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International Journal of Clinical Medicine 2021年第9期12卷 377-385页

作者： Yoko Watanabe Keiko Suzuki fumiko kojima Yoshiko Tanaka Kosaku Nitta Shinjuku Ishikawa Clinic Tokyo Japan Department of Nephrology Tokyo Women’s Medical University Tokyo Japan

Background: Malnutrition is a strong predictor of prognosis in maintenance hemodialysis patients (MHD). We previously proposed a new and simple protein-energy wasting (PEW) score that appears to be useful for assessing the risk of mortality in patients on MHD. Objectives: In the present study, we evaluated the reliability of this PEW score as a predictor of hospitalization in Japanese patients on MHD. Methods: In this single-center, prospective cohort study conducted in Japan, PEW score was calculated for 180 MHD patients. PEW score ranged from 0 (best: S1) to 4 (worst: S4) and was calculated based on nutritional indicators including serum albumin, body mass index, serum creatinine level, and protein intake. The outcome was the number of hospitalizations during the 2-year study period. Results: Thirty-six patients were hospitalized during the study period. Kaplan-Meier curves showed there were fewer hospitalizations in the group with a PEW score of 0/1 than in the group with a score of 3/4. Multivariate analysis revealed a hazard ratio for hospitalization of 3.109 for S3/4 versus S0, 2.777 for S3/4 versus S1, and 2.048 for S3/4 versus S2. Conclusion: The new and simple PEW score is a useful predictor of hospitalization in MHD patients and is also useful for identifying subgroups of MHD patients with a high risk of mortality.

关键词： Protein-Energy Wasting Hemodialysis Hospitalization Simple Score

Geriatric Nutritional Risk Index as a Simple Predictor of Mortality in Maintenance Hemodialysis Patients: A Single Center Study

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International Journal of Clinical Medicine 2015年第5期6卷 354-362页

作者： Sayaka Takahashi Keiko Suzuki fumiko kojima Yoshiko Tanaka Kosaku Nitta Department of Nephrology Shinjuku Ishikawa Clinic Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan

Background: Malnutrition is associated with higher risk of mortality in maintenance hemodialysis (MHD) patients. The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. Objectives: The purpose of the present study was to examine the significance of the GNRI as a mortality predictor in MHD patients. Methods: We retrospectively examined the GNRI of 259 MHD patients aged 59.2 ± 12.8 years, and followed up for 36 months. The patients were divided into two groups according to GNRI values of 91.0. Predictors for all-cause mortality were examined using Kaplan-Meier and Cox proportional-hazards analyses. Results: During the follow-up period of 36 months, a total of 76 patients died. Kaplan-Meier survival analysis showed that the subjects with a GNRI 91 (n = 230) (Log-rank test,

关键词： Hemodialysis Malnutrition Geriatric Nutritional Risk Index Mortality

Conjecture with water and rheological control for subducting slab in the mantle transition zone

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Geoscience Frontiers 2015年第1期6卷 79-93页

作者： fumiko Tajima Masaki Yoshida Eiji Ohtani University of California at Irvine 4164 Frederick Reines Hall4IrvineCA 92697USA Institute for Research on Earth Evolution(IFREE) Japan Agency for Marine-Earth Science and Technology(JAMSTEC) Department of Earth and Materials Science Graduate School of ScienceTohoku University

Seismic observations have shown structural variation near the base of the mantle transition zone （MTZ） where subducted cold slabs, as visualized with high seismic speed anomalies （HSSAs）, flatten to form stagnant slabs or sink further into the lower mantle. The different slab behaviors were also accompanied by variation of the ＂660 kin＂ discontinuity depths and low viscosity layers （LVLs） beneath the MTZ that are suggested by geoid inversion studies. We address that deep water transport by subducted slabs and dehydration from hydrous slabs could affect the physical properties of mantle minerals and govern slab dynamics. A systematic series of three-dimensional numerical simulation has been conducted to examine the effects of viscosity reduction or contrast between slab materials on slab behaviors near the base of the MTZ. We found that the viscosity reduction of subducted crustal material leads to a sepa- ration of crustal material from the slab main body and its transient stagnation in the MTZ. The once trapped crustal materials in the MTZ eventually sink into the lower mantle within 20 30 My from the start of the plate subduction. The results suggest crustal material recycle in the whole mantle that is consistent with evidence from mantle geochemistry as opposed to a two-layer mantle convection model. Because of the smaller capacity of water content in lower mantle minerals than in MTZ minerals, dehydration should occur at the phase transformation depth, ~660 kin. The variation of the disconti- nuity depths and highly localized low seismic speed anomaly （LSSA） zones observed from seismic P waveforms in a relatively high frequency band （~ 1 Hz） support the hypothesis of dehydration from hydrous slabs at the phase boundary. The LSSAs which correspond to dehydration induced fluids are likely to be very local, given very small hydrogen （H＋） diffusivity associated with subducted slabs. The image of such local LSSA zones embedded in HSSAs may not be necessarily captured

