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药物性放大内镜:利用微血管对肾上腺素刺激的反应辨别早期胃癌

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 27-28页

作者： fukui h. Sh.rakawa K. Nakamura T. 王晓君 Current affiliations: Dept. of Surgical andMolecular Path.logy (Drs fukui Suzuki and Fujimori) Department of Endoscopy (Drs Shirakawa and Nakamura) Department of Gastroenterology (Drs Masuyama Hiraishi and Terano) Tochigi Japan Dr.

Background: Magnifying endoscopy is a promising modality for fine observation of minute surface structures and microvessel arch.tecture in gastric lesions. Objective: To observe th. response of microvessels to epineph.ine stimulation in early gastric cancer tissues and to assess th. usefulness of magnifying ph.rmacoendoscopy for h.stologic diagnosis. Design: Th.s was a prospective pilot study. Setting: Th.s study was conducted at an academic h.spital. Patients: Twenty-nine patients with.differentiated early gastric cancer were enrolled. Interventions: Microvessels in both.th. cancerous lesion and its adjacent non-neoplastic gastric mucosa were observed by magnifying endoscopy before and after focal spray with.epineph.ine solution (0.05 mg/mL).Main Outcome Measurements and Results: After epineph.ine stimulation, noncancerous gastric mucosa surrounding th. cancerous lesion sh.wed a ch.nge in color from red to wh.te; no microvessels were evident. On th. oth.r h.nd, all th. cancerous lesions examined clearly sh.wed enh.ncement of tumor microvessels. Th. rate of detection of tumor microvessels by magnifying ph.rmacoendoscopy (100%) was significantly h.gh.r th.n th.t by magnifying endoscopy alone (41.3%). Limitations: Th.s was small pilot study. Conclusions: Magnifying ph.rmacoendoscopy with.epineph.ine is a powerful tool for assessing tumor vascularity and may contribute to th. h.stologic diagnosis of differentiated early gastric cancers before endoscopic treatment.

关键词：早期胃癌癌性微血管结构肿瘤微血管组织学诊断微小结构病变黏膜教学医院肿瘤血管结果指标

Continuous Gum Ch.wing Exercise Improves Perioral Muscle Strength

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h.alth 2024年第8期16卷 750-762页

作者： Mutsumi Takah.sh. Yogetsu Bando Takuya fukui Department of Ph.siology The Nippon Dental University School of Life Dentistry at Niigata Niigata Japan Bando Dental Clinic Ishikawa Japan Department of Sport Science Kanazawa Gakuin University of Sport Science Ishikawa Japan Japan Gymnastics Association Trampoline Committee Tokyo Japan

Objective: Th. purpose of th.s study was to examine th. effects of continuous gum ch.wing exercise on perioral muscle strength. Meth.ds: Th.rty h.alth. adults (24.1 ± 2.0 years) with.normal occlusion performed gum ch.wing exercise 3 times daily for 3 month.. Each.exercise session lasted 5 min and involved alternating of ch.wing 10 times using th. left molars and th.n 10 times using th. righ. molars, with.th. mouth.closed. Th. effect of th. exercise on oral function was evaluated by measuring tongue pressure (TP), ch.ek pressure (CP), and labial closure strength.(LCS) immediately before starting exercise, at 2 weeks and 1, 2, and 3 month. after starting exercise, and at 3 month. after cessation of exercise. Ch.nges in TP, CP, and LCS according to sex and duration of exercise were analyzed by repeated two-way ANOVA. Results: Measurements for all muscles were significantly greater in men th.n in women at all time points. After starting exercise, TP was markedly increased at 2 month. in men and women, and both.CP and LCS were markedly increased at 2 weeks in men and at 1 month.in women. Th.se effects persisted for 3 month.. Th.ee month. after cessation of exercise, TP, CP, and LCS tended to decrease, but were not significantly attenuated as compared with.3 month. after beginning of exercise in eith.r sex. Conclusion: Th. results of th.s study revealed th.t gum ch.wing exercise contributed to an improvement in perioral muscle strength. and th.t th.s effect was maintained for at least 3 month. after discontinuation of exercise.

关键词： Oral Function Gum Ch.wing Exercise Tongue Pressure Ch.ek Pressure Labial Closure Strength

Ph.sph.rylated protein ch.p combined with.artificial intelligence tools for precise drug screening

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Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： Katsuh.sa h.rimoto Yuki Suyama Tadamasa Sasaki Kazuh.ko fukui Lili Feng Meiling Sun Yamin Tang Yixuan Zh.ng Dongyin Ch.n Feng h.n SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research.Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Ph.siology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu Sch.ol Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We h.ve developed a protein array system,named"Ph.sph.-Totum",wh.ch.reproduces th. ph.sph.rylation state of a sample on th. *** protein array contains 1471 proteins from 273 known signaling *** to th. activation degrees of tyrosine kinases in th. sample,th. corresponding groups of substrate proteins on th. array are ph.sph.rylated under th. same *** addition to measuring th. ph.sph.rylation levels of th. 1471 substrates,we h.ve developed and performed th. artificial intelligence-assisted tools to furth.r ch.racterize th. ph.sph.rylation state and estimate path.ay activation,tyrosine kinase activation,and a list of kinase inh.bitors th.t produce ph.sph.rylation states similar to th.t of th. *** Ph.sph.-Totum system,wh.ch.seamlessly links and interrogates th. measurements and analyses,h.s th. potential to not only elucidate path.ph.siological mech.nisms in diseases by reproducing th. ph.sph.rylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inh.bitors.

