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Inflammatory bowel disease unclassified

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第4期12卷 280-286页

作者： Ning ZHOU Wei-xing CHEN shao-hua CHEN Cheng-fu XU You-ming li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China

Objective:Inflammatory bowel diseases (IBDs) are idiopathic,chronic,and inflammatory intestinal *** two main types,ulcerative colitis (UC) and Crohn's disease (CD),sometimes mimic each other and are not readily *** purpose of this study was to present a series of hospitalized cases,which could not initially be classified as a subtype of IBD,and to try to note roles of the terms indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU) when such a dilemma ***:Medical records of 477 patients hospitalized due to IBD,during the period of January 2002 to April 2009,were retrospectively studied in the present *** available previous biopsies from endoscopies of these patients were ***:Twenty-seven of 477 IBD patients (5.7%) had been initially diagnosed as having *** them,23 received colonoscopy and histological examinations in our hospital.A total of 90% (9/10) and 66.7% (4/6) of patients,respectively,had a positive finding via wireless capsule endoscopy (CE) and double-balloon enteroscopy (DBE).The barium-swallow or small bowel follow-through (SBFT) was performed on 11 *** changes were observed under computer tomographic (CT) scanning in 89.5% (17/19) of *** treatment strategies were employed for all ***:Our data indicate that IBDU accounts for 5.7% of initial diagnoses of *** definition of IBDU is valuable in clinical *** those who had no clear clinical,endoscopic,histological,or other features affording a diagnosis of either UC or CD,IBDU could be used parenthetically.

关键词： Inflammatory bowel disease unclassified Ulcerative colitis Crohn’s disease Subtype Diagnosis

Characteristics of Climate Change in the Lake Basin Area of Gangcha County

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Computers, Materials & Continua 2022年第10期73卷 363-379页

作者： Wenzheng Yu Aodi fu li shao Haitao liu Xin Yao Tianliang Chen Hanxiaoya Zhang School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjing210044China School of Environmental Science&Engineering Nanjing University of Information Science&TechnologyNanjing210044China Faculty of Science The University of Auckland1010New Zealand

This paper mainly was based on the average temperature,precipitation,humidity,and wind direction of Gangcha county from 1960 to *** using wavelet analysis and Mann-Kendall(M-K)mutation analysis,specifically analyzed the climate change characteristics in the lake basin area of Gangcha *** result showed that the climatic change in the lake basin area of Gangcha county is *** average temperature,average minimum temperature,average maximum temperature,and evaporation showed an increasing *** the evaporation in the study area was higher than *** average relative humidity showed a decreasing *** the sunshine and the average wind speed percentage showed a significant decreasing *** the Morelet wavelet,The time series of annual mean temperature,annual evaporation and annual sunshine percentage all have quasi3a and quasi4A periods,and the annual mean precipitation has quasi2–3A,quasi2–5A and quasi2–6A periods,which appear in 1996–2005,1962–1978 and 1978–1996 *** mean annual relative humidity has obvious quasi2–7A and quasi3A time series,which appear from 1960 to 1996,1997 to 2005 and after 2008,*** annual mean wind speed has quasi3–4A and quasi5A time series characteristics,which appear in 1964–1967,1984–1995,after 2009 and 1971–1983,*** Mann-Kendall(M-K)mutation analysis,it is found that the mutations of evaporation and the average speed of wind are *** mutation of evaporation started in 2004,and the mutation of average started in 2003.

关键词： Climate change the qinghai lake Morelet wavelet Mann-Kendall test

内皮祖细胞与间充质干细胞治疗血管支架相关疾病

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中国组织工程研究 2025年第19期29卷 4091-4101页

作者：李清音李林华张春乐付平四川大学华西医院肾脏内科肾脏病研究所四川省成都市610041 四川大学疾病分子网络前沿科学中心四川省成都市610041

背景:随着干细胞研究的发展,成体干细胞如内皮祖细胞和间充质干细胞在动脉粥样硬化、血管支架植入损伤并发症中的治疗效能逐渐被发现,由于静脉输注成体干细胞治疗疾病存在靶向性差、治疗效率低等问题,近年来对血管支架表面改性以实现内... 详细信息

