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Results of an eight Year Long Practice of Saline Bipolar Transurethral Resection of Prostate

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Open Journal of Urology 2024年第4期14卷 189-196页

作者： Sossa Jean Mangoue Moube Ariane Landry Yevi Dodji Inès Magloire Hodonou fred Avakoudjo Déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Open prostatectomy has long been the only prostatic bladder outlet obstruction’s surgery available in Benin. It is prone to postoperative bleeding and infections and is not suitable for prostate cancer-induced bladder outlet obstruction. Objective: To evaluate the first results of endoscopic surgery of prostatic bladder outlet obstruction in our environment. Patients and Method: We conducted an observational study of saline bipolar transurethral resection of prostate (B-TURP) at the former Military Teaching Hospital of Cotonou. We retrospectively collected the data from patients’ medical records from November 17, 2014, to September 7, 2022. We used excel 2019 to make a descriptive analysis of the data. Results: Saline B-TURP was performed in 60 consecutive patients. Their mean age was 69.1 years (range: 48-85). The procedure was indicated in 22 (36.7%), 32 (53.3%), 3 (5%), and 3 (5%) patients, respectively for acute urinary retention, chronic urinary retention, obstructive renal failure, and unresponsiveness to alpha-blockers. 35 patients (58.3%) had prostate cancer (PCa). 25 patients (41.7) had benign prostate hyperplasia (BPH). No patient got a blood transfusion. The duration of postoperative hospitalization was 3 days (88.3%) to 5 days (11.7%). 5 patients (8.3%), i.e., 3 BPH and 2 prostate cancer patients got preoperative urinary tract infection. The causative bacteria were escherichia coli in 3 patients (60%), Klebsiella pneumoniae in 2 patients (40%), and multi-resistant Acinetobacter as a metachronous infection to escherichia coli in 1 patient (20%). All the infections were associated with indwelling Foley catheter. 7 patients (11.7%), i.e., 3 BPH and 4 prostate cancer patients, got a second resection to recover full spontaneous micturition. Prostate size was available in the medical record of 21 BPH patients and 15 prostate cancer patients. Prostate size ranged from 22 to 123 g with a mean value of 61.1 g in BPH patients, and from 34 to 180 g with

关键词： Saline B-TURP BPH Prostate Cancer

Application of Predictive Model for efficient Cassava (Manihot esculenta Crantz) Yield in the Face of Climate Variability in enugu State, Nigeria

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American Journal of Climate Change 2024年第2期13卷 361-389页

作者： emeka Bright Ogbuene Tonia Nkiru Nwobodo Obianuju Gertrude Aloh Achoru fred emeka Josiah C. Ogbuka Vivian Amarachi Ozorme Andrew M. Oroke Obiageli Jacinta Okolo Anwara Obianuju Amara e. S. enemuo Centre for environmental Management and Control (CeMAC) University of Nigeria Nsukka Nigeria Department of Geography University of Nigeria Nsukka Nigeria Department of Geography and Meteorology Enugu State University of Science and Technology (ESUT) Enugu Nigeria School of Civil engineering Newcastle University Newcastle upon Tyne UK

Climate variability as occasioned by conditions such as extreme rainfall and temperature, rainfall cessation, and irregular temperatures has considerable impact on crop yield and food security. This study develops a predictive model for cassava yield (Manihot esculenta Crantz) amidst climate variability in rainfed zone of enugu State, Nigeria. This study utilized data of climate variables and tonnage of cassava yield spanning from 1971 to 2012;as well as information from a questionnaire and focus group discussion from farmers across two seasons in 2023 respectively. Regression analysis was employed to develop the predictive model equation for seasonal climate variability and cassava yield. The rainfall and temperature anomalies, decadal change in trend of cassava yield and opinion of farmers on changes in rainfall season were also computed in the study. The result shows the following relationship between cassava and all the climatic variables: R2 = 0.939;P = 0.00514;Cassava and key climatic variables: R2 = 0.560;P = 0.007. The result implies that seasonal rainfall, temperature, relative humidity, sunshine hours and radiation parameters are key climatic variables in cassava production. This is supported by computed rainfall and temperature anomalies which range from −478.5 to 517.8 mm as well as −1.2˚C to 2.3˚C over the years. The questionnaire and focus group identified that farmers experienced at one time or another, late onset of rain, early onset of rain or rainfall cessation over the years. The farmers are not particularly sure of rainfall and temperature characteristics at any point in time. The implication of the result of this study is that rainfall and temperature parameters determine the farming season and quantity of productivity. Hence, there is urgent need to address the situation through effective and quality weather forecasting network which will help stem food insecurity in the study area and Nigeria at large. The study made recommendations such as a

