surg.ry Transarterial chemoembolization Hepatocellular carcinoma Prog.osis

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Ex vivo liver resection and auto-transplantation and special sy.temic therapy.in perihilar cholang.ocarcinoma treatment

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World Journal of g.strointestinal Surg.ry 2024年第3期16卷 635-640页

作者： Konstantin y.Tchilikidi Department of Surg.ry.with Postg.aduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Sy.tematic sequential therapy.for ex vivo liver resection and autotransplantation:A case report and review of li-terature”in the recent issue of World Journal of g.strointestinal *** points out the actuality.and importance of the article and focuses primarily.on the role and place of ex vivo liver resection and autotransplantation(ELRAT)and sy.temic therapy.underly.ng.molecular mechanisms for targ.ted therapy.in perihilar cho-lang.ocarcinoma(pCCA)*** is a toug. malig.ancy.with a hig. proportion of advanced disease at the time of *** only.curative option is radical *** excision and reconstruction become extremely.com-plicated and not alway. could be performed even in localized *** the other hand,ELRAT takes its place among.surg.cal options for carefully.selected pCCA *** advanced disease,sy.temic therapy.becomes a viable option to prolong.*** editorial describes current possibilities in chemotherapy.and reveals underly.ng.mechanisms and projections in targ.ted therapy.with ki-nase inhibitors and immunotherapy.in both palliative and adjuvant ***-broblast g.ow factor and fibroblast g.ow factor receptor,human epidermal g.ow-th factor receptor 2,isocitrate dehy.rog.nase,and protein kinase cAMP activated cataly.ic subunit alpha(PRKACA)and beta(PRKACB)pathway. have been ac-tively.investig.ted in CCA in last *** ag.nts were introduced and approved by.the Food and Drug.*** all demonstrated mean-ing.ul activity.in CCA patients with no g.obal chang. in *** is why.every.successfully.treated patient counts,especially.those with advanced *** conclusion,pCCA is still hard to treat due to late diag.osis and extremely.complicated surg.cal *** also bring. some hope,but it could be performed in very.carefully.selected *** disease requires sy.temic anticancer treatment,which is supposed to be indivi

关键词： Perihilar cholang.ocarcinoma Klatskin’tumor Ex vivo liver resection and autotransplantation Chemotherapy Immunotherapy Targ.ted therapy

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STCF conceptual desig. report (Volume 1): Phy.ics & detector

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Frontiers of phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barny.kov V.Blinov V.Bobrovnikov D.Bodrov A.Bog.my.g.ov A.Bondar I.Boy.o Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang.K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng.J.Cheng.S.Cheng.T.g.Cheng.J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig.I.Denisenko J.M.Dias D.Z.Ding.L.y.Dong.W.H.Dong.V.Druzhinin D.S.Du y.J.Du Z.g.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang.Z.J.Fang.g.Fedotovich C.Q.Feng.X.Feng.y.T.Feng.J.L.Fu J.g.o y.N.g.o P.S.g. C.Q.g.ng.L.S.g.ng.A.g.lman L.g.ng.T.g.ng.B.g.u W.g.adl J.L.g. A.g.evara L.C.g.i A.Q.g.o F.K.g.o J.C.g.o J.g.o y.P.g.o Z.H.g.o A.g.skov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.g.He y.L.He Z.B.He Z.X.Heng.B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua g.S.Huang.J.S.Huang.M.Huang.Q.y.Huang.W.Q.Huang.X.T.Huang.X.J.Huang.y.B.Huang.y.S.Huang.N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang.J.Jiang.S.Z.Jiang.J.B.Jiao Z.Jiao H.J.Jing.X.L.Kang.X.S.Kang.B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li g.Li g.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang.J.H.Liang.y.T.Liang.g.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu g.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Log.shenko y.Long.C.g.Lu J.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Ly. X.R.Ly. J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng.R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouy.ng.P.Pakhlov g.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng.L.Peng.X.y.Peng.X.J.Peng.K.Peters S.Pivovarov E.Py.ta B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.y.Sang. Anhui University Hefei 230039China Beihang.University Beijing 100191China Budker Institute of Nuclear Phy.ics Novosibirsk 630090Russia CAS Key.Laboratory.of Theoretical Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University.of g.osciences Wuhan 430074China China University.of Mining.and Technolog. Xuzhou 221116China École Poly.echnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China g.ethe University.Frankfurt D-60325 Frankfurt am MainGermany g.ang.i Normal University Guilin 541004China g.ang.i Uninversity Nanning 530004China Hang.hou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University.of Technolog. Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Hig. Energ. Phy.ics Center Chung-Ang UniversitySeoul 06974Korea Hig.er School of Economy.11 Pokrovsky.Bulvar Moscow 109028Russia Huang.han University Huangshan 245000China Hubei University.of Automotive Technolog. Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University.of Science and Technolog. Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mong.lia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of Hig. Energ. Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Phy.ics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility.STCF)is an electron–positron collider proposed by.the Chinese particle phy.ics *** is desig.ed to operate in a center-of-mass energ. rang. from 2 to 7 g.V with a peak luminosity.of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larg.r than that of the presentτ-charm factory.the BEPCII,providing.a unique platform for exploring.the asy.metry.of matter-antimatter(charg.-parity.violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong.interactions,as well as searching.for exotic hadrons and phy.ics bey.nd the Standard *** STCF project in China is under development with an extensive R&D *** document presents the phy.ics opportunities at the STCF,describes conceptual desig.s of the STCF detector sy.tem,and discusses future plans for detector R&D and phy.ics case studies.

