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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan safak shenghan Wang Carmen Mota Reyes Ibrahim Halil gürcinar sergey Tokalov Nedim Can Cevik Kivanc görgülü Bengi su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik sever samedÖzer güldal süyen Helmut Friess güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of general surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany graduate school of Health sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician scientist Professorship for Translational Pancreatic surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

Review of Computational Approaches to Optimization Problems in Inhomogeneous Rods and Plates

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Communications on Applied Mathematics and Computation 2024年第1期6卷 236-256页

作者： Weitao Chen Chiu-yen Kao Department of Mathematics University of California at Riverside900 University AveRiversideCA92521USA Department of Mathematical sciences Claremont McKenna College850 Columbia AveClaremontCA91711USA

In this paper,we review computational approaches to optimization problems of inhomogeneous rods and *** consider both the optimization of eigenvalues and the localization of *** problems are motivated by physical problems including the determination of the extremum of the fundamental vibration frequency and the localization of the vibration *** demonstrate how an iterative rearrangement approach and a gradient descent approach with projection can successfully solve these optimization problems under different boundary conditions with different densities given.

关键词： Inhomogeneous rods and plates Bi-Laplacian Optimization of eigenvalues Localization of eigenfunctions Rearrangement

Addressing Japan’s disposal of nuclear-contaminated water from the perspective of international human rights law

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 1-9页

作者： yen-Chiang Chang Xiaonan Zhao Law school Dalian Maritime UniversityDalian 116026China Institute for Bohai and Yellow sea studies Dalian Maritime UniversityDalian 116026China

The discharge of nuclear-contaminated water containing radionuclides into the ocean by Japan will lead to its integration into the entire ecosystem through processes of circulation and biomagnification,eventually entering the human body via the food *** poses a substantial risk of irreversible damage to both the ecosystem and human health,a situation that will worsen with the ongoing discharge of such *** respect and protection of human rights represent an international consensus,and safeguarding fundamental human rights is a substantial obligation that states must undertake in accordance with both international and domestic *** the Fukushima nuclear disaster,Japan has continuously violated its international legal obligations to protect human rights in several areas,including the resettlement of disaster victims,the reduction of nuclear radiation levels,and the handling of contaminated *** actions have compromised and will continue to compromise the basic human rights of not only its citizens but also those of people worldwide,including environmental rights,the right to life,development rights,and food *** the aftermath of the Fukushima meltdown,the public and workers involved in handling nuclear contaminants have been continually exposed to high radiation levels,endangering their rights to life,development,and ***’s inadequate efforts in victim resettlement and environmental restoration have jeopardized the environmental and food rights of its citizens to live healthily and access food in an environment unaffected by nuclear *** release of nuclear-contaminated water poses a risk of Japan’s nuclear pollution to the people of neighboring countries and the global population at *** principle of human rights underpins the theory of a community with a shared future for humanity,and human rights are a crucial area of China’s active participation in United Nations affairs and global *** voicing concerns ove

关键词： Fukushima nuclearcontaminated water Crimes against humanity Remedy for violations of human rights Right to environment Right to life

study of hybrid nanofluid flow in a stationary cone-disk system with temperature-dependent fluid properties

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 677-694页

作者： A.s.JOHN B.MAHANTHEsH g.LORENZINI Center for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Karnataka 560029India school of Mathematical and statistical sciences The University of Texas Rio Grande ValleyTexas 78539U.S.A. Department of Engineering and Architecture University of ParmaParma 43124Italy

Cone-disk systems find frequent use such as conical diffusers,medical devices,various rheometric,and viscosimetry *** this study,we investigate the three-dimensional flow of a water-based Ag-Mg O hybrid nanofluid in a static cone-disk system while considering temperature-dependent fluid *** the variable fluid properties affect the dynamics and heat transfer features is studied by Reynolds's linearized model for variable viscosity and Chiam's model for variable thermal *** single-phase nanofluid model is utilized to describe convective heat transfer in hybrid nanofluids,incorporating the experimental *** model is developed as a coupled system of convective-diffusion equations,encompassing the conservation of momentum and the conservation of thermal energy,in conjunction with an incompressibility condition.A self-similar model is developed by the Lie-group scaling transformations,and the subsequent self-similar equations are then solved *** influence of variable fluid parameters on both swirling and non-swirling flow cases is ***,the Nusselt number for the disk surface is *** is found that an increase in the temperature-dependent viscosity parameter enhances heat transfer characteristics in the static cone-disk system,while the thermal conductivity parameter has the opposite effect.

