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CRISPR-Cas-like system in giant viruses:why MIMIVIRE is not likely to be an adaptive immune system

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Virologica Sinica 2016年第3期31卷 193-196页

作者： Jean-Michel claverie Chantal Abergel Structural and genomic Information Laboratory (UMR7256) CNRS Aix Marseille UniversityMediterranean Institute of Microbiology (FR 3479)

giant viruses from the Mimiviridae family（Mimivirus,Megavirus,etc.）replicate inside their Acanthamoeba host by the mean of a large intracytoplasmic virion factory within which DNA transcription and replication take ... 详细信息

关键词： likely dsDNA giant factory replication encoded silencing destruction discrimination clade

Reaction zone characterization of counter-flow diffusion flame with diluted and preheated reactants

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 278-284页

作者： Yu-ying Liu Jean-michel Most Philipp Bauer Alain claverie School of Jet Propulsion Beijing University of Aeronautics ＆ Astronautics Beijing 100083 China Laboratoire de Combustion et de Détonique （UPR 9028 au CNRS） F-86961 Futuroscope Cedex Poitiers France

Reaction zone characteristics were studied using hydroxy radical planar laser-induced fluorescence （OH-PLIF） technique for a counter-flow preheated （CH4＋N2）/（Air＋N2） diluted diffusion flames. The effects of preheat temperature and dilute ratio on the reaction zone characteristics were investigated by demonstrating the OH intensity distribution and reaction zone thickness from OH-PLIF images. Under the experimental conditions of constant cold flow velocity, the results show that the OH intensity and reaction zone thickness decrease with the increase of dilute ratio at constant preheat temperature and increase with preheat temperature at fixed dilute ratio. The OH maximum intensity shifts towards the ＂lean＂ side of counter flow at constant preheat temperature, and it shifts towards the fuel side with the increase of dilute ratio of fuel stream and towards the oxidizer side with the increase of dilute ratio of oxidizer stream respectively. The feasibility of OH as a reaction zone marker in this diluted combustion is verified further. The variation of diffusion and chemical reaction rate of reactants due to preheat and dilution contributes to the reaction zone characteristics simultaneously. The effect of strain on the flame reaction zone should be included in the future work.

关键词： counter-flow preheat diluted combustion reaction zone OH-PLIF

Protecting-group-free enantioselective tandem allylic substitution of o-phenylenediamines and o-aminophenols

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green Synthesis and Catalysis 2022年第2期3卷 185-189页

作者： Xuehua Kang Chao Qian He Yang Jicheng Shi Jerome claverie Wenjun Tang School of Physical Science and Technology Shanghai Tech UniversityShanghai 200031China State Key Laboratory of Bio-Organic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China College of Chemistry Maoming Technology Center of Organic MaterialsGuangdong University of Petrochemical TechnologyMaoming 525000China School of Chemistry and Material Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Chemistry University of SherbrookeSherbrooke J1K2R1Canada

A protecting-group-free enantioselective tandem allylic substitution of o-phenylenediamines and o-aminophenols is realized for the first time with a Pd-WingPhos catalyst,providing expedient access to a series of chiral vinylsubstituted heterocycles in excellent ee and yields under mild reaction *** protocol is applied successfully to the synthesis of a cholesteryl ester transfer protein(CETP)inhibitor.

关键词： Tandem allylic substitution WingPhos Protecting-group-free Palladium catalysis Enantioselectivity

Haplotype analysis of CLDN19 single nucleotide polymorphisms in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis

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World Journal of Pediatrics 2015年第3期11卷 272-275页

作者： Ernesto Martin-Nunez Elizabeth Cordoba-Lanus Hilaria gonzalez-Acosta Aniana Oliet Elvira Izquierdo Felix claverie-Martin Unidad de Investigacion Hospital Nuestra Senora de CandelariaSanta Cruz de TenerifeSpain Servicio de Nefrologia Hospital Severo OchoaMadridSpain Nefrologia Infantil Hospital General Gregorio MaranonMadridSpain

Background:Familial hypomagnesemia with hypercalciuria and nephrocalcinosis(FHHNC)is an autosomal recessive tubular disease caused by mutations in the CLDN16 or CLDN19 *** studies using microsatellite markers flanking the CLDN19 locus estimated that p.g20D(c.59g>A),a recurrent mutation in Spanish families,is a founder *** the present study,we assessed the haplotype of Spanish patients using single nucleotide polymorphisms(SNPs).Methods:Twenty-seven FHHNC patients were included in this *** analyzed four SNPs located in CLDN19 introns 3 and 4 by polymerase chain reaction amplification and DNA ***:Three new patients with homozygous p.g20D were *** SNP genotyping analysis showed that alleles carrying this mutation shared a common SNP ***:Our findings suggest the existence of a founder effect responsible for FHHNC in our *** for the presence of mutation p.g20D should be the first genetic screening in Spanish patients.

