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Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project

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World Journal of gastroenterology 2013年第14期19卷 2208-2216页

作者： Aldo Roda Mara Mirasoli Massimo guardigli Patrizia simoni Davide Festi Boris Afonin galina Vasilyeva Department of Chemistry "g.Ciamician" University of Bologna-Alma Mater Studiorum Department of Medical and Surgical Sciences University of Bologna-Alma Mater Studiorum State Scientific Center of Russian Federation-Institute of Biomedical Problems of the Russian Academy of Sciences(IBMP)

AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term ***:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 *** particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid *** addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal *** no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the ***:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external *** evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy *** contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same *** variability suggested that the H 2-breath

关键词： Breath test gastrointestinal inflammation gastrointestinal motility Spaceflight Stress

Unusual Detection of Lathosterol in Amniotic Fluids Investigated for the Determination of Cholesterol and 7-Dehydrocholesterol for Suspected Smith-Lemli-Opitz Syndrome

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American Journal of Analytical Chemistry 2014年第4期5卷 249-257页

作者： Veniero gambaro Fiorenza Farè Andrea Barlocco Federico Maggi giuseppe simoni Lucia Dell’Acqua Chiara Rusconi gabriella Roda Dipartimento di Scienze Farmaceutiche “Pietro Pratesi” University of Milan Milan Italy Laboratorio TOMA srl Busto Arsizio Italy

The Smith-Lemli-Opitz syndrome (SLOS), is an autosomal recessive disorder caused by a 7-dehydrocholesterol reductase deficiency, which is characterized by abnormally elevated amniotic fluid 7-DHC (7-dehydrocholesterol) concentrations. A gC/FID (gas-chromatography with a flame ionization detector) and gC/MS (gas-chromatography with a mass detector) method was optimized for the detection of cholesterol and 7-DHC in amniotic fluids. The quantitative determination of cholesterol in 39 control amniotic fluids evidenced that between the fourth and fifth month of pregnancy the levels of this analyte are quite constant, the concentration of total and free cholesterol being respectively 10.3 μg·mL﹣1 (SD = ±3.6) and 1.7 μg·mL﹣1 (SD = ±0.91), while the analysis of 60 amniotic fluids potentially related to SLOS, showed a higher variability of cholesterol levels. Moreover, in 13 samples an analyte which did not correspond either to cholesterol or to 7-DHC was detected. A gC/MS investigation allowed us to identify this compound as lathosterol, a precursor of cholesterol in the biosynthetic pathway.

关键词： Lathosterol Cholesterol SLO Syndrome Amniotic Fluid gC/FID gC/MS

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高雅运动

室内设计与装修 2006年第7期 82-85页

作者： Fulvio De simoni Samuele Martelli 许科

Pershing115’号第一次亮相就赢得满堂喝彩,在2004热那亚(意大利西北名城)国际船只展上,首次向公众展示的Pershing115’号就获得了室内设计特别奖。紧接着,在2005年摩纳哥久负盛名的航海展上它又获得大会的最高奖“Show B oats Aw ard2... 详细信息

Pershing115’号第一次亮相就赢得满堂喝彩,在2004热那亚(意大利西北名城)国际船只展上,首次向公众展示的Pershing115’号就获得了室内设计特别奖。紧接着,在2005年摩纳哥久负盛名的航海展上它又获得大会的最高奖“Show B oats Aw ard2005”。应该说,所有的奖项都不仅仅因为Per（共4页)

关键词：运动 Award 室内设计意大利造船所

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铀酰离子在TiO2表面的吸附

铀酰离子在TiO2表面的吸附

第七届全国核化学与放射化学学术讨论会

作者：吴王锁 E.simoni R．Drot 兰州大学放射化学与核环境研究所 Institut de Physique Nucléaire Groupe de RadiochimeUniversité Paris ⅪBatiment 10091406 CedexOrsayFrance

研究放射性核素在水溶液和固体表面之间的行为,首先需要研究放射性核素在各种不同条件(如不同pH值,不同表面性质)下的吸附行为。本文用间歇法, 在常温常压条件下,研究了在不同pH范围内,不同电解质溶液KNO3和NaClO4 溶液中,铀酰离子在TiO...

研究放射性核素在水溶液和固体表面之间的行为,首先需要研究放射性核素在各种不同条件(如不同pH值,不同表面性质)下的吸附行为。本文用间歇法, 在常温常压条件下,研究了在不同pH范围内,不同电解质溶液KNO3和NaClO4 溶液中,铀酰离子在TiO2两种品型(rutile,anatase)固体表而的吸附行为。结果发现,铀酰离予在rutile表面的吸附边界为pH=1．5-4．5,而在anatase表面的吸附

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乙酸对铀酰在硅胶上的吸附行为的影响

乙酸对铀酰在硅胶上的吸附行为的影响

Magic and forensic psychiatry:A case study and review of the literature

第二届全国核化学与放射化学青年学术研讨会

作者：赵羽佳 Florence MERCIER-BION grégory LEFEVRE Eric simoni 上海交通大学核科学与工程学院 Laboratoire d'Electrochimie Chimie des Interfaces et Modélisation pour I'EnergieUMR 7575CNRS/Chimie ParisTech Institut Physique Nucléaire d'Orsay CNRS/Université Paris Sud

采用宏观定量分析与微观光谱表征相结合的方法定义了铀酰在水溶液/硅胶界面上的分布形态,并重点研究了短链羧酸对铀酰在硅胶上的吸附行为的影响。研究结果表明:宏观热力学上,随乙酸浓度增加,铀酰在硅胶上的吸附率随之下降。这一现象可...

