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Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography

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World Journal of Clinical Cases 2022年第9期10卷 2773-2782页

作者： Yi Zou Na li liu-Jia-Zi shao fu-Kun liu fu-Shan Xue Xing Tao Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Sedation during endoscopic ultrasonography(EUS)poses many challenges and moderate-to-deep sedation are often *** conventional method to preform moderate-to-deep sedation is generally intravenous benzodiazepine alone or in combination with ***,this combination has some *** medication delivery may be an alternative to this sedation *** To determine,by continual reassessment method(CRM),the minimal effective dose of intranasal sufentanil(SUF)when combined with intranasal dexmedetomidine(DEX)for moderate sedation of EUS in at least 95%of patients(ED95).METHODS Thirty patients aged 18-65 and scheduled for EUS were recruited in this *** received intranasal DEX and SUF for *** dose of DEX(1μg/kg)was fixed,while the dose of SUF was assigned sequentially to the subjects using CRM to determine *** sedation status was assessed by modified observer’s assessment of alertness/sedation(MOAA/S)*** adverse events and the satisfaction scores of patients and endoscopists were *** The ED95 was intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,with an estimated probability of successful moderate sedation for EUS of 94.9%(95%confidence interval:88.1%-98.9%).When combined with intranasal 1μg/kg DEX,probabilities of successful moderate sedation at each dose level of intranasal SUF were as follows:0μg/kg SUF,52.8%;0.1μg/kg SUF,75.4%;0.2μg/kg SUF,89.9%;0.3μg/kg SUF,94.9%;0.4μg/kg SUF,98.0%;0.5μg/kg SUF,99.0%.CONCLUSION The ED95 needed for moderate sedation for EUS is intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,based on CRM.

关键词： Moderate sedation Intranasal administration Dexmedetomidine Sufentanil Continual reassessment method Endoscopic ultrasonography

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Out-of-hospital cardiac arrest in a young adult survivor with sequelae of childhood Kawasaki disease: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3583-3589页

作者： Ke-fu Zhu li-Jiang Tang shao-Ze Wu Yi-Min Tang Department of Cardiology Zhejiang Hospital

BACKGROUND Kawasaki disease(KD)is an acute type of systemic vasculitis involving small to medium-sized muscular arteries and outbreaks during *** can cause myocardial ischemia,infarction,and sudden cardiac *** present a case of a young adult survivor of out-of-hospital cardiac arrest as late KD *** SUMMARY A 29-year-old man with presumed acute KD history at the age of 5 suddenly lost consciousness while jogging and was diagnosed a sudden cardiac arrest by an emergency *** about 10 min cardiopulmonary resuscitation,return of spontaneous circulation was achieved,and the patient was transferred to our hospital.A coronary computed tomography angiogram and coronary angiography revealed extensive calcifications of left anterior descending and right coronary artery *** patient was an active individual who took exercise regularly and claimed no previous symptoms of chest pain or shortness of breath on *** most possible cause of his sudden cardiac arrest could be presumed as a thrombus within the coronary artery *** that,a thromboembolism induced extensive ischemia,and this ischemia-induced arrhythmia led to a cardiac *** Few patients who suffer a late sequela of KD can survive from out-of-hospital cardiac ***,surgical intervention,and active follow-up are extremely important for this patient to prevent occurrence of adverse events in the future.

关键词： Cardiac arrest Young adult Kawasaki disease Coronary artery aneurysm Case report

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残余胆固醇与进展为主要不良心血管事件的非罪犯病变易损斑块的相关性研究

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中国全科医学 2025年第3期28卷 299-304页

作者：杨红刘成刘森邵琪琪夭元昊付真彦新疆医科大学第一附属医院心脏中心新疆维吾尔自治区乌鲁木齐市830054

背景残余胆固醇(RC)被认为是动脉粥样硬化性心血管疾病的重要危险因素,而冠状动脉非罪犯病变(NCCLs)进展也是影响冠心病患者预后的重要因素,但是残余胆固醇与进展为主要不良心血管事件(MACE)的NCCLs易损斑块的关系尚不明确。目的探讨R... 详细信息

