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Postrecurrence Clinical Outcome of Patients with Stage I Epithelial Ovarian Cancer Who Underwent Fertility-Sparing Surgery Compared to Those with Radical Surgery

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Surgical Science 2013年第1期4卷 118-124页

作者： Hiroaki Kajiyama Kiyosumi Shibata Mika Mizuno Eiko Yamamoto Michiyasu Kawai Tetsuro Nagasaka fumitaka Kikkawa Department of Medical Laboratory Sciences School of Health Science Nagoya University Graduate School of Medicine Nagoya Japan Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan Department of Obstetrics and Gynecology Toyohashi Municipal Hospital Toyohashi Japan

Background: To examine the difference in the survival of patients with recurrent ovarian cancer who received fertility-sparing surgery (FSS) and those receiving radical surgery. Methods: Clinicopathologic data on a total of 90 patients with stage I recurrent ovarian cancer collected under the central pathological review system were subjected to survival analyses. Patients were divided into 2 groups: 1) FSS (N = 11), 2) Radical (N = 79). Results: Five-year overall survival rates of patients in the two groups were as follows: 40.8% (FSS)/44.2% (Radical), respectively. There was no significant difference in overall survival among the groups (P = 0.887). Additionally, three-year postrecurrence survival rates of patients in the two groups were 24.8% (FSS) and 25.3% (Radical) (P = 0.730). Furthermore, we accumulated 137 patients {FSS (N = 58), Radical group (N = 79)} with stage I recurrent ovarian cancer from the current study and six representative reports in the literature. Patients who experienced recurrence in the remaining ovary alone (FSS) showed a more favorable prognosis than those who had extra-ovarian site recurrence (overall survival: P = 0.021, postrecurrence survival: P = 0.069). Conclusions: Although our retrospective analysis was very preliminary, we could propose the hypothesis that patients with stage I recurrent ovarian cancer who undergo FSS may not show poorer survival rates than patients who receive radical surgery.

关键词： Recurrent Ovarian Cancer Fertility-Sparing Surgery Overall Survival Postrecurrence Survival

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Study of Argon/Molten Steel Two-Phase Flow in Refining of High Clean Steel Using Two-Fluid Model

Study of Argon/Molten Steel Two-Phase Flow in Refining of Hi...

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The 2nd International Symposium on Clean Steel(ISCS 2011)

作者： QI Feng-sheng YANG Liu LI Bao-kuan TSUKIHASHI fumitaka School of Materials and Metallurgy Northeastern University Department of Advanced Materials Science Graduate School of Frontier ScienceUniversity of Tokyo

RH vacuum degasser is a very important secondary refining device in the production of high quality *** flow field of molten steel in RH system plays a significant role in determining productivity of the *** homogeneous model and VOF method were often used to predict the flow field in RH system,but these kinds of models simplified the interaction between gas bubbles and molten *** the present work,a numerical model of a whole RH system,including vacuum degasser,immersed legs and ladle,was built based on gas-liquid two-fluid model,and it could be used to analyze the interaction between argon bubbles and molten steel,to understand the effect of the bubble size to the flow field.

关键词： RH vacuum degasser gas-liquid two-phase flow two-fluid model interaction

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Factors Affecting Japanese Pond Smelt (Hypomesus nipponensis) Stock Trajectory in Lake Kasumigaura and Kitaura

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Open Journal of Marine Science 2015年第2期5卷 210-225页

作者： Ashneel Ajay Singh Noriyuki Sunoh Shintaro Niwa fumitaka Tokoro Daisuke Sakamoto Naoki Suzuki Kazumi Sakuramoto Department of Ocean Science and Technology Tokyo University of Marine Science and Technology TokyoJapan Freshwater Branch Office Ibaraki Fisheries Research Institute Ibaraki Japan

The Japanese pond smelt (Hypomesus nipponensis) stock has been observed to fluctuate quite rigorously over the years with sustained periods of low catch in Lake Kasumigaura and Kitaura of the Ibaraki prefecture, Japan which would adversely affect the socioeconomic livelihood of the local fishermen and fisheries industry. This study was aimed at determining the factors affecting the stock fluctuation of the pond smelt through the different years in the two lakes. Through exploratory analysis it was found that the pond smelt had significant relationship with total phosphorus (TP) level in both lakes. The global mean land and ocean temperature index (LOTI) was also found to be indirectly related to the pond smelt stock in lake Kasumigaura and Kitaura at the latitude band of 24°N to 90°N (l). Both TP and LOTI had inverse relationship with pond smelt trajectory in both lakes. For both Lake Kasumigaura and Kitaura, TP for the individual lakes and LOTI (l) were used as independent variables using generalized linear model and response surface methods for modeling the stock dynamics of the pond smelt in the two lakes. Model selection was based on significant parameter estimates (p < 0.05), Akaikes Information Criterion and R2 values. Phosphorus loading is an indication of increasing anthropogenic activities in the surrounding area having negative impact on the pond smelt population. When management decisions are being made regarding pond smelt fishery and sustainability plans in the Ibaraki prefecture, the effects of TP and LOTI should be taken into account. Future research needs to be directed towards deeper understanding the mechanisms by which TP and LOTI affect pond smelt population in Lake Kasumigaura and Kitaura for more effective management.