关键词： hybrid nanofluid cone-disk system laminar flow variable fluid property Nusselt number

Bio-Inspired Intelligent Routing in WsN: Integrating Mayfly Optimization and Enhanced Ant Colony Optimization for Energy-Efficient Cluster Formation and Maintenance

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Computer Modeling in Engineering & sciences 2024年第10期141卷 127-150页

作者： V.g.saranya s.Karthik Department of Electronics and Communication Engineering Faculty of Engineering&TechnologySRM Institute of Science and TechnologyVadapalani CampusChennai600026India

Wireless sensor Networks(WsNs)are a collection of sensor nodes distributed in space and connected through wireless *** sensor nodes gather and store data about the real world around ***,the nodes that are dependent on batteries will ultimately suffer an energy loss with time,which affects the lifetime of the *** research proposes to achieve its primary goal by reducing energy consumption and increasing the network’s lifetime and *** present technique employs the hybrid Mayfly Optimization Algorithm-Enhanced Ant Colony Optimization(MFOA-EACO),where the Mayfly Optimization Algorithm(MFOA)is used to select the best cluster head(CH)from a set of nodes,and the Enhanced Ant Colony Optimization(EACO)technique is used to determine an optimal route between the cluster head and base *** performance evaluation of our suggested hybrid approach is based on many parameters,including the number of active and dead nodes,node degree,distance,and energy *** objective is to integrate MFOA-EACO to enhance energy efficiency and extend the network life of the WsN in the *** proposed method outcomes proved to be better than traditional approaches such as Hybrid squirrel-Flying Fox Optimization Algorithm(HsFLBOA),Hybrid social Reindeer Optimization and Differential Evolution-Firefly Algorithm(HsRODE-FFA),social spider Distance sensitive-Iterative Antlion Butterfly Cockroach Algorithm(sADss-IABCA),and Energy Efficient Clustering Hierarchy strategy-Improved social spider Algorithm Differential Evolution(EECHs-IssADE).

关键词： Enhanced ant colony optimization mayfly optimization algorithm wireless sensor networks cluster head base station(Bs)

Transmission of amyloid-βpathology in humans:a perspective on clinical evidence

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Neural Regeneration Research 2024年第2期19卷 390-392页

作者： Celso s.g.Catumbela Rodrigo Morales Department of Neurology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Transmission of misfolded amyloid-β(Aβ)aggregates between human subjects:Protein misfolding disorders are a family of diseases characterized by the accumulation of misfolded protein *** proteinaceous structures,also known as amyloids,are key drivers of fatal neurodegenerative disorders such as prion diseases,Alzheimer’s disease(AD),Parkinson’s disease,and others.

关键词： amyloid diseases Aβ

Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing Joshua M.Little Haochen Yang Tsai-Chun Chung Po-yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA school of Materials science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

Outcomes of early versus late irrigation and debridement of pediatric open long bone fractures

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World Journal of Orthopedics 2024年第6期15卷 539-546页

作者： Riya savla yen-Hong Kuo Nasim Ahmed Department of surgery and Trauma Hackensack Meridian School of MedicineNutleyNJ 07110United States Department of Medical sciences Hackensack Meridian School of medicineNutleyNJ 08753United States Office of Research Administration Hackensack Meridian Health Research InstituteNutleyNJ 077110United States Department of surgery Department of Trauma and Surgical Critical CareJersey Shore University Medical CenterNeptuneNJ 07754United States Department of surgery Department of Trauma and Surgical Critical CareHackensack Meridian School of MedicineNutleyNJ 07110United States

