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Journal of Hydrodynamics 2013年第1期25卷 97-111页

作者： LIU Lubo fu xu-dong WANG Guang-qian Department of Civil and Geomatics Engineering Lyles College of Engineering California State University State Key Laboratory of Hydroscience and Engineering Tsinghua University

To enhance the efficiency of a pathogen forecasting model in the beach areas of southern Lake Michigan and to reduce the computation time, the near-shore current is approximated as a channelized flow parallel to the shorelines in clockwise or anti-clock- wise direction within the accuracy tolerance range. A channelized model with a curvilinear boundary can significantly reduce the computation effort, and at the same time achieve a good agreement between the predicted and measured water surface elevations, currents, and water temperatures. The sensitivity analysis results show that the suitable channel width for the near-shore region of southern Lake Michigan should be no less than 10 kin. The modeling results of the water temperature are much less sensitive to the channel width than those of the current velocity and the water surface elevation. The modeling results also show a close correlation between the speeds of the wind and the near-shore current. The current may fully respond the wind stress with a time lag of several hours. The correlation may provide an approximate estimation of the lake circulation under some wind conditions for a practical fore- casting purpose. More complex wind-current relationships need to be described with a more sophisticated hydrodynamic model. This verified model can be used for the pathogen forecasting in the near-shore regions of southern Lake Michigan in the future.

关键词： near-shore channelized wind hydrodynamic model

Analytical solution for slope instability assessment considering impact of confined aquifer

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Journal of Central South University 2015年第4期22卷 1502-1509页

作者：冉启华钱群王光谦傅旭东苏丹阳 Institute of Hydrology and Water Resources Zhejiang University State Key Laboratory of Hydroscience and Engineering Tsinghua University

An analytical approach was presented for estimating the factor of safety(FS) for slope failure, with consideration of the impact of a confined aquifer. An upward-moving wetting front from the confined water was assumed and the pore water pressure distribution was then estimated and used to obtain the analytical expression of FS. Then, the validation of the theoretical analysis was applied based on an actual case in Hong Kong. It is shown that the presence of a confined aquifer leads to a lower FS value, and the impact rate of hydrostatic pressure on FS increases as the confined water pressure increases, approaching to a maximum value determined by the ratio of water density to saturated soil density. It is also presented that the contribution of hydrostatic pressure and hydrodynamic pressure to the slope stability vary with the confined aquifer pressure.

关键词： confined/artesian groundwater slope stability factor of safety analytical approach

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

斜坡单元支持下区域泥石流危险性AHP-RBF评价模型

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浙江大学学报（工学版） 2018年第9期52卷 1667-1675页

作者：黄启乐陈伟傅旭东武汉大学土木建筑工程学院湖北武汉430072 中国建筑五局投资管理公司湖南长沙410004

通过分析目前区域泥石流危险性评价研究中评价单元、指标体系及其提取方法、评价模型3个关键内容对评价结果的影响,将斜坡单元作为区域泥石流灾害评价的基础评价单元并提出斜坡单元的自动定量划分方法;提出区域泥石流危险性评价的指标体... 详细信息

通过分析目前区域泥石流危险性评价研究中评价单元、指标体系及其提取方法、评价模型3个关键内容对评价结果的影响,将斜坡单元作为区域泥石流灾害评价的基础评价单元并提出斜坡单元的自动定量划分方法;提出区域泥石流危险性评价的指标体系(即斜坡面积、主沟长度、斜坡相对高差、平均坡度、斜坡切割密度、平均主沟坡降、植被覆盖率、地层岩性共8个指标),并通过GIS技术提取指标体系;提出区域泥石流危险性评价的APH-RBF神经网络评价模型.以湖北省神农架林区灾害防治示范区木鱼镇为研究对象,采用已查明的泥石流灾害点的位置资料,验证本模型评价结果的合理性,为示范区的防灾减灾及村镇规划提供参考.

关键词： GIS 区域泥石流灾害危险性评价斜坡单元 AHP-RBF评价模型

石杉碱甲缓释微球的制备及其在大鼠体内的药动学与药效学研究

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中国药学杂志 2005年第19期40卷 1496-1499页

作者：符旭东高永良平其能军事医学科学院毒物药物研究所中国药科大学药剂教研室江苏南京210009

目的制备石杉碱甲聚乳酸-乳酸羟基共聚物微球,并评价其在大鼠体内的缓释效果。方法采用紫外分光光度法测定微球的包封率和载药量,采用透析袋法测定微球体外释放度。通过扫描电镜和显微镜观察微球的外观和表面形态,运用高效液相色谱法测... 详细信息

