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临床心血管病杂志 1998年第5期14卷 282-285页

作者：傅国胜单江浙江医科大学第二附属医院心内科杭州310009

目的：探讨充血性心力衰竭（CHF）患者的预后因素。方法：前瞻性研究163例CHF患者临床、心电图及血流动力学的预后价值，用多因素Cox回归模型分析各因素对预后的影响。结果：平均随访29个月，心脏性死亡59例，其中猝死34例，泵衰竭死亡1... 详细信息

目的：探讨充血性心力衰竭（CHF）患者的预后因素。方法：前瞻性研究163例CHF患者临床、心电图及血流动力学的预后价值，用多因素Cox回归模型分析各因素对预后的影响。结果：平均随访29个月，心脏性死亡59例，其中猝死34例，泵衰竭死亡19例，心肌梗死死亡6例；多因素分析示，平均主动脉压、平均肺动脉压和QTc是心脏性死亡的独立危险因素；生存率分析示，平均主动脉压≤12kPa，平均肺动脉压≥3．33kPa，QTc≥440ms，射血分数≤25％及有束支阻滞者，生存率显著降低。结论：低血压、QTc延长及伴肺动脉高压者预后不良，治疗中应防止过度降压和延长心肌复极。

关键词：充血性心力衰竭预后 Cox回归模型

血管紧张素转换酶基因多态性与冠心病危险因素的关系

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中华流行病学杂志 2000年第3期21卷 208-211页

作者：单江施育平傅国胜浙江大学医学院附属第二医院心内科杭州310009

目的　探讨血管紧张素转换酶 (ACE)基因多态性与冠心病危险因素的关系。方法　应用聚合酶链反应技术和遗传学方法 ,测定 15 9名汉族正常人、148例冠心病患者的ACE基因插入 /缺失 (I/D)多态性频率 ,并调查冠心病患者经典危险因素。结果　... 详细信息

目的　探讨血管紧张素转换酶 (ACE)基因多态性与冠心病危险因素的关系。方法　应用聚合酶链反应技术和遗传学方法 ,测定 15 9名汉族正常人、148例冠心病患者的ACE基因插入 /缺失 (I/D)多态性频率 ,并调查冠心病患者经典危险因素。结果　①ACE基因型分布与冠心病患者的年龄、性别、体重指数 (BMI)、收缩压、舒张压、总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白(LDL)、高密度脂蛋白 (HDL)、HDL2 、HDL3 、载脂蛋白 (Apo)AI、ApoB、脂蛋白〔Lp(a)〕以及高血压病(HT)、吸烟、糖尿病 (DM )和肥胖间差异均无显著性 (P均 >0 .0 5 ) ;②以ApoB <12 5mg/dl和BMI≤2 4kg/m2 ;或TC <2 30mg/dl、TG <2 0 0mg/dl、LDL <16 0mg/dl和BMI≤ 2 4kg/m2 ;及不合并HT和DM者定义为冠心病低危险亚组 ,分别与正常人比较 ,DD基因型频率 (构成比 )分别为 0 .2 5 7、0 .315和0 .2 73,均显著高于正常人 (χ2 =3.98、7.80、4.0 1,P均 <0 .0 5 )。结论　ACE基因多态性与冠心病经典危险因素无关 ,DD基因型可能是中国人冠心病的一个独立危险因素。

关键词：冠心病血管紧张素转换酶危险因素基因多态性

2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI

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Science Bulletin 2019年第3期64卷 166-179页

作者： Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen guosheng fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge Department of Cardiology Peking University First Hospital Department of Internal Medicine Gyeongsang National University School of Medicine and Cardiovascular Center Gyeongsang National University Changwon Hospital Division of Cardiology Internal Medicine Department Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Cardiology Shanghai Chest Hospital affiliated to Shanghai Jiaotong University Department of Cardiology Guangdong General Hospital Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Cardiology Chinese PLAG General Hospital Department of Cardiology General Hospital of Northern Theater Command Department of Medicine (Cardiology) Tokai University School of Medicine Inova Center for Thrombosis Research and Drug Development Inova Heart and Vascular Institute Cardiovascular Center Department of Internal Medicine Seoul National University Hospital The Heart Research Center Nominated by Korea Ministry of Health and Welfare Chonnam National University Hospital Division of Cardiology University of North Carolina Department of Cardiology Fudan University Zhongshan Hospital

East Asians are the most populous race in the world and their health status is an important global *** with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed.

