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Disaster Risk Management Through the Design Safe Cyberinfrastructure

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International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： Jean-Paul Pinelli Maria Esteva Ellen M.Rathje David Roueche Scott J.Brandenberg Gilberto Mosqueda Jamie Padgett frederick Haan Department of Mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

Quality evaluation of synthetic quorum sensing peptides used in R&D

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Journal of Pharmaceutical Analysis 2015年第3期5卷 169-181页

作者： frederick Verbeke Evelien Wynendaele Sarah Braet Matthias D'Hondt Bart De Spiegeleer Drug Quality and Registration(DruQuaR) Group Faculty of Pharmaceutical SciencesGhent University

Peptides are becoming an important class of molecules in the pharmaceutical field. Closely related peptide-impurities in peptides are inherent to the synthesis approach and have demonstrated to potentially mask biomedical experimental results. Quorum sensing peptides are attracting high interest in R＆D and therefore a representative set of quorum sensing peptides, with a requested purity of at least 95.0%, was evaluated for their purity and nature of related impurities. In-house quality control （QC） revealed a large discrepancy between the purity levels as stated on the supplier＇s certificate of analysis and our QC results. By using our QC analysis flowchart, we demonstrated that only 44.0% of the peptides met the required purity. The main compound of one sample was even found to have a different structure compared to the desired peptide. We also found that the majority of the related impurities were lacking amino acid（s） in the desired peptide sequence. Relying on the certificates of analysis as provided by the supplier might have serious consequences for peptide research, and peptide-researchers should implement and maintain a thorough in-house QC.

关键词： Quorum sensing peptides Quality Impurity profiling

Non-surgical therapy of Peyronie＇s disease

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Asian Journal of Andrology 2008年第1期10卷 79-87页

作者： frederick L. Taylor Laurence A. Levine Department of Urology Rush University Medical Center Chicago 60612 USA

The present paper provides a review of the available non-surgical treatments for Peyronie＇s disease （PD）. A review of published literature on oral, intralesional, external energy and iontophoresis therapies for PD was performed, and the published results of available treatment options reviewed. The authors＇ recommendations for appropriate non-surgical management of PD are provided. Although there are many published reports that show the efficacy of non-surgical therapies for PD, there is a lack of large scale, multicenter controlled clinical trials, which makes treatment recommendations difficult. Careful review of the literature does suggest that there are treatment options that make scientific sense and appear to stabilize the disease process, reduce deformity, and improve function. Offering no treatment at all will encourage our patients to pursue alternative treatments, which might do harm, and misses the opportunity to do some good. Clearly further work is necessary to develop safe and effective non-surgical treatments for PD.

关键词： Peyronie's disease penile induration humans injections intralesional vitamin E pentoxifylline amino acids

基于PFC2D的砂土原生各向异性微观机理数值试验

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岩土工程学报 2017年第3期39卷 518-524页

作者：张坤勇李威罗兴军 CHARKLEY Nai frederick 河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 江苏省岩土工程技术工程研究中心(河海大学) 江苏南京210098 中国建筑西南勘察设计研究院有限公司四川成都610084

采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增... 详细信息

采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增量,得到不同沉积条件下不同加载方向上砂土试样宏观应力应变曲线和力学参数。数值试验结果显示,重力沉积步数对颗粒微观长轴定向排列、平均配位数有显著影响;初步建立了砂土微观结构变化和宏观应力应变曲线及力学参数的联系;分析了砂土试样表现出的宏观原生各向异性力学特性与内部颗粒结构的关系。

关键词：离散元砂土原生各向异性微观结构

Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)

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Genomics, Proteomics & Bioinformatics 2003年第4期1卷 247-262页

作者： Raymond Kin Hi Hui Raymond Tsz Yeung Wong Chi Wai Yip frederick Chi Ching Leung Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.Department of Zoology The University of Hong Kong Hong Kong SAR China.

The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identifi-

关键词： severe acute respiratory syndrome SARS-CoV genome phylogenetics human leukocyte antigen (HLA) system molecular epidemiology

Applicability of Mean Field Approximation to Numerical Experiments of Thermal Convection during the Cooling Period of Lake Biwa

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Journal of Energy and Power Engineering 2013年第12期7卷 2220-2226页

作者： Takashi Hosoda frederick Malembeka Department of Urban Management Graduate School of Engineering Kyoto Universi~ Kyoto 615-8540 Japan Department of Civil Engineering Arusha Technical College Arusha 296 Tanzania

