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谷胱甘肽转硫酶m1和T1基因型与食管癌危险性:病例-对照研究

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中华流行病学杂志 1998年第4期19卷 195-199页

作者：林东昕唐永明陆士新 fred F.Kadlubar 中国医学科学院/协和医科大学 Division of molecular Epidemiology National Center for Toxicological ResearchJeffersonArkansas 72079USA

为探讨参与致癌物代谢的谷胱甘肽转硫酶(GST)mI和T1基因多型性与食管癌危险性的关系,以病例-对照分子流行病学方法,分析食管癌高发区河南林县的食管癌、食管上皮重度增生病例和性别、年龄配对的正常对照者(各45例)的GSTm1和GSTT1基因型... 详细信息

为探讨参与致癌物代谢的谷胱甘肽转硫酶(GST)mI和T1基因多型性与食管癌危险性的关系,以病例-对照分子流行病学方法,分析食管癌高发区河南林县的食管癌、食管上皮重度增生病例和性别、年龄配对的正常对照者(各45例)的GSTm1和GSTT1基因型分布的差异。基因组DNA来自研究对象的食管外科手术标本或细胞学检查获得的食管上皮细胞,以多重聚合酶链反应方法进行基因分型。结果:食管癌、食管上皮重度增生病例和正常对照组GSTm1基因缺失率分别为44.4%、44.4%和46.7%;GSTT1基因缺失率分别为40.0%、37.8%和51.1%,差别均无显著性。然而,正常对照者中既是GSTml阳性又是GSTT1阳性的基因型比例(22.2%)显著低于食管癌病例(40.0%)和食管上皮重度增生病例(37.8%),比值比(95%可信限)分别为4.20(1.23～14.36)和2.64(0.84～8.30)。结果提示,GSTm1或GSTT1基因多型性单独似乎与食管癌危险性无关,但两者的阳性基因型联合可能是食管癌的危险性因素。

关键词：谷胱甘肽转硫酶分子流行病学食管肿瘤

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m2m在自动化生产中潜力很大

现代制造 2015年第50期 26-27页

作者： fred Yentz

如今企业生产链的每个环节都会用到m2m技术，但它主要是以不同业务过程的实时测量为基础，为决策层提供生产和物流的具体监控结果和数据。m2m的应用实现了两个重要功能：首先是收集和管理机器数据，使其能够被加工为可用于生产的实时信... 详细信息

如今企业生产链的每个环节都会用到m2m技术，但它主要是以不同业务过程的实时测量为基础，为决策层提供生产和物流的具体监控结果和数据。m2m的应用实现了两个重要功能：首先是收集和管理机器数据，使其能够被加工为可用于生产的实时信息，如直接显示生产中的延误或自动报警，

关键词：自动化生产 m2m 实时测量业务过程实时信息自动报警直接显示生产链

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大国的解体与重生

Dermaseptin B2’s Anti-Proliferative Activity and down Regulation of Anti-Proliferative, Angiogenic and metastatic Genes in Rhabdomyosarcoma RD Cells <i>in Vitro</i>

作者： (美)大卫·m. 科兹(David m. Kotz) (美)弗雷德·威尔(fred Weir)

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Advances in Bioscience and Biotechnology 2021年第10期12卷 337-359页

作者： Ahmed A. Abdille Josephine Kimani fred Wamunyokoli Wallace Bulimo Yahaya Gavamukulya Esther N. maina Department of molecular Biology and Biotechnology Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Department of Biochemistry College of Health Sciences Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Centre for Public Health Research Kenya Medical Research Institute Nairobi Kenya Department of Biochemistry and molecular Biology Faculty of Health Sciences Busitema University Mbale Uganda Department of Biochemistry College of Health Sciences University of Nairobi Nairobi Kenya

Background: Rhabdomyosarcoma (RmS) is the most prevalent soft tissue sarcoma in children, representing approximately 50% of pediatric sarcomas and can develop in any part of the body though more frequently at the extr... 详细信息

Background: Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma in children, representing approximately 50% of pediatric sarcomas and can develop in any part of the body though more frequently at the extremities. Aim: Evaluating the in vitro anti-proliferative activity of Dermaseptin B2 on Rhabdomyosarcoma RD (CCL-136TM) cells and its effect on the expression of MYC, FGFR1, NOTCH1, and CXCR7 genes involve in processes including proliferation, angiogenesis and metastasis. methods: RD cells were grown in Dulbecco’s modified Eagle’s medium supplemented with 10% Fetal Bovine Serum. Exponentially growing cells were treated with Dermaseptin B2 and Antiproliferative activity was assayed using the resazurin and migration assays at three time-points. In order to determine the gene expression profiles of mYC, NOTCH1, FGFR1 and CXCR7, total RNA was extracted from the cells and q-RT-PCR was performed with β-Actin as reference gene. Results: Dermaseptin B2 inhibited the proliferation of RD cells in a time and concentration dependent manner as with IC50 values of 7.679 μM, 7.235 μM, 5.993 μM. The 2-dimentional wound healing assay showed inhibition of migration and motility of the RD cells at time-points of 6, 24, 48 and 72-hours with the greatest inhibition observed at 72-hours. Dermaseptin B2 downregulated the target MYC (fc;1.5013, 1.5185, 2.4144), CXCR7 (fc;2.8818, 4.4430, 3.9924), FGFR1 (fc;2.3515, 2.0809, 2.2543), NOTCH1 (fc;2.4667, 4.6274, 4.3352) genes for the three-time points respectively. NOTCH1 and CXCR7 showed higher fold changes with respect to β-Actin than MYC and FGFR1. Conclusion: The results of this study indicate that Dermaseptin B2 mily:

关键词： Dermaseptin B2 Doxorubicin RmS Angiogenesis metastasis

Trap cropping for management of the diamondback moth

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Trap cropping for management of the diamondback moth

5th International Workshop on management of the Diamondback moth and Other Crucifer Insect Pests

作者： Anthony m.Shelton Francisco Badenes-Perez fred musser Jian-Zhou Zhao Brian Nault Elizabeth Earle CAO Jun Sorrell Hatch Department of Entomology Cornell University/NYSAES Present address:Department of Entomology and Plant Pathology Mississippi State University Department of Plant Breeding and Genetics Cornell University

Trap cropping for managing the diamondback moth,Plutella xylostella(L.) has shown mixed *** trap cropping relies on the inherent characteristics of the trap crop plants themselves as well as their *** 2000 we have conducted a series of investigations on both *** ideal trap crop is one that is highly attractive for oviposition but on which the insect cannot survive,and we have

关键词： Trap cropping for management of the diamondback moth

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TFTR中的β极限破裂

国外核聚变与等离子体应用 1996年第4期 1-15页

作者： fred.,ED 尚志

在ＴＦＴＲ的高性能等离子体中观测到破裂极限「Ｋ．Ｍ．ＭｃＧｕｉｒｅｅｔａｌ．，ＰｌａｓｍａＰｈｙｓ．ＣｏｎｔｒｏｌｌｅｄＮｕｃｌｅａｒＦｕｓｉｏｎ１，４２１」。这些破裂的磁流体动力学特性基本不同于ＴＦＴＲ... 详细信息

在ＴＦＴＲ的高性能等离子体中观测到破裂极限「Ｋ．Ｍ．ＭｃＧｕｉｒｅｅｔａｌ．，ＰｌａｓｍａＰｈｙｓ．ＣｏｎｔｒｏｌｌｅｄＮｕｃｌｅａｒＦｕｓｉｏｎ１，４２１」。这些破裂的磁流体动力学特性基本不同于ＴＦＴＲ上高密度等离子体的镐β破裂发生之前不到１ｍｓ时间，有一快速增长的先兆。

