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fu-zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment

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Chinese Journal of Natural Medicines 2024年第6期22卷 501-514页

作者： CHEN Chiwei HUANG Renlun WANG Neng zheng Yifeng ZHOU Jianfu YANG Bowen WANG Xuan ZHANG Juping PAN Bo CHEN Zhiqiang WANG Shengqi WANG Zhiyu XIANG Songtao The Research Center of Integrative Cancer Medicine Discipline of Integrated Chinese and Western Medicinethe Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510000China The First Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510000China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangdong Provincial Academy of Chinese Medical SciencesGuangdong Provincial Hospital of Chinese MedicineGuangzhou 510000China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou 510000China The Research Center for Integrative Medicine School of Basic Medical SciencesGuangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China

Prostate cancer(PCa)is the second most common malignancy among men *** fu-zheng-Yi-Liu(FZYL)Formula has been widely utilized in the treatment of *** study investigates whether the FZYL Formula can inhibit PCa by tar-geting the TAMs/CCL5 *** conducted in vitro co-cultures and in vivo co-injections of PCa cells and TAMs to mimic their *** showed that the FZYL Formula significantly reduced the proliferation,colony formation,subpopulations of PCSCs,and sphere-formation efficacy of PCa cells,even in the presence of TAM ***,the Formula markedly decreased the migration,invasion,and epithelial-mesenchymal transition(EMT)of PCa cells induced by *** FZYL Formula also reversed M2 phenotype polarization in TAMs and dose-dependently reduced their CCL5 expression and secretion,with minimal cytotoxicity *** studies confirmed that the TAMs/CCL5 axis is a critical target of the FZYL Formula,as the addition of exogen-ous CCL5 partially reversed the formula’s inhibitory effects on PCSCs self-renewal in the co-culture ***,the Formula also significantly inhibited the growth of PCa xenografts,bone metastasis,and PCSCs activity in vivo by targeting the TAMs/CCL5 ***,this study not only elucidates the immunomodulatory mechanism of the FZYL Formula in PCa therapy but also highlights the TAMs/CCL5 axis as a promising therapeutic target.

关键词： Traditional Chinese medicine Tumor-associated macrophages Prostate cancer stem cells CCL5 Tumor microenvironment

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p-adic Modular Symbols and ∧-adic Modular Forms

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Acta Mathematica Sinica,English Series 2006年第2期22卷 331-338页

作者： fu zheng WANG LMAM&Department of Mathematics.Peking University

A construction of A-adic modular forms from p-adic modular symbols is described. It shows that each A linear map satisfying some certain conditions from the module of p-adic modular symbols to A corresponds to a A-adi... 详细信息

关键词： Modular symbol Manin symbol A-adic modular form

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Special Focus on Millimeter Wave Communications Techniques and Devices for 5G—Editorial

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Science China(Information Sciences) 2017年第8期60卷 5-6页

作者： fu-Chun zheng Gang WU Harbin Institute of Technology The University of York University of Electronic Science and Technology of China

Due to the rapid development of cost-effective CMOS solutions and recent experimental validation on communications over millimeter wave(mm Wave)bands,which span from 30 to 300 GHz,mm Wave communications technologies are being considered for 5G mobile systems to provide ultra-high data rates for front haul,back haul,and short or middle range broadband *** to the array gain of massive multiple-input multiple-output(m-MIMO)antenna arrays,the heavy path loss of mmWave

关键词： Wave for Editorial Special Focus on Millimeter Wave Communications Techniques and Devices for 5G MIMO on

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On the local delay and energy efficiency under decoupled uplink and downlink in HetNets

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Science China(Information Sciences) 2022年第3期65卷 225-234页

作者： Tianjie HUANG fu-Chun zheng Lifeng LAI School of Electronic and Information Engineering Harbin Institute of Technology (Shenzhen)