背景:随着干细胞研究的发展,成体干细胞如内皮祖细胞和间充质干细胞在动脉粥样硬化、血管支架植入损伤并发症中的治疗效能逐渐被发现,由于静脉输注成体干细胞治疗疾病存在靶向性差、治疗效率低等问题,近年来对血管支架表面改性以实现内皮祖细胞或间充质干细胞的局部聚集与功能调节一直是研究的焦点。目的:论述内皮祖细胞、间充质干细胞在血管支架相关疾病中的治疗进展,以及基于内皮祖细胞、间充质干细胞的血管支架设计方面的研究现状。方法:在CNKI、万方、PubMed、Web of Science数据库检索建库以来发表的相关文献。中文检索词“内皮损伤,支架植入术,血栓,内膜增生,动脉粥样硬化,内皮修复,内皮祖细胞,间充质干细胞,血管支架”;英文检索词“endothelial injury,stenting,thrombosis,intimal hyperplasia,atherosclerosis,endothelial repair,endothelial regeneration,endothelial progenitor cell,mesenchymal stem cell,vascular stent,vascular scaffold”。根据纳入和排除标准,最终对127篇文献进行综述。结果与结论:内皮祖细胞、间充质干细胞能够通过分化以及旁分泌作用治疗动脉粥样硬化及支架植入损伤并发症,其作用机制主要包括保护内皮细胞、调节炎症细胞与炎症因子表达、调节平滑肌细胞增殖和表型等。间充质干细胞在治疗应用中可能伴有血栓、血管钙化等不良反应,使用细胞外囊泡、联合使用肝素进行表面设计是解决这一问题的可行方案。目前基于内皮祖细胞的支架研究较多,主要从内皮祖细胞的募集、捕获、增殖、分化与活性等方面进行支架表面改性;血管领域基于间充质干细胞捕获的支架研究较少,但间充质干细胞来源外泌体洗脱支架被发现具有极高的治疗效能。此外一些基础疾病如糖尿病可能会对成体干细胞活性造成影响,导致基于干细胞设计的支架失去效能,因而未来在设计相应的支架时,应注意考虑这方面的影响因素。

关键词：内皮祖细胞间充质干细胞动脉粥样硬化球囊损伤支架植入损伤内膜增生表面改性

Enantioseparation of Racemic Naproxen Esters on Cellulose Tris (4-methylbenzoate) Chiral Stationary Phase

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Chinese Chemical Letters 2002年第2期13卷 151-152页

作者： Bao Hai shao Xiu Zhu XU li ZOU Xiao Yun fu Department of Chemistry Zhejiang UniversityHangzhou 310027

Several kinds of racemic naproxen ester were successfully separated on CTMB chiral stationary phase with hexane-ethanol (98:2, vol./vol.) as the mobile phase. The influence of mobile phase composition and structure of racemic naproxen ester on chiral separation was studied and the chiral recognition mechanism of CTMB was discussed.

关键词： Cellulose tris (4-methylbenzoate) naproxen chiral stationary phase enantioseparation.

Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography

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World Journal of Clinical Cases 2022年第9期10卷 2773-2782页

作者： Yi Zou Na li liu-Jia-Zi shao fu-Kun liu fu-Shan Xue Xing Tao Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Sedation during endoscopic ultrasonography(EUS)poses many challenges and moderate-to-deep sedation are often *** conventional method to preform moderate-to-deep sedation is generally intravenous benzodiazepine alone or in combination with ***,this combination has some *** medication delivery may be an alternative to this sedation *** To determine,by continual reassessment method(CRM),the minimal effective dose of intranasal sufentanil(SUF)when combined with intranasal dexmedetomidine(DEX)for moderate sedation of EUS in at least 95%of patients(ED95).METHODS Thirty patients aged 18-65 and scheduled for EUS were recruited in this *** received intranasal DEX and SUF for *** dose of DEX(1μg/kg)was fixed,while the dose of SUF was assigned sequentially to the subjects using CRM to determine *** sedation status was assessed by modified observer’s assessment of alertness/sedation(MOAA/S)*** adverse events and the satisfaction scores of patients and endoscopists were *** The ED95 was intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,with an estimated probability of successful moderate sedation for EUS of 94.9%(95%confidence interval:88.1%-98.9%).When combined with intranasal 1μg/kg DEX,probabilities of successful moderate sedation at each dose level of intranasal SUF were as follows:0μg/kg SUF,52.8%;0.1μg/kg SUF,75.4%;0.2μg/kg SUF,89.9%;0.3μg/kg SUF,94.9%;0.4μg/kg SUF,98.0%;0.5μg/kg SUF,99.0%.CONCLUSION The ED95 needed for moderate sedation for EUS is intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,based on CRM.

