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Analysis of the stress ratio of anisotropic rocks in uniaxial tests

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International Journal of Mining Science and Technology 2017年第3期27卷 531-535页

作者： Wang Miaomiao Li Pei Wu Xiaowa xu dan Key Laboratory of Shale Gas and Geoengineering Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China

The effect of structural discontinuities on the progressive failure process of anisotropic rocks should be paid particular *** crack damage stress σ_(cd),also considered as the yield strength,and the relationship between σ_(cd) and the uniaxial peak strength σ_(ucs) of anisotropic rocks for different orientations 8 of the isotropy planes with respect to the loading directions were investigated theoretically and experimentally.A theoretical relation of σ_(cd)/σ_(ucs) with the function of the shape parameter m was ***,uniaxial compression tests of shale samples were conducted for several inclinations θ.The test result of σ_(cd)/σ_(ucs) was close to the theoretical value for a given ***,both experimental results and theoretical solutions of σ_(cd)/σ_(ucs) were independent of the inclination θ while σ_(cd) andσ_(ucs) were strongly affected by θ.The strength ratio σ_(cd)/σ_(ucs) may therefore be an intrinsic property of anisotropic rocks and could be used to predict the failure of rock samples.

关键词： Anisotropic rocks Uniaxial compression test Brittle failure Crack damage stress Stress ratio

In situ FTIR Investigation of Magnetic Field Effect on Heterogeneous Photocatalytic Degradation of Benzene over Pt/TiO_(2)

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Chinese Chemical Letters 2005年第9期16卷 1275-1278页

作者： Wen ZHANG xu xu WANG Xian Zhi fu College of Chemistry ＆ Material Science Fujian Normal University Fuzhou 350007 Research Institute of Photocatalysis College of Chemistry ＆ Chemical Engineering Fuzhou University Fuzhou 350002

In situ FTIR spectroscopy was utilized to investigate the magnetic field effect on the heterogeneous photocatalytic degradation of benzene over platinized titania （Pt/TiO2）. The results revealed that the employment of magnetic field may not change the mechanism of photocatalytic degradation of benzene, however, it greatly facilitate the conversion of benzene to phenol and quinone, as well as the transformation from phenol to quinone, resulting in opening the benzene ring easily and promoting the production of CO2.

关键词： In situ FTIR magnetic field effect photocatalytic degradation Pt/TiO2

Chondroitin sulfate-mediated albumin corona nanoparticles for the treatment of breast cancer

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Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 508-518页

作者： Tiantian Tan Qin Yang dan Chen Juan Zhao Ling Xiang Jiaxing Feng xu Song Yao fu Tao Gong Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu610064China School of Pharmacy North Sichuan Medical CollegeNanchong 637100China Departments of Pharmacy Mianyang Hospital of Traditional Chinese MedicineMianyang 621000China

Chondroitin sulfate-mediated albumin corona nanoparticles were readily prepared without any chemical reaction,and their active tumor targeting and therapeutic effects were *** charged chondroitin sulfate(CS)and positively charged doxorubicin(DOX)self-assembled into nanoparticles(CS-DOX-NPs)via electrostatic *** serum albumin(BSA)was then adsorbed on the surface of CS-DOX-NPs to form albumin corona nanoparticles(BC-DOX-NPs)protected from endogenous *** to the dual effect of BSA and CS,BC-DOX-NPs interacted with the gp60,SPARC and CD44 receptors on tumor cells,facilitating their rapid and efficient transcytosis and improving their accumulation and uptake within tumor *** simultaneous presence of BSA and CS also allowed BC-DOX-NPs to target CD44 efficiently,leading to greater cellular uptake and cytotoxicity against 4 T1 cells than CS-DOX-NPs or free *** injection of BCDOX-NPs into orthotopic 4 T1 tumor-bearing mice led to greater drug accumulation at the tumor site than with CS-DOX-NPs or free DOX,resulting in significant inhibition of tumor growth and lower exposure of major organs to the drug.