采用宏观定量分析与微观光谱表征相结合的方法定义了铀酰在水溶液/硅胶界面上的分布形态,并重点研究了短链羧酸对铀酰在硅胶上的吸附行为的影响。研究结果表明:宏观热力学上,随乙酸浓度增加,铀酰在硅胶上的吸附率随之下降。这一现象可以解释为羧酸与铀酰在水溶液中形成可溶性络合物,并与硅胶上的吸附点对铀酰的表面络合形成竞争关系。

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World Journal of Meta-Analysis 2021年第1期9卷 45-50页

作者： gentian Vyshka Sandër simoni Biomedical and Experimental Department Faculty of MedicineUniversity of MedicineTirana 1005Albania Law and Jurisprudence Albanian School of MagistratesTirana 1005Albania

Forensic psychiatrists routinely appear in courts for crimes that have been perpetrated by mentally ill patients or when the defendant is suffering from a major psychiatric ***,committing crimes under the presumed effects of magic and witchcraft is uncommon.A variety of delusional thoughts and personality disorders have been imputed in aggressive behaviour that might culminate in *** patterns of a premeditated homicide,as well as the aberrations of the interpersonal relations,as a rule require long-term and close *** such,the family is a setting where such occurrences have been *** describe a case of first-degree murder by a woman who killed her mother-in-law after accusing her repeatedly of sorcery and *** complicated cases cannot be resolved without the help of forensic experts,whose role remains multifaceted and of particular importance.

关键词： Belief in magic Witchcraft Criminology Forensic psychiatry

Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

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Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio gonçalves da Costa Sousa gabriela Conceiçao de Almeida Danilo Cesar Martins Mota Rosiane Andrade da Costa simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo Daniel Pletzer Letícia Chaves de Souza glaucia Schuindt Teixeira Renato M.Silva Robert E.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-graduation Program in genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

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不稳定粘土斜坡孔隙水监测初步分析

水文地质工程地质技术方法动态 2006年第1期 24-32,23页

作者： A. simoni M. Berti M. generali C. Elmi M. ghirotti 史二岭（翻译）文宝萍（翻译） Dipartimento di Scienze della Terra e geologico-Ambientali Universita di Bologna Via Zamboni 67-40126 Bologna Italy 中国地质大学（北京）水资源与环境学院北京海淀区学院路29号 100083

我们通过监测位于亚平宁地区的一个粘土斜坡内正孔隙水压力来分析降水如何影响沿土体剖面的孔隙压力分布，从而影响斜坡稳定性。监测数据在监测滑坡活动的第一个季节（2001年8月-2002年6月）获得。研究地点位于一个复杂滑坡后缘，该处... 详细信息

我们通过监测位于亚平宁地区的一个粘土斜坡内正孔隙水压力来分析降水如何影响沿土体剖面的孔隙压力分布，从而影响斜坡稳定性。监测数据在监测滑坡活动的第一个季节（2001年8月-2002年6月）获得。研究地点位于一个复杂滑坡后缘，该处斜坡即将发生浅层滑坡，斜坡变形特征非常明显。孔隙水压力数据的初步分析显示，过去11个月其变化呈现稳定的趋势。在寒冷潮湿的季节里，饱和带通常延伸到接近地表（小于1m）。孔隙水压力测量显示，任何条件下，整个斜坡内存存明显的垂直向下水流，但其在很大程度上受顺坡水流控制。与降雨对应，浅层地表（1—3m）存在压力脉冲，与低渗透性土体相比，其滞后过程很短，并且水流有瞬时水流的特征。斜坡在观察期问破坏，孔隙水压力的瞬时反应说明其为孔隙水压力型滑坡。地下水流存在优势路径，这种现象可以解释在同样深度内一些传感器的异常反应。

关键词：监测孔隙水压力粘土斜坡滑坡亚平宁山区

比较全身MRI(WB-MRI)与中轴骨MRI(AS-MRI)对前列腺癌(PCa)骨转移瘤的检出与计量

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国际医学放射学杂志 2011年第1期34卷 101-102页

作者： F.E.Lecouvet M.Simon B.Tombal J.Jamart B.C.Vande Berg P.simoni 许亮 Department of Radiology and Medical Imaging Université Catholique de LouvainCliniques Universitaires St Luc

目的比较全身MRI(WB-MRI)和中轴骨MRI(AS-MRI)对前列腺癌(PCa)骨转移瘤的检出与计量。方法对60例存在转移瘤高风险的PCa病人行WB-MRI和AS-

关键词：前列腺癌骨 MRI 转移瘤