目的制备石杉碱甲聚乳酸-乳酸羟基共聚物微球,并评价其在大鼠体内的缓释效果。方法采用紫外分光光度法测定微球的包封率和载药量,采用透析袋法测定微球体外释放度。通过扫描电镜和显微镜观察微球的外观和表面形态,运用高效液相色谱法测定血浆浓度,采用微量羟胺法测定大鼠脑内乙酰胆碱酯酶的活性。结果微球外观圆整表面光滑。微球的粒径为63.08μm,跨距为0.73,包封率为78.08%,载药量为3.80%。石杉碱甲微球在体外可缓释21d,主要通过扩散控释机制释药,释药曲线符合Higuchi方程。大鼠肌注2.1mg微球后的最大血药浓度出现在给药后第2天,ρ_(max)为(51.47±4.70)μg·L^(-1),AUC_(0→∞)为326.11μg·d·L^(-1),MRT为8.7d。微球对大鼠皮层、纹状体和海马部位AchE活性的抑制作用可持续至给药后的第14天。石杉碱甲微球对上述3个部位AchE活性的抑制率与血浆浓度之间的关系符合Hill方程,血浓-药效的经时轨迹呈逆时针走向。结论石杉碱甲微球制备工艺简单,重现性好,体内外具有良好的缓释效果。

关键词：石杉碱甲微球聚乳酸-乳酸羟基共聚物体外释放度药动学药效学

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雅鲁藏布江中游古洪水滞流沉积物性质研究

长江流域资源与环境 2023年第5期32卷 1058-1067页

作者：吴帅虎傅旭东安阳师范学院资源环境与旅游学院河南安阳455000 清华大学水沙科学与水利水电工程国家重点实验室北京100084

对在雅鲁藏布江中游河谷鉴别的古洪水滞流沉积物(SWD)、黄土和风沙沉积物进行宏观特征观察和沉积物实验分析(粒度、磁化率和地球化学元素),总结古洪水SWD的沉积学识别标志。结果发现:藏木(ZM)、朗县(LX)和米林剖面(ML)中所夹SWD均呈现... 详细信息

对在雅鲁藏布江中游河谷鉴别的古洪水滞流沉积物(SWD)、黄土和风沙沉积物进行宏观特征观察和沉积物实验分析(粒度、磁化率和地球化学元素),总结古洪水SWD的沉积学识别标志。结果发现:藏木(ZM)、朗县(LX)和米林剖面(ML)中所夹SWD均呈现水平波状层理,结构均匀,为粉砂质细砂质地,其宏观特征与风成堆积物(如黄土和风沙沉积物)明显不同;古洪水SWD、黄土和风沙沉积物的粒度成分均总体较粗,以细砂为主,风沙沉积物的粒径明显更粗,三种沉积物中以古洪水SWD的分选性最好,其次为黄土,其原因在于古洪水SWD是经过水流分选并且在高水位滞流环境下堆积的悬移质沉积物;古洪水SWD的磁化率含量较高,可能与洪水冲刷河谷地表导致SWD的铁磁性矿物含量增高有关;古洪水SWD的粒度特征、常量元素和微量元素含量均与黄土较为接近,与风沙沉积物有较大差别,表明雅鲁藏布江中游峡谷地段古洪水SWD与黄土的物源可能有密切关系。

关键词：雅鲁藏布江古洪水滞流沉积物

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高校突发事件管理的理论误区与对策研究

重庆大学学报（社会科学版） 2009年第3期15卷 103-106页

作者：冯业栋傅旭东重庆大学党委办公室重庆400044 重庆大学期刊社重庆400044

文章以社会学的研究视角,透视了中国高校在突发事件的偶然性、突发事件的边界、应对模式和控制机制等所存在的四个理论误区,分析了产生这些误区的理论和社会根源以及由此给政策制定带来的不良影响,提出了要健全组织机构,制定管理制度,... 详细信息

文章以社会学的研究视角,透视了中国高校在突发事件的偶然性、突发事件的边界、应对模式和控制机制等所存在的四个理论误区,分析了产生这些误区的理论和社会根源以及由此给政策制定带来的不良影响,提出了要健全组织机构,制定管理制度,落实管理责任,完善处置预案,着力抓好突发事件管理的"三个体系"建设。

关键词：高校突发事件风险社会

Numerical verification of similar Cam-clay model based on generalized potential theory

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Journal of Central South University 2014年第12期21卷 4707-4713页

作者：钟志辉杨光华傅旭东温勇张玉成 School of Civil and Architectural Engineering Wuhan University Guangdong Research Institute of Water Resources and Hydropower Geotechnical Engineering Technology Center of Guangdong Province Emergency Technology Research Center of Guangdong Province for Public Events

