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新植物保护剂研究和开发中的化学动力学

农药译丛 1992年第5期14卷 1-5页

作者： A.Steinemann E.Stamm b.frei 中民瑞士Oiba-Geigy公司农业部

化学动力学是一门主要与在环境中的化合物的活动和归宿有关的交叉学科的科学.从施用的地点开始到最终受体的位置之间有关的有蒸发、光解和许多其他因子等影响着有效成份的生物利用率.由于环境意识的提高,因此却增加了新植物保护剂的生... 详细信息

化学动力学是一门主要与在环境中的化合物的活动和归宿有关的交叉学科的科学.从施用的地点开始到最终受体的位置之间有关的有蒸发、光解和许多其他因子等影响着有效成份的生物利用率.由于环境意识的提高,因此却增加了新植物保护剂的生产成本,所以尽量减少使活性丧失的因子的影响就显得比以往更为重要.因此在新的和更有效的植物保护剂的研究探索中,弄清楚新化合物的物理化学参数、转化过程和转移因子以及它们与化学结构和生物活性的关系的研究就显得十分重要.

关键词：植物保护剂化学动力学

bcl-2 over-expression inhibits pentachlorophenol metabolite-induced apoptosis in NIH3T3 cells: a possible mechanism for tumor promotion

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Bcl-2 over-expression inhibits pentachlorophenol metabolite-...

铁螯合作用通过抑制p22(phox)蛋白表达和NADPH氧化酶活性抑制核因子κb介导的粘附分子的表达

The 5th Congress of Toxicology in Developing Countries

作者： b.-Z. Zhu Y-P. Lin M.-C. Yang b. frei M.-H. Pan J.-K. Lin Y.-J. Wang Linus Pauling Institute Oregon State University. Comillis OR 97331-6512 USA College of Medicine National Cheng Kung University Tainan Taiwan ROC College of Medicine National Cheng Kung University Tainan Taiwan ROC Linus Pauling Institute Oregon State University. Comillis OR 97331-6512 USA College of Medicine National Taiwan University Taipei Taiwan ROC College of Medicine National Taiwan University Taipei Taiwan ROC College of Medicine National Cheng Kung University Tainan Taiwan ROC

＜正＞ Tetrachlorohydroquinone （TCHQ） is a major metabolite of the widely used wood preservative pentuchlorophenol （PCP）. Recenlly, we found that TCHQ was a promoter in a mouse skin carcinogenesis model. However, the mechanism is still not clear. In this study, we showed that over-expression of bcl-2 effectively suppresses TCHQ-induced apoptosis in NIH3T3 cells, as evideuced by mot-

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中国动脉硬化杂志 2007年第4期 317-317页

作者： Li L frei b 曹冬黎

An Update on Abscisic Acid Signaling in Plants and More

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Molecular Plant 2008年第2期1卷 198-217页

作者： Aleksandra Wasilewsk.a Florina Vlad Caroline Sirichandra Yulia Redko Fabien Jammes Christiane Valon Nicolas frei dit Frey Jeffrey Leung Institut des Sciences du Vegetal Centre National de la Recherche Scientifique UPR 23551 Avenue de la Terrasse Bat. 23 91190 Gif-sur-Yvette France CNRS UPR9073 Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratoire Signalisation et Regulation Coordonnee du Metabolisme Carbone et Azote Institut de Biotechnologie des Plantes (UMR8618) Universite Paris-Sud F-91405 Orsay Cedex France

The mode of abscisic acid （AbA） action, and its relations to drought adaptive responses in particular, has been a captivating area of plant hormone research for much over a decade. The hormone triggers stomatal closure to limit water loss through transpiration, as well as mobilizes a battery of genes that presumably serve to protect the cells from the ensuing oxidative damage in prolonged stress. The signaling network orchestrating these various responses is, however, highly complex. This review summarizes several significant advances made within the last few years. The biosynthetic pathway of the hormone is now almost completely elucidated, with the latest identification of the AbA4 gene encoding a neoxanthin synthase, which seems essential for de novo AbA biosynthesis during water stress. This leads to the interesting question on how AbA is then delivered to perception sites. In this respect, regulated transport has attracted renewed focus by the unexpected finding of a shoot-to-root translocation of AbA during drought response, and at the cellular level, by the identification of a b-galactosidase that releases biologically active AbA from inactive AbA-glucose ester. Surprising candidate AbA receptors were also identified in the form of the Flowering Time Control Protein A （FCA） and the Chloroplastic Magnesium Protoporphyrin-IX Chelatase H subunit （CHLH） in chloroplast-nucleus communication, both of which have been shown to bind AbA in vitro. On the other hand, the protein（s） corresponding to the physiologically detectable cell-surface AbA receptor（s） is （are） still not known with certainty. Genetic and physiological studies based on the guard cell have reinforced the central importance of reversible phosphorylation in modulating rapid AbA responses. Sucrose Non-Fermenting Related Kinases （SnRK）, Calcium-Dependent Protein Kinases （CDPK）, Protein Phosphatases （PP） of the 2C and 2A classes figure as prominent regulators in this single-cell model. Identifying their d

关键词： Abscisic Acid Signaling Plants and More

New Strigolactone Analogs as Plant Hormones with Low Activities in the Rhizosphere

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Molecular Plant 2014年第4期7卷 675-690页

作者： Francois-Didier boyer Alexandre de Saint Germain Jean-bernard Pouvreau Guillaume Clave Jean-Paul Pillot Amelie Roux Amanda Rasmussen Stephen Depuydt Dominique Lauresserguesh Nicolas frei dit Frey Thomas S.A. Heugebaert Christian V. Stevens Danny Geelen Sofie Goormachtig Catherine Rameau Institut Jean-Pierre bourgin UMR1318 Institut National de la Recherche Agronomique (INRA)-AgroParisTech Route de Saint-Cyr (RD 10) F-78026 Versailles Cedex France Centre de Recherche de Gif Institut de Chimie des Substances Naturelles UPR2301 Centre National de la Recherche Scientifique (CNRS) 1 avenue de la Terrasse F-91198 Gif-sur-Yvette Cedex France Laboratoire de biologie et de Pathologie Vegetales EA 1157 SFR 4207 QUASAV Universite de Nantes 44322 Nantes France Plant Production Faculty of Bioscience Engineering Ghent University Coupure links 653 Ghent 9000 Belgium Present address: School of biosciences Division of Plant and Crop Production The University of Nottingham Sutton Bonington Leicestershire LE12 5RD UK Department of Plant Systems biology VIB Ghent 9052 Belgium Department of Plant biotechnology and bioinformatics Ghent University Ghent 9052 Belgium Laboratoire de Recherche en Sciences Vegetales UMR 5546 Universite de Toulouse- Centre National de la Recherche Scientifique (CNRS) BP 42617 Auzeville F-31326 Castanet-Tolosan France Research Group SynbioC Department of Sustainable Organic Chemistry and Technology Faculty of Bioscience Engineering Ghent University Coupure links 653 B-9000 Gent Belgium

Strigolactones （SLs） are known not only as plant hormones, but also as rhizosphere signals for establishing symbiotic and parasitic interactions. The design of new specific SL analogs is a challenging goal in understanding the basic plant biology and is also useful to control plant architectures without favoring the development of parasitic plants. Two different molecules （23 （3＇-methyI-GR24）, 31 （thia-3＇-methyl-debranone-like molecule）） already described, and a new one （AR36）, for which the synthesis is presented, are biologically compared with the well-known GR24 and the recently identified CISA-1. These different structures emphasize the wide range of parts attached to the D-ring for the bioactivity as a plant hormone. These new compounds possess a common dimethylbutenolide motif but their structure varies in the AbC part of the molecules： 23 has the same AbC part as GR24, while 31 and AR36 carry, respectively, an aromatic ring and an acyclic carbon chain. Detailed information is given for the bioactivity of such derivatives in strigolactone synthesis or in perception mutant plants （pea rmsl and rms4, Arabidopsis max2 and, max4） for different hormonal functions along with their action in the rhizosphere on arbuscular mycorrhizal hyphal growth and parasitic weed germination.

