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Automatic Detection and Characterization of Human Veins Using Infra-Red Image Processing

Journal of Computer and Communications 2024年第9期12卷 141-159页

作者： Jean Ndoumbe Brice Ekobo Akoa Gaelle Patricia Talotsing frederic franck kounga Samuel Kaissassou Bertin Chouanmo Njo Laboratory of Computer Engineering Data Science and Artificial Intelligence Department of Computer & Telecommunications Engineering National Higher Polytechnic School Douala Cameroon Laboratory of Electrical Engineering Mechatronics and Signal Processing Department of Electrical & Telecommunications Engineering National Advanced School of Engineering Yaound Cameroon Mobile Computing and Networking Research Laboratory Department of Computer and Software Engineering Polytechnique Montreal Montreal Canada DigiPlus SARL Bonamoussadi Douala Cameroon

The detection and characterization of human veins using infrared (IR) image processing have gained significant attention due to its potential applications in biometric identification, medical diagnostics, and vein-based authentication systems. This paper presents a low-cost approach for automatic detection and characterization of human veins from IR images. The proposed method uses image processing techniques including segmentation, feature extraction, and, pattern recognition algorithms. Initially, the IR images are preprocessed to enhance vein structures and reduce noise. Subsequently, a CLAHE algorithm is employed to extract vein regions based on their unique IR absorption properties. Features such as vein thickness, orientation, and branching patterns are extracted using mathematical morphology and directional filters. Finally, a classification framework is implemented to categorize veins and distinguish them from surrounding tissues or artifacts. A setup based on Raspberry Pi was used. Experimental results of IR images demonstrate the effectiveness and robustness of the proposed approach in accurately detecting and characterizing human. The developed system shows promising for integration into applications requiring reliable and secure identification based on vein patterns. Our work provides an effective and low-cost solution for nursing staff in low and middle-income countries to perform a safe and accurate venipuncture.

关键词： Vein Detection Blood Radiation Infrared Image CLAHE Algorithm Raspberry Pi

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Allogenic banking of dental pulp stem cells for innovative therapeutics

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World Journal of Stem Cells 2015年第7期7卷 1010-1021页

作者： Pierre-Yves Collart-Dutilleul franck Chaubron John De Vos frederic J Cuisinier Bio Nano Laboratory EA 4203 Montpellier 1 University Institut Clinident Bio Pharma Biopole Clermont-Limagne INSERM U1040 Genetic Instability of Human Pluripotent Stem Cells CHRU Montpellier Hospital Saint-EloiInstitut de Recherche en Biothérapie

Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat.

关键词： Adult stem cells Multipotent stem cells Cell-based therapy Cell tissue bank

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CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery

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Cellular & Molecular Immunology 2023年第4期20卷 365-378页

作者： Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar Laurie Spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre Elodie Renaude Elodie Klajer ChloéMolimard franck Monnien frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot Christophe Borg Marie Kroemer Department of Medical Oncology Biotechnology and Immuno-Oncology PlatformUniversity Hospital of BesançonBesançonFrance INSERM EFS BFCUMR1098RIGHTUniversity of Franche-ComtéInteractions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueBesançonFrance Department of Pathology University Hospital of BesançonBesançonFrance Department of Surgery University Hospital of BesançonBesançonFrance EPIGENEXP platform University of Bourgogne Franche-ComtéBesançonFrance Department of Pharmacy University Hospital of BesançonBesançonFrance

CD226 has been reported to participate in the rescue of CD8^(+)T cell *** this study,we aimed to assess the prognostic value of CD226 in tumor-inﬁltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical *** from 43 metastases were isolated and analyzed ex vivo usingﬂow ***155 and CD3 levels in the tumor microenvironment were assessed by *** and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression ***226 expression contributes to the deﬁnition of the immune context in CRC liver metastases and primary ***226 on CD8^(+)T cells was not speciﬁcally coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver *** Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of *** expression analysis in a validation dataset conﬁrmed the prognostic value of CD226 in CRC liver metastases but not in primary *** of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 ***,CD226 expression on liver metastasis-inﬁltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery.

关键词： CD226 antigen Colorectal Neoplasms Liver metastasis Lymphocytes Tumor-Inﬁltrating

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The Marine Benthic Algae Diversity of Gabon: Case of the Rocky Foreshore of Cap Estérias

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Open Journal of Marine Science 2022年第4期12卷 127-140页

作者： Sylvie Brizard Zongo franck Estimé Ngohang Brice Didier Celce Koumba Mabert Estelle Ndombi Nzaba frederic Arnold Djounga Joseph Privat Ondo Thomas Stieglitz Département de Biologie Faculté des Sciences Université des Sciences et Techniques de MASUKU Franceville Gabon Département des Laboratoires Direction de la Recherche Ecole Nationale des Eaux et Forêts (ENEF) Cap Estérias Gabon Laboratoire Pluridisciplinaire des Sciences Ecole Normale Supérieure Libreville Gabon Centre Nationale des Données et de l’Information Océanographique IRSH CENAREST Libreville Gabon Centre Européen de Recherche et d’Enseignement des Géosciences de l’Environnement (CEREGE) Aix Marseille Université UM 34 Aix en Provence Cedex 4 France

