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Acta Pharmacologica Sinica 2005年第11期26卷 1303-1308页

作者： fu-ming shen~2, He-hui XIE~2, Gang LING, Li-ping XU, Ding-feng SU~3 Department of Pharmacology, Second Military Medical University, Shanghai 200433, China Department of Pharmacology Second Military Medical University Shanghai China

Aim: To test the synergistic effects of atenolol and amlodipine on lowering blood pressure (BP) and reducing blood pressure variability (BPV) in 2-kidney, one-clip (2K1C) renovascular hypertensive rats. Methods: Forty-eight 2K1C renovascular hypertensive rats were randomly divided into 6 groups. They were respectively given 0.8% carboxymethylcellulose sodium (control), atenolol (10.0 mg/kg), amlodipine (1.0 mg/kg), and combined atenolol and amlodipine (low dose: 5.0+0.5 mg/kg; intermediate dose: 10.0+1.0 mg/kg; high dose: 20.0+2.0 mg/kg). The drugs were given via a catheter in a gastric fistula. BP was recorded for 25 h from 1 h before drug administration to 24 h after administration. Results: Compared with BP before medication, all 3 doses of combined atenolol and amlodipine significantly decreased the BP at 24 h after administration, except for the low dose on diastolic BP. Compared with the control group, all 3 doses of combined atenolol and amlodipine significantly reduced the average BP levels for the 24 h period after administration; furthermore, the high and intermediate doses also significantly decreased the BPV levels for the same period. The q values calculated by probability sum analysis for systolic and diastolic BP for the 24 h period after administration were 2.29 and 1.45, respectively, and for systolic and diastolic BPV for the same period they were 1.41 and 1.60, respectively. Conclusion: There is significant synergism between atenolol and amlodipine in lowering and stabilizing BP in 2K1C renovascular hypertensive rats.

关键词： atenolol amlodipine blood pressure blood pressure variability hypertension

Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats

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Acta Pharmacologica Sinica 2004年第2期25卷 22-25页

作者： Ding-feng SU2, Li-ping XU, Chao-yu MIAO, He-hui XIE, fu-ming shen, Yuan-ying JIANG Department of Pharmacology, Second Military Medical University, Shanghai 200433, China Department of Pharmacology Second Military Medical University 上海 200433

AIM: Computerized analysis of blood pressure in conscious freely moving rats is a sound technique for physiologi- cal and pharmacological studies. The present work, based on this technique, was designed to introduce two useful methods for the evaluation of antihypertensive drugs in conscious spontaneously hypertensive rat (SHR). They were the directly intragastric administration of drugs and modified probability sum test for evaluating the synergism of the combination of two drugs. METHODS AND RESULTS: (1) Directly intragastric administration was used in conscious rats. A catheter was inserted into stomach immediately after arterial catheter insertion. Three days after operation, blood pressure was recorded and drug might be given intragastically via the gastric catheter. (2) Modi- fied probability sum test was used to evaluate the synergism of two drugs. The formula was: q=PA+B/(PA+PB?PA×PB). With this method, it was obtained: q=1.32 for the effects of the combination of atenolol and nitrendipine (20 mg/kg+10 mg/kg) on systolic blood pressure; q=1.41 for the effects of the combination of atenolol and amlodipine (10 mg/ kg+1 mg/kg) on systolic blood pressure. CONCLUSION: The two methods introduced by the present work will be important and useful for antihypertensive drug evaluation in conscious freely moving rats.

关键词： amlodipine atenolol blood pressure nifedipine nitrendipine spontaneously hypertensive rat

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后殖民主义视角下的约克纳帕塔法神话解读

文史哲 2005年第2期 85-90页

作者：申富英山东大学外国语学院山东济南250100

以往对福克纳的研究大多集中在对其作品的叙事结构和反奴隶制、反资本主义工商文明、博爱等主题上,尽管有学者对他的约克纳帕塔法神话作过一些探讨,但多集中在叙事功能层面;尽管有学者探讨过福克纳小说的反奴隶制、反暴力倾向,但少有人... 详细信息

以往对福克纳的研究大多集中在对其作品的叙事结构和反奴隶制、反资本主义工商文明、博爱等主题上,尽管有学者对他的约克纳帕塔法神话作过一些探讨,但多集中在叙事功能层面;尽管有学者探讨过福克纳小说的反奴隶制、反暴力倾向,但少有人将此研究与后殖民主义批评结合起来。事实上,福克纳笔下的约克纳帕塔法神话可以用后殖民主义的视角进行诠释,因为在被北方征服和占领后,美国南方文化与后殖民地文化的处境有许多相似之处,福克纳在他的约克纳帕塔法神话系列中所关注的问题也与后殖民主义者所关注的问题不谋而合。后殖民主义者往往把复兴或编造民族神话作为复兴民族文化遗产、再现被压抑的民族历史记忆和重新建构民族文化身份的重要途径,宣扬在现实中要通过忍耐和牺牲以洗清民族历史上的罪孽,并认为民族文化发展的趋势是与殖民文化“商讨”和“杂交”。福克纳在他的小说中创造了约克纳帕塔法神话,目的在于复兴南方传统文化,再现南方被压抑的历史记忆,重新建构南方人的文化身份,宣扬通过个人忍耐和牺牲洗清南方在历史上的罪过,并暗示南方文化的出路是南方文化与北方文化的“商讨”和“杂交”,即南方人应当继承南方传统文化中的精华,吸收北方文化中的有益成分,并对南方和北方文化中的不合理因素予以抵制。

关键词：福克纳约克纳帕塔法神话后殖民主义传统文化文化杂交

Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats

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Acta Pharmacologica Sinica 2006年第12期27卷 1575-1579页

作者： Ping HAN Zheng-xu CHU fu-ming shen He-hui XIE Ding-feng SU~2 Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China Department of Pharmacology School of Pharmacy Second Military Medical University Shanghai China

Aim:To investigate the possible synergism of hydrochlorothiazide andnitrendipine on reducing both blood pressure(BP)and blood pressure variabil-ity(BPV)in spontaneously hypertensive rats(SHR).Methods:Seventy ani-mals were randomly divided into seven *** doses were 5 and 10 mg/kgfor nitrendipine,10 and 20 mg/kg for hydrochlorothiazide and 10+5,20+10mg/kg,respectively,for the combination of these two drugs and 0.8% carboxym-ethylcellulose as *** drugs were given via a catheter of gastric *** was then continuously recorded for 5h from 1h before drug administrationto the end of 4th hour after drug administration,in conscious and freely ***:The effects on both BP and BPV reduction of the combination ofhydrochlorothiazide and nitrendipine were greater than the single drug in *** two drugs possessed an obvious synergism on both systolic blood pressure(q=1.79 with small dose and q=1.23 with large dose)and systolic blood pres-sure variability reduction(q=1.79 with small dose and q=1.39 with large dose)in ***:The present work clearly demonstrated that there was asynergistic effect between hydrochlorothiazide and nitrendipine in lowering andstabilizing BP in SHR.

关键词： blood pressure blood pressure variability hydrochlorothiazide hypertension nitrendipine spontaneously hypertensive rat

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可量词消去的树形偏序理论的分类

数学学报（中文版） 2014年第6期57卷 1171-1180页

作者：傅莺莺沈复兴北京工商大学理学院北京100048 北京师范大学信息科学与技术学院北京100875

提出了偏序的全序片段、序模式的概念以刻画树形偏序的结构特征,以此为基础,讨论了有最小元0的树形偏序理论的量词消去性质,给出了在语言(?)_0={<,0}及其膨胀语言下可以量词消去的这类理论的完全分类。

关键词：偏序量词消去序模式树结构

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可量词消去的带根节点的树理论

数学学报（中文版） 2015年第4期58卷 691-704页

作者：傅莺莺沈复兴北京工商大学理学院北京100048 北京师范大学信息科学与技术学院北京100875

讨论了带根节点r的有向树、无向树理论的量词消去性质,找到决定理论量词消去的三类特殊公式,并给出了在语言■_0={E,r}(E为有向边或无向边)及添加二元距离关系D_(n,n)

关键词：量词消去有向树无向树

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碱催化水热氧化法处理废弃双氯芬酸钠类药物

中国环境科学 2017年第4期37卷 1386-1393页

作者：史瑞张付申中国科学院生态环境研究中心固体废弃物处理与资源化实验室北京100085 中国科学院大学北京100049

针对废弃药物绿色处理技术匮乏的实际问题,以双氯芬酸钠(DS)药物为研究对象,探讨了碱催化水热氧化法对其的无害化处理效果,确定了相应的操作方法并优化了反应参数.利用单因素实验确定了适宜的实验因素水平,通过响应面分析法进一步解析... 详细信息

针对废弃药物绿色处理技术匮乏的实际问题,以双氯芬酸钠(DS)药物为研究对象,探讨了碱催化水热氧化法对其的无害化处理效果,确定了相应的操作方法并优化了反应参数.利用单因素实验确定了适宜的实验因素水平,通过响应面分析法进一步解析优化了多因素交互作用下的反应条件.结果表明,碱催化水热氧化法能有效通过脱氯过程实现DS的无害化处理,最佳反应参数为:H_2O_2:DS 0.3mL/mg、反应时间98min、反应温度196℃,脱氯效率优化值为99.6%,实测值为98.9%,相对误差0.70%.通过降解产物测定和解析,发现碱催化水热氧化处理DS存在2个反应路径:(1)苯环之间C-N键断裂,然后氧化开环脱氯;(2)苯环上直接羟基化,然后氧化开环脱氯.本研究为废弃DS类药物的无害化处理提供了一条绿色环保的新途径.

关键词：双氯芬酸钠水热氧化响应面分析脱氯效率

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综合能源电力系统的在线分布互联建模研究

电力自动化设备 2017年第6期37卷 11-14页

作者：鞠平沈赋吴峰河海大学能源与电气学院江苏南京211100

为了充分利用可再生能源、充分发挥多种能源与电力系统的综合优势,探讨了综合能源电力系统的概念。针对综合能源电力系统仿真分析和运行控制的需要,构建综合能源电力系统建模的研究框架。分析了综合能源电力系统建模的难点,提出了在线... 详细信息

为了充分利用可再生能源、充分发挥多种能源与电力系统的综合优势,探讨了综合能源电力系统的概念。针对综合能源电力系统仿真分析和运行控制的需要,构建综合能源电力系统建模的研究框架。分析了综合能源电力系统建模的难点,提出了在线分布互联的建模思路以及"即测-即辨-即插-即用"的建模策略,研究了模型路由的可行性。

关键词：综合能源电力系统模型路由模型接口冷-热-电联供可再生能源建模