关键词： Moderate sedation Intranasal administration Dexmedetomidine Sufentanil Continual reassessment method Endoscopic ultrasonography

Out-of-hospital cardiac arrest in a young adult survivor with sequelae of childhood Kawasaki disease: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3583-3589页

作者： Ke-fu Zhu li-Jiang Tang shao-Ze Wu Yi-Min Tang Department of Cardiology Zhejiang Hospital

BACKGROUND Kawasaki disease(KD)is an acute type of systemic vasculitis involving small to medium-sized muscular arteries and outbreaks during *** can cause myocardial ischemia,infarction,and sudden cardiac *** present a case of a young adult survivor of out-of-hospital cardiac arrest as late KD *** SUMMARY A 29-year-old man with presumed acute KD history at the age of 5 suddenly lost consciousness while jogging and was diagnosed a sudden cardiac arrest by an emergency *** about 10 min cardiopulmonary resuscitation,return of spontaneous circulation was achieved,and the patient was transferred to our hospital.A coronary computed tomography angiogram and coronary angiography revealed extensive calcifications of left anterior descending and right coronary artery *** patient was an active individual who took exercise regularly and claimed no previous symptoms of chest pain or shortness of breath on *** most possible cause of his sudden cardiac arrest could be presumed as a thrombus within the coronary artery *** that,a thromboembolism induced extensive ischemia,and this ischemia-induced arrhythmia led to a cardiac *** Few patients who suffer a late sequela of KD can survive from out-of-hospital cardiac ***,surgical intervention,and active follow-up are extremely important for this patient to prevent occurrence of adverse events in the future.

关键词： Cardiac arrest Young adult Kawasaki disease Coronary artery aneurysm Case report

残余胆固醇与进展为主要不良心血管事件的非罪犯病变易损斑块的相关性研究

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中国全科医学 2025年第3期28卷 299-304页

作者：杨红刘成刘森邵琪琪夭元昊付真彦新疆医科大学第一附属医院心脏中心新疆维吾尔自治区乌鲁木齐市830054

背景残余胆固醇(RC)被认为是动脉粥样硬化性心血管疾病的重要危险因素,而冠状动脉非罪犯病变(NCCLs)进展也是影响冠心病患者预后的重要因素,但是残余胆固醇与进展为主要不良心血管事件(MACE)的NCCLs易损斑块的关系尚不明确。目的探讨R... 详细信息

背景残余胆固醇(RC)被认为是动脉粥样硬化性心血管疾病的重要危险因素,而冠状动脉非罪犯病变(NCCLs)进展也是影响冠心病患者预后的重要因素,但是残余胆固醇与进展为主要不良心血管事件(MACE)的NCCLs易损斑块的关系尚不明确。目的探讨RC对发生MACE的NCCLs易损斑块的预测价值及长期预后的相关性。方法选取2015年2月—2022年2月于新疆医科大学第一附属医院心脏中心住院的488例冠心病患者为研究对象,通过电子病历系统收集患者基线资料,行冠状动脉造影及光学相干断层扫描OCT。入组患者在出院1、3、6和12个月接受预定随访。采用Spearman秩相关检验探究RC与NCCLs中薄纤维帽粥样硬化斑块(TCFA)斑块特征的相关性。采用多因素Logistic回归分析探究NCCLs中TCFA发生MACE的影响因素。绘制受试者工作特征曲线(ROC曲线)并计算ROC曲线下面积(AUC),探究RC对NCCLs中TCFA发生MACE的预测价值。结果共纳入488例冠心病患者,根据NCCLs是否发生MACE将患者分为发生MACE组(n=38)和未发生MACE组(n=450)。通过OCT识别NCCLs的斑块特征,共分析了749个NCCLs斑块,304个NCCLs斑块最小管腔面积(MLA)<3.5 mm^(2)。随访期间38例(7.8%)患者共发生了41例次NCCLs斑块引起的MACE事件,18例(3.7%)患者发生了支架内再狭窄,15例(3.1%)发生了不确定因素的死亡。发生MACE组患者高血压、糖尿病、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、RC、糖化血红蛋白(Hb A1c)、TCFA、MLA<3.5 mm^(2)比例高于未发生MACE组(P<0.05)。105例患者检查出TCFA,其中22例发生MACE(发生MACE的TCFA组),83例未发生MACE(未发生MACE的TCFA组)。发生MACE的TCFA组糖尿病比例与RC高于未发生MACE的TCFA组(P<0.05)。Spearman秩相关分析结果示,RC与最薄纤维帽厚度、MLA呈负相关(r_(s)=-0.665、-0.771,P<0.05),与最大脂质弧度、巨噬细胞浸润呈正相关(r_(s)=0.806、0.481,P<0.05)。多因素Logistic回归分析结果显示糖尿病(OR=3.410,95%CI=1.165~9.988,P=0.025)、高RC水平(OR=5.879,95%CI=1.436~24.073,P=0.014)是NCCLs中TCFA发生MACE的危险因素。绘制RC预测NCCLs中TCFA发生MACE的ROC曲线,结果显示AUC为0.695(95%CI=0.571~0.819,P=0.005),最佳截断值为0.606 mmol/L,灵敏度、特异度分别为0.818、0.518。结论 RC水平升高可能是冠心病患者中NCCLs易损斑块发生MACE的危险因素,对NCCLs中TCFA发生MACE有一定的预测价值。