关键词： Climate Variability Cassava (Manihot esculenta Crantz) Predictive Model Yield

Recent developments of the stoichiometric displacement model for separation processes

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Chinese Science Bulletin 2001年第21期46卷 1763-1772页

作者： GeNG Xindu fred e.Regnier WANG Yan Institute of Modern Separation Science Northwest Universitythe Key Lab of Modern Separation Science of Shaanxi ProvinceXi’an 710069China Department of Chemistry Purdue UniversityWest LafayetteIN 4 7907USA

Substantial attention has been paid to the stoi-chiometric displacement models for solute retention (SDM-R) in liquid chromatography and adsorption (SDM-A) at surfaces since they were developed. The SDM has a strongly theoretical basis and has evolved to the point that it is widely applied in chemistry, biochemistry, molecular biology and biotechnology. This review introduces the history, recent developments, and new concepts relating to the SDM, including theory, mathematical expressions, and applications across a broad range of fields.

关键词： liquid chromatography liquid-solid system stoichiomet- ric displacement retention model adsorption mechanism protein folding.

Targeted therapy in gastroesophageal cancers:past,present and future

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Gastroenterology Report 2015年第4期3卷 316-329,I0002页

作者： Janghee Woo Stacey A.cohen Jonathan e.Grim Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA Division of Medical Oncology University of WashingtonSeattleWAUSA Hospital and Specialty Medicine VA Puget Sound Health Care SystemSeattleWAUSA

Gastroesophageal cancer is a significant global problem that frequently presents at an incurable stage and has very poor survival with standard chemotherapy *** review will examine the epidemiology and molecular biology of gastroesophageal cancer and will focus on the key deregulated signaling pathways that have been targeted in the clinic.A comprehensive overview of clinical data highlighting successes and failures with targeted agents will be *** notably,HeR2-targeted therapy with the monoclonal antibody trastuzumab has proven beneficial in first-line therapy and has been incorporated into standard *** the VeGF pathway has also proven beneficial,and the VeGFR-targeted monoclonal antibody ramucirumab is now approved for second-line *** contrast to these positive results,agents targeting the eGFR and MeT pathways have been evaluated extensively in gastroesophageal cancer but have repeatedly failed to show *** increased understanding of the molecular predictors of response to targeted therapies is sorely *** the future,improved molecular pathology approaches should subdivide this heterogeneous disease entity to allow individualization of cancer therapy based on integrated and global identification of deregulated signaling *** patient selection,rational combinations of targeted therapies and incorporation of emerging immunotherapeutic approaches should further improve the treatment of this deadly disease.

关键词： esophageal cancer gastric cancer targeted therapy molecular oncology

Mathematical epidemiology:Past,present,and future

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Infectious Disease Modelling 2017年第2期2卷 113-127页

作者： fred Brauer University of British Columbia VancouverBCCanada

We give a brief outline of some of the important aspects of the development of mathematical epidemiology.

关键词： Mathematical epidemiology brief

Response of Solanum tuberosum to Myzus persicae infestation at different stages of foliage maturity

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Insect Science 2014年第6期21卷 727-740页

作者： Adriana e. Alvarez Anahi M. Alberti D'Amato W. fred Tjallingii Marcel Dicke Ben Vosman Laboratory of entomology Wageningen University 6700 EH Wageningen Plant Breeding Wageningen UR 6700 AA Wageningen ePG systems 6703CJ Wageningen the Netherlands

Young leaves of the potato Solanum tuberosum L. cultivar Kardal contain resistance factors to the green peach aphid Myzuspersicae （Sulzer）（Hemiptera： Aphididae） and normal probing behavior is impeded. However, M. persicae can survive and reproduce on mature and senescent leaves of the cv. Kardal plant without problems. We compared the settling ofM. persicae on young and old leaves and analyzed the impact of aphids settling on the plant in terms of gene expression. Settling, as measured by aphid numbers staying on young or old leaves, showed that after 21 h significantly fewer aphids were found on the young leaves. At earlier time points there were no difference between young and old leaves, suggesting that the young leaf resistance factors are not located at the surface level but deeper in the tissue. Gene expression was measured in plants at 96 h postinfestation, which is at a late stage in the interaction and in compatible interactions this is long enough for host plant acceptance to occur. In old leaves of cv. Kardal （compatible interaction）, M. persicae infestation elicited a higher number of differentially regulated genes than in young leaves. The plant response to aphid infestation included a larger number of genes induced than repressed, and the proportion of induced versus repressed genes was larger in young than in old leaves. Several genes changing expression seem to be involved in changing the metabolic state of the leaf from source to sink.