This paper describes the applicability of a stochastic model to the numerical experiments of thermal convection carried out under the condition of the northern part of Lake Biwa, Shiga Prefecture, Japan. It was shown in the previous study that the temporal changes of vertical water temperature distributions during the cooling period between September and February can be reproduced by a simple 3D-CFD model. It was also pointed out that the spatial distributions of cooled water body sinking to the bottom due to water surface cooling represent similar features of forest gap distribution, which can be clarified by a stochastic model. The basic features of numerical experiments on thermal convection such as the spatial distribution of cooled water body are firstly shown with several cooling rates at water surface. Then, a stochastic model, which was originally introduced to explain forest gap dynamics, is shown with its MFA （mean field approximation） as first approximation of stochastic model. It is pointed out through the comparison of theoretical results by MFA with tuned model constants to numerical experiments that MFA with some refinement can be applicable to reproduce the basic features of simulated results to some extent, although further investigations are required to clarify the applicability of the model to more detailed mechanism of thermal convection such as size distribution of cooled water body, phase change of flow pattern, etc..

关键词： Thermal convection lake hydrodynamics Lake Biwa stochastic model.

Mapping of QTLs and candidate genes associated with multiple phenotypic traits for Huanglongbing tolerance in citrus

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Horticultural Plant Journal 2023年第4期9卷 705-719页

作者： Ming Huang Mikeal L. Roose Qibin Yu Ed Stover David G. Hall Zhanao Deng frederick G.Gmitter Jr. Key Laboratory of Plant Hormones and Development Regulation of Chongqing College of Life SciencesChongqing UniversityChongqing 401331China Citrus Research and Education Center University of FloridaLake AlfredFL 33850United States Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92521United States United States Horticultural Research Laboratory Agricultural Research ServiceUnited States Department of AgricultureFort PierceFL 34945United States Gulf Coast Research and Education Center University of FloridaWimaumaFL 33598United States

Huanglongbing(HLB)is the most devastating disease for citrus *** Liberibacter asiaticus(C Las),vectored by Asian citrus psyllid(ACP,Diaphorina citri Kuwayama),is the most common pathogen causing the *** citrus varieties are highly susceptible to HLB,whereas trifoliate orange(Poncirus trifoliata)is considered highly tolerant to *** F1 segregating population and their parent trifoliate orange and sweet orange,which had been exposed to intense HLB pressure for three years,was evaluated for disease symptoms,ACP colonization,C Las titer and tree vigor repeatedly for two to three *** orange and sweet orange showed significant differences for most of the phenotypic traits,and the F1 population exhibited a large variation.A high-density SNP-based genetic map with 1402 markers was constructed for trifoliate orange,which exhibited high synteny and high coverage of its reference genome.A total of 26 quantitative trait locus(QTLs)were identified in four linkage groups LG-t6,LG-t7,LG-t8 and LG-t9,of which four QTL clusters exhibit a clear co-localization of QTLs associated with different *** genome-wide analysis of gene expression in response to C Las infection in‘Flying Dragon’and‘Larger-Flower DPI-50-7’trifoliate orange,85 differentially expressed genes were found located within the QTL *** them,seven genes were classified as defense or immunity protein which exhibited the highest transcriptional change after C Las *** results indicate a quantitative genetic nature of HLB tolerance and identified candidate genes that should be valuable for searching for genetic solutions to HLB through breeding or genetic engineering.

关键词： Candidatus liberibacter QTL mapping Phenotyping F1 population Poncirus Citrus

Effectiveness of Wastewater-Based Epidemiology as an Early Warning Tool to Detect SARS-CoV-2 (COVID-19)

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Resistance switching for RRAM applications

Health（健康） 2024年第7期 635页

作者： Rakib Ahmed Chowdhury Daniel E.Meeroff Sumaiya Sharmin Alamgir Kabir Sara Hollenbeck Valerie Dalencourt Thu Nguyen Zack Farmer frederick Bloetscher Waseem Asghar Stacey Volnick

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Science China(Information Sciences) 2011年第5期54卷 1073-1086页

作者： CHEN frederick T. LEE HengYuan HSU YenYa CHEN PangShiu LIU WenHsing TSAI ChenHan SHEU ShyhShyuan TSAI MingJinn Nanoelectronic Technology Division Electronics and Optoelectronics Research Laboratories Industrial Technology Research Institute (ITRI) Department of Chemical and Materials Engineering Ming Shin University of Science and Technology

Resistive random access memory (RRAM or ReRAM) is a non-volatile memory (NVM) technology that consumes minimal energy while offering sub-nanosecond switching. In addition, the data stability against high temperature and cycling wear is very robust, allowing new NVM applications in a variety of markets (au- tomotive, embedded, storage, RAM). Based on sudden conduction through oxide insulators, the characteristics of RRAM technology have still yet to be fully described. In this paper, we present our current understanding of this very promising technology.

关键词： random access memory storage oxide breakdown oxygen vacancies