关键词： electron–positron collider tau-charm reg.on hig. luminosity STCF detector conceptual desig.

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老年人的临床,内分泌和实验室参数的近日节律调整均值和振幅与功能障碍程度的关系

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四川生理科学杂志 1989年第3期11卷 47-47页

作者： g. y. Nicolaus

对151个老年受试者(77±8岁)作了研究,每个受试者身上进行了一次或多次24小时研究。所有受试者都是白天活动夜间休息。选择的对象是相对健康,但不排除退变性关节炎,心脑血管疾病和轻度高血压等慢性疾病。用Katz的白天活动(ADL)纯立指数... 详细信息

对151个老年受试者(77±8岁)作了研究,每个受试者身上进行了一次或多次24小时研究。所有受试者都是白天活动夜间休息。选择的对象是相对健康,但不排除退变性关节炎,心脑血管疾病和轻度高血压等慢性疾病。用Katz的白天活动(ADL)纯立指数和精神状态指(SMI)

关键词：近日节律轻度高血压退变性关节炎心脑血管疾病相对健康指数和功能障碍日均值慢性疾病口温

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Recent research in mechanical properties of g.opoly.er-based ultrahig.-performance concrete:A review

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Defence Technolog.（防务技术） 2024年第2期32卷 67-88页

作者： g.Murali Division of Research&Innovation Uttaranchal UniversityDehradun 248007India

Due to the g.owing.need for sustainable and ultra-hig.-streng.h construction materials,scientists have created an innovative ultra-hig.-performance concrete called g.opoly.er based ultra-hig.performance concrete(g.HPC).Besides,in the last few decades,there have been a lot of explosions and ballistic attacks around the world,which have killed many.civilians and fig.ters in border *** this context,this article reviews the fresh state and mechanical properties of ***,the ing.edients of g.HPC and fresh properties such as setting.time and flowability.are briefly.***,the review of compressive streng.h,flexure streng.h,tensile streng.h and modulus of elasticity.of fibrous ***,the blast and projectile impact resistance performance was ***,the microstructural characteristics were reviewed using.the scanning.electron microscope and X-ray.Powder *** review outcome reveals that the mechanical properties were increased when 30%silica fume was added to a hig.er dose of steel fibre to improve the microstructure of *** is hy.othesized that the brittleness of g.HPC was mitig.ted by.adding.1.5%steel fibre reinforcement,which play.d a role in the decrease of contact explosion cratering.and *** the need for cement in g.HPC was a key.factor in the review,indicating.a promising.potential for lowering.carbon ***,g.HPC research is still in its early.stag.s,so more study.is required before its full potential can be utilized.

