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Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

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Genes & Diseases 2024年第2期11卷 532-534页

作者： Wenxiang Lu Ying Wang Tao Luo fuyu Li Yali Jiang Jinke Wang Weizhong Zhang Yunfei Bai State Key Lab of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of HealthYiningXinjiang 835000China Department of Ophthalmology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The biogenesis and functions of extrachromosomal circular DNA(eccDNA)have been studied for several ***,the heterogeneity of eccDNA is largely *** this study,we purified and sequenced eccDNA and RNA using a method that simultaneously extracts DNA and RNA from cultured cells treated with iron *** discovered that the characteristics of eccDNA are altered by iron stress,particularly on genic and CpG islands regions,suggesting a biogenesis mechanism induced by transcription.

关键词： breast nanoparticles characterization

dual-Defect Engineering Strategy Enables High-durability Rechargeable Magnesium-Metal Batteries

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Nano-Micro Letters 2024年第9期16卷 449-461页

作者： fuyu Chen Bai‑Qing Zhao Kaifeng Huang Xiu‑Fen Ma Hong‑Yi Li Xie Zhang Jiang Diao Jili Yue Guangsheng Huang Jingfeng Wang Fusheng Pan National Innovation Center for Lndustry‑Education Integration of Energy Storage Technology School of Materials Science and EngineeringChongqing UniversityChongqing 400044People’s Republic of China National Magnesium Alloy Material Engineering Technology Research Center Chongqing UniversityChongqing 400044People’s Republic of China Materials and Energy Division Beijing Computational Science Research CenterBeijing 100193People’s Republic of China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044People’s Republic of China

Rechargeable magnesium-metal batteries(RMMBs)are promising next-generation secondary batteries;however,their development is inhibited by the low capacity and short cycle lifespan of *** various strategies have been devised to enhance the Mg^(2+)migration kinetics and structural stability of cathodes,they fail to improve electronic conductivity,rendering the cathodes incompatible with magnesium-metal ***,we propose a dual-defect engineering strategy,namely,the incorporation of Mg^(2+)pre-intercalation defect(P-Mgd)and oxygen defect(Od),to simultaneously improve the Mg^(2+)migration kinetics,structural stability,and electronic conductivity of the cathodes of *** lamellar V_(2)O_(5)·nH_(2)O as a demo cathode material,we prepare a cathode comprising Mg_(0.07)V_(2)O_(5)·1.4H_(2)O nanobelts composited with reduced graphene oxide(MVOH/rGO)with P-Mgd and *** Od enlarges interlayer spacing,accelerates Mg^(2+)migration kinetics,and prevents structural collapse,while the P-Mgd stabilizes the lamellar structure and increases electronic ***,the MVOH/rGO cathode exhibits a high capacity of 197 mAh g^(−1),and the developed Mg foil//MVOH/rGO full cell demonstrates an incredible lifespan of 850 cycles at 0.1 A g^(−1),capable of powering a light-emitting *** proposed dual-defect engineering strategy provides new insights into developing high-durability,high-capacity cathodes,advancing the practical application of RMMBs,and other new secondary batteries.

关键词： Rechargeable magnesium-metal batteries dual-defect engineering Vanadium-based cathode High durability Lamellar structure

Pushing the high-k scalability limit with a superparaelectric gate layer

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Journal of Advanced Ceramics 2024年第4期13卷 539-547页

作者： Kun Wang Chao Liu Yuan Zhang fuyu Lv Jun Ouyang Houbing Huang Rui-Long Yang Yu-Yao Zhao Hongbo Cheng Hanfei Zhu Xiaoming Shi Yun Tian Institute of Advanced Energy Materials and Chemistry Jinan Engineering Laboratory for Multi-scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Key Film Materials&Application for Equipments(Hunan Province) School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China Advanced Research Institute of Multidisciplinary Science and School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China

To meet the expectation set by Moore’s law on transistors,the search for thickness-scalable high dielectric constant(k)gate layers has become an emergent research *** investigations have failed to solve the“polarizability–scalability–insulation robustness”*** this work,we show that this trilemma can be solved by using a gate layer of a high k ferroelectric oxide in its superparaelectric(SPE)*** the SPE,its polar order becomes local and is dispersed in an amorphous matrix with a crystalline size down to a few nanometers,leading to an excellent dimensional scalability and a good field-stability of the k *** an example,a stable high k value(37±3)is shown in ultrathin SPE films of(Ba_(0.95),Sr_(0.05))(Zr_(0.2),Ti_(0.8))O_(3)deposited on LaNiO_(3)-buffered Pt/Ti/SiO_(2)/(100)Si down to a 4 nm thickness,leading to a small equivalent oxide thickness of~0.46 *** aforementioned characteristic microstructure endows the SPE film a high breakdown strength(~10.5 MV·cm^(−1)for the 4 nm film),and hence ensures a low leakage current for the operation of the complementary metal oxide semiconductor(CMOS)***,a high electrical fatigue resistance is displayed by the SPE *** results reveal a great potential of superparaelectric materials as gate dielectrics in the next-generation microelectronics.