关键词： TFTR β极限破裂等离子体先兆热猝灭

影响矩作为测度单篇论著影响力的评价指标探讨

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大学图书馆学报 2014年第5期32卷 12-18页

作者：王术叶鹰南京大学信息管理学院南京210093

把评价视向由针对学术主体转向针对学术客体,提出着眼于单篇论著影响力评价的影响矩指标。影响矩m被定义为单篇论著影响学者力A及其影响跨度D的乘积,m越大,影响越大。通过对测算样本集和校验样本集的数据分析,显示影响矩m与总被引C及h... 详细信息

把评价视向由针对学术主体转向针对学术客体,提出着眼于单篇论著影响力评价的影响矩指标。影响矩m被定义为单篇论著影响学者力A及其影响跨度D的乘积,m越大,影响越大。通过对测算样本集和校验样本集的数据分析,显示影响矩m与总被引C及h指数的相关系数都在0.6以上,表明影响矩可以作为测评单篇论著影响力的独立指标。

关键词：影响矩影响学者力论文影响力单篇论著评价学术评价指标

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Primary lymphomas of the genitourinary tract:A population-based study

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Asian Journal of Urology 2020年第4期7卷 332-339页

作者： Carlotta Palumbo Elio mazzone Francesco A.mistretta Sophie Knipper Zhe Tian Paul Perrotte Francesco montorsi Shahrokh F.Shariat fred Saad Claudio Simeone Alberto Briganti Alessandro Antonelli Pierre I.Karakiewicz Cancer Prognostics and Health Outcomes Unit University of Montreal Health CenterMontrealQuebecCanada Urology Unit ASST Spedali Civili of BresciaDepartment of Medical and Surgical SpecialtiesRadiological Science and Public HealthUniversity of BresciaBresciaItaly Division of Experimental Oncology Unit of UrologyUrological Research Institute(URI)IRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Department of Urology European Institute of OncologyMilanItaly martini Klinik University Medical Center Hamburg-EppendorfHamburgGermany Division of Urology University of Montreal Hospital Center(CHUM)MontrealQuebecCanada Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia

Objective:We performed a population-based analysis focusing on primary extranodal lymphoma of either testis,kidney,bladder or prostate(PGUL).methods:We identified all cases of localized testis,renal,bladder and prostate primary lymphomas(PL)versus primary testis,kidney,bladder and prostate cancers within the Surveillance,Epidemiology,and End Results database(1998e2015).Estimated annual proportion change methodology(EAPC),multivariable logistic regression models,cumulative incidence plots and multivariable competing risks regression models were ***:The rates of testis-PL,renal-PL,bladder-PL and prostate-PL were 3.04%,0.22%,0.18%and 0.01%,*** with PGUL were older and more frequently *** rates significantly decreased for renal-PL(EAPC:5.6%;pZ0.004)and prostate-PL(EAPC:3.6%;pZ0.03).In multivariable logistic regression models,older ager independently predicted testis-PL(odds ratio[OR]:16.4;pmale gender independently predicted bladder-PL(OR:5.5;pmulative incidence plots showed significantly higher 10-year cancer-specific mortality(CSm)rates for testis-PL,renal-PL and prostate-PL versus their primary genitourinary *** multivariable competing risks regression models,only testis-PL(hazard ratio[HR]:16.7;pm ***:PGUL rates are extremely low and on the decrease in kidney and prostate but stable in testis and *** to primary genitourinary tumors,PGUL are associated with worse CSm for testis-PL and renal-PL but not for bladder-PL and prostate-PL,even after adjustment for other-cause mortality.

关键词： Bladder lymphoma Genitourinary neoplasm Genitourinary Primary extranodal lymphoma Prostate lymphoma Renal lymphoma Testis lymphoma Survival

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天气尺度臭氧光化学与全球对流层臭氧收支

气象科技 1986年第6期 56-61页

作者： Jack Fishman fred m.Vukovich 张云荣郭陆军

1.引言最近许多研究都强调对流层臭氧的重要性(比如见Levy 1984;Fishman 1985;Levy等1985;Logan 1985),这是由于臭氧在对流层光化学过程中起了核心作用以及作为温室效应的气体在地球气候系统中的重要性。尽

关键词：臭氧净光光化学过程对流层对流圈低层大气收支天气尺度