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上海市社区卫生服务能力提升的路径探索

健康发展与政策研究 2024年第3期27卷 201-205页

作者：付晨上海市卫生健康委员会上海200125

社区是开展医疗卫生服务最基础的单位,社区卫生是卫生健康高质量发展的重要环节。本文通过回顾上海市社区卫生服务的发展历程,分析现况,从完善“全科+专科”医疗服务模式、扩充社区药品配备、夯实家庭医生签约服务制度、打造社区卫生“... 详细信息

社区是开展医疗卫生服务最基础的单位,社区卫生是卫生健康高质量发展的重要环节。本文通过回顾上海市社区卫生服务的发展历程,分析现况,从完善“全科+专科”医疗服务模式、扩充社区药品配备、夯实家庭医生签约服务制度、打造社区卫生“三中心一诊室”服务品牌和充分发挥医保杠杆作用5个方面介绍上海市提升社区卫生服务能力的实践路径,以期为新时期社区卫生服务发展提供参考。

关键词：社区卫生基层卫生服务服务能力提升路径

Intergeneric chromosome-specific painting reveals differential chromosomal transmission from Tripidium arundinaceum in sugarcane progeny

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Journal of Integrative Agriculture 2024年第11期23卷 3751-3762页

作者： Fan Yu Zehuai Yu Jin Chai Xikai Yu chen fu Xinwang Zhao Hailong Chang Jiawei Lei Baoshan chen Wei Yao Muqing Zhang Jiayun Wu Qinnan Wang Zuhu Deng State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangxi Key Laboratory for Sugarcane Biology College of Agriculture Guangxi University National Engineering Research Center for Sugarcane Fujian Agriculture and Forestry University Institute of Nanfan & Seed Industry Guangdong Academy of Sciences Key Laboratory of Sugarcane Biology and Genetic Breeding Ministry of Agriculture and Rural Affairs/Fujian Agriculture and Forestry University

Sugarcane has recently attracted increasing attention for its potential as a source of sugar and bioethanol, so increasing its yield is essential to ensure the sugar security and bioenergy production. Intergeneric hybridization is a highly efficient method to produce new genetic variants of crop plants, particularly those species with high ploidy such as sugarcane(Saccharum spp.). Tripidium arundinaceum exhibits many desirable agronomic traits, and has been widely studied to produce hybrids with improved stress tolerance and other characteristics in sugarcane breeding. However, the genetic relationship between T. arundinaceum and Saccharum species, and the individual T. arundinaceum chromosomal compositions in sugarcane hybrids are still elusive. Here we used whole-genome single-nucleotide polymorphisms(SNPs) to ascertain the phylogenetic relationships between these species and found that T. arundinaceum is more closely related to Saccharum than Sorghum, in contrast to the previous narrow genetic analyses using chloroplast DNA. Additionally, oligonucleotide(oligo)-based chromosome-specific painting derived from Saccharum officinarum was able to distinctly identify the chromosomes of T. arundinaceum. We developed the oligo-genomic in situ hybridization(GISH) system for the first time, to unveil the novel chromosome translocations and the transmission of individual T. arundinaceum chromosomes in sugarcane progeny. Notably,we discovered that the chromosomal transmission of T. arundinaceum exhibited several different inheritance modes,including n, 2n, and over 2n in the BC1 progenies. Such inheritance patterns may have resulted from first division restitution(FDR) or FDR+nondisjunction of a chromosome with the sister chromatids in the second meiosis division/second division restitution(FDR+NSC/SDR) model during meiosis. These results will be of substantial benefit for the further selection of T. arundinaceum chromosomes for sugarcane genetic improvement.

关键词： sugarcane Tripidium arundinaceum chromosome painting Oligo-FISH chromosomal transmission

能量感知的点云视频流传输与边缘卸载联合优化

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通信学报 2024年第5期45卷 80-89页

作者：刘威朱雨乐付晨王希华中科技大学电子信息与通信学院湖北武汉430074

针对点云视频流媒体传输需要调度各类计算和传输资源,而现有工作较少考虑终端显示设备的计算任务带来的能耗问题,提出了一种移动边缘计算辅助的点云视频流传输方案,根据接入带宽和点云视频内容将部分计算任务从终端卸载到边缘完成。该... 详细信息

