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Current status of radiation therapy for prostate cancer

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Nuclear Science and Techniques 2007年第2期18卷 65-72页

作者： fu shen SUNYi LU Yaohong Section of Molecular Radiobiology RadioDepartment of Radiation Oncology the Sixth People＇s Hospital of Shanghai Jiaotong University Shanghai 200233 China

Radiotherapy for the treatment of prostate cancer has been extensively explored in the past. Along with the comprehensive understanding of the biology of prostate cancer and rapid advances in terms of technology, the out- come of treatment for the patients with prostate cancer has improved. The authors review radiotherapy as the primary treatment for the disease, with particular emphasis on the technological advances from both the radiobiological and radiophysics aspects. Nonconventional fractionated irradiation like hyper- or hypo-fractionation has been imple- mented in the clinic, the final results still need to be confirmed in the future. Technological advances like IMRT, IGRT, in the last two decades have significantly improved the delivery of external radiotherapy to the prostate. This has re- sulted in an overall increase in the total dose that can be safely delivered to the prostate, which has led to modest im- provements in the biochemical outcome. However, establishing the standard therapy for prostate cancer remains con- troversial. It is hoped that the next decades will bring continued advances in the development of biologicals that will further improve current clinical outcomes.

关键词：前列腺癌放射治疗现状分形 IMRT IGRT

Microstructure and mechanical properties of Ti-Cu amorphous coating synthesized on pure Cu substrate by mechanical alloying method

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Rare Metals 2020年第10期39卷 1222-1228页

作者： Cheng Chen Xiao-mei Feng Yi-fu shen School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211800China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Mechanical alloying method was applied to fabricate coating with amorphous structure on pure Cu *** microstructure,the phase composition and the mechanical properties including microhardness and wear resistance of the coating were,respectively,characterized and *** results show that the coating is rough but *** has favorable adhesion to the *** coating is made up of an inner composite layer and an outer amorphous *** microhardness and the wear resistance of the pure Cu substrate are improved because of the bilayer *** formation mechanism of the coating was *** as-synthesized coating is considered to be effective to strengthen the surface of pure Cu substrate.

关键词： Coating Amorphous Mechanical alloying Surface reinforcement

Potential applications of synchrotron radiation to the treatment of cancer

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Nuclear Science and Techniques 2013年第1期24卷 1-6页

作者： SHI Zeliang ZHOU Shuhui fu shen Department of Radiation Oncology Shanghai No.6 People's Hospital Affiliated to Shanghai Jiaotong University Medical College of Soochow University Radiology and Protection Institute

Although conventional radiotherapy remains to be one of the most useful treatments for cancer, it is not the best strategy to maximize the effects on the tumors and minimize the damage to the surrounding tissues due to its physical and biological characteristics. Synchrotron radiation (SR) with uniquely physical and biological advantages may represent an innovative approach for cancer treatment. In recent years, SR-based photon activation therapy, stereotactic synchrotron radiation therapy and micro-beam radiation treatment have been developed, and the results of in vitro and in vivo experiments are very promising. It is necessary to understand the physical and radiobiological principle of those novel strategies before the approach is applied to the clinic. In this paper, we summarize the advances of SR in terms of physical, radiobiological advantages and its potential clinical applications. With the successful operation of shanghai synchrotron radiation, good opportunities in China have been provided for investigations on the treatment of cancer with synchrotron radiation.

关键词：同步加速器辐射治疗临床应用癌症同步辐射光源放射生物学放射治疗生物特性

Effect of process parameters on the microstructure and properties of laser-clad FeNiCoCrTi0.5 high-entropy alloy coating

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International Journal of Minerals,Metallurgy and Materials 2020年第5期27卷 630-639页

作者： Ying Zhang Teng-fei Han Meng Xiao Yi-fu shen College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics(NUAA)Nanjing 210016China Nanjing Institute of Advanced Laser Technology Nanjing 210038China