From the mathematical principles, the generalized potential theory can be employed to create constitutive model of geomaterial directly. The similar Cam-clay model, which is created based on the generalized potential theory, has less assumptions,clearer mathematical basis, and better computational accuracy. Theoretically, it is more scientific than the traditional Cam-clay models. The particle flow code PFC3 D was used to make numerical tests to verify the rationality and practicality of the similar Cam-clay model. The verification process was as follows: 1) creating the soil sample for numerical test in PFC3 D, and then simulating the conventional triaxial compression test, isotropic compression test, and isotropic unloading test by PFC3D; 2)determining the parameters of the similar Cam-clay model from the results of above tests; 3) predicting the sample's behavior in triaxial tests under different stress paths by the similar Cam-clay model, and comparing the predicting results with predictions by the Cam-clay model and the modified Cam-clay model. The analysis results show that the similar Cam-clay model has relatively high prediction accuracy, as well as good practical value.

关键词： generalized potential theory similar Cam-clay model modified Cam-clay model numerical test PFC3D

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降雨和蒸发对土质边坡稳定性的影响

岩土力学 2006年第5期27卷 778-781,786页

作者：魏宁茜平一傅旭东武汉大学土木与建筑工程学院武汉430072 广东水利水电学院广州510635

降雨入渗降低边坡的稳定性,蒸发增加边坡的稳定性,降雨和蒸发对边坡稳定性的定量研究是很有意义的。采用蒸发和降雨模型对边坡进行非饱和-非稳定渗流分析,用总凝聚力表示的Bishop极限平衡法计算边坡安全系数。采用数值方法对算例土质边... 详细信息

降雨入渗降低边坡的稳定性,蒸发增加边坡的稳定性,降雨和蒸发对边坡稳定性的定量研究是很有意义的。采用蒸发和降雨模型对边坡进行非饱和-非稳定渗流分析,用总凝聚力表示的Bishop极限平衡法计算边坡安全系数。采用数值方法对算例土质边坡进行了研究,得到了孔隙水压力随时间变化的关系、边坡安全系数随时间变化的关系。结果显示:土体中孔隙水压力与天气条件、边坡安全系数与天气条件之间存在滞后关系;降雨和蒸发对边坡的表层滑动稳定性影响非常大,对深层滑动稳定性影响相对较小;降雨过程中边坡的临界滑动面由较深位置向较浅位置转变,蒸发过程则相反。

关键词：非饱和土非饱和-非稳定渗流边坡稳定降雨和蒸发有限单元法

盐酸奈必洛尔-羟丙基-β-环糊精包合物的制备及表征

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中国新药杂志 2018年第8期27卷 954-959页

作者：周云符旭东毕诗涛中国人民解放军武汉总医院药剂科武汉430070 湖北中医药大学药学院武汉430065

目的:制备盐酸奈必洛尔-羟丙基-β-环糊精(hydroxypropyl-β-cyclodextrin,HP-β-CD)包合物,同时考察HP-β-CD提高盐酸奈必洛尔溶解度的效果。方法:应用溶液搅拌-冷冻干燥法制备包合物,采用L9(34)正交设计,以盐酸奈必洛尔与羟丙基-β-... 详细信息

目的:制备盐酸奈必洛尔-羟丙基-β-环糊精(hydroxypropyl-β-cyclodextrin,HP-β-CD)包合物,同时考察HP-β-CD提高盐酸奈必洛尔溶解度的效果。方法:应用溶液搅拌-冷冻干燥法制备包合物,采用L9(34)正交设计,以盐酸奈必洛尔与羟丙基-β-环糊精投料比(摩尔比)、包合温度、包合时间、乙醇浓度为因素,以包封率为指标筛选最佳工艺;通过相溶解度法、红外分光光度法和X-射线粉末衍射法对包合物进行验证;以高效液相色谱法(HPLC)测定包合物的包封率和溶解度。结果:最佳包合工艺为盐酸奈必洛尔与羟丙基-β-环糊精投料比(摩尔比)为1∶1,包合温度40℃,包合时间4 h,乙醇浓度80%(V/V);验证实验表明,盐酸奈必洛尔-羟丙基-β-环糊精包合物形成,相溶解度图呈AL型,物理混合物图谱与包合物图谱存在显著差别;以最佳工艺制备包合物,HPLC法测定其包封率达(73.69±0.10)%,药物经包合后在纯化水和p H 6.8磷酸盐缓冲液中的溶解度分别增大了3.18和11.10倍。结论:溶液搅拌-冷冻干燥法制备包合物方法合理可行,改善了药物的溶解性能。

关键词：盐酸奈必洛尔羟丙基-β-环糊精环糊精包合结构验证溶解度