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Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities

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World Journal of Gastroenterology 2017年第25期23卷 4624-4631页

作者： Guang-Lan Chen ye Zhang Wang-Yue Wang Xue-Liang Ji Fei Meng Pei-Song Xu Ning-Min Yang fu-qiang ye Xiao-Chen Bo Department of Gastroenterology Lishui People's Hospital Department of Research Service Zhiyuan Medical Inspection Institute Co. LTD Department of Radiation Toxicology and Oncology Beijing Institute of Radiation Medicine People's Republic of China

AIM To investigate alterations in the fecal microbiome using 16 S r RNA amplicon sequencing in couples in the same cohabitation *** Fecal samples were collected from eight ulcerative colitis(UC) patients and their healthy partners at Lishui People's Hospital, Zhejiang Province, China. DNA was extracted and the variable regions V3 and V4 of the 16 S r RNA genes were PCR amplified using a two-step protocol. Clear reads were clustered into operational taxonomic units(OTUs) at the 97% sequence similarity level using UCLUST v1.2.22. The Wilcoxon rank-sumtest(R v3.1.2) was used to compare inter-individual differences. Differences with a P value < 0.05 were considered statistically *** Fecal microbial communities were more similar among UC patients than their healthy partners(P = 0.024). UC individuals had a lower relative abundance of bacteria belonging to the Firmicutes, especially Blautia, Clostridium, Coprococcus and Roseburia(P < 0.05). Microbiota dysbiosis was detected in UC patients and their healthy partners. Relevant genera included Akkermansiam, Bacteroides, Escherichia, Lactobacillales, Klebsiella and Parabacteroides. The enriched pathways in fecal samples of UC patients were related to lipid and nucleotide metabolism. Additionally, the pathways involved in membrane transport and metabolism of cofactors and vitamins were more abundant in the healthy *** Our results suggested that the microbial composition might be affected in healthy partners cohabiting with UC patients, especially in terms of microbiota dysbiosis.

关键词： Ulcerative colitis Patients Healthy partner Fecal microbial communities Microbiota dysbiosis

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对多次单采血小板献血者外周血象部分参数变化的观察

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中国输血杂志 2017年第1期30卷 75-76页

作者：叶盛郑珊峡傅强南京红十字血液中心江苏南京210003

目的探讨多次反复捐献单采血小板对献血者外周血象部分参数的影响。方法选择2013年1月-2015年12月间,连续2年捐献机采血小板且每年捐献16次以上的献血者54例,每献血3次取样1次,共12次,比较其献血前的外周血象4项指标的变化。结果比较血... 详细信息

目的探讨多次反复捐献单采血小板对献血者外周血象部分参数的影响。方法选择2013年1月-2015年12月间,连续2年捐献机采血小板且每年捐献16次以上的献血者54例,每献血3次取样1次,共12次,比较其献血前的外周血象4项指标的变化。结果比较血小板(Plt)、红细胞计数(RBC)和红细胞比容(Hct),多次献血前后差异无统计学意义(P>0.05);血红蛋白(Hb)多次献血后和初次献血时比较,差异均有统计学意义(P<0.05)。结论多次捐献单采血小板可以使献血者血红蛋白降低。

关键词：献血者单采血小板外周血象

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A COVID-19 case report from asymptomatic contact:implication for contact isolation and incubation management

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Infectious Diseases of Poverty 2020年第3期9卷 128-128页

作者： Chang-qiang Zhu Shi-Ding Gao Yan Xu Xiao-Hong Yang fu-qiang ye Le-Le Ai Rui-Chen Lv Bin Zhang Yin Li Heng Lv Yun-Sheng Liu Chun-Meng Shi Chun-Hui Wang Wei-Long Tan Centre for Diseases Prevention and Control of Eastern Theater Nanjing 210002China 不详