With the proliferation of the Internet of Things, uplink transmission performance has become more and more important. Moreover, with the traditional coupled uplink(UL)/downlink(DL) access(CUDA) mode, it is becoming hard to improve the system performance of UL in ultra dense heterogeneous networks(UDN, or Het Nets). In this paper, we have conducted a UL performance comparison study for the decoupled UL/DL access(DUDA) mode over the CUDA mode in UDN. The key performance indicators of local delay and energy efficiency(EE) were investigated with respect to SIR threshold, ratio of small cell base station(SBS) and macro cell base station(MBS) densities, and fractional power control(FPC) *** and simulation results confirm that the local delay is lower and the EE is higher under DUDA than under CUDA, and as such the DUDA mode is superior to the CUDA mode for the UL performance of UDN.

关键词： coupled and decoupled UL/DL access HetNets stochastic geometry local delay energy efficiency UDN

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The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1

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Protein & Cell 2012年第5期3卷 372-382页

作者： Shuai Wang Jing Long Chun-fu zheng State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China

Herpes simplex virus type 1(HSV-1)is a common hu-man pathogen causing cold sores and even more se-rious *** can establish a latent stage in sensory ganglia after primary epithelial infections,and reacti-vate in response to stress or *** studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent ***,It has been deter-mined that promyelocytic leukemia(PML)nuclear bod-ies(NBs),small nuclear sub-structures,contribute to the repression of HSV-1 infection in the absence of functional *** this review,we discuss the funda-mentals of the interaction between ICP0 and PML NBs,suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.

关键词： herpes simplex virus type 1(HSV-1) reac-tivation ICP0 promyelocytic leukemia(PML) speckled pro-tein of 100 kDa(Sp100)

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Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 8-24页

作者： Qin fu Chen HE zheng-rong MAO Department of Pathology and Pathophysiology School of Medicine Zhejiang University Hangzhou 310058 China

Epstein-Barr virus(EBV),a human gammaherpesvirus carried by more than 90% of the world's population,is associated with malignant tumors such as Burkitt's lymphoma(BL),Hodgkin lymphoma,post-transplant lymphoma,extra-nodal natural killer/T cell lymphoma,and nasopharyngeal and gastric carcinomas in immune-compromised *** the process of infection,EBV faces challenges:the host cell environment is harsh,and the survival and apoptosis of host cells are precisely *** when host cells receive sufficient survival signals may they *** establish efficiently a lytic or long-term latent infection,EBV must escape the host cell immunologic mechanism and resist host cell apoptosis by interfering with multiple signaling *** review details the apoptotic pathway disrupted by EBV in EBV-infected cells and describes the interactions of EBV gene products with host cellular factors as well as the function of these factors,which decide the fate of the host *** relationships between other EBV-encoded genes and proteins of the B-cell leukemia/lymphoma(Bcl) family are ***,EBV seems to contribute to establishing its own latency and the formation of tumors by modifying events that impact cell survival and proliferation as well as the immune response of the infected *** discuss potential therapeutic drugs to provide a foundation for further studies of tumor pathogenesis aimed at exploiting novel therapeutic strategies for EBV-associated diseases.

关键词： Epstein-Barr virus Bcl family members Apoptosis Drugs therapy

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A unified approach of energy and data cooperation in energy harvesting WSNs

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Science China(Information Sciences) 2018年第8期61卷 170-182页

作者： Roomana YOUSAF Rizwan AHMAD Waqas AHMED fu-chun zheng School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Electrical Engineering Pakistan Institute of Engineering and Applied Sciences School of Electronic and Information Engineering Harbin Institute of Technology