针对点云视频流媒体传输需要调度各类计算和传输资源,而现有工作较少考虑终端显示设备的计算任务带来的能耗问题,提出了一种移动边缘计算辅助的点云视频流传输方案,根据接入带宽和点云视频内容将部分计算任务从终端卸载到边缘完成。该方案建立了一个联合优化模型,在网络资源、终端和边缘算力资源的约束下,最大化用户观看体验收益并最小化终端设备能耗。实验表明,相比于对比方案,所提方案在不同条件下均可提升用户观看质量并降低终端设备能耗。

关键词：点云视频流能量感知移动边缘计算联合优化

含有非热电子和陷俘离子的复杂等离子体中非线性尘埃声波的传播特征

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物理学报 2024年第7期73卷 252-261页

作者：林麦麦宋晨光王明月陈富艳西北师范大学物理与电子工程学院兰州730070

本文研究了同时含有非热(nonthermal)电子和陷俘(trapped)离子分布的复杂等离子体系统中非线性尘埃声波的传播特征.首先,利用线性化方法推导得到非线性尘埃声波的色散关系.接着,借助Sagdeev势方法推导得到表征非线性尘埃声波运动的二维... 详细信息

本文研究了同时含有非热(nonthermal)电子和陷俘(trapped)离子分布的复杂等离子体系统中非线性尘埃声波的传播特征.首先,利用线性化方法推导得到非线性尘埃声波的色散关系.接着,借助Sagdeev势方法推导得到表征非线性尘埃声波运动的二维自治系统、Sagdeev势方程和Sagdeev势函数的具体表达式.然后,依据数值模拟的方法分析了多种系统因素对二维自治系统相图的重要影响.结果表明:含有nonthermal电子和trapped离子的复杂等离子体系统中同时存在线性周期波、非线性周期波和孤立波.接下来,通过讨论Sagdeev势函数随系统参数的变化规律发现:该复杂等离子体系统中仅存在振幅大于零的压缩型孤立波.最后,探讨多种系统因素对非线性尘埃声孤波的振幅、宽度和波形等传播特征的重要影响.结果显示:马赫数、nonthermal电子和trapped离子以及尘埃颗粒未扰动的数密度、温度及荷电量等参数对该复杂等离子体系统中非线性尘埃声孤波的振幅、宽度和波形等传播特性均具有显著影响,且该结果与Sagdeev势函数的分析结果保持一致.

关键词：非线性尘埃声孤波 Sagdeev势方法非热电子分布陷俘离子分布

Biological factors driving colorectal cancer metastasis

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-Xing An Zhao-Jin Yu chen fu Min-Jie Wei Long-Hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at *** Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial *** median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 *** is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor *** patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological *** genomic and nongenomic events can induce subclone diversity,which leads to cancer and *** the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular ***,cancer cells presenting neoantigens can be recognized and eliminated by the immune *** this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle *** remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains *** review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

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花青素—淀粉智能指示膜的制备及性能研究

粮油食品科技 2024年第4期32卷 129-135页

作者：袁虎陈复生河南工业大学粮油食品学院河南郑州450001 中原食品实验室河南漯河462300

以淀粉为原料,花青素为功能性物质,采用静电纺丝法制备了淀粉纳米纤维智能指示膜,并研究其结构和性能。结果表明:花青素负载量的增加会增大纤维直径和指示膜的水接触角。指示膜的晶态决定其力学性能,花青素添加到10%以上时指示膜结晶度... 详细信息

以淀粉为原料,花青素为功能性物质,采用静电纺丝法制备了淀粉纳米纤维智能指示膜,并研究其结构和性能。结果表明:花青素负载量的增加会增大纤维直径和指示膜的水接触角。指示膜的晶态决定其力学性能,花青素添加到10%以上时指示膜结晶度较高其断裂应力也随之升高,达到了12.0 MPa,但断裂伸长率减小到了5.8%。加入花青素的指示膜热稳定性有所提升。静电纺丝过程不会改变淀粉和花青素的分子结构,指示膜的指示功能主要是通过花青素中酚羟基的电离状态改变引起颜色变化实现,抗氧化功能是酚羟基提供的还原性赋予的。这些结果证明了淀粉花青素智能指示膜具有良好的指示性,可用于监测食品品质变化。

关键词：淀粉花青素静电纺丝法纳米纤维智能指示膜

频域多方向C-UNet及动态损失的工业烟尘图像分割

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控制理论与应用 2024年第3期41卷 543-554页

作者：张大锦刘辉陈甫刚赵安昆明理工大学信息工程与自动化学院云南昆明650500 昆明理工大学云南省人工智能重点实验室云南昆明650500 云南昆钢电子信息科技有限公司云南昆明650302