关键词： Pond Smelt Lake Kasumigaura Lake Kitaura Phosphorus Surface Temperature

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Effect of Steel Slag on Soil Fertility and Plant Growth

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Journal of Agricultural Chemistry and Environment 2022年第3期11卷 209-221页

作者： Zakirul Islam Quoc Thinh Tran Shohei Koizumi fumitaka Kato Kimio Ito Kiwako S. Araki Motoki Kubo Department of Biotechnology Faculty of Life Sciences Ritsumeikan University Noji Higashi 1-1-1 Kusatsu Shiga Japan Advanced Technology Research Laboratories Research and Development Nippon Steel Corporation 20-1 Shintomi Futtsu Chiba Japan Resource and Process Solution Division Mineral Resources Department Nippon Steel Corporation 20-1 Shintomi Futtsu Chiba Japan

The effective utilization of steel slag, a byproduct produced in large quantities from the steel refining process, is an important issue. Because steel slag contains abundant mineral components, the effects of steel slag on soil bacterial biomass and plant mineral uptake were analyzed in this study. The soil pH increased in proportion to the amount of steel slag added. A lower concentration (0.2% to 1%) of steel slag addition did not change the bacterial biomass. However, a higher concentration of steel slag (above 1%) had a negative effect on bacterial biomass. A lower amount of steel slag (0.2% to 1%) addition in soil leads to increased mineral (Ca, Mg, and Fe) uptake and plant growth in Brassica rapa var. periviridis and Spinacia oleracea L. However, mineral uptake by the plants decreased when a large amount of steel slag (above 1%) was added to the soil. Low concentrations of steel slag (0.2% to 1%) in soil had positive effects on plant growth, mineral uptake of plants, and bacterial biomass.

关键词： Bacterial Biomass Mineral Uptake Nitrogen Circulation Phosphorus Circulation Plant Growth Steel Slag

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A study on sleep architecture in patients with chronic respiratory failure under long-term oxygen therapy—Focused on the influence of ventilatory failure (high CO2) elements on the patient’s sleep architecture

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Health 2013年第8期5卷 14-20页

作者： Tsuguo Nishijima Keisuke Hosokawa fumitaka Mito Tetsuya Kizawa Susumu Takahashi Hiroshi Kagami Akira Suwabe Shigeru Sakurai Department of Laboratory Medicine Iwate Medical University School of Medicine Morioka Japan Department of Respirology Hachinohe Red Cross Hospital Hachinohe Japan Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan

Sleep disturbance related symptoms are common in patients with long-term oxygen therapy (LTOT). Essentially, there were only few previous reports about the sleep architecture in patients with respiratory disease, such as chronic obstructive pulmonary disease (COPD). This study aims to clarify the objective sleep state and the elements that affect sleep architecture in Chronic Respiratory Failure (CRF) patients with focus on clinical cases of chronic hypercapnia. 13 subjects with chronic respiratory failure were enrolled in the study. All the subjects were pre-evaluated by pulmonary function test and Arterial blood gas analysis (ABG) including exercise testing. Polysomnography (PSG) test was performed in each subject with supplemental oxygen. The estimated base line PaCO2 value that reflects overall PaCO2 including sleep period was calculated using equation of PaCO2[2.4×(HCOˉ3)-22]from obtained ABG value just before PSG test. 6 subjects were classified as hypercapnic group (base line PaCO2 ≥ 45 mmHg) and 7 subjects were non-hypercapnic group (base line PaCO2 < 45 mmHg). Latency persistent sleep of PSG data was significant higher in patients with hypercapnic than non-hypercapnic (p < 0.01). Periodic Limb Movement was seen in 23.6% of the subjects, however there was no contribution for arousals. Other PSG data include mean SpO2 were no significant difference. This study suggests that patients with estimated hypercapnia had more disturbed sleep architecture especially significant loss of sleep latency than non-hypercapnic patient with chronic respiratory failure under LTOT. Nocturnal PaCO2 level or ventilatory function may contribute to sleep disturbance in patients with estimated hypercapnia during LTOT.