FeNiCoCrTi0.5 coatings with different process parameters were fabricated by laser cladding. The macro-morphology, phase, microstructure, hardness, and wear resistance of each coating were studied. The smoothness and dilution rate of the FeNiCoCrTi0.5 coating generally increased with the increase of specific energy(Es), which is the laser irradiation energy received by a unit area. FeNiCoCrTi0.5 coatings at different parameters had bcc, fcc, and Ti-rich phases as well as equiaxed, dendritic, and columnar structures. When Es increased, the size of each structure increased and the distribution area of the columnar and dendritic structures changed. The prepared FeNiCoCrTi0.5 coating with the Es of 72.22 J·mm-2 had the highest hardness and the best wear resistance, the highest hardness of the coating reached HV 498.37, which is twice the substrate hardness. The average hardness of the FeNiCoCrTi0.5 coating with the Es of 72.22 J·mm-2 was 15.8% higher than the lowest average hardness of the coating with the Es of 108.33 J·mm-2. The worn surface morphologies indicate that the FeNiCoCrTi0.5 coatings exhibited abrasive wear.

关键词： high-entropy alloy coating 45 steel laser cladding microstructure wear resistance

The role of high-energy computed radiography(CR)in radiotherapy

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Nuclear Science and Techniques 2009年第1期20卷 31-36页

作者： LI Zhaobin SUN Yi LU Yaohong fu shen Department of Radiation Oncology the No.6 Hospital of Shanghai JiaoTong University Shanghai 200233 China

Computed radiography(CR)imaging has high irradiation tolerance and it is easy to archive CR images along with other image information by Digital Imaging and Communications in Medicine(DICOM)format,and to process *** can be used in radiation Quality Control(QC)task and verification of treatment *** this paper,the role of high-energy CR in radiation oncology is *** patients were imaged by CR system and EPID before *** verification images were acquired with 1–2 MU(Monitor Unit)using 6 MV *** for a linac was done with film and high-energy CR to collect the data on daily,weekly and monthly *** QC included Multileaf Collimators(MLC)calibration and mechanical iso-centre *** was also adapted to verify patient position,the film was used to compare with digitally reconstructed radiographs(DRR)and portal image from EPID. Treatment setting-up was verified based on the result of *** quality verification images could be acquired by the CR *** to EPID,the results showed that the system was suitable for practical use to acquire daily verification images,and it was useful to fulfill part of quality assurance(QA)in radiation *** quality of image acquired by the high-energy CR system is comparable or even better than DRRs and portal images. The final treatment set-up for the patients could be verified more accurately with the CR system.

关键词：计算机X摄影方法影像效果图像融合医学应用

Formation mechanism and mechanical properties of surface nanocrystallized Ti-6Al-4V alloy processed by surface mechanical attrition treatment

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Rare Metals 2023年第4期42卷 1343-1352页

作者： Yi-Feng Li Cheng Chen J.Ranabhat Yi-fu shen College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China

In the present work,surface mechanical attrition treatment(SMAT)was proposed to achieve surface nanocrystallization on Ti-6Al-4V surface via high-energy planetary ball milling method using a planetary ball *** characteristics of microstructure were studied using different *** nanocrystallization is achieved on Ti-6Al-4V *** process of refinement could be summarized into four *** the refinement process,the reticular continuous beta phase performs a significant role,it cracked,broke up and moved to each side along the grain *** movement of beta grains has the capabilities of effectively optimizing the grain orientation and accelerating the further refinement of alpha *** also plays an important role during the *** grain orientation between different types of grains seems to be larger than that of same type *** interface will be divided into smaller nanocrystalline grains once the dislocation density breaks the ***,the balance will be achieved again and owns a higher critical value which cannot be broken,then a stable grain size can be achieved *** results of microhardness,friction coefficient and wear mass loss tests of SMAT samples indicate that the mechanical behaviors of substrate are greatly enhanced after this novel SMAT treatment.