BACKgROUND Open long bone fractures are a major concern for pediatric patients due to the risk of surgical site infection(ssI).Early studies have recommended irrigation and debridement of open fractures within 6 hours-8 hours for the prevention of *** to the American College of surgeons(ACs)Best Practice guidelines,in 2015,irrigation and debridement should be done within 24 *** To identify whether early irrigation and debridement,within 8 hours,vs late,between 8 hours and 24 hours,for pediatric open long bone fractures impacts rate of *** Using retrospective data review from the National Trauma Data Bank,Trauma Quality Improvement Project(TQIP)of *** database is own by the ACs and it is the largest database for trauma quality program in the *** matching analysis was performed for the *** There were 390 pediatric patients with open long bone fractures who were incl-uded in the *** completing propensity score matching,we had 176 patients in each category,irrigation and debridement within 8 hours and irrigation and debridement between 8 hours and 24 *** found no significant differences between each group for the rate of deep ssI which was 0.6%for patients who received surgical irrigation and debridement within 8 hours and 1.1%for those who received it after 8 hours[adjusted odd ratio(AOR):0.5,95%CI:0.268-30.909,P>0.99].For the secondary outcomes studied,in terms of length of hospital stay,patients who received irrigation and debridement within 8 hours stayed for an average of 3.5 days,and those who received it after 8 hours stayed for an average of 3 days,with no significant difference found,and there were also no sig-nificant differences found between the discharge dispositions of the *** Our findings support the recommendation for managing open long bone fractures from the ACs:Complete surgical irrigation and debridement within 24 hours.

关键词： Pediatric trauma Open tibia fracture Irrigation and debridement Timing of intervention surgical site infection

Metric and Upper Dimension of Extended Annihilating-Ideal graphs

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Algebra Colloquium 2024年第2期31卷 221-238页

作者： s.Nithya g.Elavarasi genghua Fan Department of Mathematics St.Xavier's College(Autonomous)Palayamkottai 627002Tamil NaduIndia Afiliated to Manonmaniam sundaranar University Abishekapatti Tirunelveli 627012Tamil NaduIndia Pg and Research Department of Mathematics St.Xavier's College(Autonomous)Palayamkottai 627002Tamil NaduIndia Affiliated to Manonmaniam sundaranar University Abishekapatti Tirunelveli 627012Tamil NaduIndia 不详

The metric dimension problem is called navigation problem due to its application to robot navigation in *** this concept has wide applications in motion planning,sonar and loran station,and so *** this paper,we study certain results on the metric dimension,upper dimension and resolving number of extended annihilating-ideal graph EAg(R)associated to a commutative ring R,denoted by dim M(EAg(R)),dim+(EAg(R))and res(EAg(R)),*** we prove the finiteness conditions of dim M(EAg(R))and dim+(EAg(R)).In addition,we characterize dim M(EAg(R)),dim+(EAg(R))and res(EAg(R))for artinian rings and the direct product of rings.

关键词： extended annihilating-ideal graph metric dimension upper dimension resolving number

High glucose reduces Nrf2-dependent cRAgE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EgCg

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Food science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-Hao Wu Yin-Hsuan Chang Chin-Lin Hsu sheng-Yi Chen gow-Chin yen graduate Programs of Nutrition science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina school of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

soluble receptor for advanced glycation end products(sRAgE)acts as a decoy sequestering of RAgE ligands,thus preventing the activation of the ligand-RAgE axis linking human ***,the molecular mechanisms underlying sRAgE remain *** this study,THP-1 monocytes were cultured in normal glucose(Ng,5.5 mmol/L)and high glucose(Hg,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAgE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EgCg)in response to Hg challenge were also *** enhanced intracellular reactive oxygen species(ROs)generation and RAgE *** secretion of sRAgE,including esRAgE and cRAgE,was reduced under Hg conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the Hg effects were counteracted by siRAgE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and Hg interfered with this *** data reinforce the notion that RAgE and Nrf2 might be sRAgE-regulating *** Hg conditions,the treatment of EgCg reduced ROs generation and RAgE ***-stimulated cRAgE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited Hg-mediated NLRP3 inflammasome activation at least partly by stimulating sRAgE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EgCg) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAgE) soluble RAgE(sRAgE)