关键词： Ph.sph.-Totum protein array signal transduction path.ays artificial intelligence tools drug screening

Zn含量对于Cu-Mn-Zn/ZrO_(2)催化剂CO_(2)加氢合成甲醇性能的影响研究

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燃料化学学报（中英文） 2024年第3期52卷 293-304页

作者：王世威杨金海周宏利肖福魁赵宁中国科学院山西煤炭化学研究所煤炭高效低碳转化全国重点实验室山西太原030001 中国科学院大学北京100049

通过溶胶-凝胶方法制备了一系列不同Zn含量的Cu-Mn-Zn/ZrO_(2)催化剂,并通过XRD、BET、TPR、N_(2)O吸附、XPS、TPD和in-situ DRIFTS进行了表征。结果表明,随着Zn含量增加,催化剂上CO_(2)加氢反应的活性增加。在所有样品中,Cu_(3)MnZn_(0... 详细信息

通过溶胶-凝胶方法制备了一系列不同Zn含量的Cu-Mn-Zn/ZrO_(2)催化剂,并通过XRD、BET、TPR、N_(2)O吸附、XPS、TPD和in-situ DRIFTS进行了表征。结果表明,随着Zn含量增加,催化剂上CO_(2)加氢反应的活性增加。在所有样品中,Cu_(3)MnZn_(0.5)Zr_(0.5)(CMZZ-0.5)在250℃和5 MPa条件下具有最高的CO_(2)转化率(6.5%)和甲醇选择性(73.7%)。表征结果表明,Zn进入Cu_(1.5)Mn_(1.5)O_(4)尖晶石结构,形成ZnOx,导致催化剂表面羟基含量的增加,同时增加了Cu0和Cu^(α+)的含量,改善了h.(2)和CO_(2)的活化能力。此外,通过原位漫反射红外光谱研究了CO_(2)转化为甲醇的途径。

关键词： CO_(2)加氢甲醇 Cu-基催化剂表面羟基

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铁路隧道套衬加固施工技术

江苏建材 2024年第1期 106-107页

作者：张福奎中铁十六局集团第二工程有限公司天津300162

结合贵广客运专线怀集至肇庆东贵广场段隧道套衬整治施工案例,详细阐述了隧道套衬加固等一系列的整治技术,并在套衬施工阶段按照隧道现场整治情况及施工工艺持续进行优化调整。该段隧道经套衬加固整治效果显著,达到了预期目标,为类似的... 详细信息

结合贵广客运专线怀集至肇庆东贵广场段隧道套衬整治施工案例,详细阐述了隧道套衬加固等一系列的整治技术,并在套衬施工阶段按照隧道现场整治情况及施工工艺持续进行优化调整。该段隧道经套衬加固整治效果显著,达到了预期目标,为类似的隧道套衬加固施工提供了经验参考。

关键词：铁路隧道套衬施工技术

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珠穆朗玛峰山麓三个典型冰川湖泊变化数据集内容与研发

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全球变化数据学报（中英文） 2017年第1期1卷 86-92,209-215页

作者：陈文波福井弘道土光智子刘闯冯强勾鹏石瑞香日本庆应义塾大学SFC研究所藤泽2520882 日本中部高等学術研究所春日井4878501 中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 中国科学院遥感与数字地球研究所北京100101 中国科学院青藏高原研究所北京100101

喜马拉雅山是地球上除了南北极以外的冰川分布面积最大的地带之一,且是气候变化的敏感区域。冰川面积的变化可以成为区域气候变化的指示器。本研究运用时间序列分析方法,以三个坐落在珠穆朗玛峰山脚下的冰川湖泊——绒布湖(中国)、卡达... 详细信息

喜马拉雅山是地球上除了南北极以外的冰川分布面积最大的地带之一,且是气候变化的敏感区域。冰川面积的变化可以成为区域气候变化的指示器。本研究运用时间序列分析方法,以三个坐落在珠穆朗玛峰山脚下的冰川湖泊——绒布湖(中国)、卡达湖(中国)和伊姆伽湖(尼泊尔)面积的变化为研究对象;通过遥感图像和DEM数据得到冰川湖泊数据集,数据格式为ArcGIS的.sh.格式和Google earth..kmz格式。本数据集的属性库包括:时期、湖泊名称、湖泊面积、传感器类型和湖泊位置。数据表明,绒布湖在1976年尚未出现水体,至2014年水面面积达到580,239m^2;卡达湖自1976年面积389,317m^2至2014年增至809,388m^2;伊姆伽湖面积自1976年284,411 m^2至2014年增至1,260,218 m^2。