关键词： Stagnant slab Discontinuity depth variation Deep water transport by subduction Crustal separation Crustal recycling

Changes in microbial community composition in the leaf litter of successional communities after volcanic eruptions of Mount Usu, northern Japan

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Journal of Mountain Science 2016年第9期13卷 1652-1662页

作者： Michiru OTAKI fumiko TAKEUCHI Shiro TSUYUZAKI Graduate School of Environmental Science Hokkaido University

Changes in the fungal and bacterial biomass and community structure in litter after the volcanic eruptions of Mount Usu, northern Japan were investigated using a chronosequence approach, which is widely used for analyzing vegetation succession. The vegetation changed from bare ground （10 years after the eruptions） with little plant cover and poor soil to monotonic grassland dominated by Polygonum sachalinense with undeveloped soil （33 years） and then to deciduous broad-leaved forest dominated by Populus maximowiczii with diverse species composition and well-developed soil （100 years）. At three chronosequential sites, we evaluated the compositions of phospholipid fatty acids （PLFAs）, carbon （C） and nitrogen （N） contents and the isotope ratios of C （δ13C） and N （δ15N） in the litter of two dominant species, Polygonum sachalinense and Populus maximowiezii. The C/N ratio, δ13C and δ15N in the litter of these two species were higher in the forest than that in the bare ground and grassland. The PLFAs gradually increased from the bare ground to the forest, showing that microbial biomass increased with the development of the soil and/or vegetation. The fungi-to-bacteria ratio of PLFA was constant at 5.3 ± 1.4 in all three sites, suggesting that fungi were predominant. A canonical correspondence analysis suggested that the PLFA comoosition was related to the successional ages and the developing soil properties （P 〈 0.05, ANOSIM）. The chrono- sequential analysis effectively detected the successional changes in both microbial and plant communities.

关键词： Volcanic succession Fungi-to-bacteriaratio Litter decomposition Microbial community Phospholipid fatty acids (PLFAs) Primary succession

The Literary Imagination of the White Pagoda and Dynastic Change in Early Ming Hangzhou

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2015年第1期9卷 54-74页

作者： fumiko JOO East Asian Studies Program Krieger School of Arts & Sciences Johns Hopkins University Baltimore MD 21218 USA

This article examines the literary imaginations of the White Pagoda and demonstrates a shift in its representation from a metaphor for the Song court＇s fate to a fantastic site for the subjugation of unworldly beings. In the late thirteenth century, the Yuan-appointed Tibetan Buddhist monk Yang Lianzhenjia exhumed the imperial mausoleums of the defeated Southern Song, built the White Pagoda on the site of the old Southern Song palace in Hangzhou, and interred the exhumed bones under it. Enthusiastic Song loyalists thus considered the White Pagoda to be a symbol of a humiliating past in which the Mongol Yuan dynasty occupied the south. Meanwhile, Qu You, an early-Ming writer from Hangzhou, began to imagine that the White Pagoda served to pacify the innocent, lonely dead who died during the Song-Yuan social disturbance. Investigating the discourse of the early Ming literati in regard to the pagoda site and the supernatural in early Ming Hangzhou leads to the conclusion that the literary imagination of the White Pagoda would have also contributed to the development of the White Snake Legend, where a white serpent spirit was subdued under Thunder Peak Pagoda in Hangzhou.