关键词： East Asian Coronary artery disease Antiplatelet Bleeding

普伐他汀对慢性心力衰竭患者血浆脑钠素水平及心功能的影响

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临床心血管病杂志 2007年第8期23卷 588-589页

作者：钱志贤傅国胜浙江大学医学院附属邵逸夫医院心内科

目的:探讨普伐他汀对慢性心力衰竭(CHF)患者血浆脑钠素(BNP)水平和心功能的影响。方法:将56例CHF患者随机分为普伐他汀组(30例)和对照组(26例),2组均给予常规治疗,普伐他汀组另加普伐他汀10mg,qn,疗程8周。测定治疗前、后左心室舒张末内... 详细信息

目的:探讨普伐他汀对慢性心力衰竭(CHF)患者血浆脑钠素(BNP)水平和心功能的影响。方法:将56例CHF患者随机分为普伐他汀组(30例)和对照组(26例),2组均给予常规治疗,普伐他汀组另加普伐他汀10mg,qn,疗程8周。测定治疗前、后左心室舒张末内径(LVDd)、左心室射血分数(LVEF)、血浆BNP浓度的变化。结果:普伐他汀治疗8周后,血浆BNP浓度由(218.6±64.2)ng/L降至(149.4±50.1)ng/L(P<0.01);LVEF由(34.4±3.4)%升至(45.4±4.9)%(P<0.05),LVDd由(65.5±5.1)mm降至(45.4±4.9)mm(P<0.05),与对照组比较均差异有统计学意义;且患者血浆BNP降低值与LVEF增加存在负相关(r=-0.71,P<0.01),而与LVDd减少呈正相关(r=0.79,P<0.05)。结论:普伐他汀能明显改善心功能,抑制血浆BNP增高。

关键词：心力衰竭,充血性脑钠素心室功能,左普伐他汀

Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of myocardial infarction: Study in Chinese Han population and meta-analysis in Asian countries

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Role of methylenetetrahydrofolate reductase 677C->T polymorp...

2015年老年医学学术年会

作者： Wenbin Zhang Min Wang Pei Zhang Zhimin Xue guosheng fu Junbo Ge Yi Luan Department of Cardiology Biomedical Research (Therapy) Center Sir Run Run Shaw HospitalCollege of Medicine Zhejiang University Shanghai Institute of Cardiovascular Diseases of Zhongshan Hospital Fudan University Institute of Biomedical Science Fudan University

Background: The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T is thought to be a risk factor for coronary heart disease (CHD), but it remains unclear whether the MTHFR C677T variant is associated with its worst situation - myocardial infarction (MI) - in Chinese Han or Asian ***: To investigate the role of MTHFR C677T polymorphism in the development of MI in Chinese Han and Asian ***: Unrelated 551 controls with no history or clinic evidence of CHD or MI and 304 age-matched MI patients diagnosed with coronary angiography in Zhongshan Hospital were recruited in this study. DNA was extracted from peripheral blood and genotypes were determined by polymerase chain reaction (PCR). The genotype distributions were tested. A subsequent meta-analysis was performed to identify the association in Asian ***: Conventional risk factors and biochemical factors for CHD such as hypertension, diabetes mellitus and LDL exerted no significant difference between two groups. Genotype frequencies among cases and controls were compatible with Hardy-Weinberg equilibrium (HWE). The frequencies of CC, CT, and TT genotypes were 28%, 46%, 26% for patients with MI and 31%, 52%, 17% for matched control group (p<0.01). T allele frequency in MI patients was slightly higher compared to thatof controls (49% vs. 43%, OR = 0.785, 95% CI = 0.644-0.958, p = 0.017). A total of 16 studies including ours were identified for meta-analysis, involving 4053 patients and 6791 controls. It showed recessive genotype model of MTHFR C677T polymorphism - but not dominant genotype model - was significantly associated with a greater risk of MI in Asian population. There was a 48%, 37%, 47% increase in the risk of MI for TT homozygote when compared with CC wild type, CT heterozygote, and the combination of CT and ***: Our study demonstrates that MTHFR gene variant C677T is a risk factor for MI in Chinese Han Population and TT genotype is associa

关键词： methylenetetrahydrofolate reductase myocardial infarction Chinese Han Population

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吸附重金属离子活性炭再生工艺分析

山西化工 2018年第1期38卷 18-20页

作者：付国胜大同煤业金鼎活性炭有限公司山西大同037001

现如今,随着科技的发展以及时代的进步,我国环保部门也取得了较大的发展,并对环境治理和环境保护等问题投入了更多的重视。由于重离子是一种具有极大危害的污染物,对含重离子的物质进行一定环保的处理是十分必要的。鉴于此,着重分析研... 详细信息

现如今,随着科技的发展以及时代的进步,我国环保部门也取得了较大的发展,并对环境治理和环境保护等问题投入了更多的重视。由于重离子是一种具有极大危害的污染物,对含重离子的物质进行一定环保的处理是十分必要的。鉴于此,着重分析研究了吸附重金属离子活性炭再生工艺,并对其实验结果进行了分析,旨在为我国环保行业的进一步发展献力。