背景残余胆固醇(RC)被认为是动脉粥样硬化性心血管疾病的重要危险因素,而冠状动脉非罪犯病变(NCCLs)进展也是影响冠心病患者预后的重要因素,但是残余胆固醇与进展为主要不良心血管事件(MACE)的NCCLs易损斑块的关系尚不明确。目的探讨RC对发生MACE的NCCLs易损斑块的预测价值及长期预后的相关性。方法选取2015年2月—2022年2月于新疆医科大学第一附属医院心脏中心住院的488例冠心病患者为研究对象,通过电子病历系统收集患者基线资料,行冠状动脉造影及光学相干断层扫描OCT。入组患者在出院1、3、6和12个月接受预定随访。采用Spearman秩相关检验探究RC与NCCLs中薄纤维帽粥样硬化斑块(TCFA)斑块特征的相关性。采用多因素Logistic回归分析探究NCCLs中TCFA发生MACE的影响因素。绘制受试者工作特征曲线(ROC曲线)并计算ROC曲线下面积(AUC),探究RC对NCCLs中TCFA发生MACE的预测价值。结果共纳入488例冠心病患者,根据NCCLs是否发生MACE将患者分为发生MACE组(n=38)和未发生MACE组(n=450)。通过OCT识别NCCLs的斑块特征,共分析了749个NCCLs斑块,304个NCCLs斑块最小管腔面积(MLA)<3.5 mm^(2)。随访期间38例(7.8%)患者共发生了41例次NCCLs斑块引起的MACE事件,18例(3.7%)患者发生了支架内再狭窄,15例(3.1%)发生了不确定因素的死亡。发生MACE组患者高血压、糖尿病、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、RC、糖化血红蛋白(Hb A1c)、TCFA、MLA<3.5 mm^(2)比例高于未发生MACE组(P<0.05)。105例患者检查出TCFA,其中22例发生MACE(发生MACE的TCFA组),83例未发生MACE(未发生MACE的TCFA组)。发生MACE的TCFA组糖尿病比例与RC高于未发生MACE的TCFA组(P<0.05)。Spearman秩相关分析结果示,RC与最薄纤维帽厚度、MLA呈负相关(r_(s)=-0.665、-0.771,P<0.05),与最大脂质弧度、巨噬细胞浸润呈正相关(r_(s)=0.806、0.481,P<0.05)。多因素Logistic回归分析结果显示糖尿病(OR=3.410,95%CI=1.165~9.988,P=0.025)、高RC水平(OR=5.879,95%CI=1.436~24.073,P=0.014)是NCCLs中TCFA发生MACE的危险因素。绘制RC预测NCCLs中TCFA发生MACE的ROC曲线,结果显示AUC为0.695(95%CI=0.571~0.819,P=0.005),最佳截断值为0.606 mmol/L,灵敏度、特异度分别为0.818、0.518。结论 RC水平升高可能是冠心病患者中NCCLs易损斑块发生MACE的危险因素,对NCCLs中TCFA发生MACE有一定的预测价值。

关键词：冠心病冠状动脉粥样硬化血脂异常主要不良心血管事件冠状动脉非罪犯病变残余胆固醇相关性研究

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海上漂浮式光伏多浮体间电缆跨接方法研究

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工程科学学报 2025年第2期47卷 389-400页

作者：孔祥玉邵阳苹付强俞露杰刘宏斌天津市新能源电力变换传输与智能控制重点实验室(天津理工大学) 天津300384 天津大学电气自动化与信息工程学院天津300072

浮体间跨接电缆因设计不合理,在运行期间出现过度弯曲、拉伸、与浮体碰撞等现象,影响系统可靠运行.针对跨浮体电缆容易出现疲劳失效的问题,本文提出一种海上漂浮式光伏多浮体间电缆跨接方法.首先,对浮体结构进行分析,确定典型六边形浮... 详细信息

浮体间跨接电缆因设计不合理,在运行期间出现过度弯曲、拉伸、与浮体碰撞等现象,影响系统可靠运行.针对跨浮体电缆容易出现疲劳失效的问题,本文提出一种海上漂浮式光伏多浮体间电缆跨接方法.首先,对浮体结构进行分析,确定典型六边形浮体间的电缆跨接方案.其次,通过分析浮体结构对跨接方案的影响,确定电缆跨浮体设计步骤中的关键参数与限制条件;通过与现阶段跨接电缆保护手段对比,提出一种通过合理规划跨接参数满足运行要求的方法,建立电缆跨接方案两阶段求解框架;采用信赖域粒子群算法在第一阶段求解出跨接方案变量的可行解区域,第二阶段在可行解区域中求解出疲劳寿命最大值作为跨接方案最优解.最后,在Orcaflex软件搭建电缆跨接模型对最终方案进行校验,通过算例分析验证本文所提方法的有效性.研究表明,通过对合理规划跨接电缆路径,可以在一定程度上缓解电缆的弯曲状态,降低疲劳损伤,可以在运行年限期间可靠运行.

