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Reciprocal interactions between gut microbiota and autophagy

World Journal of Gastroenterology 2021年第48期27卷 8283-8301页

作者： Pierre Lapaquette Jean-Baptiste Bizeau Niyazi Acar Marie-Agnès Bringer UMR PAM A 02.102 University Bourgogne Franche-ComtéAgrosup DijonDijon 21000France Eye and Nutrition Research Group Centre des Sciences du Goût et de l'AlimentationAgroSup DijonCNRSINRAEUniversitéBourgogne Franche-ComtéDijon 21000France

A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution,forming an interkingdom *** gut offers a favorable ecological niche for microbial communities,with the whole body and external factors(e.g.,diet or medications)contributing to modulating this ***,the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other ***,failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or *** microbial and host processes are devoted to facing up the stress that could alter the symbiosis,ensuring the resilience of the *** these processes,autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and *** cytoprotective mechanism,which is ubiquitous and operates at basal level in all tissues,can be rapidly down-or upregulated at the transcriptional,post-transcriptional,or post-translational levels,to respond to various stress *** of its sensitivity to all,metabolic-,immune-,and microbial-derived stimuli,autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host *** this review,we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral ***,we describe the autophagy-related mechanisms affecting the gut *** conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota.

关键词： Gut microbiota Autophagy Probiotic Brain Liver Muscle

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小儿双动脉瓣下室间隔缺损的外科治疗

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上海医学 1993年第3期16卷 139-141页

作者：缪维洲谢亚藩张建新上海市儿童医院胸心外科

本文报道我院1986～1990年双动脉瓣下室间隔缺损重4例,占同期室缺修补术的21%。双动脉瓣下室缺常伴主动脉右冠瓣脱垂(15例),主动脉瓣关闭不全(4例),肺动脉高压症(23例)。因此,一俟确诊应早期手术。经肺动脉根部切口修补室缺。有主动脉... 详细信息

本文报道我院1986～1990年双动脉瓣下室间隔缺损重4例,占同期室缺修补术的21%。双动脉瓣下室缺常伴主动脉右冠瓣脱垂(15例),主动脉瓣关闭不全(4例),肺动脉高压症(23例)。因此,一俟确诊应早期手术。经肺动脉根部切口修补室缺。有主动脉闭锁不全者,行主动脉瓣折叠悬吊术。术后随访,有1例主闭需再次手术替换主动脉瓣,其余病例经多普勒超声随访,均未见主动脉瓣病变和残余漏。作者还就病理、手术方法作了详细讨论,指出5岁以前关闭缺损可防止主动脉关闭不全的发生。

关键词：室间隔缺损外科手术儿童

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Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer?

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Oncology and Translational Medicine 2017年第4期3卷 156-159页

作者： Jianfei Zhu Jinyan Yuan Yawei Dou Wei Tian shudong Li Hongtao Wang Zhe Li Department of thoracic s.rgery Shannxi Provincial People's Hospital Department of thoracic s.rgery Yanan University Affiliated Hospital

Objective Previous studies have proven that cumulative smoking dose predicts the prevalence of epidermal growth factor receptor(EGFR) mutations. The aim of this study was to investigate the relationship between smoking-related factors and EGFR mutation status. Methods samples were collected from 195 smokers with non-small cell lung cancer(NsCLC) who underwent surgical resection and the presence of EGFR mutations(exons 19 and 21) were determined by real-time polymerase chain reaction(RT-PCR).Results EGFR gene mutations were present in 33(16.9%) patients who were smokers; the patients were divided into three groups according to the smoking index(sI). The incidence of EGFR mutations decreased from 38.9% in mild smokers to 8.1% in severe smokers(P = 0.001). Compared to daily smoking dose(P = 0.547), initial smoking age(P = 0.085) and duration of smoking history had a larger effect on EGFR mutation status(P = 0.002).Conclusion Although there is a decrease in the incidence of mutations with increasing sI, there were still around 17% of smokers with NsCLC that harbored EGFR mutations, so it is necessary to test for EGFR mutation status in smokers with NsCLC.

关键词： epidermal growth factor receptor (EGFR) mutation smoking non-small cell lung cancer (NsCLC)

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A Novel Approach to Multiphase Flow Metering using PIV and Tracer Dilution

A Novel Approach to Multiphase Flow Metering using PIV and T...

