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Long-term thermal-aging stability of oxide-dispersion-strengthened ferritic steels at 753 K

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Journal of Iron and Steel Research International 2018年第7期25卷 776-784页

作者： Shuai Xu Zhang-jian Zhou shao-fu li Hao-dong Jia School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Oxide-dispersion-strengthened （ODS） ferritic steels are promising candidates for structural applications in the future nuclear reactors. The higher chromium contents of ODS ferritic steels, the better the corrosion resistance, which can meet the harsh corrosion environment of the advanced reactors. However, increasing the Cr content may also lead to the brittleness of the ODS steels when serving at high temperatures. The ODS ferritic steels with different Cr contents （12, 16 and 18 wt% Cr, respectively） were fabricated by mechanical alloying, hot isostatic pressing and forging. Mechanical properties and microstructure evolution of the ODS ferritic steels after aging at 753 K for 2000 h were investigated. It is found that both Vickers hardness and yield strength of 18%Cr ODS ferritic steel were strongly increased and the impact energy was decreased after aging at 753 K. In order to explore the reasons for changes in the mechanical properties, the fracture surfaces were characterized by scanning electron microscopy, and microstructures after aging were observed by transmission electron microscopy. The impact fracture of 18%Cr ODS ferritic steel belongs to quasi-cleavage facture, which is consistent with its very low impact energy. The grain size and dispersed oxide particles of different ODS steels are very stable. M23C6 carbide and M2C carbide were found in 12%Cr ODS steel and 16%Cr ODS steels, respectively.

关键词： Oxide-dispersion-strengthened ferritic steel Aging stability - Mechanical property Microstructure

Effects of Solution Depletion and Segregation Oxidation on Morphology of Modified 310 Austenitic Stainless Steel

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Journal of Iron and Steel Research International 2016年第4期23卷 393-400页

作者： Hong-ying SUN Qiang HE Zhang-jian ZHOU Man WANG Guang-ming ZHANG shao-fu li Key Laboratory of Key functional Parts of Machine Anyang Institute of TechnologyAnyang 455002HenanChina School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

The oxidation morphologies of modified 310 steel exposed in 900 and 1 100 ℃ air were investigated. A double layer morphology consisting of a （Cr, Mn）-rich outer layer and a fine Cr-rich inner layer was formed at 900℃. It was related to the breakaway oxidation induced by the Cr-depletion and the Mn-segregation in inner layer. Some Cr-rich oxides with amorphous state were formed along grain boundaries. And some new finer oxide grains, voids and Cr-rich precipitates were observed in spallation areas at 1 100℃. Correspondingly, the oxidation kinetic curve dropped with the spallation of scale and increased with the formation of some new oxide grains. It was caused by segregation of Cr and the transformation of oxides from Cr2O3 to the volatile oxides at elevated temperature. XRD analysis showed that the precipitates were mainly composed of CrO3. Segregation and depletion for solutions were also discussed by oxidation diffusion mechanisms.

关键词： austenitic stainless steel SEM morphology oxidation segregation element

Da-Cheng-Qi Decoction(大承气汤)Combined with Lactobacillus Acidophilus Improves Gastrointestinal function of Traumatic Brain-Injured Model Mice

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Chinese Journal of Integrative Medicine 2020年第10期26卷 762-768页

作者： fu shao-li ZHU li-na YIN Hua-hua JIANG Yan ZHU Jing-ci Department of Nursing School of NursingThird Military Medical UniversityChongqing(400038)China Orthopedics Department of Chongqing Traditional Chinese Medicine Hospital Chongqing(400021)China

Objective To investigate the effects of Da-Cheng-Qi Decoction(DCQD,大承气汤)combined with Lactobacillus acidophilus(LA)on the recovery of gastrointestinal(GI)function in traumatic brain-injured(TBI)*** A total of 150 male C57BL/6 mice were randomly divided into sham-injury,normal saline(NS),DCQD(0.4 mL/day),LA(⩾1×1010 cfu/day LA),DCQD+LA(LA administration at the same dosage after 4 h of feeding DCQD),and½DCQD+LA groups(LA administration at the same dosage after 4 h of feeding½DCQD dose)by a random number table,5–8 mice in each *** sever TBI model was constructed according to Feeney’s enhanced gravitational forces of free *** days 1,3,and 7 post-TBI,plasma diamine oxidase(DAO)and D-lactic acid levels were assessed by enzyme-linked immunosorbent assay(EliSA).Occludin expression in the intestinal epithelium was assessed by Western blot *** electron microscopy(TEM)was used to observe the morphological changes in the network structure of interstitial cells of Cajal(ICC)and change of enteric nervous system-ICC-smooth muscle cell(ENS-ICC-SMC).Immunofluorescence staining was used to detect changes in the network structure of the *** Compared with the NS group,occludin expression in the DCQD+LA group significantly increased on Day 1,3,and 7 post-TBI(Plity in mice after *** combination of DCQD and LA was more effective than their respective monotherapies.