关键词：吸附重金属离子活性炭再生工艺

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巨大右冠状动脉瘤1例

临床心血管病杂志 2018年第11期34卷 1141-1144页

作者：张杰芳傅国胜浙江大学医学院附属邵逸夫医院心内科浙江杭州310053

巨大冠状动脉瘤（直径大于20mm）是一种罕见的疾病,患病率为0.02%,是冠状动脉瘤样扩张较为罕见的一种类型。目前指南认为手术切除可能是有潜在生命危险如破裂、血栓和远端冠状动脉栓塞等患者的最佳选择。巨大冠状动脉瘤发病隐匿,症状不... 详细信息

巨大冠状动脉瘤（直径大于20mm）是一种罕见的疾病,患病率为0.02%,是冠状动脉瘤样扩张较为罕见的一种类型。目前指南认为手术切除可能是有潜在生命危险如破裂、血栓和远端冠状动脉栓塞等患者的最佳选择。巨大冠状动脉瘤发病隐匿,症状不典型,一旦造成心肌梗死等严重并发症,病死率高,因此早期诊断尤其重要。

关键词：巨大冠状动脉瘤冠状动脉瘤样扩张心肌梗死

基质金属蛋白酶-9与急性冠状动脉综合征的临床相关性研究

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临床心血管病杂志 2005年第3期21卷 150-152页

作者：方崇峰陈样新傅国胜温州医学院附属台州医院心内科浙江临海317000 浙江大学医学院附属第二医院心内科

目的:探讨血清基质金属蛋白酶 9(MMP 9)与急性冠状动脉综合征(ACS)的关系。方法:经冠状动脉造影(CAG)确诊的冠心病患者85例,其中ACS患者(ACS组)58例,包括急性心肌梗死(AMI)22例,不稳定型心绞痛(UAP)36例;稳定型心绞痛组(SAP组)27 例;另... 详细信息

目的:探讨血清基质金属蛋白酶 9(MMP 9)与急性冠状动脉综合征(ACS)的关系。方法:经冠状动脉造影(CAG)确诊的冠心病患者85例,其中ACS患者(ACS组)58例,包括急性心肌梗死(AMI)22例,不稳定型心绞痛(UAP)36例;稳定型心绞痛组(SAP组)27 例;另设对照组 24 例。用酶联免疫吸附法(ELISA)测定各病例造影前及行PTCA者术后血清MMP 9浓度。结果:在造影前,ACS组、SAP组及对照组血清 MMP 9 浓度分别为(26.85±6.25)、(17.35±7.12)、(16.83±5.92)μg/L;此外,ACS组内 AMI和 UAP患者血清 MMP 9 浓度分别为(32.56±6.55)、(24.78±5.76)μg/L。AMI及UAP患者与SAP组之间MMP 9浓度差异有统计学意义,SAP组与对照组之间差异无统计学意义;ACS组内,AMI与UAP患者之间差异无统计学意义。血清 MMP 9 水平与C反应蛋白(CRP)、WBC、冠状动脉病变评分、冠状动脉狭窄程度之间呈明显的正相关,与冠状动脉病变支数、肌钙蛋白 I(cTnI)、肌酸激酶同工酶(CK MB)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL C)、低密度脂蛋白胆固醇(LDL C)、PLT间无明显相关性。PTCA术后 l d MMP 9 浓度均较术前要明显升高。结论:ACS患者血清MMP 9浓度明显升高,其水平与冠状动脉内粥样硬化斑块的稳定性密切相关,提示其有助于冠心病的危险分层。

关键词：急性冠状动脉综合征基质金属蛋白酶-9

Initial measurement of ultrafast charge exchange recombination spectroscopy on the EAST tokamak

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Plasma Science and Technology 2024年第5期26卷 40-46页

作者：蒋军李颖颖陈冉符佳吕波余羿徐国盛叶民友 School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026People’s Republic of China Enn Science and Technology Development Co.Ltd. Langfang 065001People’s Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082People’s Republic of China

Ultrafast charge exchange recombination spectroscopy(UF-CXRS)has been developed on the EAST tokamak(Yingying Li et al 2019 fusion ***.146522)to measure fast evolutions of ion temperature and toroidal ***,we report the preliminary diagnostic measurements after relative sensitivity *** measurement results show a much higher temporal resolution compared with conventional CXRS,benefiting from the usage of a prismcoupled,high-dispersion volume-phase holographic transmission grating and a high quantum efficiency,high-gain detector *** the UF-CXRS diagnostic,the fast evolutions of the ion temperature and rotation velocity during a set of high-frequency small-amplitude edgelocalized modes(ELMs)are obtained on the EAST tokamak,which are then compared with the case of large-amplitude ELMs.

关键词： ultrafast charge exchange recombination spectroscopy EAST diagnostic measurements