关键词： strigolactones synthetic analogs Pisum sativum Arabidopsis root parasitic plants Gigaspora rosea plant growth regulator.

Late biliary complications in human alveolar echinococcosis are associated with high mortality

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World Journal of Gastroenterology 2014年第19期20卷 5881-5888页

作者： Pascal frei benjamin Misselwitz Meher K Prakash Alain M Schoepfer bettina M Prinz Vavricka beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka Division of Gastroenterology and Hepatology University Hospital Zurich8091 ZurichSwitzerland Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois1011 LausanneSwitzerland Swiss Hepato-Pancreatico-biliary and Transplantation Center Department of SurgeryUniversity Hospital Zurich8091 ZurichSwitzerland Division of Gastroenterology and Hepatology Stadtspital Triemli8063 ZurichSwitzerland

AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with ***:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of *** compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival ***:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary *** patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of *** most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before *** surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk *** the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome.

关键词： Alveolar echinococcosis biliary strictures biliary

中元古代具有高的Cr同位素分异特征和高的大气氧浓度

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矿物岩石地球化学通报 2018年第5期37卷 902-902页

作者：袁超 Canfield D E Zhang S C Frank A b Wang X M Wang H J Su J Ye Y T frei R.

中元古代的大气氧浓度一直都不确定,然而该时期大气氧浓度对真核生物的爆发生长却具有重要意义。前人通过沉积物中的Cr同位素研究,认为中元古代具有非常低的大气氧浓度(当今氧水平的0.1%),并不足以使得中元古代真核生物生长以及后期新... 详细信息

中元古代的大气氧浓度一直都不确定,然而该时期大气氧浓度对真核生物的爆发生长却具有重要意义。前人通过沉积物中的Cr同位素研究,认为中元古代具有非常低的大气氧浓度(当今氧水平的0.1%),并不足以使得中元古代真核生物生长以及后期新元古代冠群生物的演化。

关键词：中元古代氧浓度同位素大气 Cr 特征和分异真核生物

中元古代具有高的Cr同位素分异特征和高的大气氧浓度

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矿物岩石地球化学通报 2018年第6期37卷 1180-1180页

作者： D.E.Canfield S.C.Zhang A.b.Frank X.M.Wang H.J.Wang J.Su Y.T.Ye R.frei 袁超

大气氧对生命大爆发具有重要意义。然而。前人通过Cr同位素研究表明,中元古代时期具有非常低的大气氧浓度(当今氧水平的0.1%),并不足以使得中元古代真核生物大爆发。Cr同位素是揭示大气氧化历史的一个非常有用的办法。由于Cr^3+物相发... 详细信息

大气氧对生命大爆发具有重要意义。然而。前人通过Cr同位素研究表明,中元古代时期具有非常低的大气氧浓度(当今氧水平的0.1%),并不足以使得中元古代真核生物大爆发。Cr同位素是揭示大气氧化历史的一个非常有用的办法。由于Cr^3+物相发生大陆氧化性风化作用,Cr同位素会发生分馏,重的53Cr同位素会倾向于进入氧化的镉酸盐中(Cr^4+),从而使得残留相(Cr^3+)中亏损重Cr同位素。

关键词： Cr^3+ 中元古代同位素氧浓度大气特征和分异生命大爆发

胎盘功能不全胎儿的胎盘磁共振扩散加权成像研究

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国际医学放射学杂志 2011年第1期34卷 86-页

作者： H.M.bonel b.Stolz L.Diedrichsen K.frei b.Saar b.Tutschek 刘颖 Institute for Diagnostic Interventional and Pediatric RadiologyInselspitalUniversity of Bern

目的对有或无胎儿宫内发育迟缓(IUGR)并可疑胎盘功能不全的胎儿行胎盘磁共振扩散加权成像评估。材料与方法此项研究经伦理委员会批准。

关键词：胎盘 ADC 胎儿胎盘功能功能不全磁共振扩散加权成像