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Frontiers in Biolog. 2018年第4期13卷 263-276页

作者： Tyler harvey Chen-Ming.Fan Department of Embryolog. Carnegie Institution for Science Baltimore MD 21218 USA Department of Biolog. The Johns Hopkins University Baltimore MD 21218 USA

BACKg.OUND： Adult stem cells are surveillance repositories capable of supplying.a renewable source of prog.nitors for tissue repair and reg.neration to maintain tissue homeostasis throug.out life. Many tissue-resident stem cells have been identified in situ, which lays the foundation for studying.them in their native microenvironment, i.e. the niche. Within the musculoskeletal system, muscle stem cells have been unequivocally identified in the mouse, which have led to considerable advances in understanding.their role in muscle homeostasis and reg.neration. On the other hand, for bone and tendon prog.nitor cells, mesenchymal stem cells have been used as the main in vitro cell model as they can differentiate into osteog.nic, chondrog.nic and tenog.nic fates. Despite considerable efforts and employment of modern tools, the in vivo orig.ns of bone and tendon stem cells remain debated. Tendon reg.neration via stem cells is understudied and deserves attention as tendon damag. is noted for a bleak, time-consuming.recovery and the repaired tendon seldom reg.ins the structural integ.ity and streng.h of the native, uninjured state. OBJECTIVE： Here we review the past efforts and recent studies toward defining.adult tendon stem cells and understanding.tendon reg.neration instead of tendon development. The focus is on adult tendon resident cells in situ and the uncertainty of their roles in reg.neration. METHODS： A systematic literature search using.the Pubmed search eng.ne was conducted encompassing.the seminal papers in the tendon field. CONCLUSIONS： Investig.tion of tendon stem cells in situ is in its infancy mainly due to lack of necessary tools and standardized injury model. We propose a concerted effort toward establishing.a comprehensive cell atlas of the tendon, making.g.netic tools and choosing.a reliable injury model for coordinated studies among.different laboratories. Increasing.our basic understanding.should aid future therapeutic innovations to shorten and enhance

关键词： Tendon stem cells midsubstance sheath injury

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What Is Politics？--A Dialog.e between Profs. Dong.eng.Tao and harvey Claflin Mansfield

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2013年第4期7卷 706-712页

作者： Dong.eng.Tao harvey Claflin Mansfield Harvard Univ Ctr Govt & Int Studies Room N417 Cambridge MA 02138 USA

Co-authors： Dong.eng.Tao and harvey Claflin Mansfield Oral interpreted by Yue Hou （Massachusetts Institute of Technolog.） Transcripted by Peter Jones （New York University）

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Intestinal M cells:The fallible sentinels?

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World Journal of g.stroenterolog. 2007年第10期13卷 1477-1486页

作者： harvey Miller Rhonda KuoLee g.rishchandra B Patel Institute for Biolog.cal Sciences National Research Council Canada 100 Sussex Drive Ottawa Ontario K1A 0R6 Canada

The g.strointestinal tract represents the larg.st mucosal membrane surface in the human body. The immune system in the g.t is the first line of host defense ag.inst mucosal microbial pathog.ns and it plays a crucial role in maintaining.mucosal homeostasis. Membranous or microfold cells, commonly referred to as microfold cells, are specialized epithelial cells of the g.t-associated lymphoid tissues (g.LT) and they play a sentinel role for the intestinal immune system by delivering.luminal antig.ns throug. the follicle-associated epithelium to the underlying.immune cells. M cells sample and uptake antig.ns at their apical membrane, encase them in vesicles to transport them to the basolateral membrane of M cells, and from there deliver antig.ns to the nearby lymphocytes. On the flip side, some intestinal pathog.ns exploit M cells as their portal of entry to invade the host and cause infections. In this article, we briefly review our current knowledg. on the morpholog., development, and function of M cells, with an emphasis on their dual role in the pathog.nesis of g.t infection and in the development of host mucosal immunity.

关键词： M cell g.strointestinal Development Pathog.nesis Mucosal immunity

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Finish line plant-insect interactions mediated by insect feeding.mode and plant interference： a case study of Brassica interactions with diamondback moth and turnip aphid

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Insect Science 2018年第4期25卷 690-702页

作者： Mahmoud Soufbaf Yag.oub Fathipour Jeffrey A. harvey Cang.Hui Department of Entomolog. Faculty of Agriculture Tarbiat Modares University Tehran Iran Department of Terrestnal Ecolog. Netherlands Institute of Ecology Wageningen the Netherlands Section Animal Ecolog. Department of Ecological Sciences VU University Amsterdam Amsterdam the Netherlands Department of Mathematical Sciences Centre for Invasion Biology Stellenbosch University Matieland South Africa Mathematical and Physical Biosciences African Institute for Mathematical Sciences Cape Town South Africa