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The 9th International Conference on Measurement and Control of Granular Materials,(MCGM’2011)(Global High Level Academic seminar)

作者： Charles Adam Uleh Ian french Nigeria LNG Ltd Bonny IslandNigeria Teesside University Borough RoadMiddlesbroughUnited Kingdom

This paper introduces a prototype multiphase flow metering system, named "Uletech", for multiphase flow measurement. The "Uletech" Multiphase Flow Meter (UMFM) is based on the combination of particle recognition and the use of Laser Imaging Technology in the form of Particle Imaging Velocimetry (PIV). PIV uses tracer particles which follow the gas or liquid phase. The high resolution digital laser cameras identify/recognize all the different sizes of particle (gas, oil and water) in a multiphase flow. The cameras have sufficiently high resolutions (pixel size) to "see" the tracer particles. The prevailing conditions of high pressure and temperature of the flow regimes makes actual measurement a great challenge. The velocity differences between phases (hold up and slip) means unless the velocities of individual phases and concentrations are known, the true flow rate is practically impossible to obtain. The system comprised of two cameras, laser source, optical arrangement, computer data acquisition system, synchronizer and MATLAB based software. An algorithm that correlates the camera’s view to the volume within the pipe has been developed through this research. The computer acquires image signals from the upstream and/or downstream cameras, and carries out the calculation of cross correlation between the two image frames so that the velocity of each pixel can be found. A Gas Liquid Chromatograph (GLC) provides the composition (concentration) of the gas and the liquid hydrocarbon (HC). The product of phase velocity and phase concentration provides the flow rate of the individual phase. This work provides theoretical analysis and experimental validations, and discusses the advantages of the system and its further development.

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非小细胞肺癌分子病理检测临床实践指南(2024版)

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中华病理学杂志 2024年第10期53卷 981-995页

作者：国家病理质控中心中华医学会病理学分会中华医学会肿瘤学分会肺癌学组中国抗癌协会肺癌专业委员会中国胸部肿瘤研究协助组师晓华应建明梁智勇吴一龙陆舜不详中国医学科学院北京协和医学院北京协和医院病理科北京100730 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院病理科北京100021 广东省人民医院肿瘤内科广东省肺癌研究所广州510080 上海市胸科医院上海交通大学附属胸科医院肿瘤科上海200030

非小细胞肺癌(non-small cell lung cancer,NsCLC)精准治疗显著提高了患者疗效,包括靶向治疗及免疫治疗,其前提是精准的分子分型。选择准确、快速、恰当的检测方法,全面筛选出适用靶向和免疫药物的目标人群具有重要临床意义。随着临床... 详细信息

非小细胞肺癌(non-small cell lung cancer,NsCLC)精准治疗显著提高了患者疗效,包括靶向治疗及免疫治疗,其前提是精准的分子分型。选择准确、快速、恰当的检测方法,全面筛选出适用靶向和免疫药物的目标人群具有重要临床意义。随着临床对分子病理检测内涵需求的不断增加,尤其是我国临床实践数据的不断积累、新型治疗药物及适用人群的扩展,亟待对NsCLC分子病理检测的实践指导内容进行更新。本指南在原有内容的基础上更新了分子病理检测人群的范围,增加了表皮生长因子受体(EGFR)外显子20插入突变作为靶向治疗必检位点,增加了RET、BRAF及NTRK基因变异作为必检基因变异,优化了检测策略。同时,本指南更加注重依据循证医学证据,对推荐意见证据质量级别及推荐意见级别进行了分级,以供使用者参考。本指南为全面准确的NsCLC分子病理检测提供指导。

关键词：分子病理检测临床实践指南非小细胞肺癌精准治疗靶向治疗推荐意见基因变异检测策略

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Gold and Base Metals Associated with Uranium Mineralization in some Lower Carboniferous Rock Units in the Wadi Abu El Mogheirat Area, southwestern sinai, Egypt

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Acta Geologica sinica(English Edition) 2021年第6期95卷 2087-2099页

作者： Osama R.sALLAM Abdalla s.ALsHAMI Abd Elhadi A.ABBAs E.GUIBAL Nuclear Materials Authority CairoEgypt Institut Mines Telecom-Mines Ales Centre des Materiaux des Mines d’AlesUniversityMontpellierFrance

The Lower Carboniferous sediments at Wadi Abu El Mogheirat consist of four stratigraphic formations, from base upwards: Um Bogma, El Hashash, Magharet El Maiah and Abu Zarab formations. The most-concentrated radioactive anomalies at Wadi Abu El Mogheirat are in the middle member of the Um Bogma Formation. The gibbsitic marl in this formation shows the highest uranium contents(around 710 ppm). Gibbsitic marl and black gibbsite of the middle Um Bogma Formation show higher enrichment in Co, Cu, Mn, Ni, Pb, Zn, U, V, Ce and Th. Black gibbsite contains the highest total rare earth elements concentration, especially in terms of LREEs, while gibbsitic marl contains the highest content of HREEs. Anomalous contents of gold at Wadi Abu El Mogheirat are recorded for the first time in the gibbsitic marl(content: 10.4 ppm), black gibbsite(2.8 ppm) of the middle member of the Um Bogma Formation and in the siltstones of the El Hashash Formation(0.6 ppm). Gibbsitic marl shows the presence of uranothorite, celestite, zircon, atacamite, barite, xenotime and rutile. These characteristic demonstrate that the middle member of the Um Bogma Formation constitutes a potential source for gold. This conclusion is reinforced by the potential to exploit other metals such as Co, Cu, Mn, Ni, Pb, Zn, U, V, Th and Ce as by-products.

关键词： gibbsite rare earth elements Um Bogma

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Molecular phylogeny of Pneumocystis based on 5.8s rRNA gene and the internal transcribed spacers of rRNA gene sequences

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science China(Life sciences) 2008年第5期51卷 445-452页

作者： LI ZiHui1,2, FENG XianMin1, LU siQi1, ZHANG Fan1, WANG FengYun1 & HUANG song1 1 Department of Pathogenic Biology, Capital Medical University, Beijing 100069, China 2 Beijing Tuberculosis and thoracic Tumor Research Institute, Beijing 101100, China Department of Pathogenic Biology Capital Medical University Beijing China Beijing Tuberculosis and thoracic Tumor Research Institute Beijing China

To clarify the phylogenetic relationships and species status of Pneumocystis, the 5.8s rRNA gene and the internal transcribed spacers (ITs, 1 and 2) of Pneumocystis rRNA derived from rat, gerbil and human were amplified, cloned and sequenced. The genetic distance matrix of six Pneumocystis species compared with other fungi like Taphrina and saccharomyces indicated that the Pneumocystis genus contained multiple species including Pneumocystis from gerbil. The phylogenetic tree also showed that Pneumocystis from human and monkey formed one group and four rodent Pneumocystis formed another group. Among the four members, Pneumocystis wakefieldiae was most closely related to Pneumocystis murina and Pneumocystis carinii, and was least related to gerbil Pneumocystis.

关键词： Pneumocystis phylogeny 5.8s rRNA gene internal transcribed spacers

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screening primary racemic amines for enantioseparation by derivatized polysaccharide and cyclofructan columns

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Journal of Pharmaceutical Analysis 2016年第6期6卷 345-355页

作者： Yeeun Lim Zachary s.Breitbach Daniel W.Armstrong Alain Berthod Department of Chemistry University of Texas at ArlingtonPlanetarium Place Institut des sciences Analytiques CNRSUniversité de Lyon

It is a challenge to separate the enantiomers of native chiral amines prone to deleterious silanol interactions. Aset of 39 underivatized chiral primary amines was screened for enantiomeric separation. seven recentlyintroduced commercial chiral columns were tested. They included six polysaccharide based chiral stationaryphases (CsP) with bonded derivatives, ChiralPak? IA, IB, IC, ID, IE and IF columns and a cyclofructanderivatized CsP, Larihc? CF6-P column. Both the normal phase (NP) mode with heptane/alcohol mobile phasesand the polar organic (PO) mode with acetonitrile/alcohol were evaluated. It was found that the cyclofructanbased CsP demonstrated the highest success rate in separating primary amines in the PO mode with only onechiral amine not resolved. It is shown that, when screening the columns, there is no standard optimal condition;an excellent mobile phase composition for one column may be poorly suited to another one. Althoughbutylamine was a good mobile phase additive for the polysaccharide columns in both PO and NP modes, it wasdetrimental to the enantio-recognition capability of the cyclofructan column. Triethylamine was the appropriatesilanol screening agent for this latter column.

关键词： Chiral primary amines Cyclofructan Bonded polysaccharide Enantiomeric separation

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Pulmonary Hypertension Reaction with protamine Reversal of Heparin ’ s Anticoagulant Effect

Pulmonary Hypertension Reaction with protamine Reversal of H...

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The Fifth China International Congress on thoracic and cardiovasculal s.rgery

作者： Wu Junfeng Department of Cardiac and thoracic s.rgery Pan Yun People Hospital. Gang Dong. China.

＜正＞ Objective:After cardiopulmonary bypass（CPB）,protamine reversal of heparin’s anticoagulanteffect can produce some hemodynanic changes such as pulmonary arterial pressure increased,centralvenous pressure increased and systemic arterial pressure *** purpose of the present studywas to investigate pulmonary hypertension reaction with protamine reversal of heparin’s anticoagulanteffect after CPB on patients of congenital heart disease with serious pulmonary hypertension（sPH）.

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试钛灵在矿物微量化学分析中的应用

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地球与环境 1976年第4期 28-31页

作者： W.J.french s.J.Adams 李小舫

Hey 指出用大约1毫克试样进行矿物化学分析应该是可能的。最近,我们尝试从岩石薄片上切割一些颗粒来进行分析,以测定元素的范围,取用矿物总量不超过1毫克。我们认为,如果能用一份溶液来操作,对建立这一所需方法是比较理想的。

关键词：克分子浓度络合物醋酸盐摩尔浓度配位化合物乙酸盐矿物光密度摄影密度溶液浓度岩石样品岩样氢氟酸氟化物

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