关键词： high-k transistors Moore's law superparaelectric insulation robustness

Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

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Oncology Research 2024年第2期32卷 339-351页

作者： JUAN SHEN WEIYU ZHANG QINQIN JIN fuyu GONG HEPING ZHANG HONGLIANG XU JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG SHUGUANG ZHOU School of Big Data and Artificial Intelligence Anhui Xinhua UniversityHefei230088China Department of Gynecology and Obstetrics Maternity and Child Healthcare Hospital Affiliated to Anhui Medical UniversityAnhui Province Maternity and Child Healthcare HospitalHefei230001China Department of Gynecology and Obstetrics The Fifth Clinical College of Anhui Medical UniversityHefei230032China Departments of Breast Surgery Fuyang Women and Children’s HospitalFuyang236000China Departments of Pathology Anhui Province Maternity and Child Health HospitalHefei230001China Department of Pain The First Affiliated Hospital of Anhui Medical UniversityHefei230032China Department of Gynecology and Obstetrics Linquan Maternity and Child Healthcare HospitalFuyang236400China

Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of ***,it is critical to identify novel biomarkers for the prognostic assessment of ***:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO ***1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western *** sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell ***,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA *** application of the nomogram was further validated in an immunotherapy ***:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA ***,PLK1 expression level,age and stage were identified as independent prognostic factors of *** the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low *** also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA *** addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive ***:PLK1 expression and immune cell infiltration can predict post-immunotherapy pr

关键词： Breast invasive carcinoma(BRCA) Polo-like kinase 1(PLK 1) Random forest(RF) Support vector machine(SVM) Immune infiltration

Moiré superlattices arising from growth induced by screw dislocations in layered materials

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Chinese Physics B 2024年第7期33卷 72-77页

作者：田伏钰 Muhammad Faizan 贺欣孙远慧张立军 State Key Laboratory of Integrated Optoelectronics Key Laboratory of Automobile Materials of MOE and College of Materials Science and Engineering Jilin UniversityChangchun 130012China Suzhou Laboratory Suzhou 215123China

Moiré superlattices(MSLs) are modulated structures produced from homogeneous or heterogeneous two-dimensional layers stacked with a twist angle and/or lattice mismatch. Enriching the methods for fabricating MSL and realizing the unique emergent properties are key challenges in its investigation. Here we recommend that the spiral dislocation driven growth is another optional method for the preparation of high quality MSL samples. The spiral structure stabilizes the constant out-of-plane lattice distance, causing the variations in electronic and optical properties. Taking SnS_(2) MSL as an example, we find prominent properties including large band gap reduction(~ 0.4 e V) and enhanced optical activity. Firstprinciples calculations reveal that these unusual properties can be ascribed to the locally enhanced interlayer interaction associated with the Moiré potential modulation. We believe that the spiral dislocation driven growth would be a powerful method to expand the MSL family and broaden their scope of application.

关键词： Moirésuperlattices interlayer interaction spiral dislocation layered materials

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农村普通中学生自尊与社会支持的关系

中国健康心理学杂志 2007年第6期15卷 542-544页

作者：杜富裕熊剑峰李文虎中国.江西师范大学教育学院南昌330022

目的探讨农村普通中学生自尊与社会支持的关系。方法采用自尊量表(SES),社会支持量表对256名农村普通中学学生进行调查。结果自尊在性别、家庭收入方面没有显著差异,在年级、成绩方面有显著差异,社会支持高低组只有对支持的利用度有显... 详细信息

目的探讨农村普通中学生自尊与社会支持的关系。方法采用自尊量表(SES),社会支持量表对256名农村普通中学学生进行调查。结果自尊在性别、家庭收入方面没有显著差异,在年级、成绩方面有显著差异,社会支持高低组只有对支持的利用度有显著差异,社会支持总分及对支持的利用度和自尊有显著的相关,这两项对自尊都有正向预测作用。结论农村普通中学生自尊和社会支持存在关系。

关键词：农村普通中学中学生自尊社会支持

鼠伤寒沙门菌Ssek3基因的序列特征分析与表达纯化

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中华微生物学和免疫学杂志 2017年第11期37卷 849-855页

作者：杜付玉廖成水杨亚东王晓利郁川李银聚程相朝张春杰河南科技大学动物科技学院洛阳市活载体生物材料与动物疫病防控重点实验室洛阳471023 河南科技大学医学院医学机能学实验教学中心洛阳471023

目的研究鼠伤寒沙门菌Ssek3基因的序列结构特征及蛋白表达纯化.方法从鼠伤寒沙门菌SL1344株获得Ssek3基因的序列,利用生物信息学方法进行系统性分析,并进行原核表达及纯化.结果软件预测分析结果显示,SseK3蛋白由335个氨基酸,72个氨... 详细信息

目的研究鼠伤寒沙门菌Ssek3基因的序列结构特征及蛋白表达纯化.方法从鼠伤寒沙门菌SL1344株获得Ssek3基因的序列,利用生物信息学方法进行系统性分析,并进行原核表达及纯化.结果软件预测分析结果显示,SseK3蛋白由335个氨基酸,72个氨基酸残基组成,蛋白质理论相对分子质量（Mr）为37.89×103,分子式为C1700 H2629 N463O497S12,等电点为6.7,属于稳定存在的亲水蛋白质.该蛋白质无信号肽也无跨膜区,属于膜内蛋白,含有5个N-糖基化位点、3个O-糖基化位点、33个磷酸化位点、22个B细胞线性结合位点和11个T细胞结合位点以及21个二硫键位点.二级结构中,α-螺旋（Hh）占34.03％（114个）,伸展链（Ee）占21.49％（72个）,β-折叠（Tt）占8.96％（30个）,无规则卷曲（Cc）占35.52％（119个）.实验结果显示,Ssek3基因大小为1008 bp,SDS-PAGE分析显示,Ssek3基因在原核表达系统中以分泌蛋白形式存在,表达的融合蛋白大小（Mr）约为40×103.结论本研究成功克隆了鼠伤寒沙门菌Ssek3基因,对其进行序列分析和原核表达,为深入探究Ssek3蛋白在鼠伤寒沙门菌感染宿主细胞中的作用提供资料.

关键词：鼠伤寒沙门菌 Ssek3基因克隆原核表达生物信息学分析

基于改进Res-UNet网络的织物瑕疵图像识别方法

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毛纺科技 2024年第7期52卷 100-106页

作者：于光许张富宇河南经贸职业学院河南郑州450018

复杂花色织物的纹理和色彩常常是非规则的,导致织物表面瑕疵识别难度较高。针对上述问题,研究一种基于改进Res-UNet网络的织物表面瑕疵图像识别方法。采集织物图像并对其实施灰度化、去噪以及直方图均衡化处理,利用蝙蝠算法求取最佳提... 详细信息

复杂花色织物的纹理和色彩常常是非规则的,导致织物表面瑕疵识别难度较高。针对上述问题,研究一种基于改进Res-UNet网络的织物表面瑕疵图像识别方法。采集织物图像并对其实施灰度化、去噪以及直方图均衡化处理,利用蝙蝠算法求取最佳提取网络层数,通过增加特征提取网络层数改进Res-UNet网络,利用改进后的Res-UNet网络识别织物表面瑕疵,并且采用迁移学习算法进一步优化识别模型的参数,实现织物表面瑕疵准确识别。结果表明:本文方法应用下,无论是素色样本,还是花色样本,其识别系数均达到0.9以上,相比基于标签嵌入方法的织物瑕疵识别方法和双路高分辨率转换网络的布匹瑕疵检测方法,本文方法对复杂花色样本的轮廓系数识别更高,适用性更好,识别能力更强。

关键词：改进Res-UNet网络织物表面瑕疵图像采集预处理图像识别

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工业锅炉数字化设计与数字孪生综述

化工管理 2024年第12期 89-92页

作者：张富玉杜增辉兰州石化职业技术大学甘肃兰州730060 中海壳牌石油化工有限公司广东惠州516082

工业锅炉作为现代工业中重要的能源设备之一,扮演着至关重要的角色,数字化设计和数字孪生是智能制造领域中的关键技术之一,因此文章旨在综述工业锅炉数字化设计和数字孪生的研究进展和应用前景。数字孪生技术可以实时监测和分析工业锅... 详细信息

工业锅炉作为现代工业中重要的能源设备之一,扮演着至关重要的角色,数字化设计和数字孪生是智能制造领域中的关键技术之一,因此文章旨在综述工业锅炉数字化设计和数字孪生的研究进展和应用前景。数字孪生技术可以实时监测和分析工业锅炉的运行情况,提供设备状态的即时反馈。同时,数字孪生还能够进行设备的故障诊断和预测,提前采取维修和保养措施,从而减少停机时间和维修成本。综上所述,工业锅炉数字化设计和数字孪生是智能制造领域中的重要研究方向,文章通过综述相关研究进展和应用前景,旨在促进工业锅炉数字化设计和数字孪生技术的应用和发展,为提高工业锅炉的性能和效率作出贡献。

关键词：数字孪生智能制造工业锅炉