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World Journal of Gastroenterology 2016年第48期22卷 10523-10531页

作者： Masaki Miyazawa Mitsuru Matsuda Masaaki Yano Yasumasa Hara fumitaka arihara Yosuke Horita Koichiro Matsuda Akito Sakai Yatsugi Noda Department of Internal Medicine Toyama Prefectural Central Hospital

Gastric adenocarcinoma of the fundic gland(chief cellpredominant type, GA-FG-CCP) is a rare variant of welldifferentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis.

关键词： Narrow-band imaging Pepsinogen-I Fundic gland Gastric adenocarcinoma Chief cell

Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection

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World Journal of Gastroenterology 2015年第26期21卷 8208-8214页

Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was *** treated five cases of GA-FG with endoscopic submucosal *** tumors were small and located in the upper third of the *** tumors were macroscopically identified as 0-IIa and one was identified as 0-Ⅱ***-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the *** tumors arose from the deep layer of the lamina propria mucosae and showed submucosal *** invasion was seen only in one case,while no venous invasion was *** tumors were positive for pepsinogen-Ⅰ and MUC6 by *** showed p53 overexpression,and the labeling index of Ki-67 was low in all *** cases have been free from recurrence or ***,we discussed the clinicopathological features of GA-FG in comparison with past reports.

关键词： Gastric adenocarcinoma of fundic glandtype Pepsinogen-Ⅰ Chief cell Endoscopic diagnosis Narrow-band imaging with magnifying endoscopy Endoscopic submucosal dissection

Benefits of endoscopic gallbladder stenting following percutaneous transhepatic gallbladder drainage

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2902-2909页

作者： fumitaka Niiya Naoki Tamai Masataka Yamawaki Jun Noda Tetsushi Azami Yuichi Takano Fumiya Nishimoto Masatsugu Nagahama Division of Gastroenterology Department of Internal MedicineShowa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BACKGROUND Endoscopic transpapillary gallbladder drainage is challenging because of the complexity of the procedure and high incidence of adverse events(AEs).To overcome these problems,endoscopic gallbladder stenting(EGBS)after percutaneous transhepatic gallbladder drainage(PTGBD)can be effective,as it mitigates inflammation and *** To examine the benefits of EGBS after PTGBD to assess its efficacy and impact on *** We retrospectively analyzed data from 35 patients who underwent EGBS after PTGBD at a single center between January 2016 and December *** primary outcomes were technical success and AEs,and the rate of recurrent cholecystitis was *** addition,the reasons for the failure of the procedure were *** Among the 35 patients,the technical success rate was 77.1%and the final contrast of the cystic duct was successful in 97.1%of *** incidence of early AEs was relatively low(11.4%),with no instances of cystic duct *** rate of recurrent cholecystitis was 3.7%,and no other biliary events were *** EGBS after PTGBD may be significantly beneficial,with a substantial success rate and minimal AEs in both short-and long-term follow-ups.

关键词： Endoscopy Gallbladder Stents Drainage Adverse events Cholecystitis Follow-up Cystic duct

Large Eddy Simulation for Unsteady Turbulent Field in Thin Slab Continuous Casting Mold

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Journal of Iron and Steel Research International 2011年第S2期18卷 243-250页

作者： fumitaka Tsukihashi Department of Advanced Materials Science Graduate School of Frontier Science University of Tokyo Kashiwa 277-8561 Japan

The unsteady turbulent flow during the continuous casting of steel is important, because it influences critical phenomena that affect steel quality. Unsteady three-dimensional flow in the mold region of the liquid pool during continuous casting of steel slabs has been computed using realistic geometries starting from the submerged inlet nozzle to the mold. The cassette filter function was used to deal with unsteady Navier-Stokes equation, and then the turbulent flow in the thin slab CCM was simulated with the large eddy simulation method combined with the Smagorinsky sub-grid scale model in this paper. And the model was verified by the Particle Image Velocimetry (PIV) experimental results which was got from a relate scientific literature. In this thesis, by means of LES, the flow characteristics in the thin slab CCM were acquired, such as the vortex distribution, the formation of the large eddy coherent structures, development, shedding and fracture process. In the same time, the turbulent asymmetric distribution was revealed even the nozzle in the centre position. Interactions between the two halves cause large velocity fluctuations near the meniscus. And the vortex is located at the low velocity side adjacent to the SEN. Along with the unsteady time development, the unsteady turbulent large vortex structures of the liquid steel in the CCM presented periodic bias flow distribution, and the period is about 20 seconds.

