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Sulfonylation from sodium dithionite or thiourea dioxide

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Chinese Chemical Letters 2021年第1期32卷 461-464页

作者： fu-sheng he Min Yang shengqing Ye Jie Wu School of Pharmaceutical and Materials Engineering E/Institute for Advanced Studies Taizhou UniversityTaizhou 318000China School of Basic Medicine Gannan Medical UniversityGanzhou 341000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The cheap and easily available sodium dithionite and thiourea dioxide have been used as the source of sulfonyl group in the synthesis of sulfones and sulfonamides *** with other methods for the sulfonylation reactions,the strategies using sodium dithionite or thiourea dioxide provide an alternative and complementary route to diverse sulfonyl *** the reaction process,sulfur dioxide anion radical is the key intermediate,which is usually generated from a single electron transfer under suitable *** advantages using sodium dithionite or thiourea dioxide in the sulfonylation reactions include mild conditions and broad substrate scope with excellent functional group *** applications by using sodium dithionite and thiourea dioxide in organic transformations will be anticipated.

关键词： Sodium dithionite Thioureadioxide Sulfones Sulfonamides Sulfur dioxide anion radical

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Photoredox-Catalyzed functionalization of Alkenes w ith Thiourea Dioxide:Construction of Alkyl Sulfones or Sulfonamides

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Chinese Journal of Chemistry 2020年第4期38卷 361-366页

作者： Yuewen Li Jin-Biao Liu fu-sheng he Jie Wu School of Pharmaceutical and Materials Engineering&Institute for Advanced Studies Taizhou University1139 Shifu AvenueTaizhouZhejiang 318000Chino School of Metallurgical and Chemical Engineering Jiangxi University of Science and TechnologyGonzhouJiangxi 341000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Ling ling RoadShanghai 200032China

Summary of main observation and conclusion Sulfonylation of alkenes through photoredox-catalyzed functionalization of alkenes with thiourea dioxide under visible-ight rradiation is achleved,The reaction of alkenes,thiourea dioxide and electropiles provides a green and fficient access to alkyl sul-fones and sulfonamides.A broad reaction scope is presented with good functional group compat bility and excellent regiaselectivity.A plausible mecha-nism involving a radical addition process with sulfur dioxide rpdical anion(SO2-)derived from the oxidation of sulfur dioxide anion(S02^-2) is proposed,which is supported by fluorescence quenching experiments.

关键词： dioxide redox anion

Nitrosoarenes as Nitrogen Source for Generation of Sulfonamides with the Insertion of Sulfur Dioxide under Metal-Free Conditions

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Chinese Journal of Chemistry 2020年第10期38卷 1098-1102页

作者： Xuefeng Wang Yanmei Lin Jin-Biao Liu fu-sheng he Yunyan Kuang Jie Wu Department of Chemistry Fudan University2005 Songhu RoadShanghai 200438China Schoo/of Pharmaceutical and Materials Engineering&Institute for Advanced Studies Taizhou University1139 Shifu AvenueTaizhouZhejiang 318000China School of Metollurgical and Chemical Engineering Jiangxi University of Science and TechnologyGanzhouJiangxi 341000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China

Summary of main observation and conclusion A metal-free reaction of nitrosoarenes,aryldiazonium tetrafluoroborates,and sulfur dioxide under mild conditions is developed,giving rise to sulfonamides in moderate to good *** transformation proceeds eficiently at room temperature in the presence of cyclohexa-1,4-diene with a broad reaction *** functional group compatibility is observed,including cyano,halo,and ester.A plausi-ble mechanism involving a radical process with the insertion of sulfur dioxide is proposed,and cyclohexa-1,4-diene serves as the reductant during the transformation.

关键词： dioxide sulfur Sulfur

Initial experience with circumferential pulmonary vein ablation guided by fusion of magnetic resonance imaging with three-dimensional electroanatomic mapping

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Chinese Medical Journal 2006年第12期119卷 1047-1052页

作者： TANG Kai MA Jian MA fu-sheng JIA Yu-he ZHANG Shu Center of Arrhythmia Diagnosis and Treatment Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037China

Catheter ablation for the treatment of atrial fibrillation （AF） has been a focal target ofelectrophysiological study in recent years. Up to date, circumferential pulmonary vein ablation （CPVA） guided by three-dimensional （3-D） electreanatomic mapping （Carto, USA） has been one of the most favourable procedures for the treatment of AF. However, it is still difficult to acquire the detailed information on number, location, and branching pattern of all pulmonary veins （PVs） when the 3-D electroanatomic mapping system is used alone.

关键词： circumferential pulmonary vein ablation magnet resonance imaging three-dimensional electroanatomic mapping atrial fibrillation

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Enantioselective [3+2] Cycloaddition of Azomethine Ylides with β-Amino Nitroalkene Catalyzed by a Novel N,O-Ligand/Cu（I） Complex

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Enantioselective [3+2] Cycloaddition of Azomethine Ylides wi...

Asymmetric Synthesis of Highly functionalized Pyrrolidine Derivatives via Catalytic 1,3-Dipolar Cycloaddition

中国化学会第29届学术年会

作者： fu-sheng he Xingxin Yu Wei-Ping Deng Shanghai Key Laboratory of New Drug Design ＆ School of Pharmcy East China University of Science and Technology

The catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to substituted olefins provides a powerful and atom economical approach for the preparation of highly-functionalized pyrrolidines,1 which can serve as valuable building blocks for natural products, bio-active molecules and organocatalysts.2 Among them, enantiopure 3,4-diaminopyrolidines were found to be important scaffolds in HIV protease inhibitors, DPP-4 inhibitors as well as salen-type chiral ligands.3 However, despite the impressive effort made in asymmetric 1,3-dipolar cycloaddition during the past few decades, the process with β-amino α,β-unsaturated alkenes as dipolarphiles has rarely been explored. Based on previous work,4 the cycloaddition of azomethine ylides to β-amino nitroalkene catalyzed by a novel N,O-ligand/Cu（I） complex is developed, affording 4-nitro-3-aminopyrrolidines in high yields with excellent diastereoselectivities and enantioselectivities.

关键词： 4-nitro-3-aminopyrrolidines asymmetric catalysis azomethine ylides cycloaddition

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Asymmetric Synthesis of Highly Functionalized Pyrrolidine De...

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-x Mo medium heavy alloy

手性中国2014学术研讨会

作者： Wu-Lin Yang fu-sheng he Xingxin Yu Wei-Ping Deng Shanghai Key Laboratory of New Drug Design ＆ School of Pharmacy East China University of Science and Technology

＜正＞Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to electron-deficient alkenes has arguably been one of the most ideal synthetic strategies for the stereoselective construction of highly fiinctionalized chiral pyrrolidines,especially those with spiro quaternary *** dipolarophiles employed in these reactions are 2-oxoindolin-3-ylidene 1,whileα-alkylidene succinimides and P-amino

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China Foundry 2025年

作者： Guo-xin Cao Jian-xin Dong Yong-sheng he he Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan fu School of Materials Science and Engineering University of Science and Technology Beijing Xi'an Superalloy Technology Co. Ltd. School of Materials Science and Engineering Beijing Institute of Technology Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou University

In this study,a novel Ni-W-Co-Mo medium heavy alloy (MHA) was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-xM o alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypoeutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-xM o alloys is Mo-induced solid solution strengthening and precipitation strengthening.

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Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2001年第4期7卷 537-541页

作者： fu-sheng Wang Li-he Xing Ming-Xu Liu Chuan-Lin Zhu Hui-Gang Liu Hui-Fen Wang Zhou-Yun Lei Division of Biological Engineering,~2 Fourth Department of Liver Diseases,Beijing Institute of Infectious Diseases,Beijing Hospital of Infectious Diseases,Beijing 100039,China Division of Biological Engineering Beijing Institute of Infectious Diseases 26 Fengtai Road Beijing 100039 China. fswang@***

AIM: To identify the property of dendritic cells (DCs) of peripheral blood monocytes (PBMC) in patients with chronic HBV infection. METHODS: Twenty patients with persistent HBV infection were included in this study, 10 healthy subjects being used as a control group. The peripheral blood mononuclear cells (PBMC) of T cell-depleted populations were incubated and induced into mature dendritic cells in the RPMI-1640 medium in the presence of cytokines GM-CSF, IL-4, FLt-3,TNF-alpha and 100mL.L(-1 )of fetal calf serum for a total of 10-12 days. The expressions of surface markers on DCs were evaluated using flow cytometric analysis. ELISA method was used to determine the cytokine levels of interleukin-12 (IL-12) and IL-10 in the supernatant produced by DCs. For detection of the stimulatory capacity of DCs to T cell proliferation, mytomycin C-treated DC were incubated with allogenic T cells. RESULTS: A typical morphology of mature DCs from healthy subjects and HBV-infected patients was induced in in vitro incubation, but the proliferation ability and cellular number of DCs from HBV-infected patients significantly decreased compared with healthy individuals. In particular, the expression levels of HLA-DR, CD80 (B7-1) and CD86 (B7-2) on DC surface from patients were also lower than that from healthy individuals (0.46 vs 0.92 for HLA-DR, 0.44 vs 0.88 for CD80 and 0.44 vs 0.84 for CD86,Phe stimulatory capacity and production of IL-12 of DCs from patients in allogenic mixed lymphocyte reaction (AMLR) significantly decreased, but the production level of nitric oxide (NO) by DCs simultaneously increased compared with healthy subjects (86 +/- 15 vs 170 +/- 22 micromol.L(-1), P he patients with chronic HBV infection have the defective function and immature phenotype of dendritic cells, which may be associated with the inability of efficient presentation of HBV antigens to host immune system for the clearance of HBV.

关键词： Adolescent Adult Antigens, Surface Cell Division Child Dendritic Cells Female Flow Cytometry hepatitis B, Chronic Humans Interleukin-10 Interleukin-12 Male Middle Aged Nitric Oxide Research Support, Non-U.S. Gov't

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CheN LIN ZHONG LUJI HUANG fu CheNG XINDAN sheng XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI he China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy