检索结果-南通市图书馆

Robust H_∞ control for aseismic structures with uncertainties in model parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

earthquake engineering and engineering Vibration 2007年第4期6卷 409-416页

作者：宋刚林家浩赵岩 W. Paul Howson fred W Williams State Key Laboratory of Structural Analysis for Industrial equipment Faculty of Vehicle Engineering and Mechanics Dalian University of Technology Cardiff School of engineering Cardiff University Cardiff CF24 3AA Wales U.K.

This paper presents a robust H∞ output feedback control approach for structural systems with uncertainties in model parameters by using available acceleration measurements and proposes conditions for the existence of such a robust output feedback controller. The uncertainties of structural stiffness, damping and mass parameters are assumed to be norm-bounded. The proposed control approach is formulated within the framework of linear matrix inequalities, for which existing convex optimization techniques, such as the LM1 toolbox in MATLAB, can be used effectively and conveniently. To illustrate the effectiveness of the proposed robust H∞ strategy, a six-story building was subjected both to the 1940 e1 Centro earthquake record and to a suddenly applied Kanai-Tajimi filtered white noise random excitation. The results show that the proposed robust H∞ controller provides satisfactory results with or without variation of the structural stiffness, damping and mass parameters.

关键词： structural control robust H∞ control linear matrix inequality dynamic output feedback parameter uncertainty seismic excitation

Pristine point of zero charge (p.p.z.c.) and zeta potentials of boehmite’s nanolayer and nanofiber surfaces

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Smart and Nano Materials 2016年第1期7卷 1-21页

作者： Leonid A.Kaledin fred Tepper Tatiana G.Kaledin Department of Chemistry Argonide Corporation291 Power CourtSanfordFL 32771USA

The pristine point of zero charge(p.p.z.c)and zeta potential as a function of pH of boehmite oxide/hydroxide(α-Al_(2)O_(3)·H_(2)O)have been determined for three filter *** active component in the first two filter media is boehmite nanofibers,only 2 nm in diameter and about 300 nm *** nanofibers create high zeta potential(ζtrue≥46 mV)in aqueous solutions in the pH range of 3–*** *** were determined to be 11.60±0.15 for nanofibers grafted onto microglass fibers and 11.40±0.15 for agglomerated *** the third filter media,a boehmite nanolayer in the form of monocrystalline oxide/hydroxide with a thickness of approximately 1.2 nm is electroadhesively deposited onto siliceous support material with large surface area of about 50 m^(2)/g,therefore forming a highly electropositive composite of boehmite nanolayer on the second highly electronegative ***’s oxide-hydroxide nanolayer surface creates high zeta potential(ζtrue≥50 mV)in aqueous solutions in the pH range of 3–*** *** was determined to be 11.38±*** reported values are within accuracy,but they are much higher than the values reported in the literature.X-ray powder diffraction data were supplemented by microscopy,infrared spectroscopy in order to characterize fully synthetic boehmite surfaces.

关键词： Boehmite’s nanolayer pristine point of zero charge(p.p.z.c) zeta potential isoelectric point(i.e.p.)

Use of perioperative chemotherapy in colorectal cancer metastatic to the liver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2019年第5期7卷 301-311,I0001页

作者： Lynn K.Symonds Stacey A.cohen Division of Oncology University of WashingtonSeattleWAUSA Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA

A curative-intent approach may improve survival in carefully selected patients with oligometastatic colorectal *** treatments are most frequently administered to patients with isolated liver metastasis,though they may be judiciously considered for other sites of *** be considered for curative intent with surgery,patients must have disease that can be definitively treated while leaving a sufficient functional liver *** chemotherapy may be used for upfront resectable disease as a test of tumor biology and/or for upfront unresectable disease to increase the likelihood of resectability(so-called‘conversion’chemotherapy).While conversion chemotherapy in this setting aims to improve survival,the choice of a regimen remains a complex and highly individualized *** this review,we discuss the role of RAS status,primary site,sidedness,and other clinical features that affect chemotherapy treatment selection as well as key factors of patients that guide individualized patient-treatment recommendations for colorectal-cancer patients being considered for definitive treatment with metastasectomy.

关键词： metastatic colorectal cancer perioperative chemotherapy conversion chemotherapy liver resection KRAS steatohepatitis

Dynamics and functions of e‑cadherin complexes in epithelial cell and tissue morphogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2023年第4期5卷 585-601页

作者： Na Zhang Matthias Häring fred Wolf Jörg Großhans Deqing Kong Department of Biology Philipps University35043 MarburgGermany Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN) Georg August University Göttingen37073 GöttingenGermany

Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.e-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens *** the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual e-cadherin–catenin complex with e-cadherin superclusters,contractile actomyosin and mechanics of the cortex and *** nanoscale architecture of e-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adjust to junctional tension and mechano-transduction by reinforcement or weakening of specific features of the *** post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in e-cadherin function has remained ***,we provide an overview of the e-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,***,we review the computational modelling in e-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the e-cadherin complexes.

关键词： Nanoscale architectures Phosphorylation Glycosylation Computational modelling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

同态空间和表示空间

数学译林 2009年第4期28卷 305-318页

作者： fred cohen 吴杰(编译) 高曼(编译)

1．引言很多数学问题都与具有一些特殊性质的群的子群有关系，例如[1]建立了辫子群的一些子群与球面同伦群的重要关系．本文所要介绍的，是通过研究同态空间及表示空间，我们可以得到一些群的子群的性质，主要参考文献是[4]，[5],[6]，... 详细信息

1．引言很多数学问题都与具有一些特殊性质的群的子群有关系，例如[1]建立了辫子群的一些子群与球面同伦群的重要关系．本文所要介绍的，是通过研究同态空间及表示空间，我们可以得到一些群的子群的性质，主要参考文献是[4]，[5],[6]，[7]及[8]．我们先介绍同态空间及表示空间的定义，然后再看几个同态空间的例子．

关键词：表示空间态空间特殊性质辫子群数学问题参考文献同伦群球面

Comparative analysis of Solanum stoloniferum responses to probing by the green peach aphid Myzus persicae and the potato aphid Macrosiphum euphorbiae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2013年第2期20卷 207-227页

作者： Adriana e. Alvarez Viviana G. Broglia Anahi M. Alberti D'Amato Doret Wouters edwin van der Vossen elisa Garzo W. fred Tjallingii Marcel Dicke Ben Vosman Laboratory of entomology Wageningen University P.O. Box 8031 6700 EH 2Plant Breeding Wageningen UR P.O. Box 386 6700 AAWageningen The Netherlands Plant Breeding Wageningen UR P.O. Box 386 6700 AA Wageningen The Netherlands

Plants protect themselves against aphid attacks by species-specific de- fense mechanisms. Previously, we have shown that Solanum stoloniferum Schlechtd has resistance factors to Myzus persicae Sulzer （Homoptera： Aphididae） at the epidermal/mesophyll level that are not effective against Macrosiphum euphorbiae Thomas （Homoptera： Aphididae）. Here, we compare the nymphal mortality, the pre-reproductive development time, and the probing behavior of M. persicae and M. euphorbiae on S. stoloniferum and Solanum tuberosum L. Furthermore, we analyze the changes in gene expression in S. stoloniferum 96 hours post infestation by either aphid species. Although the M. euphorbiae probing behavior shows that aphids encounter more probing constrains on phloem activities-longer probing and salivation time- on S. stoloniferum than on S. tuberosum, the aphids succeeded in reaching a sustained ingestion of phloem sap on both plants. Probing by M. persicae on S. stoloniferum plants resulted in limited feeding only. Survival of M. euphorbiae and M. persicae was affected on young leaves, but not on senescent leaves of S. stoloniferum. Infestation by M. euphorbiae changed the expression of more genes than M. persicae did. At the systemic level both aphids elicited a weak response. Infestation orS. stoloniferum plants with a large number ofM. persicae induced morphological changes in the leaves, leading to the development of pustules that were caused by disrupted vascular parenchyma and surrounding tissue. In contrast, an infesta- tion by M. euphorbiae had no morphological effects. Both plant species can be regarded as good host for M. euphorbiae, whereas only S. tuberosum is a good host for M. persicae and S. stoloniferum is not. Infestation ofS. stoloniferum by M. persicae or M. euphorbiae changed the expression of a set of plant genes specific for each of the aphids as well as a set of common genes.

