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Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer

当代医学科学（英文） 2024年第4期44卷 833-840页

作者： Jun-he CHEN Cheng-ming WEI Qian-yu LIN Zi WANG fu-ming zhang Mei-na SHI Wen-jian LAN Chang-gang SUN Wan-jun LIN Wen-zhe MA State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and TechnologyMacau 999078China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Traditional Chinese Medicine Weifang Medical UniversityWeifang 261053China

Objective:Colorectal cancer(CRC),a prevalent malignancy worldwide,has prompted extensive research into anticanccr *** Chinese medicinal materials offer promising avenues for cancer management due to their diverse pharmacological *** study investigated the effects of Notopterygium incisum,a traditional Chinese medicine named Qianghuo(QH),on CRC cells and the underlying ***:The sulforhodamine B assay and colony formation assay were employed to assess the effect of QH extract on the proliferation of CRC cell lines HCT116 and *** iodide(PI)staining was utilized to detect cell cycle progression,and PE Annexin V staining to detect *** blotting was conducted to examine the levels of apoptotic proteins,including B-cell lymphoma 2-interacting mediator of cell death(BIM),B-cell lymphoma 2(Bcl-2),Bcl-2-associated X protein(BAX)and cleaved caspase-3,as well as BIM stability after treatment with the protein synthesis inhibitor *** expression of BAX was suppressed using lentivirus-mediated shRNA to validate the involvement of the BIM/BAX axis in QH-induced *** in vivo effects of QH extract on tumor growth were observed using a xenograft ***,APCMin+mice were used to study the effects of QH extract on primary intestinal ***:QH extract exhibited significant in vitro anti-CRC activities evidenced by the inhibition of cell proliferation,perturbation of cell cycle progression,and induction of ***,QH extract significantly increased the stability of BIM proteins,which undergo rapid degradation under unstressed *** of BAX,the downstream effector of BIM,significantly rescued QH-induced ***,the in vitro effect of QH extract was recapitulated in *** extract significantly inhibited the tumor growth of HCT116 xenografts in nude mice and decreased the number of intestinal polyps in the APCMin+***:QH extract promot

关键词： Notopterygium incisum B-cell lymphoma 2-interacting mediator of cell death apoptosis colorectal cancer

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System Identification Method for Evaluating the Effect of Thickness Error on Backcalculated Pavement Layer Moduli

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上海交通大学学报 2004年第z2期38卷 182-187页

作者： ZHONG Yan-hui WANG fu-ming zhang Bei CAI Ying-chun Dalian University of Technology Dalian116024 P. R. China Zhengzhou University Zhengzhou450002 P. R. China Zhengzhou University Zhengzhou450002 P. R. China Zhengzhou University Zhengzhou450002 P. R. China Chonging University Chongqing400044 P. R. China Dalian University of Technology Dalian116024 P. R. China Zhengzhou University Zhengzhou450002 P. R. China

Based on system identification theory and FWD testing data, the effect of thickness error on backcalculating pavement layer moduli is studied and the method of singular value decomposition (SVD) is presented to solve the morbidity problem of sensitivity matrix in this *** results show that the thickness error has great effects on the backcalculated pavement layer moduli. The error of backcalculated moduli can be controlled within the range of ±15% by limiting the thickness error within the range of ±5%.

关键词： system identification singular value decomposition (SVD) backcalculation pavement falling weight deflectometer (FWD) moduli thickness

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Synthesis and Antioxidant Activity of Sapriparaquinone Analogues

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Chinese Chemical Letters 2006年第9期17卷 1177-1180页

作者： Fei DENG fu Jun zhang ming ZHAO Yi Ping WANG Jin Sheng zhang State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

Twenty two sapriparaquinone derivatives were synthesized and their antioxidant activities were evaluated in vitro. Many of this kind of compounds demonstrated potent antioxidant activity against lipid peroxidation, especially compound 7 （IC50 = 3.7 μg/mL）. The preliminary structure-activity relationship of sapriparaquinone derivatives was discussed.

关键词： Synthesis sapriparaquinone antioxidant activity.

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Effect of Al content in molten steel on interaction between MgO-C refractory and SPHC steel

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Journal of Iron and Steel Research International 2024年第4期31卷 838-848页

作者： fu-bin Gao fu-ming Wang Xiang zhang Tian-yu Du Xin-hua Wangg School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Handan Iron and Steel Company Hegang GroupHandan 056015HebeiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The effect of Al content in molten steel on the interaction between SPHC steel(0.005-0.068 wt.%Al,and 19×10^(-4)-58×10^(-4)wt.%O)and MgO-C refractory(11.63 wt.%C)was ***-metallic inclusions in the steel were examined at various periods(0,5,15,30,45,and 60 min)as well as the MgO-C interface after 60 min of corrosion at 1600℃.The results show that when MgO-C refractory comes into contact with SPHC steel,the refractory interface consists of three layers arranged from the innermost to the outermost,including the original refractory layer,the dense MgO layer,and the iron infiltration *** carbon in the MgO-C refractories and the Al content in the molten steel undergo a reaction with the MgO in the refractories,resulting in an increase in Mg concentration in the *** Al content in the molten steel from 0.005 to 0.068 wt.%causes a spinel layer to appear at the interface,and the disappearance time of Al_(2)O_(3) inclusions in the steel decreases from 60 to 30 min,while the average MgO content in inclusions ***,controlling the Al content in the molten steel and the smelting duration can help regulate the formation of spinel inclusionsinthe steel.

关键词： MgO-C refractory SPHC steel Inclusion-Spinel Al-killed steel Interfacial reaction

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Preparation and Rheological Characterization of Long Chain Branching Polyglycolide

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Chinese Journal of Polymer Science 2024年第8期42卷 1177-1184页

作者： Wei-Lin Liu ming-fu Lyu Heng-Yuan zhang Jian-Ye Liu Shi-Jun zhang Beijing University of Chemical Technology Beijing 100029China SINOPEC(Beijing)Research Institute of Chemical Industry Co. Ltd.Beijing 100013China

The long chain branching(LCB)polyglycolide(PGA)was successfully prepared by the successive reactions of the terminal hydroxyl groups of PGA with triglycidyl isocyanurate(TGIC)and pyromellitic dianhydride(PMDA).The influence of LCB produced by functional group reaction on rheological and crystallization behavior was studied and discussed through linear rheology,uniaxial elongation and DSC(differential scanning calorimetry).The much higher viscosity and the more notable strain hardening behavior of modified PGA indicates the LCB with high degree of entanglements are *** melt strength of PGA is finally improved greatly and can make su re that the supercritical CO_(2)foaming can be carried out successfully.

关键词： Polyglycolide(PGA) Long chain branching(LCB) Rheology

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A multifunctional electrolyte additive for zinc-ion capacitors with low temperature resistant and long lifespan

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Journal of Energy Chemistry 2024年第7期94卷 477-485页

作者： ming Sun Zekai zhang Shuqing fu Yifan zhang Ruoyu Wang Hongchun Mu Cheng Lian Wenqiang Wang Gengchao Wang Shanghai Engineering Research Center of Hierarchical Nanomaterials Shanghai Key Laboratory of Advanced Polymeric MaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai Engineering Research Center of Hierarchical NanomaterialsFrontiers Science Center for Materiobiology and Dynamic Chemistryand School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Aqueous zinc-ion capacitors (ZICs) are considered as potential candidates for next generation electrochemical energy storage devices due to their high safety and low ***,the existing aqueous ZICs usually have the problems of zinc dendrite growth and unsatisfactory performance at low ***,an erythritol (Eryt) additive with inhibition of zinc dendrites and anti-freezing capability was introduced into the *** experimental characterization and theoretical calculation confirm that the Eryt adsorbed on the surface of zinc anodes regulates the deposition orientation of Zn^(2+) and inhibits the formation of *** also reconstructs the solvation structure in the electrolyte to reduce water activity,enabling the electrolyte to have a lower freezing point for operation at low *** the assistance of Eryt,the Zn||Zn symmetric cell exhibits a long cycle life of 2000 h,while the ZIC assembled with activated carbon (AC) cathode and zinc anode (Zn||AC) maintains a capacity retention of 98.2% after 30,000 cycles at a current density of 10 A g^(-1)(even after 10,000 cycles at-20°C,the capacity retention rate reached 94.8%.).This work provides a highly scalable,low-cost and effective strategy for the protection of the anodes of low-temperature aqueous ZICs.

关键词： Zinc-ioncapacitors Electrolyte additive Dendrite-free Freeze-resistant electrolyte

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Deep Guided Attention Network for Joint Denoising and Demosaicing in Real Image

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Chinese Journal of Electronics 2024年第1期33卷 303-312页

作者： Tao zhang Ying fu Jun zhang School of Computer Science and Technology Beijing Institute of Technology Advanced Reasearch Institute of Multidisciplinary Science Beijing Institute of Technology

Denoising(DN) and demosaicing(DM) are the first crucial stages in the image signal processing pipeline. Recently, researches pay more attention to solve DN and DM in a joint manner, which is an extremely undetermined inverse problem. Existing deep learning methods learn the desired prior on synthetic dataset, which limits the generalization of learned network to the real world data. Moreover, existing methods mainly focus on the raw data property of high green information sampling rate for DM, but occasionally exploit the high intensity and signalto-noise(SNR) of green channel. In this work, a deep guided attention network(DGAN) is presented for real image joint DN and DM(JDD), which considers both high SNR and high sampling rate of green information for DN and DM, respectively. To ease the training and fully exploit the data property of green channel, we first train DN and DM sub-networks sequentially and then learn them jointly, which can alleviate the error accumulation. Besides, in order to support the real image JDD, we collect paired raw clean RGB and noisy mosaic images to conduct a realistic dataset. The experimental results on real JDD dataset show the presented approach performs better than the state-of-the-art methods, in terms of both quantitative metrics and qualitative visualization.

关键词： Training Visualization Inverse problems Green products Noise reduction Pipelines Signal processing

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Research on a New Coding System for Vibrating Feeder Design

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International Journal of Plant Engineering and Management 2010年第2期15卷 90-96页

作者： fu Cai-an zhang ming DING Wei School of Mechanical Engineering Jiangnan University Wuxi 214122 P. R. China

The sUdeway design is the key in the design of the disc vibrating feeder. However, no reliable theoretical guidance has come into existence, which greatly restricted the application of CAD（ Computer-aided design）. In order to feed the application of CAD technology, we must make improvements to the existing coding method. Based on the similarity principle of Group Technology and existing coding system, a new coding method applicable to slide- way design is brought forward. The existing coding system could get optimized by means of analysing and studying the influence imposed by the parts＇ shape and posture features. More detailed information about the parts could be supplied by the new coding system, which makes the design simpler, more convenient and more accurate with the subjoin of the initial and targeted codes.

关键词： slideway design group technology new coding method posture features

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Photoinduced Dehalocyclization to Access Oxindoles Using Formate as a Reductant

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Chinese Journal of Chemistry 2024年第11期42卷 1203-1208页

作者： Wei Ge Jia-Xin Wang ming-Chen fu Yao fu Hefei National Research Center for Physical Sciences at the Microscale iChEMCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyUniversity of Science and Technology of ChinaHefeiAnhui230026 China Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering Hefei University of TechnologyHefeiAnhui230009 China

Herein,we report an efficient and practical protocol for the photoinduced dehalocyclization of ortho-halophenylacrylamides with formate by the engagement of a CO_(2) radical anion to access substituted *** method proceeds smoothly under mild conditions and exhibits a wide range of substrate as well as remarkable functional group compatibility.

关键词： Formate CO_(2)Radical ions Oxindole Photocatalysts Cyclization Organohalides

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Grain size effect on the assembly quality of micro-scaled barrel formed by microforming

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Advances in Manufacturing 2024年第1期12卷 19-32页

作者： Dien Hu Jieyichen Fang Feng Zeng ming-Wang fu Department of Mechanical Engineering Research Institute of Advanced ManufacturingThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China Xiamen Yulong Machinery Co.Ltd. Xiamen361023FujianPeople’s Republic of China

In this research,a method employing micro-extrusion was designed to produce the micro-scaled barrel-shaped parts with complex geometrical features to study the feasibility of the proposed microforming method and its grain size effect on the formability of the complicated internal features in terms of deformation behavior,material evolution,accuracy of dimensions and final components *** results reveal that the deformation behavior is highly affected by grain size and becomes unpredictable with increased grain *** addition,assembly parameters including feature dimension,tolerance and coaxiality also vary with grain size,and the variation of grain size needs to be accommodated by different assembly types,viz.,clearance fit or transition *** the microstructural evolution aspect,it was identified there were two dead zones and four shear bands,and the formation of these deformation zones was barely affected by the variation in grain *** bulges,cracks,and fracture induced voids were observed on the surface of the final components,tailoring the microstructure of the working material with finer grains could significantly avoid these *** study advances the understanding of forming microparts by extrusion processes and provides guidance for microforming of similar microparts.

关键词： Microformed part Size effect Extrusion Microstructural evolution Dimensions Assembly accuracy

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