工业烟尘污染等级监测中烟尘的准确分割是污染等级判定的重要前提.针对边缘模糊且方向多变烟尘在特征提取过程中边缘方向细节信息提取困难、分割不准确的问题,本文提出一种频域多方向C-UNet及动态损失的工业烟尘图像分割方法.首先,通过... 详细信息

工业烟尘污染等级监测中烟尘的准确分割是污染等级判定的重要前提.针对边缘模糊且方向多变烟尘在特征提取过程中边缘方向细节信息提取困难、分割不准确的问题,本文提出一种频域多方向C-UNet及动态损失的工业烟尘图像分割方法.首先,通过构建轮廓波多方向分解下采样结构增强编码阶段烟尘边缘方向信息的提取能力;其次,通过轮廓波变换提取烟尘8个边缘方向细节信息进行跳跃连接,提升持续采样过程中细节信息的表达准确度;然后,构建轮廓波细节重构上采样结构增强解码阶段烟尘边缘细节信息的恢复能力;最后,提出一种动态加权策略构建组合损失函数来优化训练网络,增强网络对烟尘边缘特征的提取能力.结果表明,本文方法与U-Net和其他同类方法相比在指标上有较好提升,改善了烟尘边缘分割不准确的问题,在不同烟尘场景上的分割效果也优于现有分割模型.

关键词：工业烟尘图像分割轮廓波变换特征提取动态损失函数

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战后日本现代化发展的依附性特征及发展制约

日本学刊 2024年第3期 1-25,169页

作者：崔岩富晨辽宁大学日本研究所辽宁大学国际经济政治学院

中国式现代化建设进入了新的发展阶段,要求我们更深入地思考国际现代化的理论与发展经验。战后日本确立的不对等的日美同盟关系决定了其现代化发展具有依附性特征。20世纪80年代发生的日美“经济战”对日本经济及社会发展产生了重大冲击... 详细信息

中国式现代化建设进入了新的发展阶段,要求我们更深入地思考国际现代化的理论与发展经验。战后日本确立的不对等的日美同盟关系决定了其现代化发展具有依附性特征。20世纪80年代发生的日美“经济战”对日本经济及社会发展产生了重大冲击,在双方经济博奔过程中日本做出重大妥协,在经济增长、产业发展等方面遭受了巨大损失,被动地实行全面结构改革而陷入了西方新自由主义的陷阱。这表明战后日本现代化发展对美国的依附并不仅限于政治领域,在经济领域也存在较强的依附性。简要比较中日两国现代化模式的差异,更加显示出日本模式存在的内在缺陷与中国道路的优越性,对发展中国家的现代化模式与路径选择具有重要的借鉴价值。

关键词：日本现代化化依附性特征吉田路线中国式现代化新发展格局

Photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination compounds as potential bactericidal agent against Xanthomonas oryzae ***

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Chinese Chemical Letters 2024年第1期35卷 401-405页

作者： Yu Shi Zhao-Sheng Zhang Jiang Shao chen fu Lan-Tu Xiong Zhao-Dong Li Zi-Ning Cui National Key Laboratory of Green Pesticide Integrative Microbiology Research CentreGuangdong Province Key Laboratory of Microbial Signals and Disease ControlCollege of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China Henry Fok School of Biology and Agriculture Shaoguan UniversityShaoguan 512005China College of Materials and Energy South China Agricultural UniversityGuangzhou 510642China

A series of photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination derivatives was rationally synthesized based on diversity-oriented synthesis via cross coupling of 1,3-dienes,amines and fluoroalkyl *** reaction featured good function group tolerance and a broad substrate scope,which could be extended to the late-stage modification of bioactive *** activity of all the compounds against Xanthomonas oryzae ***(Xoo)was *** them,compound E14 showed significant activity against Xanthomonas oryzae ***(Xoo)with half maximal effective concentration(EC50)value of 6.61μmol/*** pot experiments,the results showed that E14 could control rice bacterial blight with protective and curative efficiencies of 37.5%and 63.2%at 200μg/mL,***,a plausible mechanism for antibacterial behavior of E14 was proposed by electron microscopy,flow cytometry,reactive oxygen species detection,and biofilm *** current work,it can promote the development of photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkyl amination compounds as prospective antibacterial agent bearing an intriguing mode of action.

关键词： 1,3-Diene-selective fluoroalkylamination derivatives Xanthomonas oryzae pv.oryzae Antibacterial activity Electron microscopy Reactive oxygen Flow cytometry