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dream of the water children

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Dream of the water children

Compression characteristics of saturated.r.-compacted glacial tills in Tianmo Gully of Tibet, China

作者： fredrick d. Kakinami Cloyd.

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Journal of Mountain Science 2019年第7期16卷 1661-1674页

作者： CHEN Lei-lei ZHOU Gordon G.d MU Qing-yi CUI Kahlil fredrick SONG dong-ri Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China department of Civil Engineering Xi'an Jiaotong UniversityXi'an 710049China

Glacial tills are highly compressible soils composed of loosely cemented sandy silt *** role,for instance,as initial filler materials in geo-technical projects along temperate glacier regions warrant a systematic evaluation of their compressive *** such,we carry out a series of onedimensional compression tests on re-compacted glacial till samples obtained from Tianmo Gully,Tibet,with the aims of evaluating their compressive behavior und.r.controlled initial stress *** yield stress was determined from the void.r.tio versus consolidation pressure(e-log)*** compression and swelling behaviors were observed d.r.ng the primary and second.r. compressions of the consolidation *** the compression curves,a correlation can be found between the consolidation stress and the void *** addition,we find that the compression curves of glacial tills collapse into a single curve when normalized by the compression *** experimental results in this study provide a basic und.r.tanding of the compression characteristics of the glacial tills in Tibet,China.

关键词： Glacial till Compression characteristics One-dimensional consolidation tests Consolidation stress Compression curve

Effects of water content on the shear behavior and critical state of glacial till in Tianmo Gully of Tibet, China

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Journal of Mountain Science 2019年第8期16卷 1743-1759页

作者： ZHOU Gordon G.d. CHEN Lei-lei MU Qing-yi CUI Kahlil fredrick E. SONG dong-ri Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of Sciences(CAS)Chengdu 610041China University of Chinese Academy of Sciences Beijing 100049China department of Civil Engineering Xi'an Jiaotong UniversityXi'an 710049China

Glacial tills are widely distributed in Tibet, China, and are highly susceptible to landslides und.r.intense rainfalls. Failures of the slope d.r.ng rainfall are closely related to the shear behavior of glacial tills at different moisture conditions. This study investigates the shear behavior and critical state of saturated and unsaturated glacial tills through a series of drained d.r.ct shear tests. The tests were conducted on two types of compacted glacial tills with different water contents and total normal stresses. A strain softening mode of failure is observed for all water content conditions accompanied by noticeable dilation. dilatancy is found to decrease with increasing water content. Unsaturated samples showed increased.r.tes of dilation as water content is decreased for all applied normal stresses a behavior which cannot be predicted well by classical stressdilatancy models. Furthermore, it was found that the Critical State Line(CSL), plotted on the(e-ln) plane, can be used to define the shear behavior of unsaturated glacial tills at different water *** CSL of saturated glacial tills run parallel to this line. The experimental results in this study are aimed to provide a basic und.r.tanding to the und.r.ying failure mechanisms of glacial tills.

关键词： Glacial till Shear behavior Water content dilatancy d.r.ct shear test Critical state

Influence of inflow discharge and bed erodibility on outburst flood of landslide dam

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Journal of Mountain Science 2019年第4期16卷 778-792页

作者： ZHOU Ming-jun ZHOU Gordon G.d. CUI Kahlil fredrick E. SONG dong-ri LU Xue-qiang Key Laboratory of Mountain Hazards and Earth Surface Process/Institute of Mountain Hazards and Environment Chinese Academy of Sciences University of Chinese Academy of Sciences

Accurate prediction of the hydrographs of outburst floods induced by landslide dam overtopping failure is necessary for hazard prevention and mitigation. In this study, flume model tests on the breaching of landslide dams were conducted. Unconsolidated soil materials with wide grain size distributions were used to construct the dam. The effects of different upstream inflow discharges and downstream bed soil erosion on the outburst peak discharge were investigated. Experimental results reveal that the whole hydrodynamic process of landslide dam breaching can be divided into three stages as defined by clear inflection points and peak discharges. The larger the inflow discharge, the shorter the time it takes to reach the peak discharge, and the larger the outburst flood peak discharge. The scale of the outburst floods was found to be amplified by the presence of an erodible bed located downstream of the landslide dam. This amplification decreases with the increase of upstream inflow. In addition, the results show that the existence of an erodible bed increases the density of the outburst flow, increasing its probability of transforming from a sediment flow to a debris flow.

关键词： Landslide dam Inflow discharge Erodible bed Outburst flood

Structure of the 40S ribosomal subunit of Plasmodium falciparum by homology and de novo modeling

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Acta Pharmaceutica Sinica B 2017年第1期7卷 97-105页

作者： Harrison Ndung'u Mwangi Peter Wagacha Peterson Mathenge fredrick Sijenyi Francis Mulaa Center for Biotechnology and Bioinformatics Chiromo CampusUniversity of Nairobi.HEP Bioinformatics Consultants Ltd. department of Computing Informatics University of Nairobi dNA Software Inc. department of Biochemistry Riverside DriveChiromo CampusUniversity of Nairobi

Generation of three dimensional structures of macromolecules using in silico structural modeling technologies such as homology and de novo modeling has improved dramatically and increased the speed by which tertiary structures of organisms can be generated. This is especially the case if a homologous crystal structure is already available. High-resolution structures can be rapidly created using only their sequence information as input, a process that has the potential to increase the speed of scientific discovery. In this study, homology modeling and structure prediction tools such as rNA123 and SWISS–MOdEL were used to generate the 40 S ribosomal subunit from Plasmodium falciparum. This structure was modeled using the published crystal structure from Tetrahymena thermophila, a homologous eukaryote. In the absence of the Plasmodium falciparum 40 S ribosomal crystal structure, the model accurately depicts a global topology, second.r. and tertiary connections, and gives an overall root mean square deviation(rMSd) value of 3.9 ? relative to the template's crystal structure. deviations are somewhat larger in areas with no homology between the templates. These results demonstrate that this approach has the power to identify motifs of interest in rNA and identify potential drug targets for macromolecules whose crystal structures are unknown. The results also show the utility of rNA homology modeling software for structure determination and lay the groundwork for applying thisapproach to larger and more complex eukaryotic ribosomes and other rNA-protein complexes. Structures generated from this study can be used in in silico screening experiments and lead to the determination of structures for targets/hit complexes.

关键词： ribosome 40S subunit rNA structure Plasmodium falciparum 3d modeling de novo Homology

FAIr Equivalency, regulatory Framework and Adoption Potential of FAIr Guidelines in Health in Kenya

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data Intelligence 2022年第4期4卷 852-866,1035,1039-1040,1052页

作者： Ester Thea Inau reginald Nalugala William Muhadi Nandwa fredrick Obwanda Antony Wachira Antonio Cartaxo Universitätsmedizin Greifswald D-17475 GreifswaldGermany Tangaza University College P.O.Box 15055Karen Nairobi Code 00509Kenya Pumwani Hospital 968100200 Nairobi KenyaKenya VOdAN Africa Kenya Strathmore University P.O.Box 32243-00600Ngara RdNairobiKenya Leiden University 2311 EZthe Netherlands

This study explored the regulatory framework in Kenya that may facilitate the implementation of the FAIr Guidelines in health research, as well as the possibility of adopting the FAIr Guidelines at the national level. Fourteen key documents pivotal to the emerging digital health sector in Kenya were identified and analysed using a comprehensive coding and labelling approach based on a binary system for whether or not they mention the FAIr Guidelines or terms and vocabulary related to the FAIr Guidelines. The analysis revealed gaps in data stewardship that could be filled by the implementation of the FAIr Guidelines and, although the documents analysed do not explicitly mention the FAIr Guidelines, FAIr Equivalent terminology and practices are mentioned in varying detail. However, our analysis shows that there are still no provisions for the introduction and implementation of the FAIr Guidelines in health research in Kenya. Therefore, we recommend that the lead.r.hip be provided with a comprehensive introduction to the FAIr Guidelines, success stories about the FAIrification of data and.r.search infrastructure in other parts of the world, and a demonstration of the steps needed for the FAIrification of health data in Kenya.

关键词： data stewardship Health Kenya FAIr Guidelines FAIr Equivalency

外汇汇率对肯尼亚纳罗比上市公司股票价格的影响

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外汇汇率对肯尼亚纳罗比上市公司股票价格的影响

作者： fredrick Muimi Ilai 江西财经大学

学位级别：硕士

汇率市场和股票市场之间的相互作用在维持全球金融系统稳定方面起着至关重要的作用。因为汇率是各个经济体中的主要宏观经济变量之一,所以许多研究试图分析汇率对股票市场的影响。为了研究汇率对股票价格的影响,许多学者采用了不同的方... 详细信息

汇率市场和股票市场之间的相互作用在维持全球金融系统稳定方面起着至关重要的作用。因为汇率是各个经济体中的主要宏观经济变量之一,所以许多研究试图分析汇率对股票市场的影响。为了研究汇率对股票价格的影响,许多学者采用了不同的方法,提出了汇率波动会导致股票价格以流动为导向的理论(d.r.busch and Fisher,1980)。也有研究发现,两者存在单向因果关系,即汇率是股票价格的“Granger原因”。此外,以股票为导向的理论认为,股票价格会导致汇率上涨。本文试图研究汇率对肯尼亚内罗毕证券交易所上市公司股票价格的影响。本文使用2003年至2018年的季度时间序列数据,并采用NSE-20指数来衡量股票价格。同时,以通货膨胀率、利率、经济增长率以及外汇汇率变量被作为股票价格的主要决定因素。本文采用自回归分布式滞后(ArdL)模型来确定汇率与股票价格之间是否存在协整关系,并且还进行了长期模型分析,以确定汇率和其他宏观经济因素对股票价格的边际影响。根据ArdL边界检验的实证结果发现:汇率、通货膨胀率、利率、经济增长和股票价格之间存在长期的关系,并且长期关系收敛。Granger因果关系检验结果表明,汇率与股票价格之间存在负的单向因果关系。此外,长期模型分析显示,在5%的显著性水平上,汇率对股票价格产生负面影响。而长期模型分析发现,在5%的显著性水平上,通货膨胀率、利率和经济增长率在统计上的影响并不显著。

关键词：汇率股票价格 ArdL ECM 格兰杰因果关系检验 Cusum稳定性测试

development of a Qualitative near Infrared Screening Method for Quality Consistency Assessment of Virgin Sunflower Oil

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Spectral Analysis review 2017年第3期5卷 25-36页

作者： fredrick Luyangi Eliangiringa Kaale Vicky Manyanga Veronica Mugoyela Tanzania Food and drugs Authority Dodoma Tanzania department of Medicinal Chemistry Muhimbili University of Health and Allied Sciences (MUHAS) Dar es Salaam Tanzania Pharm r&d Lab School of Pharmacy Muhimbili University of Health and Allied Sciences (MUHAS) Dar es Salaam Tanzania

Near infrared spectroscopy offers advantages in the analysis of vegetable oils such as rapidity, relative cost-effectiveness, and usually no need for sample preparation. Virgin Sunflower oils were used as reference stand.r.s to develop spectra library for qualitative identification and validation of the method. This model was validated by correct classification method using positive and negative control samples. Various market samples of virgin sunflower oil were purchased and compared with spectra library. The results of spectral analysis of reference library and market samples were correlated using Mahalanobis distance method. Analysis involved 22 market samples. When these samples were matched against calibration samples, 4 samples out of 22 which are about 18.2% were not matched by the reference model. These market samples had Mahalanobis distance values between 4.2 and 6.7, which are greater than maximum permissible value of 3. Some of adulterants mentioned were Korie oil and pumpkin seeds oil.

关键词： Mahalanobis distance Near Infrared Mean Center Correction and Virgin Sunflower Oil

Influencing mechanism of pre-existing nanoscale Al5Fe2 phase on Mg-Fe interface in friction stir spot welded Al-free ZK60-Q235 joint

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Journal of Materials Science & Technology 2020年第7期42卷 220-228页

作者： r.Z.Xu Q.Yang d.r.Ni B.L.Xiao C.Z.Liu Z.Y.Ma Institute of Metal research Chinese Academy of SciencesShenyang110016China College of Material Science and Engineering Shenyang Aerospace UniversityShenyang110136China department of Materials Science and Engineering University of Illinois at Urbana-Champaign1304 W Green StUrbanaIL61801United States fredrick Seitz Materials research Laboratory University of Illinois at Urbana-Champaign104 S Goodwin AveUrbanaIL61801United States

Al-free ZK60 magnesium (Mg) alloy sheet was selected as substrate material of Mg-steel pinless friction stir spot welding (FSSW), avoiding the effect of the Al element in the substrate on the alloying reaction of Mg-iron (Fe) interface. The sound FSSW joint of ZK60 Mg alloy and Q235 steel with a hot-dipped aluminum (Al)-containing zinc (Zn) coating was successfully realized. The detailed microstructural examinations proved that Al5Fe2 phase at the Mg-Fe interface came from the pre-existing Al5Fe2 phase in the coating and acted as the transition layer for promoting the metallurgical bonding of Mg and Fe. The interfaces with well-matched lattice sites among Fe, Al5Fe2 and Mg were formed d.r.ng FSSW. A low energy interface with good match of lattice sites ((002)Al5Fe2//(110)Fe, [110]Al5Fe2//[113]Fe) between Al5Fe2 and Fe was identified. For the interface between Al5Fe2 and Mg, an orientation relationship of (622)Al5Fe2//(3112)Mgand[158]Al5Fe2//[2423]Mg was observed. The tensile-shear load of the ZK60-steel joint could.r.ach 4.6 kN. Moreover, the joint fracture occurred at the interface between the Al5Fe2 layer and the Mg alloy substrate, suggesting the brittle fracture characteristic.

关键词： dissimilar welding Friction stir spot welding Magnesium alloys Steels Zinc coating