关键词： traumatic brain-injury Da-Cheng-Qi Decoction Lactobacillus acidophilus intestinal mucosal barrier gastrointestinal motility

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志贺菌基因组进化研究进展

生物化学与生物物理进展 2016年第11期43卷 1029-1037页

作者：杨朗邱少富李鹏宋宏彬军事医学科学院疾病预防控制所北京100071

志贺菌属(Shigella)是引起全球范围内细菌性痢疾的重要病原菌.近年来,多重耐药型和新血清型志贺菌的不断出现给志贺菌的监测和防控带来了新的挑战.基因组学的快速发展为深入了解志贺菌的进化来源、变异机制及传播规律等提供了极大的帮助... 详细信息

志贺菌属(Shigella)是引起全球范围内细菌性痢疾的重要病原菌.近年来,多重耐药型和新血清型志贺菌的不断出现给志贺菌的监测和防控带来了新的挑战.基因组学的快速发展为深入了解志贺菌的进化来源、变异机制及传播规律等提供了极大的帮助,对控制细菌性痢疾的蔓延具有重要的科学意义.本文首先从遗传来源角度探讨志贺菌与大肠杆菌的进化关系及其可能的分子机制,随后对福氏、宋内和1型痢疾志贺菌的基因组进化进展进行了总结,详细描述了它们的时空分布特点以及耐药基因变异在进化中所发挥的作用,以期为志贺菌的研究和防控提供参考.

关键词：志贺菌基因组进化关系大肠杆菌

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

静注人免疫球蛋白在治疗自身免疫疾病和炎症所引发皮肤病的应用

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中国生物制品学杂志 2017年第1期30卷 106-111页

作者：于引航傅绍兰杨莉李常禄哈尔滨派斯菲科生物制药股份有限公司黑龙江哈尔滨150025

静注人免疫球蛋白(intravenous immunoglobulin,IVIG)是由多种蛋白组成,包括IgG、IgM、IgA、IgE抗体及少量的白蛋白,还包括氯化钠、麦芽糖等物质。由于IVIG从健康人血浆中提取,因此含有多种人体所需要的自然抗体,一直以来被用作治疗传... 详细信息

静注人免疫球蛋白(intravenous immunoglobulin,IVIG)是由多种蛋白组成,包括IgG、IgM、IgA、IgE抗体及少量的白蛋白,还包括氯化钠、麦芽糖等物质。由于IVIG从健康人血浆中提取,因此含有多种人体所需要的自然抗体,一直以来被用作治疗传染性疾病和免疫缺陷疾病。近些年发现IVIG可以治疗多种临床疾病,包括自身免疫和炎症疾病及其所引起的多种皮肤科相关疾病。本文针对IVIG治疗因自身免疫系统紊乱或炎症引发的皮肤疾病的应用作一综述。

关键词：静注人免疫球蛋白自身免疫疾病炎症皮肤疾病

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钒钛磁铁精矿球团还原性研究

有色金属（冶炼部分） 2017年第1期 49-52页

作者：周兰花曾富洪杨绍利攀枝花学院四川攀枝花617000

通过钒钛磁铁精矿—煤—Na_2CO_3球团的加热试验,考察了温度、配碳量、Na_2CO_3配加量等因素对矿还原性的影响,探讨了Na_2CO_3的作用机理。采用回归正交法设计试验,统计分析试验结果发现:温度、配碳量、Na_2CO_3配加量对矿还原有显著的... 详细信息

通过钒钛磁铁精矿—煤—Na_2CO_3球团的加热试验,考察了温度、配碳量、Na_2CO_3配加量等因素对矿还原性的影响,探讨了Na_2CO_3的作用机理。采用回归正交法设计试验,统计分析试验结果发现:温度、配碳量、Na_2CO_3配加量对矿还原有显著的影响,其中温度影响最大;较低温度下,Na_2CO_3对碳气化反应能产生明显的正催化作用,促进矿中铁氧化物的还原。在配碳2.33 mol、1 260℃、Na_2CO_3配加0.014mol、30min的条件下,钒钛磁铁精矿的还原度为94.56%,金属化率91.67%,金属铁颗粒明显生成。

关键词：钒钛磁铁精矿球团金属化率回归正交法

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li fu Tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun fu Hong-Wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs