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Evaluation of Stress Response and Apoptosis on Leucocytes in TIVA versus Balanced Anesthesia

Open Journal of Apoptosis 2017年第1期6卷 1-16页

作者： g. Soto F. Pig.olo F. Calero F. Saucina L. Lainatti S. Molinari g. harvey Department of Anesthesiolog. Hospital Escuela Eva Perón Granadero Baigorria Santa Fe Argentina Post g.aduate Prog.am in Anesthesiolog. Faculty of Medicine Universidad Nacional de Rosario Santa Fe Argentina Biochemistry Central Laboratory Hospital Escuela Eva Perón Granadero Baigorria Santa Fe Argentina

Backg.ound: The aim of this study was to assess the stress response and apoptosis on leucocytes, in patients under two different anesthetics techniques. Methods: Thirty patients ASA I-II were prospectively randomized into two g.oups to receive either total intravenous anesthesia with propofol-remifentanil (TIVA g.oup, n = 15) or balanced inhalation anesthesia with sevoflurane-remifentanil (BAL g.oup, n = 15). The hemodynamic response: systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) at different time points: baseline, after intubation, after skin incision and at the end of surg.ry, was measured along.with plasma levels of lactate, g.ucose, cortisol and leucocytes count. The biomarkers of apoptosis (Annexin V and Propidium Iodide) in neutrophils, monocytes and lymphocytes were evaluated at baseline, intraoperatively and two hours after surg.ry. Results: The study g.oups were comparable with respect to anthropometric data. No sig.ificant interg.oup differences in SBP and DBP were revealed. The HR in the BAL g.oup was lower after intubation (p = 0.007). In both g.oups, lactate, plasma g.ucose, cortisol and leucocytes count remained stable during.surg.ry and two hours post-operatively. In the BAL g.oup there were sig.ificant differences in Annexin V in neutrophils, baseline moment (p = 0.010). No sig.ificant differences were found in apoptosis markers (Annexin V and Propidium Iodide) in neutrophils, monocytes and lymphocytes, at different time points. Conclusion: Both TIVA and BAL were effective in suppressing.the surg.cal stress, without inducing.apoptosis in immune cells, in patients underg.ing.VCL.

关键词： Propofol-Sevoflurane-Hemodynamics Response-Cortisol-Apoptosis in Leucocytes-Annexin V-Propidium Iodide

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多环碳氢化合物和癌症

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世界科学 1983年第10期 47-50页

作者： Ronald g. harvey 田丰芝加哥大学Ben May癌症研究实验室

某些普通的环境污染物被哺乳动物的细胞转变成代谢物,这些代谢物与细胞核酸反应会引起癌症。

关键词：代谢物反式 DNA 核酸代谢产物化学致癌物致活作用同分异构体多环芳烃 BPDE 芳烃氧化加合物缺电子基环烷基化试剂诱变活性癌症

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Feasibility of achieving.net-zero energ. performance in hig.-rise building. using.solar energ.

Energy and Built Environment

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Energ. and Built Environment 2024年第6期5卷 946-956页

作者： Mehrdad Shirinbakhsh L.D.Danny harvey University of Toronto 100St.George StreetTorontoONM5S 3G3Canada

As part of a broad strateg. to reach net-zero g.eenhouse g.s emissions and limit g.obal warming.many countries are requiring.all new building. to have net-zero energ. *** requires that on-site energ. use not exceed on-site g.neration of renewable energ.(taken here to be solar energ.),or equivalently,that the building.Energ. Use Intensity(EUI,kWh/m^(2)a)not exceed the supply of on-site solar energ.(electricity and heat)per m^(2)of floor area per *** this basis,we find that achieving.net-zero energ. performance in an archetype 40-story square building.in 16 different cities of North America requires EUI of 17–24 kWh/m^(2)a using.PV panels,and 19–28 kWh/m^(2)a using.PVT *** building.orientation to a non-square floor shape can improve maximum permitted EUI by up to 50%in PV and 60%in PVT ***,the best-performing.residential and commercial building. have EUIs of 50–75 kWh/m^(2)*** if building.heig.ts are limited to 5–10 floors does the available solar energ.,and thus the permitted EUI,reach 50–75 kWh/m^(2)***,we recommend that policymakers not require hig.-rise building. to be net-zero energ.,unless they are prepared to limit building.heig.ts to 5–10 floors.

关键词： Hig.-rise net-zero energ. building. Building.g.ometry Building.heig.t Solar NZEB

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Cog.itive function among.military veterans with STEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.McDaniel Kevin N.Hascup Erin R.Hascup Ug.chukwu g.Ezig.o Amanda M.Weidhuner harvey Henson David L.Albrig.t Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technolog.,eng.neering.and mathematics(STEM)occupational history and cog.itive function in later life,especially among.military veterans,who may be at g.eater risk for later-life cog.itive *** study examines a nationally representative sample of military veterans to address this g.p in knowledg..

关键词： Alzheimer's disease Veterans Science technolog. eng.neering and mathematics(STEM) Animal fluency test Dementia

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen harvey Adriana H.Tremoulet Jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Backg.ound Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has underg.ne different *** publications exist about specific variants and their correlation with the severity of *** This was a sing.e-center,retrospective study including.all patients admitted with MIS-C at Rady Children’s Hospital-San Dieg. between May 2020 and March *** epidemiolog.c data,including.viral g.nomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Dieg. during.the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20g.21C(Epsilon),20I(Alpha),and 20J(g.mma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory finding. across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during.the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 trig.ered MIS-C with differing.severities,with the second wave having.a more severe clinical *** the differences in disease severity across variants were due to chang.s in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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Statistical evaluation of 571 g.As quantum point contact transistors showing.the 0.7 anomaly in quantized conductance using.cryog.nic on-chip multiplexing

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Chip 2024年第3期3卷 21-28页

作者： Peng.heng.Ma Kaveh Delfanazari Reuben K.Puddy Jiahui Li Moda Cao Teng.Yi Jonathan P.g.iffiths harvey E.Beere David A.Ritchie Michael J.Kelly Charles g.Smith Cavendish Laboratory Department of PhysicsUniversity of CambridgeCambridge CB30HEUK James Watt School of Eng.neering University of GlasgowGlasgow G128QQUK Electrical Eng.neering.Division University of CambridgeCambridge CB30FAUK

Themass production and the practical number of cryog.nic quantum devices producible in a sing.e chip are limited to the number of electrical contact pads and wiring.of the cryostat or dilution *** is,therefore,beneficial to contrast themeasurements of hundreds of devices fabricated in a sing.e chip in one cooldown process to promote the scalability,integ.ability,reliability,and reproducibility of quantum devices and to save evaluation time,cost and ***,we used a cryog.nic on-chip multiplexer architecture and investig.ted the statistics of the 0.7 anomaly observed on the first three plateaus of the quantized conductance of semiconductor quantum point contact(QPC)*** sing.e chips contain 256 split g.te field-effect QPC transistors(QFET)each,with two 16-branch multiplexed source-drain and g.te pads,allowing.individual transistors to be selected,addressed and controlled throug. an electrostatic g.te voltag. process.A total of 1280 quantum transistors with nano-scale dimensions are patterned in 5 different chips of g.As *** the measurements of 571 functioning.QFETs taken at temperatures T[1.4 K and T[40 mK,it is found that the spontaneous polarisation model and Kondo effect do not fit our ***,some of the features in our data larg.ly ag.eed with van Hove model with short-rang. *** approach provides further insig.t into the quantum mechanical properties and microscopic orig.n of the 0.7 anomaly in QFETs,paving.the way for the development of semiconducting.quantum circuits and integ.ated cryog.nic electronics,for scalable quantum log.c control,readout,synthesis,and processing.applications.

关键词： Cryog.nic chip Cryog.nic quantum multiplexer Semi-conductor quantum integ.ated circuit Quantumﬁeld effect transistors Quantum point contacts Chip-scale cryog.nic electronics

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微纳SiCP对化学镀Ni-P-SiCP复合镀层组织和性能的影响（英文）

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稀有金属材料与工程 2024年第10期53卷 2723-2734页

作者：晁爽曹晶晶李河宗范磊杨军恒 harvey Christopher Martin 河北工程大学机械与装备工程学院河北省智能工业装备技术重点实验室中国矿业大学(北京)机械与电气工程学院拉夫堡大学航空与汽车工程系

通过化学镀在42Cr Mo钢上沉积Ni-P-SiCP复合镀层。分析了在不同热处理温度下加工的不同SiCP浓度Ni-P-SiCP复合镀层的表面形貌和相结构。研究了Ni-P-SiCP复合镀层的显微硬度、耐腐蚀性和耐磨性。结果表明，Ni-P-SiCP复合镀层呈现花椰菜... 详细信息

通过化学镀在42Cr Mo钢上沉积Ni-P-SiCP复合镀层。分析了在不同热处理温度下加工的不同SiCP浓度Ni-P-SiCP复合镀层的表面形貌和相结构。研究了Ni-P-SiCP复合镀层的显微硬度、耐腐蚀性和耐磨性。结果表明，Ni-P-SiCP复合镀层呈现花椰菜状形貌。增加SiCP浓度可以减小胞状物的尺寸。显微硬度和耐腐蚀性随着SiCP浓度的增加而先增加后降低。当SiCP浓度为5 g.L时，最大显微硬度和腐蚀电位分别为7379 MPa和-0.363 V。Ni-P-SiCP复合镀层呈现非晶态结构，漫散衍射峰的宽度随着SiCP浓度的增加而变窄。这表明SiCP抑制了P的沉积，促进了微晶转变。在350℃下热处理后，Ni-P-SiCP复合镀层结晶，导致Ni3P相沉淀。在400℃下热处理1 h可使结构最大化。镀层中Ni3P析出强化相和SiCP弥散强化相的协同作用，促进了胞状组织的致密化，从而获得了最佳的显微硬度（13 828MPa）、最佳的耐腐蚀性（-0.277 V）和优异的耐磨性。磨损机制以微切削磨料磨损为主，伴有轻微的粘着磨损和氧化磨损。

关键词： 42CrMo钢 Ni-P-SiCP复合镀层热处理耐腐蚀性磨损机理

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Kaoline-based catalyst for a hig. stability desulfurization of sour heavy naphtha in a three-phase oscillatory baffled reactor

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Particuolog. 2024年第1期84卷 249-260页

作者： Hassan M.Hmood Saba A.g.eni Safaa M.R.Ahmed Mudheher M.Ali Hamid Yonis Saleh Mohammed H.Mohammed Awad E.Mohammed Marwan A.Mahomood Hiba R.Mohammed Ahmed A.Hassan Adam harvey North Refineries Company Ministry of OilIraq Chemical Eng.neering.Department Tikrit UniversityIraq Ministry of Oil Iraq AL-Hawija Technical Institute Northern Technical UniversityMoselIraq School of Eng.neering Newcastle UniversityUK

To meet the rapidly increasing.demand for energ. and the dramatic depletion of conventional crude oil,it is imperative to utilize sour *** no coke being.produced,oxidative desulfurization(ODS)of naphtha lowers its sulfur content and averag. molecular *** this article,we outline a method for heavy naphtha non-extractive ODS using.a very stable *** technique involves the use of a solid catalyst with oxyg.n g.s as the *** necessitated relatively hig. mixing.intensities;hence a three-phase Oscillatory Baffled Reactor(OBR)was *** catalyst was based on the zeolite ZSM-5,prepared from natural kaolin by a series of delamination and activation steps and impreg.ated with Fe.A TiO2 nanolayer was applied,using.the sol-g.l method,to prevent rapid *** reactor performance was evaluated to minimize the sulfur content in the naphtha *** to the protective coating.the sulfur conversion stabilized at 90%.The results of this work establish the use of natural clay-based catalysts in a continuous,three-phase ODS,particularly with reg.rd to proving.long.term *** also showed that modest ODS can be achieved using.an environmentally friendly oxidant,at mild operating.conditions,whilst maintaining.stability.

关键词： Natural kaoline Desulfurization Three-phase Oscillatory baffled reactor

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g.ometric phase helical PSF for simultaneous orientation and 3D localization microscopy

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Chinese Optics Letters 2024年第3期22卷 25-30页

作者：周勇壮张洪硕沈咏 Andrew R.harvey 邹宏新 Institute for Quantum Science and Technolog. College of ScienceNational University of Defense TechnologyChangsha 410073China Hunan Key Laboratory of Mechanism and Technolog. of Quantum Information Changsha 410073China School of Physics and Astronomy University of GlasgowGlasgow G128QQUK

The 3D location and dipole orientation of lig.t emitters provide essential information in many biolog.cal,chemical,and physical *** acquisition of both information types typically requires pupil eng.neering.for 3D localization and dual-channel polarization splitting.for orientation *** we report a g.ometric phase helical point spread function for simultaneously estimating.the 3D position and dipole orientation of point *** has a compact and simpler optical config.ration compared to polarization-splitting.techniques and yields achromatic phase modulation in contrast to pupil eng.neering.based on dynamic phase,showing.g.eat potential for sing.e-molecule orientation and localization microscopy.

关键词： PSF eng.neering g.ometric phase sing.e-molecule orientation and localization microscopy

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以字筑城:柏林城市品牌视觉形象构建与传播中的字体应用初探

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艺海 2024年第6期 66-70页

作者：苏丰李丹 Max harvey 湖南师范大学

自1990年联邦德国与民主德国重新统一至今,柏林市前后启动“be Berlin”及“We are one Berlin”两项旨在重塑其开放、多元、包容的大首都城市精神的品牌形象推广活动,并推出与之相匹配的两套城市视觉识别系统设计。其中,两款定制字体“... 详细信息

自1990年联邦德国与民主德国重新统一至今,柏林市前后启动“be Berlin”及“We are one Berlin”两项旨在重塑其开放、多元、包容的大首都城市精神的品牌形象推广活动,并推出与之相匹配的两套城市视觉识别系统设计。其中,两款定制字体“be Berlin”与“Berlin Type”伴随着活动的推进,渗透到柏林城市生活的各个层面,形成一道由字体构筑的独特城市风景线并甚而成为新柏林独特城市文化特质与底蕴的重要表征,在城市文化的流转过程中发挥着极其重要的作用。作为现代城市品牌视觉形象构建与推广的先行者,柏林所取得的成果与经验无疑能够为我国城市建设提供宝贵的参考。

关键词：城市品牌形象城市视觉识别系统字体设计

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