Background:As of 2 March,2020,at least 80151 coronavirus disease 2019(COVID-19)cases were reported in *** of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to *** patients got infected through only asymptomatic *** study aimed to report the epidemic features and lab identification of a patient confirmed with COVID-19 infection through only asymptomatic *** presentation:A 44-year-old man,who lived in Nanchang,Jiangxi Province,China until 6 March 2020,suffered from cough on 27 January *** symptoms appeared on 28 January,with a maximum temperature of 38.8℃,accompanied by cough,sore throat,headache,fatigue,muscle ache,joint ache,and other *** symptoms continued until he was hospitalized on 30 *** conventional polymerase chain reaction assay was positive for the throat swab *** patient,along with his wife and son,drove from Nanchang to back to Honghu City,Hubei Province,on 23 January *** staying with his parents and brother’s family for 3 days,the patient drove back to Nanchang and arrived on 25 *** the way back home,they stopped by Tongshan service area,Hubei Province,without any close contact with other *** arriving home in Nanchang City,Jiangxi Province,none of them left their *** addition,his parents stayed at home for 20 days with his younger brother’s family before they got *** younger brother and one of his brother’s children visited Wuhan on 5 January and came home on 6 January ***:This report suggested that,in the early phase of COVID-19 pneumonia,routine screening could miss patients who were virus *** travel history is of paramount importance for the early detection and isolation of severe acute respiratory syndrome coronavirus 2 cases.

关键词： COVID-19 Coronavirus Infection Particular contacting

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin fu Xiaoting Yang Ya Yu Kang Zhou Xiaoyang ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen fuqiang Fan Yuhang Li Yu fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

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Effects of LW-AFC,a new formula derived from Liuwei Dihuang decoction,on intestinal microbiome in senescence-accelerated mouse prone 8 strain,a mouse model of Alzheimer disease

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中国药理学与毒理学杂志 2017年第10期31卷 987-987页

作者： Xiao-rui CHENG Jian-hui WANG fu-qiang ye Xiao-rui ZHANG Feng LIU Gang LIU Ming NI Shan-yi QIAO Wen-xia ZHOU Yong-xiang ZHANG State Key Laboratory of Toxicology and Medical Countermeasures Beijing 100850 China Department of TCM and Neuroimmunopharmacology Beijing Institute of Pharmacology and Toxicology Beijing 100850 China Department of Biotechnology Beijing Institute of Radiation Medicine Beijing 100850 China

OBJECTIVE To investigate the effects of LW-AFC,a new formula derived fromLiuwei Dihuang decoction,on gut microbiota and the behavior of learning and memory of SAMP8 mice,a mouse model of Alzheimer Disease(AD),and identify the specific intestinal microbiota correlating with cognitive *** Morris-water maze test,novel object recognition test and shuttle-box test were conducted to observe the ability of learning and memory.16S rRNA amplicon sequencing(Illumina,San Diego,CA,USA)was employed to investigate gut *** The treatment of LW-AFC improved cognitive impairments of SAMP8 mice,including spatial learning and memory ability,active avoidance response,and object recognition memory *** data indicated that there were significantly 8 increased and 12 decreased operational taxonomic units(OTUs)in the gut microbiota of SAMP8 mice compared with senescence accelerated mouse resistant 1(SAMR1) strains,the control of SAMP8 *** treatment of LW-AFC altered 22(16 increased and 6 decreased)OTUs in SAMP8 mice and among them,15 OTUs could be reversed by LW-AFC treatment resulting in a microbial composition similar to that of SAMR1 *** further showed that there were7(3 negative and 4 positive correlation)OTUs significantly correlated with all the three types of cognitive abilities,at the order level,including Bacteroidales,Clostridiales,Desulfovibrionales,CW040,and two unclassified ***-AFC had influences on bacterial taxa correlated with the abilities of learning and memory in SAMP8 mice and restored them to SAMR1 *** The effects of LW-AFC on improving cognitive impairments of SAMP8 mice might be via modulating intestinal microbiome and LW-AFC could be used as a potential anti-AD agent.