关键词：冠心病冠状动脉粥样硬化血脂异常主要不良心血管事件冠状动脉非罪犯病变残余胆固醇相关性研究

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海上漂浮式光伏多浮体间电缆跨接方法研究

工程科学学报 2025年第2期47卷 389-400页

作者：孔祥玉邵阳苹付强俞露杰刘宏斌天津市新能源电力变换传输与智能控制重点实验室(天津理工大学) 天津300384 天津大学电气自动化与信息工程学院天津300072

浮体间跨接电缆因设计不合理,在运行期间出现过度弯曲、拉伸、与浮体碰撞等现象,影响系统可靠运行.针对跨浮体电缆容易出现疲劳失效的问题,本文提出一种海上漂浮式光伏多浮体间电缆跨接方法.首先,对浮体结构进行分析,确定典型六边形浮... 详细信息

浮体间跨接电缆因设计不合理,在运行期间出现过度弯曲、拉伸、与浮体碰撞等现象,影响系统可靠运行.针对跨浮体电缆容易出现疲劳失效的问题,本文提出一种海上漂浮式光伏多浮体间电缆跨接方法.首先,对浮体结构进行分析,确定典型六边形浮体间的电缆跨接方案.其次,通过分析浮体结构对跨接方案的影响,确定电缆跨浮体设计步骤中的关键参数与限制条件;通过与现阶段跨接电缆保护手段对比,提出一种通过合理规划跨接参数满足运行要求的方法,建立电缆跨接方案两阶段求解框架;采用信赖域粒子群算法在第一阶段求解出跨接方案变量的可行解区域,第二阶段在可行解区域中求解出疲劳寿命最大值作为跨接方案最优解.最后,在Orcaflex软件搭建电缆跨接模型对最终方案进行校验,通过算例分析验证本文所提方法的有效性.研究表明,通过对合理规划跨接电缆路径,可以在一定程度上缓解电缆的弯曲状态,降低疲劳损伤,可以在运行年限期间可靠运行.

关键词：漂浮式光伏电缆跨浮体连接疲劳失效信赖域粒子群

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Quantum Algorithm Design:Techniques and Applications

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Journal of Systems Science & Complexity 2019年第1期32卷 375-452页

作者： shao Changpeng li Yang li Hongbo Academy of Mathematics and Systems Science University of Chinese Academy of Sciences Chinese Academy of Sciences

In recent years, rapid developments of quantum computer are witnessed in both the hardware and the algorithm domains, making it necessary to have an updated review of some major techniques and applications in quantum algorithm *** this survey as well as tutorial article, the authors ?rst present an overview of the development of quantum algorithms, then investigate ?ve important techniques: Quantum phase estimation, linear combination of unitaries, quantum linear solver, Grover search, and quantum walk, together with their applications in quantum state preparation, quantum machine learning, and quantum search. In the end, the authors collect some open problems in?uencing the development of future quantum algorithms.

关键词： Quantum algorithm quantum computation quantum machine learning quantum search quantum walk