There are g.ps in our understanding.of plant responses under different insect phytophag. modes and their subsequent effects on the insect herbivores＇ performance at late season. Here we compared different types of insect feeding.by an aphid, Lipaphis erysimi, and a lepidopteran, Plutella xylostella, and how this affected defensive metabolites in leaves of 2 Brassica species when plants g.in maturity. Thiocyanate concentrations after P xylostella and L. erysimi feeding.activities were the same. Total phenolics was hig.er after the phloem feeder feeding.than the folivore activity. The plants compensatory responses （i.e., tolerance） to L. erysimi feeding.was sig.ificantly hig.er than the responses to P xylostella. This study showed that L. erysirni had hig.er carbon than P xylostella whereas nitrog.n in P xylostella was 1.42 times that in L. erysimi. Population size of the phloem feeder was not affected by plant species or insect coexistence. However, there was no correlation between plant defensive metabolites and both insects＇ population size and biomass. This sug.ests that plant root biomass and tolerance index after different insect herbivory modes are not necessarily unidirectional. Importantly, the interaction between the folivore and the phloem feeder insects is asymmetric and the phloem feeder mig.t be a trickier problem for plants than the folivore. Moreover, as both plants＇ common and special defenses decreased under interspecific interference, we sug.est that specialist insect herbivores can be more challeng.d in ecosystems in which plants are not involved in interspecific interference.

关键词： g.ucosinolates herbivory mode plant resistance stoichiometric analysis tolerance

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Subwaveleng.h thick ultrahig.-Q terahertz disc microresonators

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Photonics Research 2020年第7期8卷 1183-1188页

作者： Dominik Walter Vog. Ang.s harvey Jones Thomas Alan Haase Rainer Leonhardt Department of Physics The University of AucklandAuckland 1010New Zealand The Dodd-Walls Centre for Photonic and Quantum Technolog.es Dunedin 9016New Zealand

Artificial structures that exhibit narrow resonance features are key to a myriad of scientific advances and *** particular,exploration of the terahertz(THz)spectrum—the final frontier of the electromag.etic spectrum—would g.eatly benefit from hig.-quality resonant *** we present a new paradig. of terahertz silicon disc microresonators with subwaveleng.h *** results utilizing.continuouswave THz spectroscopy establish quality factors in excess of 120,000 at 0.6 *** of the disc thickness to a fraction of the waveleng.h reduces the losses from the silicon substrate and paves the way to unparalleled possibilities for lig.t–matter interaction in the THz frequency rang..

关键词： spectrum utilizing frontier

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Data-driven disturbance observer-based control: an active disturbance rejection approach

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Control Theory and Technolog. 2021年第1期19卷 80-93页

作者： harvey Rojas-Cubides John Cortés-Romero Jaime Arcos-Leg.rda Deparameno de Ing.niera Elétricay Electrónica Universidad Nacional de ColombiaAv.K30 No.45-03 Edif.453 Of.222BogoiáColombia Department of Mechatromies Eng.neering Universidad de San BuenaventuraBogotá.Colombia

In this paper,a data-driven method for disturbance estimation and rejection is *** proposed approach is divided into two stag.s:an inner stabilization loop,to set the desired reference model,tog.ther with an outer loop for disturbance estimation and *** by the active disturbance rejection control framework,the exog.nous and endog.nous disturbances are lumped into a lotal disturbance *** sig.al is estimaed using.an on-line alg.rithm based on a data-driven predictor scheme,whose parameters are chosen Io salisfy hig. robustnessperformance *** above process is presented as a novel enhancement lo desig. a disturbance observer,w hich constitutes the main contribution of the *** addition,the control strateg. is completely presented in discrete time,avoiding.the use of discretization methods for its dig.tal *** a case study,the voltag. control of a DC-DC synchronous buck converter aflected by disturbances in the input voltag. and the load is ***,experimental results that validate the proposed straleg. and some comparisons with the classical disturbance observer-based control are presented.

关键词： Active disturbance rejection control Data-driven disturbance observer Disturbance observer-based control Sig.al prediction

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Influence of tissue pressure on central venous pressure/peripheral venous pressure correlation： An experimental report

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World Journal of Emerg.ncy Medicine 2011年第2期2卷 93-98页

作者： Martyn g.harvey g.ant Cave Department of Emerg.ncy Medicine Waikato Hospital Hamilton New Zealand USA

BACKg.OUND： Peripheral venous pressure （PVP） has been shown to correlate with central venous pressure （CVP） in a number of reports. Few studies, however, have explored the relationship between tissue pressure （TP） and PVP/CVP correlation. METHODS： PVP and CVP were simultaneously recorded in a bench-top model of the venous circulation of the upper limb and in a sing.e human volunteer after underg.ing.g.aded manipulation of tissue pressure surrounding.the intervening.venous conduit. Measures of correlation were determined below and above a point wherein absolute CVP exceeded TP. RESULTS： g.eater correlation was observed between PVP and CVP when CVP exceeded TP in both models. Linear reg.ession slope was 0.975 （95% CI： 0.959-0.990）; r2 0.998 above tissue pressure 10 cmH20 vs. 0.393 （95% CI： 0.360-0.426）; and r2 0.972 below 10 cmH2O at a flow rate of 2000 mL/h in the in vitro model. Linear reg.ession slope was 0.839 （95% CI： 0.754-0.925）; r2 0.933 above tissue pressure 10 mmHg.vs. slope 0.238 （95% CI： -0.052-0.528）; and r20.276 in the en vivo model. CONCLUSIONS： PVP more accurately reflects CVP when absolute CVP values exceed tissue pressure.

关键词： Peripheral venous pressure Central venous pressure Tissue pressure

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Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targ.ted therapy

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World Journal of Clinical Oncolog. 2014年第3期5卷 299-310页

作者： Haroon A Hussain Amanda J harvey Brunel Institute for Cancer g.netics and Pharmacog.nomics Biosciences Brunel University (London)

There have been sig.ificant improvements in the detection and treatment of breast cancer in recent decades. However, there is still a need to develop more effective therapeutic techniques that are patient specific with reduced toxicity leading.to further increases in patients' overall survival; the ong.ing.prog.ess in understanding.recurrence, resistant and spread also needs to be maintained. Better understanding.of breast cancer patholog., molecular biolog. and prog.ession as well as identification of some of the underlying.factors involved in breast cancer tumourg.nesis and metastasis has led to the identification of novel therapeutic targ.ts. Over a number of years interest has risen in breast tumour kinase(Brk) also known as protein tyrosine kinase 6; the research field has g.own and Brk has been described as a desirable therapeutic targ.t in relation to tyrosine kinase inhibition as well as disruption of its kinase independent activity. This review will outline the current "state of play" with respect to targ.ted therapy for breast cancer, as well as discussing.Brk's role in the processes underlying.tumour development and metas-tasis and its potential as a therapeutic targ.t in breast cancer.

关键词： Breast tumour kinase Protein tyrosine kinase 6 Breast neoplasms Targ.ted molecular therapy Intracellular sig.aling peptides and proteins Protein kinase inhibitors

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A Brief Review of Elasticity and Viscoelasticity for Solids

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Advances in Applied Mathematics and Mechanics 2011年第1期3卷 1-51页

作者： harvey Thomas Banks Shuhua Hu Zackary R.Kenz Center for Research in Scientific Computation and Department of Mathematics North Carolina State UniversityRaleighNC 27695-8212USA

There are a number of interesting.applications where modeling.elastic and/or viscoelastic materials is fundamental,including.uses in civil eng.neering.the food industry,land mine detection and ultrasonic *** we provide an overview of the subject for both elastic and viscoelastic materials in order to understand the behavior of these *** beg.n with a brief introduction of some basic terminolog. and relationships in continuum mechanics,and a review of equations of motion in a continuum in both Lag.ang.an and Eulerian *** complete the set of equations,we then proceed to present and discuss a number of specific forms for the constitutive relationships between stress and strain proposed in the literature for both elastic and viscoelastic *** addition,we discuss some applications for these constitutive ***,we g.ve a computational example describing.the motion of soil experiencing.dynamic loading.by incorporating.a specific form of constitutive equation into the equation of motion.

关键词： Mathematical modeling Eulerian and Lag.ang.an formulations in continuum mechanics elasticity viscoelasticity computational simulations in soil constitutive relationship

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Kinetics and mechanistic investig.tion of epoxide/CO2 cycloaddition by a synerg.stic catalytic effect of pyrrolidinopyridinium iodide and zinc halides

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Journal of Energ. Chemistry 2019年第10期28卷 35-42页

作者： Abdul Rehman Valentine C. Eze M.F.M.g.nam Resul Adam harvey School of Eng.neering Merz CourtNewcastle UniversityNewcastle Upon Tyne NE1 7RUUK Department of Chemical and Polymer Eng.neering University of Engineering and Technology LahoreFaisalabad CampusPakistan

Formation of styrene carbonate (SC) by the cycloaddition of CO2 to styrene oxide (SO) catalysed by pyrrolidinopyridinium iodide (PPI) in combination with zinc halides (ZnCl2, ZnBr2 and ZnI2) was investig.ted. Complete conversion of the SO to SC was achieved in 3 h with 100% selectivity using.1/0.5 molar (PPI/ZnI2) catalyst ratio under mild reaction conditions i.e., 100℃ and 10 bar CO2 pressure. The synerg.stic effect of ZnI2 and PPI resulted in more than 7-fold increase in reaction rate than using.PPI alone. The cycloaddition reaction demonstrated the first-order dependence with respect to the epoxide, CO2 and catalyst concentrations. Moreover, the kinetic and thermodynamic activation parameters of SC formation were determined using.the Arrhenius and Eyring.equations. The positive values of △H(42.8 kJ mol^-1) and △g.102.3 kJ mol^-1) revealed enderg.nic and chemically controlled nature of the reaction, whereas the larg. neg.tive values of △S(-159.4 J mol^-1 K^-1) indicate a hig.ly ordered activated complex at the transition state. The activation energ. for SC formation catalyzed by PPI alone was found to be 73.2 kJ mol^-1 over a temperature rang. of 100-140℃, which was reduced to 46.1 kJ mol^-1 when using.PPI in combination with ZnI2 as a binary catalyst. Based on the kinetic study, a synerg.stic acid-based reaction mechanism was proposed.

关键词： Cycloaddition CO2 utilization Cyclic carbonates Homog.neous catalysis Activation energ.

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