Energy harvesting(EH) provisioned wireless sensor nodes are key enablers to increase network life time in modern wireless sensor networks(WSNs). However, the intermittent nature of the EH process necessitates management of nodes’ limited data and energy buffer capacity. In this paper, a unified mathematical model for a cooperative EHWSN with an opportunistic relay is presented. The energy and data causality constraints are expressed in terms of throughput, available energy, delay and transmission *** finite energy buffers, data buffers and discrete transmission rates(as defined in the standard IEEE 802.15.4) at the nodes, different intuitive online power allocation policies at the relay are *** results show that a policy achieving high throughput is less fair and vice versa. Therefore, a joint rate and power allocation policy(JRPAP) is proposed in this study which provides a better trade off between fairness, throughput and energy over intuitive policies. Based on the JRPAP results, we propose to use data aggregation(DA) to achieve throughput gain at lower buffer sizes. In addition, the notion of energy aggregation(EA) is introduced to achieve throughput gain at higher buffer sizes. Combining both EA and DA further improves the overall throughput at all buffer sizes.

关键词： energy harvesting energy causality data causality energy aggregation data aggregation opportunistic relay

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Argillization mechanics of rock from the Xing’anling Group in the Beier depression of the Hailar basin

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Journal of China University of Mining and Technology 2008年第2期18卷 237-240页

作者： LIU Qin-fu fu zheng YANG Bao-quan College of Resources and Safety Engineering China University of Mining ＆ Technology Beijing 100083 China Research Institute of Oil Production Engineering in Daqing Oilfield Daqing Heilongjiang 163001 China

The reservoir of the Xing'anling Group in the Beier depression of the Hailar basin is loosely cemented with many tuffaceous *** causes argillization and collapse of the grain framework of the reservoir sandstones.A detailed study on the characteristics of rocks and minerals was carried out through polarized microscope,X-ray diffraction,X-ray fluorescence,SEM and energy spectrum *** results indicate that the reason for argillization is the abundant pyroclastic,and especially tuffaceous,grains in the *** alkaline component is relatively high in some *** are easily altered to montmorillonite in ***+montmorillonite swells strongly when exposed to *** is the fundamental reason for the reservoir's argillization and plugging.

关键词： Xing'anling Group clay mineral tuff Na^+-montmorillonite argillization

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Generation and Display System of Measurement Matrix Based on DMD

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Journal of Beijing Institute of Technology 2018年第4期27卷 493-502页

作者： Wenzhao Gu fu zheng Guangjie Zhai National Space Science Center Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China

A measurement matrix is the key to sampling and signal reconstruction during the process of compressed *** the basis of digital light processing(DLP)technology,ageneration and display system of measurement matrix based on digital micro-mirror device(DMD)is proposed and well *** this system,the generation and controlling of measurement matrix are implemented on a PC,which reduces the hardware requirement to generate a random matrix and overcomes the difficulty of the hardware implementation for the random *** can set up the display number of the measurement matrix,the mode of display and display time according to the requirements from *** display information can be designed to complete the display of measurement matrix with a better *** system can be easily embedded into a variety of compressed sensing applications,which can be used to generate and display the corresponding measurement matrice with strong *** addition,the DMD of this system will be used as a spatial optical modulator to manipulate near-infrared light in a fast,accurate and efficient way in several applications such as in 3D scanning devices and spectrometers.

关键词： measurement matrix digital micro-mirror device(DMD) compressed sensing Gaussian random matrix

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Antibiotics management in severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 653-654页

作者： fu-zheng Tao Rong-Lin Jiang Intensive Care Unit Taizhou Integrated Traditional Chinese and Western Medicine HospitalTaizhou 310075China Intensive Care Unit the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006China

Severe acute pancreatitis(SAP)is a common and critical *** is life-threatening at any time if multiple organ dysfunction *** may develop secondary infection,often iatrogenic[1].To treat infected SAP,appropriate antibiotic use and nosocomial management is critical,along with adequate drainage of the infected foci and optimizing the immune *** only is the use of powerful antibiotics necessary to minimize mortality,but early use is also necessary to reduce the occurrence of drug-resistant ***,antibiotic management is clinically important and requires careful attention.

关键词： pancreatitis acute function

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