关键词：冰川湖泊数据绒布湖卡达湖伊姆伽湖珠穆朗玛峰

Deep belief network-h.dden Markov model based nonlinear equalizer for VCSEL based optical interconnect

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Science Ch.na(Information Sciences) 2020年第6期63卷 155-163页

作者： fukui TIAN Ch.anch.an YANG State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Engineering and Computer Science Peking University

Th. data center h.s developed rapidly over th. past few years, leading to th. demand for h.gh.speed data transmission. Vertical cavity surface emitting lasers(VCSELs) based optical interconnect is evolving to 100 Gb/s and beyond, wh.ch.makes nonlinear distortions difficult to be compensated or equalized by conventional equalizers. Moreover, th. ch.llenge becomes very complicated for conventional equalizers because of th. presence of inter-symbol interference(ISI) togeth.r with.th. nonlinear distortions. So many neural network based DSP algorith.s such.as artificial neural network(ANN) h.ve been proposed to mitigate th. distortions. h.wever, ANN h.s th. limitations th.t sample's relevant information is not considered,leading to degradation in ANN's performance and h.gh.computational complexity. In th.s paper, in order to maintain an excellent capability of mitigating nonlinear distortions like oth.r neural network based equalizers wh.le considering th. sample's relevant information to reduce th. computational complexity, we propose a deep belief network-h.dden Markov model(DBN-h.M) based nonlinear equalizer wh.ch.is tested in a PAM-4 modulated VCSEL and multimode fiber(MMF) optical interconnect link experimentally. Th. BER performance can be greatly improved compared with.conventional DSP algorith.s. In addition, th. computational complexity of DBN-h.M based equalizer can be about 41% lower th.n th.t of ANN based meth.d with.a similar BER performance.

关键词： sh.rt-range optical interconnect vertical cavity surface emitting laser(VCSEL) nonlinear equalizer deep belief network(DBN) h.dden Markov model(h.M)

钙铈基催化剂上碳酸丙烯酯和甲醇制备碳酸二甲酯的研究

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燃料化学学报（中英文） 2024年第4期52卷 545-552页

作者：郭炯杨金海史依琳赵宁肖福魁姜新东沈阳化工大学辽宁/沈阳功能染颜料重点实验室辽宁沈阳110142 中国科学院山西煤炭化学研究所煤炭高效低碳转化全国重点实验室山西太原030001

采用溶胶凝胶法制备了不同比例的钙铈基催化剂,并研究了其对于碳酸丙烯酯和甲醇制备碳酸二甲酯的酯交换反应性能。结果表明,Ca∶Ce=9的催化剂在反应时间2 h.温度40℃,甲醇与碳酸丙烯酯物质的量比为15∶1,催化剂用量为碳酸丙烯酯用量4%... 详细信息

采用溶胶凝胶法制备了不同比例的钙铈基催化剂,并研究了其对于碳酸丙烯酯和甲醇制备碳酸二甲酯的酯交换反应性能。结果表明,Ca∶Ce=9的催化剂在反应时间2 h.温度40℃,甲醇与碳酸丙烯酯物质的量比为15∶1,催化剂用量为碳酸丙烯酯用量4%的条件下,碳酸丙烯酯转化率达到91.1%,碳酸二甲酯选择性达到91.7%。采用XRD、N2吸附-脱附、FT-IR、XPS和CO_(2)-TPD对催化剂进行了表征。结果表明,催化剂表面的氧空穴越多,中等碱性位数量越多,越有利于甲醇的活化,催化剂的活性越好。

关键词：钙铈基催化剂碳酸二甲酯酯交换固体碱

Effects of water saturation and loading rate on direct sh.ar tests of andesite

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Journal of Rock Mech.nics and Geotech.ical Engineering 2022年第2期14卷 653-662页

作者： Tiansh. Bao Kimih.ro h.sh.ba Katsunori fukui Department of Systems Innovation The University of TokyoTokyo113-8656Japan

For estimating th. long-term stability of underground framework,it is vital to learn th. mech.nical and rh.ological ch.racteristics of rock in multiple water saturation ***,th. majority of previous studies explored th. rh.ological properties of rock in air-dried and water saturated conditions,as well as th. water effects on compressive and tensile *** th.s study,andesite was subjected to direct sh.ar tests under five water saturation conditions,wh.ch.were controlled by varying th. wetting and drying *** tests were conducted at alternating displacement rates under th.ee vertical *** results reveal th.t th. sh.ar strength.decreases exponentially as water saturation increases,and th.t th. increase in sh.ar strength.with.a tenfold increase in displacement rate is nearly constant for each.of th. vertical *** on th. findings of th. sh.ar tests in th.s study and th. compression and tension tests in previous studies,th. influences of both.water saturation and loading rate on th. h.ek-Brown failure criterion for th. andesite was *** results indicate th.t th. brittleness index of th. andesite,wh.ch.is defined as th. ratio of uniaxial compressive strength.to tensile strength.is independent of both.water saturation and loading rate and th.t th. influences of th. water saturation dependence and th. loading rate dependence of th. failure criterion can be converted between each.oth.r.

关键词： Direct sh.ar test Water saturation Loading rate dependence Failure criterion