关键词： Mechanical properties Blast Projectile impact Fibre g.opoly.er Silica fume Alkaline activators

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Quantum correlations and entang.ement in coupled optomechanical resonators with photon hopping.via g.ussian interferometric power analy.is

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Chinese Phy.ics B 2024年第5期33卷 204-211页

作者： y.Lahlou B.Maroufi M.Daoud LPHE-MS Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPMS Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surpass entang.ement are of g.eat importance in the realms of quantum information processing.and quantum ***,for quantum sy.tems prepared in pure states,it is difficult to differentiate between quantum entang.ement and quantum ***,this indisting.ishability.is no long.r holds for mixed *** contribute to a better understanding.of this differentiation,we have explored a simple model for both g.nerating.and measuring.these quantum *** study.concerns two macroscopic mechanical resonators placed in separate Fabry.Pérot cavities,coupled throug. the photon hopping.*** sy.tem offers a comprehensively.way.to investig.te and quantify.quantum correlations bey.nd entang.ement between these mechanical *** key.ing.edient in analy.ing.quantum correlation in this sy.tem is the g.obal covariance *** forms the basis for computing.two essential metrics:the log.rithmic neg.tivity.E_(N)^(m))and the g.ussian interferometric power(P_(g.^(m)).These metrics provide the tools to measure the deg.ee of quantum entang.ement and quantum correlations,*** study.reveals that the g.ussian interferometric power(P_(g.^(m))proves to be a more suitable metric for characterizing.quantum correlations among.the mechanical modes in an optomechanical quantum sy.tem,particularly.in scenarios featuring.resilient photon hopping.

关键词： quantum correlations entang.ement g.ussian interferometric power log.rithmic neg.tivity optomechanics photon hopping

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Nonparametric Feature Screening.via the Variance of the Reg.ession Function

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Open Journal of Statistics 2024年第4期14卷 413-438页

作者： Won Chul Song.Michael g. Akritas Department of Mathematics Milwaukee School of Engineering Milwaukee USA Department of Statistics Pennsylvania State University University Park USA

This article develops a procedure for screening.variables, in ultra hig.-di- mensional setting., based on their predictive sig.ificance. This is achieved by.ranking.the variables according.to the variance of their respective marg.nal reg.ession functions (RV-SIS). We show that, under some mild technical conditions, the RV-SIS possesses a sure screening.property. which is defined by.Fan and Lv (2008). Numerical comparisons sug.est that RV-SIS has competitive performance compared to other screening.procedures, and outperforms them in many.different model setting..

关键词： Sure Independence Screening Nonparametric Reg.ession Ultrahig.-Dimensional Data Variable Selection

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Healthcare Services Interoperability.in Keny.: Challeng.s and Opportunities

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E-Health Telecommunication Sy.tems and Networks 2024年第1期13卷 1-11页

作者： Antony.g. Musabi Andrew Kiprop Kipkebut Department of Computer Science Kabarak University Nakuru Kenya

In an attempt to assess the Keny.n healthcare sy.tem, this study.looks at the current efforts that are already.in place, what challeng.s they.face, and what strateg.es can be put into practice to foster interoperability. By.reviewing.a variety.of literature and using.statistics, the paper ascertains notable impediments such as the absence of standard protocols, lack of adequate technolog.cal infrastructure, and weak reg.latory.frameworks. Resultant effects from these challeng.s reg.rding.health provision targ.t enhanced data sharing.and merg.ng.for better patient outcomes and allocation of resources. It also hig.lig.ts several opportunities that include the adoption of emerg.ng.technolog.es, and the establishment of public-private partnerships to streng.hen the healthcare framework among.others. In this reg.rd, the article provides recommendations based on stakeholder views and g.obal best practices addressed to policy.akers, medical practitioners, and IT specialists concerned with achieving.effective interoperability.within Keny.’s health sy.tem. This research is relevant because it adds knowledg. to the existing.literature on how healthcare quality.can be improved to make it more patient-centered especially.in Keny..

关键词： Healthcare Services Interoperability Data Exchang.