This study has allowed to classify the marine macroalgae from the intertidal zone on the Atlantic side of Cap Estérias (Gabon). This area has a rich biodiversity but very few studies in the knowledge of benthic macroalgae have been done. The first study on the knowledge of the algae of the Gabonese coast was made in February 1974 by John and Lawson. This article has been revised to transcribe books and our study would aim to update the existing collection. The algae census is spread over a year from August 2020 to August 2021 and is the first detailed study carried out over a year, with regard to this part of the Gabonese coast. This study has allowed to know the specific diversity, to determine the structure of the flora and its spread out over time. The results show a significant algal diversity of thirty five (35) identified species. Three classes of macroalgae were determined and the percentage of species in the class (%EC): Floridaophyceae at 50% EC, Phaeophyceae at 30% EC and Ulvophyceae at 20% EC. The red algae are the most common in the area with sixteen (16) species determined against twelve (12) species of brown algae and seven (7) species of green algae. The Phaeophyceae class presents the Dictyotaceae family which is the most diverse with 7 species found. Some species seen appear in the collection of John et al., but others are new species encountered in Gabon such as Caulerpa sertularioides, Bryopsis plumosa (two Ulvophytes), Padina arborescens which is a Pheophyte and Galaxaura filamentosa, Digenea simplex,Hildenbrandia rubra, Asparagopsis armata and Caulacanthus ustulatus which are Rhodophytes. Some species are permanently present, they are found in all seasons but with significant abundance from July to September.

关键词： Marine Algae Taxa Atlantic Ocean Cap Estérias

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The safety and efficacy of palbociclib in older patients with advanced breast cancer in a real-world setting

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 15-27页

作者： Etienne Gouton Louis Tassy Joëlle Micallef Amir Meskine Renaud Sabatier Maud Cecile-Herry Cécile Braticevic Anthony Goncalves frederic Viret Alexandre de Nonneville Coline Montegut franck Rouby Frederique Rousseau Department of Medical Oncology Institut Paoli-CalmettesMarseille 13009France Aix-Marseille Univ CNRS U7258INSERM U1068Institut Paoli-CalmettesCRCMMarseille 13009France Department of Clinical Pharmacology Régional Center of Pharmacovigilance Marseille-Provence-CorseAssistance Publique-Hôpitaux de MarseilleAix-Marseille Univ.Neurosciences InstituteMarseille 13005France

Aims:Palbociclib has been approved in combination with endocrine therapy(ET)for hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2-)advanced breast cancer(ABC),regardless of *** though ABC is one of the most prevalent cancers in older patients,very few patients≥65 years old were included in pivotal ***,the current study evaluated the safety and efficacy of palbociclib in“real-world”routine treatment of unselected older patients with HR+/***:Data were collected on patients>70 years old who were treated with palbociclib plus ET for HR+/HER2-ABC in our *** analyzed safety data(CTCAE v4.0 criteria)and outcomes,such as progression-free survival(PFS)and overall survival(OS),as well as any associations between main geriatric characteristics and our ***,we assessed safety at a national level by analyzing all palbociclib-related adverse events(AEs)reported in the French Pharmacovigilance Database(FPVD)during the same ***:From February 2016 to July 2019,52 patients were identified with a median age of 80.9 years,of whom 88%presented an *** most common grade 3-4 AE was neutropenia(64%).Median PFS and OS were nine months and not reached,*** FPVD reports 227 cases of palbociclib-related AEs,with older and younger patients sharing similar ***:Palbociclib is well tolerated in older patients with efficacy comparable to that in younger ***,the addition of palbociclib to ET should be evaluated individually in this older and frailer subgroup.

关键词： Advanced breast cancer palbociclib older patients tolerance efficacy pharmacovigilance

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The Marine Benthic Algae Diversity of Gabon: Case of the Rocky Foreshore of Cap Estérias

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Open Journal of Marine Science（海洋科学期刊） 2022年第4期

作者： sylvie brizard zongo franck estimé ngohang brice didier celce koumba mabert estelle ndombi nzaba frederic arnold djounga joseph privat ondo thomas stieglitz

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地质学家和第一次世界大战

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环球科学 2019年第7期 78-83页

作者：弗兰克·阿诺弗雷德里克·西米安邓艺杭(翻译) CDP咨询公司法国地质与矿产研究局(BRGM)出版社不详

怎么保障100万匹马每匹每天15-60升的饮水量?怎么使躲藏在战壕中的无数士兵免于泥泞的困扰?这些便是地质学家们在第一次世界大战中面临的挑战。这篇来自《科学美国人》法国版的文章回顾了地质学家在一战中的关键作用。

关键词：第一次世界大战地质学家《科学美国人》饮水量

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