关键词： continuous casting mold unsteady large eddy simulation vortex coherent structures

Study of Argon/Molten Steel Two-Phase Flow in Refining of High Clean Steel Using Two-Fluid Model

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Journal of Iron and Steel Research International 2011年第S2期18卷 176-181页

作者： TSUKIHASHI fumitaka Department of Advanced Materials Science Graduate School of Frontier Science University of Tokyo Kashiwa 277-8561 Japan

RH vacuum degasser is a very important secondary refining device in the production of high quality steels. The flow field of molten steel in RH system plays a significant role in determining productivity of the equipment. The homogeneous model and VOF method were often used to predict the flow field in RH system, but these kinds of models simplified the interaction between gas bubbles and molten steel. In the present work, a numerical model of a whole RH system, including vacuum degasser, immersed legs and ladle,was built based on gas-liquid two-fluid model, and it could be used to analyze the interaction between argon bubbles and molten steel, to understand the effect of the bubble size to the flow field.

关键词： RH vacuum degasser gas-liquid two-phase flow two-fluid model interaction

Phase Equilibrium for the CaO-SiO_2-FeO-P_2O_5 System at 1673K for Dephosphorization With Multi Phase Flux

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Journal of Iron and Steel Research International 2011年第S2期18卷 84-86页

作者： Hiroyuki MATSUURA fumitaka TSUKIHASHI Graduate School of Frontier Sciences The University of Tokyo Kashiwa Chiba 277-8561 Japan

Development of the efficient hot metal dephosphorization processes during steelmaking process is one of the most essential topics for the production of high grade clean steels. Since the formation of solid solution composed of tricalcium phosphate and dicalcium silicate could obtain a considerable mass transfer of phosphorus from liquid slag into solid phase during hot metal dephosphorization, itcould obviously sustain a high phosphatecapacityof theliquid slag without huge consumption of lime or addition of fluxes, such as fluorite. The above outlines are the main idea of multi phase flux dephosphorization. For the last few decades, many studies have been done towards the scientific principles and the commercial utilization of this technique. However, the reaction mechanism by using multi phase fluxes remains unclear even by now due tolack of evidence. Based on those previous works, providing a reliable and available phase diagram for the fundamental understanding of the reaction mechanism of multi phase flux dephosphorization has become the main purpose of present research. As well known, the CaO-SiO2-FeO-P2O5 slag is the main component of current steelmaking process. Hence the CaO-SiO2-FeO-P2O5 system at equilibrium has been studied at 1673K with low oxygen partial pressure. The solid phase coexisting with liquid flux is approved to be the solid solution composed of CaO, SiO2 and P2O5. Phosphorus distributes mainly in solid solution rather than liquid phase.

关键词： steelmaking dephosphorization multi phase flux thermodynamics phase diagram

An Analytical Expression of Magic Angle Spinning Nuclear Magnetic Resonance Free Induction Decay in Two-Site Exchange Problem

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Chinese Physics Letters 1998年第6期15卷 453-454页

作者： SHEN Yi-min KAJI Hironori HORII fumitaka Analytical Center Fudan UniversityShanghai 200433 Institute for Chemical Research Kyoto UniversityUjiKyoto 611Japan

An analytical expression of free induction decay has been derived for calculating the magic angle spinning sideband patterns of nuclear magnetic resonance spectra in a two-site exchange *** expression has been confirmed by comparing the calculated spinning sideband patterns for powdered crystalline dimethyl sulfone at different exchange rates with experimentally measured spectra at various temperatures.