关键词： Chondroitin sulfate Bovine serum albumin Self-assembly Doxorubicin Cancer therapy

Adsorption and Desorption Characteristics of Cadmium Ion by Ash-Free Biochars

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Journal of Renewable Materials 2020年第7期8卷 801-818页

作者： Li fu Xianying xu Guiquan fu Renduo Zhang Hujun Liu College of Forestry Gansu Agricultural UniversityLanzhou730070China State Key Laboratory Breeding Base of Desertification and Aeolian Sand Disaster Combating Gansu Desert Control Research InstituteLanzhou730070China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Sun Yat-sen UniversityGuangzhou510006China

The aim of this study was to investigate adsorption and desorption characteristics of cadmium ion(Cd(II))by ash-free biochars and the adsorption *** were prepared using peanut shell,bamboo,and Sophora japonica ***-free biochars were obtained by treating the biochars with acid *** and desorption data from batch experiments were analyzed using the Langmuir and Freundlich models and three adsorption kinetics models(i.e.,the Pseudo second-order,Elovich model,and the Intraparticle diffusion models).Results showed that the acid elution improved the pore structure of biochars,increased C content and aromatic functional group content,enhanced biochars hydrophobicity and adsorption capacity for Cd(II).Ash-free peanut shell biochar showed the best Cd(II)adsorption performance among the *** of ash-free peanut shell biochar reached the equilibrium within 6 h with adsorption capacity of 34.2 mg/*** adsorption conditions were optimized by orthogonal *** Cd(II)removal efficiency achieved 91.7%with the optimized condition:initial concentration of Cd(II)of 50 mg/L,pH of 5,adsorption time of 12 h,and temperature of 15°*** adsorption of Cd(II)by the six biochars was best described with the Langmuir model,indicating that the adsorption was a physical-chemical composite *** desorption isotherm showed the hysteresis between adsorption and *** main mechanism of Cd(II)adsorption of the ash-free biochars was a complex interaction of physical and chemical reactions,mainly including electrostatic adsorption,cationic-π,and ligand exchange.

关键词： Ash-free biochars Cd(II) adsorption desorption

Simulation of wind-driven circulation and temperature in the near-shore region of southern Lake Michigan by using a channelized model

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Journal of Hydrodynamics 2013年第1期25卷 97-111页

作者： LIU Lubo fu xu-dong WANG Guang-qian Department of Civil and Geomatics Engineering Lyles College of Engineering California State University State Key Laboratory of Hydroscience and Engineering Tsinghua University

To enhance the efficiency of a pathogen forecasting model in the beach areas of southern Lake Michigan and to reduce the computation time, the near-shore current is approximated as a channelized flow parallel to the shorelines in clockwise or anti-clock- wise direction within the accuracy tolerance range. A channelized model with a curvilinear boundary can significantly reduce the computation effort, and at the same time achieve a good agreement between the predicted and measured water surface elevations, currents, and water temperatures. The sensitivity analysis results show that the suitable channel width for the near-shore region of southern Lake Michigan should be no less than 10 kin. The modeling results of the water temperature are much less sensitive to the channel width than those of the current velocity and the water surface elevation. The modeling results also show a close correlation between the speeds of the wind and the near-shore current. The current may fully respond the wind stress with a time lag of several hours. The correlation may provide an approximate estimation of the lake circulation under some wind conditions for a practical fore- casting purpose. More complex wind-current relationships need to be described with a more sophisticated hydrodynamic model. This verified model can be used for the pathogen forecasting in the near-shore regions of southern Lake Michigan in the future.

关键词： near-shore channelized wind hydrodynamic model

Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays

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Genomics, Proteomics & Bioinformatics 2018年第6期16卷 416-427页

作者： Wenfang Zhou Mojie Duan Weitao fu Jinping Pang Qin Tang Huiyong Sun Lei xu Shan Chang dan Li Tingjun Hou College of Pharmaceutical Sciences Zhejiang University State Key Laboratory of Computer Aided Design and Computer Graphics (CAD&GC) Zhejiang University State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsChinese Academy of Sciences Institute of Bioinformatics and Medical Engineering School of Electrical and Information EngineeringJiangsu University of Technology

Androgen receptor(AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the conformational changes in AR that may affect the recruitment of coactivators and downstream response of AR signaling ***, AR ligands have great potential to treat these diseases. In this study, we searched for novel AR ligands by performing a docking-based virtual screening(VS) on the basis of the crystal structure of the AR ligand binding domain(LBD) in complex with its agonist. A total of 58 structurally diverse compounds were selected and subjected to LBD affinity assay, with five of them(HBP1-3, HBP1-17, HBP1-38, HBP1-51, and HBP1-58) exhibiting strong binding to AR-LBD. The IC50 values of HBP1-51 and HBP1-58 are 3.96 m M and 4.92 m M, respectively, which are even lower than that of enzalutamide(Enz, IC50= 13.87 m M), a marketed second-generation AR antagonist. further bioactivity assays suggest that HBP1-51 is an AR agonist, whereas HBP1-58 is an AR antagonist. In addition, molecular dynamics(MD) simulations and principal components analysis(PCA) were carried out to reveal the binding principle of the newlyidentified AR ligands toward AR. Our modeling results indicate that the conformational changes of helix 12 induced by the bindings of antagonist and agonist are visibly different. In summary,the current study provides a highly efficient way to discover novel AR ligands, which could serve as the starting point for development of new therapeutics for AR-related diseases.

关键词： Androgen receptor AR ligand Virtual screening AR agonist AR antagonist

Manipulating Single-Photon Transport Properties in an Asymmetrical Waveguide Coupled to a Whispering-Gallery Resonator Containing a Two-Level Atom

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Chinese Physics Letters 2014年第4期31卷 9-12页

作者： ZHOU Tao ZANG Xiao-Fei xu dan-Hua School of Mathematics and Physics Shanghai University of Electric Shanghai 200090 Engineering Research Center of Optical Instrument and System (Ministry of Education) and Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology Shanghai 200093

A hybrid system containing an asymmetrical waveguide coupled to a whispering-gallery resonator embedded with a two-level atom is designed to investigate single-photon transport properties. The transmission and reflection amplitudes are obtained via the discrete coordinates approach. Numerical simula, tion demonstrates that a tri- frequency photon attenuator is realized by controlling the couplings between the asymmetrical waveguide and the whispering-gallery resonator. The phase shift, group delay and dissipation effects of the transmitted single-photon are also discussed.

关键词： PHOTON transport theory WAVEGUIDES RESONATORS ENERGY dissipation ELECTROMAGNETISM

Recent progress in thin film fluorescent probe for organic amine vapour

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Science China Chemistry 2016年第1期59卷 3-15页

作者： Yanyan fu Wei xu Qingguo He Jiangong Cheng State Key Lab of Transducer Technology

There are great needs for real-time detection of volatile organic amines(VOA)through low-cost detection methods in public health,food safety,and environmental monitoring *** thin-film fluorescent probe(OTFFP)is expected to become a new and efficient means of detecting VOA because of its fast response,high sensitivity,no contamination to the analyte and ease to prepare a portable *** with the mature detection methods in solution,research on solid fluorescence sensing has been less *** this article,we review recent progress in OTFFP research for VOA *** mainly focus on the new fluorescent sensing mechanisms applied in solid state in recent years and the design principle of probes for different types of organic amines(such as primary amine,secondary amine,tertiary amine and aromatic amine).We also review the material structures of these probes and the strategies to enhance their sensitivity or selectivity.

关键词： fluorescence volatile amine thin-film probe

The Linkage between Two Types of El Ni?o Events and Summer Streamflow over the Yellow and Yangtze River Basins

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Advances in Atmospheric Sciences 2020年第2期37卷 160-172页

作者： dan WANG Aihui WANG Lianlian xu Xianghui KONG Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100029China

It is generally agreed that El Nino can be classified into East Pacific(EP)and Central Pacific(CP)***,little is known about the relationship between these two types of El Ni?o and land surface climate *** study investigates the linkage between EP/CP El Ni?o and summer streamflow over the Yellow and Yangtze River basins and their possible *** the Yellow River basin,the anomalous streamflow always manifests as positive(negative)in EP(CP)years,with a correlation coefficient of 0.39(-0.37);while over the Yangtze River basin,the anomalous streamflow shows as positive in both EP and CP years,with correlation coefficients of 0.72 and 0.48,*** of the surface hydrological cycle indicate that the streamflow is more influenced by local evapotranspiration(ET)than precipitation over the Yellow River basin,while it is dominantly affected by precipitation over the Yangtze River *** different features over these two river basins can be explained by the anomalous atmospheric circulation,which is cyclonic(anticyclonic)north(south)of 30°N over East *** years are dominated by two anticyclones,which bring strong water vapor convergence and induce more precipitation but less ET,and subsequently increase streamflow and flooding *** CP years,especially over the Yellow River basin,two cyclones dominate and lead to water vapor divergence and reduce moisture ***,the ET enhances mainly due to local high surface air temperature,which further evaporates water from the *** a result,the streamflow decreases,which will then increase the drought risk.

关键词： summer streamflow EP El Nino CP El Nino Yellow River basin Yangtze River basin