关键词：漂浮式光伏电缆跨浮体连接疲劳失效信赖域粒子群

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Study on gold concentrate leaching by iodine-iodide

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International Journal of Minerals,Metallurgy and Materials 2013年第4期20卷 323-328页

作者： Hai-xia Wang Chun-bao Sun shao-ying li Ping-feng fu Yu-guo Song liang li Wen-qing Xie Key Laboratory of the Ministry of Education of China for High-Efficient Mining and Safety of Metal Mines University of Science and Technology Beijing China Gold Association Shuangqishan Gold Mine

Gold extraction by iodine-iodide solution is an effective and environment-friendly method. In this study, the method using iodine-iodide for gold leaching is proved feasible through thermodynamic calculation. At the same time, experiments on flotation gold concentrates were carried out and encouraging results were obtained. Through optimizing the technological conditions, the attained high gold leaching rate is more than 85%. The optimum process conditions at 25℃ are shown as follows： the initial iodine concentration is 1.0%, the iodine-to-iodide mole ratio is 1：8, the solution pH value is 7, the liquid-to-solid mass ratio is 4：1, the leaching time is 4 h, the stirring intensity is 200 r/mim, and the hydrogen peroxide consumption is 1%.

关键词： gold extraction leaching iodine iodides

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Synthesis, Crystal Structure and Antibacterial Activities of 3-[3-Methyl-(2-thienyl)methyl- enehydrazinocarbonyl]-(1H)-1,2,4-triazole

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1286-1289页

作者： YANG Jian-Guo PAN fu-You shao Hong Office of Assets Administration Taizhou University Zhejiang 317000 China Department of Chemistry Taizhou University Zhejiang 317000 China

The title compound, C9H9N5OS, was synthesized by the reaction of 3-（1H）-1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic system, space group P2 1/n with a = 9.5550（10）, b = 11.9847（12）, c = 10.1074（11） A,β= 112.995（2）° V= 1065.47（19） A^3, Z = 4,μ = 0.290 mm^-1, Mr= 235.27, Dc = 1.467 g/cm^3 and F（000） = 488. The structure was solved by direct methods and refined to R = 0.0449. The crystal structure involves intermolecular hydrogen bonds of N-H…O and N-H…N as well as intramolecular hydrogen bond of N-H…N. Its biological activity has also been determined showing this type of compounds has certain antibacterial activity.

关键词： synthesis crystal structure antibacterial activities (1H)-1,2,4-triazole

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辽朝详稳渊源新论

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古代文明（中英文） 2025年第1期19卷 117-127,M0006,M0007页

作者：田富吉林大学历史文化学院吉林长春130012

以往学界多认为辽朝详稳源于突厥语“sangun”,为将军之意。本文通过考证详稳与相温、相公、将军等概念的异同,认为辽朝详稳一词源自汉语“相”,“稳”是指契丹语语法中修饰“详”字的附加成分。辽朝详稳官职来源于突厥、回鹘、吐蕃等... 详细信息

以往学界多认为辽朝详稳源于突厥语“sangun”,为将军之意。本文通过考证详稳与相温、相公、将军等概念的异同,认为辽朝详稳一词源自汉语“相”,“稳”是指契丹语语法中修饰“详”字的附加成分。辽朝详稳官职来源于突厥、回鹘、吐蕃等边疆民族之“相”制,又在“会同改制”过程中脱离其原义,遂成为一种特殊的部族官职。

关键词：辽朝详稳相相温国相

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Ionic Radius Dependent Kinetic Behavior for the Self-Assemblyand Chiral Amplification of Lanthanide Tetrahedral Cages