关键词： cDNA microarrays electrical penetration graph insect-plant interactions,Solanum tuberosum wild potato

Detection of tumor stem cell markers in pancreatic carcinoma cell lines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 92-97页

作者： Monika Olempska Patricia Alice eisenach Ole Ammerpohl Hendrik Ungefroren fred Fandrich Holger Kalthoff Department of General and Thoracic Surgery University Hospital Schleswig-Holstein Campus Kiel Arnold Heller Str. 7 24 105 Kiel Germany

BACKGROUND: Cancer of the pancreas is the fourth leading cause of cancer death in industrialized countries. In malignancy, actively proliferating cells may be effectively targeted and killed by anti-cancer therapies, but stem cells may survive and support re-growth of the tumor. Thus, new strategies for the treatment of cancer clearly will also have to target cancer stem cells. The goal of the present study was to determine whether pancreatic carcinoma cell growth may be driven by a subpopulation of cancer stem cells. Because previous data implicated ABCG2 and CD133 as stem cell markers in hematopoietic and neural stem/progenitor cells, we analyzed the expression of these two proteins in pancreatic carcinoma cell lines. MeTHODS: Five established pancreatic adenocarcinoma cell lines were analyzed. Total RNA was isolated and real- time RT-PCR was performed to determine the expression of ABCG2 and CD133. Surface expression of ABCG2 and CD133 was analyzed by flow cytometric analysis. ReSULTS: All pancreatic carcinoma cell lines tested expressed significantly higher levels of ABCG2 than non-malignant fibroblasts or two other malignant non- pancreatic cell lines, i.e., SaOS2 osteosarcoma and SKOV3 ovarian cancer. elevated CD133 expression was found in two out of five pancreatic carcinoma cell lines tested. Using flow cytometric analysis we confirmed surface expression of ABCG2 in all five lines. Yet, CD133 surface expression was detectable in the two cell lines, A818-6 and PancTu1, which exhibited higher mRNA ***: Two stem cell markers, ABCG2 and CD133 are expressed in pancreatic carcinoma cell lines. ABCG2 and/or CD133 positive cells may represent subpopulation of putative cancer stem cells also in this malignancy. Because cancer stem cells are thought to be responsible for tumor initiation and its recurrence after an initial response to chemotherapy, they may be a very promising target for new drug developments.

关键词： pancreatic adenocarcinoma cancer stem cells stem cell markers ABCG2 CD133

Internet literacy 4th ed.

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Internet literacy

芳酰基硫脲类克鲁斯氏锥体虫半胱氨酸蛋白酶小分子抑制剂的合成及活性研究(英文)

2006年

作者： fred T. Hofstetter

Includes bibliographical references and index.

ISBN: (纸本)007321454X

Includes bibliographical references and index.

关键词： Internet literacy.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

中国药物化学杂志 2002年第4期12卷 200-204页

作者：郭春方林杜小慧 McKeRROW James H cohen fred e 沈阳药科大学制药工程学院辽宁沈阳110016 School of Pharmacy University of aliforniaSan Francisco School of Pharmacy University of CaliforniaSan Francisco

目的通过设计、合成芳酰基硫脲类化合物发现新的克鲁斯氏锥体虫半胱氨酸蛋白酶小分子抑制剂。方法通过芳酰基硫代异氰酸酯和取代苯胺的反应合成芳酰基硫脲类化合物 ,化合物的结构经HRMS(eI)和1 H NMR光谱确证。结果共合成了 2 0个芳酰... 详细信息

目的通过设计、合成芳酰基硫脲类化合物发现新的克鲁斯氏锥体虫半胱氨酸蛋白酶小分子抑制剂。方法通过芳酰基硫代异氰酸酯和取代苯胺的反应合成芳酰基硫脲类化合物 ,化合物的结构经HRMS(eI)和1 H NMR光谱确证。结果共合成了 2 0个芳酰基硫脲类化合物 ,化合物的体外抑制克鲁斯氏锥体虫半胱氨酸蛋白酶的活性测定结果表明 :所合成的化合物均有一定的抑制克鲁斯氏锥体虫半胱氨酸蛋白酶的活性 ,其中化合物Id和In的活性高于对照药tf 175的活性。

关键词：芳酰基硫脲合成抑制剂克鲁斯氏锥体虫半胱氨酸蛋白酶活性