关键词： Chronic Respiratory Failure Long-Term Oxygen Therapy Sleep Architecture Periodic Leg Movement Disorder

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两位置交换问题魔角旋转核磁共振时域信号的准确解(英文)

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波谱学杂志 1999年第6期16卷 485-493页

作者：沈伊民 HironoriKAJI fumitakaHORII 复旦大学分析测试中心上海200433 京都大学化学研究所

已知两位置交换分子运动速率对于静态13CNMR谱的影响是由一简单代数关系决定，它已成为分析固体中分子运动的常规方法．慢速的魔角旋转可以保留边带，所产生的边带型原则上也可用来分析分子运动，只是缺乏象静态谱那样的简单的关系，以... 详细信息

已知两位置交换分子运动速率对于静态13CNMR谱的影响是由一简单代数关系决定，它已成为分析固体中分子运动的常规方法．慢速的魔角旋转可以保留边带，所产生的边带型原则上也可用来分析分子运动，只是缺乏象静态谱那样的简单的关系，以至于在实际应用上是不可行的．本文给出作者所发现的存在分子运动时魔角旋转核磁共振自由诱导衰减信号的解析表达式的理论推导，提供分析固体分子运动的理论谱计算公式．我们选择二甲矾（dimethylsulfone）作为模型化合物，记录其不同温度下13CNMR谱，又计算了两个甲基做两位置交换运动的理论谱．理论谱与实验谱定性一致．定量上，边带强度存在一些差别，但边带宽度符合很好．通过理论谱与实验谱的比较，得到交换速率与温度的对应关系．虽然本文限于化学位移各向异性相互作用两位置交换问题，但容易推广到偶极作用多位置交换问题．

关键词：核磁共振魔角旋转位置交换时域信号

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电磁制动对薄板坯连铸结晶器涡流的影响

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鞍钢技术 2009年第2期 51-56页

作者： Baokuan LI fumitaka TSUKIHASHI 张维维

开发了数学模型,以研究电磁制动(EMBR)对薄板坯连铸结晶器涡流的影响。结晶器内熔融钢水由结晶器浸入式水口(SEN)的两个侧孔流出。采用低雷诺数k-ε紊流模型计算有效粘度。数学模拟表明,即使在水口外形对称和注流稳定的条件下也能产生... 详细信息

开发了数学模型,以研究电磁制动(EMBR)对薄板坯连铸结晶器涡流的影响。结晶器内熔融钢水由结晶器浸入式水口(SEN)的两个侧孔流出。采用低雷诺数k-ε紊流模型计算有效粘度。数学模拟表明,即使在水口外形对称和注流稳定的条件下也能产生非对称的涡流。模拟中的非对称流动由数据冗余引起,数据冗余代替了实际生产中的水口堵塞、水口不对中和随机湍流等。涡流强度取决于由水口出流角和拉速决定的结晶器表面流速。施加静态磁场可以显著抑制涡流和改变涡流形态,但不能将其彻底消除。表面流速随线圈电流的减小而显著降低,同时结晶器内的波高明显变小。此外,浸入式水口附近由涡流引起的失稳区逐渐变得稳定。结晶器下部的下降流流速受到抑制并形成活塞流。

关键词：连铸电磁制动薄板坯涡流数学模型

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Protocol for laparoscopic cholecystectomy: Is it rocket science?

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World Journal of Gastroenterology 2016年第47期22卷 10287-10303页

作者： Tomohide Hori fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura Department of Gastrointestinal and General Surgery Tenriyorodusoudanjyo Hospital Department of Gastrointestinal Surgery Mitsubishi Kyoto Hospital Department of Anesthesiology Mitsubishi Kyoto Hospital Department of Gastroenterology and Hepatology Mitsubishi Kyoto Hospital Department of Hepatobiliary Pancreatic Surgery Kyoto University Hospital

Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical ***, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies.

关键词： Laparoscopic cholecystectomy Gallbladder Critical view of safety biliary injury Protocol

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Thrombotic microangiopathy-like disorder after living-donor liver transplantation:A single-center experience in Japan

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World Journal of Gastroenterology 2011年第14期17卷 1848-1857页

作者： Tomohide Hori Toshimi Kaido fumitaka Oike Yasuhiro Ogura Kohei Ogawa Yukihide Yonekawa Koichiro Hata Yoshiya Kawaguchi Mikiko Ueda Akira Mori Yasutsugu Takada Hiroto Egawa Atsushi Yoshizawa Shinji Uemoto Hajime Segawa Kimiko Yurugi Takuma Kato Kanako Saito Linan Wan Mie Torii Feng Chen Ann-Marie T Baine Lindsay B Gardner Departments of Hepato-pancreato-biliary Transplant and Pediatric Surgery Kyoto University Hospital Kyoto 606-8507 Japan Department of Critical Care Medicine Kyoto University Hospital Kyoto 606-8507 Japan Department of Transfusion Medicine and Cell Therapy Kyoto University Hospital Kyoto 606-8507 Japan Department of Cellular and Molecular Immunology Mie University Hospital Graduate School of Medicine Mie 514-8507 Japan Department of Neuroscience Mayo Clinic Florida FL 32224 United States

AIM:To investigate thrombotic microangiopathy (TMA)in liver transplantion,because TMA is an infrequent but life-threatening complication in the transplantation field. METHODS:A total of 206 patients who underwent living-donor liver transplantation (LDLT) were evaluated,and the TMA-like disorder (TMALD) occurred in seven recipients. RESULTS:These TMALD recipients showed poor outcomes in comparison with other 199 recipients. Although two TMALD recipients successfully recovered,the other five recipients finally died despite intensive treatments including repeated plasma exchange (PE) and re-transplantation. Histopathological analysis of liver biopsies after LDLT revealed obvious differences according to the outcomes. Qualitative analysis of antibodies against a disintegrin-like domain and metalloproteinase with thrombospondin type 1 motifs (ADAMTS-13) were negative in all patients. The fragmentation of red cells,the microhemorrhagic macules and the platelet counts were early markers for the suspicion of TMALD after LDLT. Although the absolute values of von Willebrand factor (vWF) and ADAMTS-13 did not necessarily reflect TMALD,the vWF/ADAMTS-13 ratio had a clear diagnostic value in all cases. The establishment of adequate treatments for TMALD,such as PE for ADAMTS-13 replenishment or treatments against inhibitory antibodies,must be decided according to each case. CONCLUSION:The optimal induction of adequate therapies based on early recognition of TMALD by the reliable markers may confer a large advantage for TMALD after LDLT.

关键词： Thrombotic microangiopathy Liver transplan-tation von Willebrand factor A disintegrin-like domain and metalloproteinase with thrombospondin type 1 motifs Complication

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Patterns of Recurrence and Their Significance in Patients with Endometrial Carcinoma —For Improved Follow-Up after Initial Treatment 

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Surgical Science 2013年第2期4卷 154-159页

作者： Fumi Utsumi Hiroaki Kajiyama Kiyosumi Shibata Hiroko Mitsui Ryuichiro Sekiya Mika Mizuno Shiro Suzuki Tomokazu Umezu Eiko Yamamoto fumitaka Kikkawa Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Objectives: The aim of this study was to identify the patterns of recurrence and their significance in patients with endometrial carcinoma (EMCA). Patients and Methods: After a search of the medical records from single institutions, a total of 49 patients with relapsed endometrial carcinoma were retrospectively evaluated. Various clinical information was examined, including the site of recurrence, detection procedure, and presence or absence of any symptom at the time of recurrence. Furthermore, the postrecurrence survival analysis was based on the Kaplan-Meier method. Results: The median follow-up period of all patients was 39.4 months (5.8 - 293.1). In all, twenty-five (51.0%) patients experienced recurrence within 12 months after the final treatment. At the time of recurrence, 15 (30.6%) and 34 (69.4%) patients were symptomatic and asymptomatic, respectively. Among the 34 asymptomatic patients, recurrence was detected by CT scan in 14 (28.6%), tumor markers alone in 14 (28.6%), and pelvic examination/ultrasound scan in 5 (10.2%). There was no relapsed case detected by vaginal vault cytology alone. The 5-year postrecurrence survival rates in symptomatic and asymptomatic patients were 57.5 and 36.6 months, respectively (P = 0.2973). After recurrence, 12 patients underwent debulking surgery, and 37 received salvage chemotherapy or radiotherapy. The postrecurrence survival of patients receiving surgery did not differ from that of those with chemotherapy/radiotherapy (P = 0.9198). Conclusion: Although imaging studies and tumor marker measurement contributed to the early detection of recurrence, they did not necessarily improve the prognosis postrecurrence.

关键词： Endometrial Carcinoma Recurrence Site Postrecurrence Survival Symptomatic Vaginal Vault Cytology

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