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Chinese Journal of Chemistry 2023年第7期41卷 797-804页

作者： shao-Jun Hu Xiao-Qing Guo li-Peng Zhou li-Xuan Cai Chong-Bin Tian Qing-fu Sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian350002 China University of Chinese Academy of Sciences Beijing100049 China

Comprehensive Summary Understanding the kinetic process during the self-assembly and chiral amplification of metal-organic polyhedra(MOPs)is critical for the rational preparation of chiral ***,we report the ionic radius dependent kinetic processes for the self-assembly and chiral amplification of Ln4L4-type(Ln,Lanthanides;L,ligand)lanthanide tetrahedral *** chiral Eu4(LR)4 tetrahedral cage is structurally characterized by nuclear magnetic resonance(NMR),electrospray ionization time-of-flight mass spectrometry(ESI-TOF-MS),and single crystal X-ray *** study on the stereo-controlled self-assembly of circularly polarized luminescence(CPL)-active Ln4(LR)4(Ln=LaIII,PrIII and EuIII)tetrahedra manifests that the larger ionic radius of Ln leads to faster assembly ***-ligand cage assembly experiments with chiral LR/S,achiral Lac and Ln(1:3:4 molar ratio)reveal that the self-assembly and chiral amplification occur synchronously for the LaIII and PrIII cages,while two distinct steps,i.e.,first self-assembly and then chiral amplification,are observed for the EuIII *** distinct kinetic behavior is attributed to different ligands exchange rates among the mixed-ligand Ln4L4 *** work provides fundamental guidance for fabrication and property-optimization of chiral lanthanide-based molecular materials.

关键词： Chiral lanthanide tetrahedron Self-assembly Chiral amplification Kinetic lonic radius

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Asymmetric twin-field quantum key distribution with both statistical and intensity fluctuations

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Communications in Theoretical Physics 2020年第6期72卷 37-42页

作者： shao-fu He Yang Wang Jia-Ji li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhouHenan 450001China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefeiAnhui 230026China

Twin-field quantum key distribution(TF-QKD)is a disruptive innovation which is able to overcome the rate-distance limit of QKD without trusted *** the proposal of the first TF-QKD protocol,theoretical and experimental breakthroughs have been made to enhance its ***,there still exist some practical issues waiting for *** this paper,we examine the performances of asymmetric TF-QKD protocol with unstable light sources and limited data *** statistical fluctuations of the parameters are estimated employing Azuma’s *** numerical simulations,we compare the secret key rates of the asymmetric TF-QKD protocol with different data sizes and variant intensity fluctuation *** results demonstrate that both statistical and intensity fluctuations have significant impacts on the performance of asymmetric TF-QKD.

关键词： twin-field quantum key distribution asymmetrical losses statistical fluctuations intensity fluctuations

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Design,synthesis and bioassay of the emerging photo-responsive fungicides

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Chinese Chemical Letters 2023年第8期34卷 223-226页

作者： Wen fu Xinyue Hu Qinglong Yuan Zhiping Xu Jiagao Cheng Zhong li Xusheng shao Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism School of PharmacyEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Precise and spatiotemporal control over the pesticide remains to be a *** efficient controlled release systems(CRSs)have been developed to support the precise delivery of active ***,we incorporated the photoremovable protecting groups(PRPGs)into phenamacril(PHE)and obtained two photo-responsive fungicides of NV-PHE and *** 4,5-dimethoxy-o-nitrobenzyl(NV)or 7-diethylaminocoumarin(DEACM)-caged PHE could release the active molecule PHE after irradiation of UV light and blue light,*** properties and in-vitro/vivo fungicidal activities of NV-PHE and DEACM-PHE demonstrated the feasibility for light controlled release of ***-PHE could release 98%PHE by illumination of blue *** irradiated DEACM-PHE could preserve the similar bioactivity of PHE,and significantly improve the in-vitro/vivo fungicidal activities compared to the non-irradiated *** optical controlled release of PHE from DEACM-PHE enabled the precise and spatiotemporal delivery of PHE,diversifying the development of CRSs for pesticide,and providing environmentfriendly agricultural applications with high pesticide efficiency.

关键词： Phenamacril Controlled release Photoremovable protecting groups Spatiotemporal Significant difference

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