关键词： Bei Qiong fall of the Song dynasty Hangzhou history SouthernSong imperial mausoleums Qu You White Pagoda White Snake Legend YangLianzhenjia

p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy

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World Journal of Gastroenterology 2005年第36期11卷 5696-5700页

作者： fumiko Sunada Masayuki Itabashi Hisanao Ohkura Toshiyuki Okumura Departments of Internal Medicine Pathology Radiology Ibaraki Prefectural Central Hospital and Cancer Center Koibuchi 6528 Tomobe-machi Nishiibaraki-gun Ibaraki-ken Japan

AIM： Esophageal squamous cell carcinoma is generally sensitive to chemoradiotherapy （CRT）, but some cases are not. Using a retrospective analysis, we aimed to identify the predictors of the response by esophageal squamous cell carcinoma to definitive CRT. METHODS： The intensities of expression of p53, Ki67, Bci-2, Bax, olclin D1, VEGF, CDC25B, and metallothionein （MT） were evaluated immunohistochemically in the biopsy specimens obtained before CRT, and the intensities of their expression were tested for correlations with the clinical effects of CRT. RESULTS： The esophageal squamous cell carcinomas with negative p53, positive CDC25B, and negative MT expression were found to be significantly more sensitive to CRT. In addition, p53 positivity and CDC25B positivity respomd well to CRT. CONCLUSION： Esophageal squamous cell carcinomas with negative p53,positive CDC25B, and negative MT expressions respond well to CRT. Even with p53 positivity, if with CDC25B positivity, CRT can be expected. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： p83 CDC25B Metallothionein Chemoradiotherapy Esophageal squamous cell carcinomas

Acute and delayed psychiatric sequelae among patients hospitalised with COVID-19:a cohort study using LIFE study data

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General Psychiatry 2022年第3期35卷 173-182页

作者： fumiko Murata Megumi Maeda Chieko Ishiguro Haruhisa Fukuda Department of Health Care Administration and Management Kyushu University Graduate School of Medical SciencesFukuokaJapan National Center for Global Health and Medicine ShinjukukuTokyoJapan

Background Characterising the psychiatric sequelae of coronavirus disease 2019(COVID-19)can inform the development of long-term treatment ***,few studies have examined these sequelae at different time points after COVID-19 *** The study aimed to investigate the incidences and risks of acute and delayed psychiatric sequelae in patients hospitalised with COVID-19 in *** This retrospective cohort study was conducted using a database comprising healthcare claims data from public health insurance enrollees residing in a Japanese *** analysed a primary cohort comprising patients hospitalised with COVID-19 between March 2020 and July 2021 and two control cohorts comprising patients hospitalised with influenza or other respiratory tract infections(RTI)during the same *** calculated the incidences of acute(1–3 months after infection)and delayed(4–6 months after infection)psychiatric *** sequelae were identified using diagnosis codes and categorised as mood/anxiety/psychotic disorder,mood disorder,anxiety disorder,psychotic disorder or *** logistic regression models were used to estimate the odds ratios(ORs)of psychiatric sequelae occurrence after COVID-19 infection compared with influenza and other *** The study population with acute psychiatric sequela consisted of 662 patients with COVID-19,644 patients with influenza,and 7369 patients with RTI who could be followed for 3 months;the study population with delayed psychiatric sequelae consisted of 371 patients with COVID-19,546 patients with influenza,and 5397 patients with RTI who could be followed for 6 *** the analysis of acute psychiatric sequelae,COVID-19 had significantly higher odds of mood/anxiety/psychotic disorder(OR:1.39,p=0.026),psychotic disorder(OR:2.13,p<0.001),and insomnia(OR:2.59,p<0.001)than influenza,and significantly higher odds of insomnia(OR:1.44,p=0.002)and significantly lower odds of anxiety disorder(OR:0.56,p<0.

关键词： patients psychiatric sequelae

A case of advanced intrahepatic cholangiocarcinoma successfully treated with chemosensitivity test-guided systemic chemotherapy

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World Journal of Gastroenterology 2009年第41期15卷 5228-5231页

作者： Kazumichi Abe Takeru Wakatsuki fumiko Katsushima Kyoko Monoe Yukiko Kanno Atsushi Takahashi Junko Yokokawa Hiromasa Ohira Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan

Intrahepatic cholangiocarcinoma （ICC） is a relatively rare and highly fatal neoplasm that arises from the biliary epithelium. Prognosis is generally poor and survival is limited to a few months. Here we present a case of advanced ICC successfully treated by chemosensitivity test-guided systemic chemotherapy combining S-1 and cisplatin （CDDP）. A 65-year-old woman with a liver tumor was referred to our hospital on November 21, 2007. Abdominal ultrasonography and computed tomography （CT） showed low-density masses of 50 and 15 mm in diameter, respectively in segment w of the liver and in the enlarged lymph node in the para-aorta. Ultrasonography-guided fine needle biopsy diagnosed the tumors as ICC. Since the patient was inoperable for lymph node metastasis, she underwent systemic chemotherapy with gemcitabine. Six months afcer initiation of chemotherapy, CT revealed ICC progression in the liver and pleural dissemination with pleural effusion. The patient was admitted to our hospital for anticancer drug sensitivity testing on June 9, 2008. Based on the sensitivity test results, we elected to administer systemic chemotherapy combining S-1 and CDDP. Two months into the second chemotherapy treatment, CT revealed a reduction of the tumors in the liver and lymph node and a decrease in pleural *** eight cycles of the second chemotherapy, 17 mo after ICC diagnosis, she is alive and well with no sign of recurrence. We conclude that chemosensitivity testing may effectively determine the appropriate chemotherapy regimen for advanced ICC.

关键词： Chemosensitivity testing Cholangiocarcinoma, Cisplatin Liver neoplasms Gemcitabine S-1 Systemic chemotherapy

Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms： a double-blind, placebo-controlled randomized and dose-ranging study

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Asian Journal of Andrology 2008年第4期10卷 651-658页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To conduct a double-blind, placebo-controlled randomized and dose-ranging study to evaluate the safety and efficacy of the extract of Ganoderma lucidum （G. lucidum） in men with lower urinary tract symptoms （LUTS）. Methods： We enrolled male volunteers （〉 50 years） with an International Prostate Symptom Score （IPSS; questions 1-7）〉 5 and a prostate-specific antigen （PSA） value 〈 4 ng/mL. Volunteers were randomized into groups of placebo （n = 12）, G. lucidum of 0.6 mg （n = 12）, 6 mg （n = 12） or 60 mg （n = 14）, administered once daily. Efficacy was measured as a change from baseline in IPSS and the peak urine flow rate （Qmax）. Prostate volume and residual urine were estimated by ultrasonography, and blood tests, including PSA levels, were measured at baseline and at the end of the treatment. Results： The overall administration was well tolerated, with no major adverse effects. Statistical significances in the magnitude of changes between the experimental groups were observed at weeks 4 and 8. No changes were observed with respect to Qmax, residual urine, prostate volume or PSA levels. Conclusion： The extract of G. lucidum was well tolerated and an improvement in IPSS was observed. The recommended dose of the extract of G. lucidum is 6 mg in men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial

Process of Decision-Making of Anti-Cancer Treatment in Elderly Patients with Advanced Lung Cancer

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Health 2017年第12期9卷 1644-1659页

作者： fumiko Koyama Kumi Suzuki Doctoral Program Graduate School of Nursing Osaka Medical College Osaka Japan Faculty of Nursing Osaka Medical College Osaka Japan

The aim of this study was to identify the decision-making process of anti-cancer treatment in elderly patients with advanced lung cancer. Semi-structured interviews were conducted with 17 patients aged 70 and above to collect data on their feelings and thoughts from the time of diagnosis till they made treatment decisions. The data was analyzed using the Modified Grounded Theory Approach that was modified by Prof. Yasuhito Kinoshita. We found the process to be composed of six categories. The results showed that elderly patients with advanced lung cancer were panicked over unavoidable death when informed of stage IV lung cancer and offered suggestions about anti-cancer treatment. However, trying to accept the situation where death is imminent, patients reconsidered having cancer in older age and recognized a desire to survive even in older age. This process diverged into two paths: one group of patients changed their ideas from radical to life-prolonging treatment by recognizing a desire to survive even in older age and then made anti-cancer treatment decisions by carefully choosing treatment that would allow to carry on their usual way of life;the other group of patients made treatment decisions by carefully choosing physicians to whom they could entrust their life in older age. These findings suggest that it is important for nurses to: 1) encourage patients to talk in order to have them think about what they have valued and want to value in the rest of their life;2) assess if patients prefer to decide on their own by carefully choosing treatment or entrust treatment decisions to physicians;and 3) offer support according to patients’ preferences.

关键词： Advanced Lung Cancer Elderly Anti-Cancer Treatment Decision-Making