关键词： Alzheimer disease LW-AFC Liuwei Dihuang decoction microbiome senescence-accelerated mouse prone 8 strain

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水文地质条件工程地质分区在工程中的应用

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工程建设与设计 2018年第21期 69-70,73页

作者：孙慧刘胜乾付强叶飞河北省地质环境监测院石家庄050021

水文地质既是一种社会资源,又是自然环境的组成部分.在工程建设过程中,必须认真研究水文地质条件,提升经济效益、社会效益与生态效益.工程施工应结合水文地质条件与工程地质条件,通过水文地质条件进行工程地质分区,切实保障工程地质的... 详细信息

水文地质既是一种社会资源,又是自然环境的组成部分.在工程建设过程中,必须认真研究水文地质条件,提升经济效益、社会效益与生态效益.工程施工应结合水文地质条件与工程地质条件,通过水文地质条件进行工程地质分区,切实保障工程地质的稳定性.论文主要探讨了工程地质勘察中水文地质研究的内容和水文地质条件工程地质分区在工程中的应用.

关键词：水文地质条件工程地质分区工程建设应用

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急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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Dark channel prior based blurred image restoration method using total variation and morphology

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Journal of Systems Engineering and Electronics 2015年第2期26卷 359-366页

作者： Yibing Li qiang fu Fang ye Hayaru Shouno College of Information and Communication Engineering Harbin Engineering University Department of Information and Communication Engineering University of Electro-Communications

The blurred image restoration method can dramatically highlight the image details and enhance the global contrast, which is of benefit to improvement of the visual effect during practical ap- plications. This paper is based on the dark channel prior principle and aims at the prior information absent blurred image degradation situation. A lot of improvements have been made to estimate the transmission map of blurred images. Since the dark channel prior principle can effectively restore the blurred image at the cost of a large amount of computation, the total variation （TV） and image morphology transform （specifically top-hat transform and bottom- hat transform） have been introduced into the improved method. Compared with original transmission map estimation methods, the proposed method features both simplicity and accuracy. The es- timated transmission map together with the element can restore the image. Simulation results show that this method could inhibit the ill-posed problem during image restoration, meanwhile it can greatly improve the image quality and definition.

关键词： image restoration dark channel prior total variation (TV) morphology transform

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Quantum Cyclotron Orbits of a Neutral Atom Trapped in a Triple Well with a Synthetic Gauge Field

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Chinese Physics Letters 2012年第6期29卷 17-19页

作者： WANG qiang ye Chong fu Li-Bin Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190 National Laboratory of Science and Technology on Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088 Center for Applied Physics and Technology Peking UniversityBeijing 100871

The strong effective magnetic fields with flux to the order of one flux quantum per plaquette has been realized for ultracold atoms,and the quantum cyclotron orbit of a single atom in a single plaquette exposed to the magnetic field was directly revealed recently [***.107 (2011) 255301].We study the quantum cyclotron orbits of a bosonic atom in a triple well with a synthetic gauge field,and find that the dynamics of the atom in real space is similar to a classical dynamic *** is interesting that the billiard-like motion is a signature of the quantum evolution of the three-level system,and its behaviors are determined by the ratio of the two energy gaps of the three energy levels.

关键词： energy magnetic signature

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Improving Damping Properties and Thermal Stability of Epoxy/Polyurethane Grafted Copolymer by Adding Glycidyl POSS

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Chinese Journal of Polymer Science 2018年第11期36卷 1297-1302页

作者： Ge-Liang Zhu Di Han ye Yuan Feng Chen qiang fu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University

Modified castor oil-based epoxy resin （EP）/polyurethane （PU） grafted copolymer by glycidyl polyhedral oligomeric silsesquioxane （glycidyl POSS） was synthesized. The damping properties, thermal stability, mechanical properties and morphology of the grafted copolymer modified by glycidyl POSS were studied systematically. The results revealed that the incorporation of glycidyl POSS improved the damping performance evidently and broadened damping temperature range, especially when the glycidyl POSS content was 0.2%-1%. At the same time, there was a slight increase in thermal stability with the increase of POSS content. The tensile properties changed with the change of the copolymer＇s Tg, decreased at low POSS contents and increased at high POSS contents. This modified copolymer has the potential to be used as film damping material or constrained damping layer.

关键词： Epoxy Polyurethane POSS Damping Thermal stability

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