关键词： exchange spectra crystalline

The effect of basic fibroblast growth factor on regeneration in a surgical wound model of rat submandibular glands

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International Journal of Oral Science 2016年第1期8卷 16-23页

作者： fumitaka Kobayashi Kenichi Matsuzaka Takashi Inoue Department of Clinical Pathophysiology Tokyo Dental CollegeTokyoJapan

This study developed an animal model of surgically wounded submandibular glands （SMGs） and investigated the effects of collagen gel with basic fibroblast growth factor （bFGF） on tissue regeneration of surgically wounded SMGs in vivo. The animal model was produced by creating a surgical wound using a 3-mm diameter biopsy punch in SMGs. The wound was filled with collagen gel with bFGF （bFGF group） or without bFGF （control group）. In the animal model of surgically wounded SMGs, salivary glands without scar tissue around the wound area were observed with smaller areas of collagen gel. Small round and spindle-shape cells invaded the collagen gel in both groups after operation day （AOD） 5, and this invasion dramatically increased at AOD 7. Host tissue completely replaced the collagen gel at AOD 21. The invading immune cells in the group treated with collagen gel with bFGF were positive for vimentin, g-smooth muscle actin （αSMA）, CD49f, c-kit and AQP5 at AOD 7. Similarly, the mRNA expression of vimentin, αSMA, CD49f, keratin 19 and AQP5 was also increased. This study suggests that the use of collagen gels with bFGF improves salivary gland regeneration.

关键词： animal model basic fibroblast growth factor collagen immunohistochemistry salivary gland wound healing

Recycling of ironmaking and steelmaking slags in Japan and China

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 739-749页

作者： Hiroyuki Matsuura Xiao Yang Guangqiang Li Zhangfu Yuan fumitaka Tsukihashi Graduate School of Engineering The University of TokyoTokyo 113-8656Japan Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China The University of Tokyo Tokyo 113-8656Japan

The mass production of steel is inevitably accompanied by large quantities of *** treatment of ironmaking and steelmaking slags is a great challenge in the sustainable development of the steel *** and China are two major steel producing countries that have placed a large emphasis on developing new technologies to decrease slag emission or promote slag *** are almost completely reused or recycled in ***,due to stagnant infrastructural investments,future applications of slags in conventional sectors are expected to be *** new functions or applications of slags has become a research priority in *** example,the utilization of steelmaking slags in offshore seabeds to create marine forests is under *** is the top steel producer in the *** utilization ratios of ironmaking and steelmaking slags have risen steadily in recent years,driven largely by technological *** example,hot stage processing of slags for materials as well as heat recovery techniques has been widely applied in steel plants with good ***,increasing the utilization ratio of basic oxygen furnace slags remains a major *** innovations in slag recycling are crucial for the steel industries in Japan and ***,the current status and developing trends of utilization technologies of slags in both countries are reviewed.

关键词： ironmaking steelmaking slag recycling seawater stabilization

Biological removal of selenate in saline wastewater by activated sludge under alternating anoxic/oxic conditions

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Frontiers of Environmental Science & Engineering 2019年第5期13卷 39-49页

作者： Yuanyuan Zhang Masashi Kuroda Shunsuke Arai fumitaka Kato Daisuke Inoue Michihiko Ike Division of Sustainable Energy and Environmental Engineering Graduate School of EngineeringOsaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Nippon Steel&Sumitomo Metal Corporation 20-1 ShintomiFuttsuChiba 293-8511Japan

Selenium (Se)-containing industrial wastewater is often coupled with notable salinity. However, limited studies have examined biological treatment of Se-containing wastewater under high salinity conditions. In this study, a sequencing batch reactor (SBR) inoculated with activated sludge was applied to treat selenate in synthetic saline wastewater (3% w/v NaCl) supplemented with lactate as the carbon source. Start-up of the SBR was performed with addition of 1–5 mM of selenate under oxygen-limiting conditions, which succeeded in removing more than 99% of the soluble Se. Then, the treatment of 1 mM Se with cycle duration of 3 days was carried out under alternating anoxic/oxic conditions by adding aeration period after oxygen-limiting period. Although the SBR maintained soluble Se removal of above 97%, considerable amount of solid Se remained in the effluent as suspended solids and total Se removal fluctuated between about 40 and 80%. Surprisingly, the mass balance calculation found a considerable decrease of Se accumulated in the SBR when the aeration period was prolonged to 7 h, indicating very efficient Se biovolatilization. Furthermore, microbial community analysis suggested that various Se-reducing bacteria coordinately contributed to the removal of Se in the SBR and main contributors varied depending on the operational conditions. This study will offer implications for practical biological treatment of selenium in saline wastewater.

关键词： Activated sludge Selenate reduction Saline wastewater Sequencing batch reactor Alternating anoxic/oxic conditions Selenium biovolatilization