关键词： Surface nanocrystallization Dual-phase titanium alloy SMAT Mechanical properties

Biomimetic Preparation of Magnetite/Chitosan Nanocomposite via In Situ Composite Method ——Potential Use in Magnetic Tissue Repair Domain

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Chemical Research in Chinese Universities 2006年第6期22卷 792-796页

作者： HU Qiao-ling WU Jia CHEN fu-ping shen Jia-cong Institute of Polymer Composites Zhejiang University Hangzhou 310027 P. R. China

This study focused on the preparation of magnetic chitusan nanocompesite that has a potential application to bone repair and regeneration using an in situ composite method where chitosan membrane was used as the template and NaOH was used as the precipitant. X-ray diffraction analysis results show the formation of magnetite in the chitosan matrix. From the magnetic measurement, it could be concluded that the magnetic chitosan rods were superparamagnetic,and that this is the unique property of nanomagnetite. Macroscopical layer structure of the magnetic chitosan rods was observed from the photographs after mechanical test, and the microlayer structure of the rods was observed from the images of scanning electron microscopy. The mechanism for preparing the rods was discussed in detail. Transmission electron microscope was used to investigate the magnetite particles in the chitosan matrix and from the images it was concluded that the magnetite particles dispersed well in chitosan matrix with particle size of about 10 nm. The mechanical properties of the magnetic chitosan rods were measured and the blending strength was found to be 98. 8 MPa. The mechanical properties did not decline when compared with those of the pure chitosan materials.

关键词： Chitosan Magnetite In situ compositing Red

Multi-verse optimizer based parameters decision with considering tool life in dry hobbing process

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Advances in Manufacturing 2021年第2期9卷 216-234页

作者： Heng-Xin Ni Chun-Ping Yan shen-fu Ni Huan Shu Yu Zhang State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400030People’s Republic of China Hefei Meiya Photoelectric Technology Co.Ltd Hefei 230088People’s Republic of China

Dry hobbing has received extensive attention for its environmentally friendly processing *** to the absence of lubricants,hobbing process is highly dependent on process parameters combination since using unreasonable parameters tends to affect the machining ***,the consideration of tool life is frequently ignored in gear ***,to settle the above issues,a multiobjective parameters decision approach considering tool life is ***,detailed quantitative analysis between process parameters and hobbing performance,i.e.,machining time,production cost and tool life is ***,a multi-objective parameters decision-making model is constructed in search for optimum cutting parameters(cutting velocity v,axial feed rate f_(a))and hob parameters(hob diameter d_(0),threads z_(0)).Thirdly,a novel algorithm named multi-objective multi-verse optimizer(MOMVO)is utilized to solve the presented model.A case study is exhibited to show the feasibility and reliability of the proposed *** results reveal that(i)a balance can be achieved among machining time,production cost and tool life via appropriate process parameters determination;(ii)optimizing cutting parameters and hob parameters simultaneously contributes to optimal objectives;(iii)considering tool life provides usage precautions support and process parameters guidance for practical machining.

关键词： Process parameters Decision-making Tool life Dry hobbing Multi-objective multi-verse optimizer(MOMVO)

A preliminary clinic dosimetry study for synchrotron radiation therapy at SSRF

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Nuclear Science and Techniques 2013年第6期24卷 7-11页

作者： LI Zhaobin SHI Zeliang ZHANG Qing WANG Yong fu shen The 6th People's Hospital of Shanghai Jiaotong University

Synchrotron radiation(SR)represents a unique and innovative anti-cancer treatment due to its unique physical features,including high flux density,and tunable and collimated radiation *** aim of this work is to assess the dosimetric properties of SR in Shanghai Synchrotron Radiation Facility(SSRF)for potential applications to clinical radiation *** experiments were performed with 34 and 50 keV X-rays on the BL13W biomedical beamline of SSRF and the 6 MV X-rays from ARTISTE linac for the dosimetry *** percentage depth dose(PDD)and the surface dose of the SR X-rays and the 6 MV photon beams were performed in solid water phantom with Gafchromic EBT3 *** curves are normalized to the maximum calculated *** depth of full dose buildup is about 10μm deeper for the monoenergetic X-ray beams of 34 and 50 *** beam transmits through the phantom,with a linear attenuation *** profile in the horizontal plane shows that the dose distribution is uniform within the facula,while the vertical profile shows a Gaussian distribution of the *** penumbra is less than 0.2 mm in the horizontal *** EBT film may be a useful and convenient tool for dose measurement and quality control for the high space and density *** is therefore important to gain a thorough understanding about the physical features of SR before this novel technology can be applied to clinical practice.

关键词：上海同步辐射装置剂量学特性辐射治疗临床实践光源 SSRF X射线束线性衰减系数