关键词： chronic kidney disease founder effect gene mutation nephrocalcinosis

适用于探井中的薄储层实时高分辨率地层评价和地层测试方法

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测井与射孔 2007年第2期10卷 46-51页

作者： M．claverie 袁爽（译）不详大庆测试技术服务分公司

薄储层在马来盆地日益成为海上勘探的目标。这些储层表现为垂向呈非均质性且包括领导储层流动特性。本文描述了确定这种储层特性的实时高分辨率地层评价和地层测试方法。薄储层的地层评价有以下几个目的：①判断可能的油气层；②通过地... 详细信息

薄储层在马来盆地日益成为海上勘探的目标。这些储层表现为垂向呈非均质性且包括领导储层流动特性。本文描述了确定这种储层特性的实时高分辨率地层评价和地层测试方法。薄储层的地层评价有以下几个目的：①判断可能的油气层；②通过地层测试和取样确定产能和流体类型；③计算纯产层厚度及误差范围。由于地层几何形态和岩性的原因，所以评价过程比较复杂。储层厚度通常小于地层评价测井仪的分辨率。储层岩性为粉砂，呈细粒结构，所以要求有高质量的井眼电阻率图像才能确定其几何形态。探井为评价储层的勘探前景提供了最好的机会，但因为操作的限制和经济的限制，不可能对每一个可能储层都进行取心或测试。因此，实时评价方法必须确切地判断勘探远景，以便进行下一步测试。本文要描述的实时地层评价包括以下几个步骤：（1）针对以下参数进行现场岩石物性分析：①孔隙度；②粘土、矿物和流体的体积；③根据gR能谱元素产额、核及声波孔隙度以及阵列电阻率测井资料得到的渗透率；（2）识别薄层并通过电阻率成像仪计算砂层总有效厚度；（3）验证现场岩石物性分析结果以及开始读取测井数据后2h之内的井眼图像，并设计电缆测试和取样程序。用一种模块式电缆地层测试器测量储层岩石的现场压力并建立流体梯度，判断流体界面。除此之外，通过预测试分析估算局部地层渗透率，并来验证用地层评价方法判断薄层的产能。

关键词：薄储层实时高分辨率地层评价地层测试

Major Results and Research Challenges in Cotton Molecular genetics at CIRAD(France)

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棉花学报 2008年第S1期20卷 16-页

作者： LACAPE Jean-marc claverie M DESSAUW D gIBAND M VIOT C CIRAD UMR-DAP Montpellier France

CIRAD(Montpellier,France) develops research activities centered on tropical and sub-tropical agricultural *** others crops,cotton is the focus of a series of research programs in different disciplines from economics to *** areas in genetics and breeding relate to(1) genetic diversity,(2) cultivar development through classical and molecular breeding,and(3)

关键词： gene QTL France Major Results and Research Challenges in Cotton Molecular genetics at CIRAD

译解人类基因组:计算机科学家在生物学中面临的挑战

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科学对社会的影响 1990年第4期39卷 28-37页

作者： Jean-Michel claverie 张大卫巴斯德研究所实验室

全面译解人类基因组的计划需要建立高分辨率的遗传图,需要确定构成基因组的数以万计DNA片段的有序集(称为“物理图谱”),需要测定构成人类基因组的30亿个核苷酸的准确排列顺序。目前运用的或正在研究的实验策略是依靠计算机科学的各个方... 详细信息

全面译解人类基因组的计划需要建立高分辨率的遗传图,需要确定构成基因组的数以万计DNA片段的有序集(称为“物理图谱”),需要测定构成人类基因组的30亿个核苷酸的准确排列顺序。目前运用的或正在研究的实验策略是依靠计算机科学的各个方面:自动化、模拟、计算、计划管理、数据库等。这一庞大计划虽属生物学范畴,但其成功首先要靠所用信息技术的质量,或许还要靠数据库和数据表达领域的新概念的出现。

关键词：计算机人类基因组

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透射电子显微镜在微纳米电子学的应用

国外科技新书评介 2013年第4期 15-16页

作者： Alain claverie 杜利东不详中国科学院电子学研究所

1932年Ruska发明了以电子束为光源的透射电子显微镜（TEM），电子束的波长要比可见光和紫外光短得多，并且电子束的波长与发射电子束的电压平方根成反比，也就是说电压越高波长越短，目前TEM的分辨力可达0．2nm。

关键词：透射电子显微镜纳米电子学应用电子束紫外光可见光波长平方根

geochemistry of Cretaceous Sea Rocks from the LEO-3X Well in the Eastern Abidjan Margin, Côte d’Ivoire Offshore Basin

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Open Journal of geology 2023年第10期13卷 1139-1150页

作者： Chia Marie Reine Kokoa Lassey Lou Soholy Ange claverie Ahouré Nguessan Donald Allialy Marc Ephrem Coulibaly Sougo Aoua Affian Kouadio UFR/STRM Felix Houphouet-Boigny University of Abidjan Abidjan C&#244te d’Ivoire UFR/ARHAI San Pedro University of C&#244te d’Ivoire San Pedro C&#244te d’Ivoire Sciences and Techniques Alassane Ouattara University of Bouaké Bouaké C&#244te d’Ivoire

In this study, we apply geochemical and statistical analyses to evaluate the source rocks and kerogen type of Cretaceous sediments from the Cote d’Ivoire sedimentary basin. The geochemical analysis includes pyrolysis data such as total organic carbon (TOC%), generation source potential (S2) and hydrogen index (HI). The results of the cluster analysis separated the source rocks in the study area into two main groups. 1) Source rocks characterized by HI > 300 (mg/g), TOC from 1.76% to 3.19% by weight, and S2 from 6.55 to 14.46 (mg/g), indicating good to excellent source rocks with type II kerogen and are capable of generating oil. 2) Source rocks characterized by HI between 200 and 300 (mg/g), TOC from 1.6 to 2.02 wt%, and S2 from 3.45 to 5.36 (mg/g) indicating medium to good source rocks with type II-III kerogen and capable of generating a mixture of oil and gas.

关键词： Bedrock Kerogen Offshore Basin Cretaceous Côte d’Ivoire