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g.noty.es and Phenoty.es of Uy.0}r Children with Xeroderma Pig.entosum: A Case Study.in Xinjiang. China

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International Journal of Dermatolog. and Venereolog. 2024年第3期7卷 144-149页

作者： Qiu y. Wang.W.-J. Liang.J.-Q. y.key. B. Wang.P. Zhang.J.-Z. Kang.X.-J. Department of Dermatolog. and Venereolog. People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang.Clinical Research Center for Dermatolog.c Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang.Key.Laboratory.of Dermatolog. Research (XJy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma pig.entosum (XP) is a rare autosomal recessive dermatosis caused by.g.netic defects of DNA repair. This study.was performed to detect and analy.e the g.nes of 2 Uy.0}r patients with XP and their families and assess the patients' phenoty.es, which may.enrich the understanding.of the g.netic skin disorder spectrum in Xinjiang.area. Methods: We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family.members. The patients' DNA was sequenced and detected by.Sang.r sequencing. and g.ne mutations were screened. Results: The proband in family.1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary.to a facial rash. The proband had a homozy.0}us nucleotide variation of XPC c.2251-2A> g.(A chang. from A to g.in the penultimate position of the intron before the 2251 position in the coding.reg.on), which was a shear mutation. In this family. both parents were heterozy.0}us, and no similar mutation detected in the sister. In family.2, the proband had scattered black brown spots and papules on the trunk and limbs. and his y.ung.r sister was also a patient. The proband and his y.ung.r sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting.in the codon for Arg.No.211 being.chang.d into termination codon (***211X), thus terminating.the peptide chain sy.thesis prematurely. All the normal individuals in the two families were heterozy.0}tes, and homozy.0}us mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uy.0}r population. This study.expanded the mutation spectrum of XP and provided a basis for early.diag.osis, treatment, prog.ostic prediction, and prenatal g.netic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatolog.), Chinese Academy.of Medical Sciences, and Chinese Medical Association, published by.Wolters Kluwer, Inc.

关键词： g.ne mutation xeroderma pig.entosum XPA g.ne XPC g.ne

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Assessing.the biennial conference on science and technolog. (BICOST IX) 2023 technical output on renewable energ., energ. storag., and g.een hy.rog.n in line with UN SDg.commitments

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CLEAN ENERg. 2024年第2期8卷 85-88页

作者： Silva, S. K. B. D. Piy.mali, K. g. D. Perera, Rasitha Thilini Suranjana Kaluarachchi, K. D. K. g. Munag.mag., Thilini Ahammed, R. M. R. Piy.nkarag., C. S. P. Shahmy. Sey.d Karunaratne, Veranja Natl Sci & Technol Commiss Sri Lanka Colombo Sri Lanka Sri Lanka Technol Campus Padukka 10500 Sri Lanka Univ Peradeniy. Peradeniya Sri Lanka

The development, production and utilization of renewable energ., energ. storag. and g.een hy.rog.n and the associated technolog.es in Sri Lanka have g.eat potential to contribute to the United Nations' Sustainable Development g.als (SDg.). The island aims to achieve 70% electricity.g.neration from renewable energ. sources by.2030 (within the targ.t of 40% utilization of renewable energ. sources for the entire energ. g.neration of the country.by.2030). The power sector has to invest US$11 billion from 2023 to 2030 to contribute to reaching.this targ.t. This commentary.aims to provide a critical perspective on the recommendations of the report from the National Science and Technolog. Commission's 9th biennial conference in 2023 on science and technolog., the sub-thematic technical report on clean energ., energ. storag. and g.een hy.rog.n in line with the SDg. in the Sri Lankan context. The technical report provides insig.tful recommendations for Sri Lanka's energ. sector under three main sections: renewable energ., energ. storag. and g.een hy.rog.n. Also, it explores the potential of various renewable energ. sources, energ. storag. sy.tems and g.een hy.rog.n as sustainable solutions to address the country.s energ. challeng.s while emphasizing.the spillover effects of them, which could contribute to the enterprise's job creation and uplift the economy. This commentary.provides a critical perspective on clean energ., energ. storag. and g.een hy.rog.n in line with the United Nations SDg. in the Sri Lankan context based on a recent report from the National Science and Technolog. Commission of Sri Lanka. g.aphical Abstract

关键词： renewable energ. energ. storag. g.een hy.rog.n sustainable development g.als Sri Lanka social economic environmental sustainable affordable

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