关键词： cDNA microarrays green peach aphid insect-plant interactions potato

DeSIGN FOR AVAILABILITY:A HOLISTIC APPROACH TO CReATe VALUe FOR MANUFACTUReRS AND CUSTOMeRS OF CAPITAL GOODS

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Journal of Systems Science and Systems engineering 2012年第4期21卷 403-421页

作者： Lydie P.M.SMeTS Geert-Jan van HOUTUM fred LANGeRAK School of Industrial & Systems engineering Eindhoven University of Technologythe Netherlands

This research introduces a holistic framework called Design for Availablhty that uses me principles of Lean Sigma and Design for X to cost-effectively optimize the availability of capital goods （i.e., technical systems used in the production of end-products or -services such as medical systems, airplanes, and manufacturing equipment） throughout their entire lifetime. Manufacturers require such a framework because users of capital goods increasingly insist on high system availability levels against reduced lifetime costs. The Design for Availability framework allows manufacturers to determine the current status of system availability and associated lifetime costs, and to identify opportunities to create additional value for themselves and their customers. A case study at a global manufacturer of capital goods in the food processing industry illustrates how the framework can be used in practice and to what extent the manufacturer and customers may profit from applying Design for Availability.

关键词： Design for X system availability MTTR MTTF MTTS lifecycle costs capital goods

Collapse of the endemic lizard Podarcis pityusensis on the island of Ibiza mediated by an invasive snake

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Current Zoology 2022年第3期68卷 295-303页

作者： elba MONTeS fred KRAUS Brahim CHeRGUI Juan M.PLeGUeZUeLOS Department of Zoology Faculty of Biological SciencesUniversity of Valenciac/Dr.Moliner50BurjassotE-46100 ValenciaSpain Department of ecology and evolutionary Biology University of MichiganAnn ArborMI 48109USA Laboratoire ecologie SystématiqueConservation de la BiodiversitéFacultédes Sciences de TétouanUniversitéAbdelmalek EssaâdiBP 2121 El M’HannechTétouanMorocco Department of Zoology Faculty of SciencesGranada UniversityGranada E-18071Spain

The invasive snake Hemorrhois hippocrepis colonized the island of Ibiza(Balearic Islands)in 2003 as stowaways inside trunks of olive trees imported for *** has quickly spread since 2010,posing a threat to the island’s only remaining endemic vertebrate,the Ibiza wall lizard Podarcis *** map the yearly expansion rate of the snake and estimate via transect surveys how severely it affects the distribution and abundance of the endemic *** well,we surveyed 9 of 30 small lizard populations on islets surrounding Ibiza that have been isolated since the Last Glacial *** had invaded 49%of Ibiza’s land area by 2018,and censuses show a critical contrast in lizard abundance between areas with and without snakes;almost all censuses in areas without snakes show lizard presence whereas nearly all censuses in areas with *** lack lizard ***,at least one subspecies previously thriving on one of the offshore islets has become extinct,and there have been several snakes recorded swimming between Ibiza and the surrounding ***,lizard populations have been dramatically reduced or have vanished within the range of the snake,and our results quantitatively support upgrading this species’threat level for *** study can inform to programs to manage invasive snake populations and to conservation actions to recover the endemic lizard.

关键词： Balearic Islands conservation extinction Hemorrhois hippocrepis lizard census

Supporting flexible regulation of crisis management by means of situated artificial institution

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Frontiers of Information Technology & electronic engineering 2016年第4期17卷 309-324页

作者： Maiquel De BRITO Lauren THeVIN Catherine GARBAY Olivier BOISSIeR Jomi fred HUBNeR Federal University of Santa Catarina UFSC/CTC/DAS/PPGEAS-PO Box 476FlorianopolisSC 88040-900Brazil LIG/Universite de Grenoble Grenoble 38041France Laboratoire Hubert Curien UMR CNRS 5516 Institut Henri FayolMINES Saint-EtienneSaint-Etienne 42023France

This paper highlights the use of situated artificial institution(SAI) within a hybrid, interactive,normative multi-agent system to regulate human collaboration in crisis management. Norms regulate the actions of human actors based on the dynamics of the environment in which they are situated. This dynamics results from both environment evolution and actors' actions. Our objective is to situate norms in the environment in order to provide a context-aware crisis regulation. However, this coupling must be a loose one to keep both levels independent and easyto-change in order to face the complex and changing crisis situations. To that aim, we introduce a constitutive level between environmental and normative states providing a loose coupling of normative regulation with environment evolution. Norms are thus no more referring to environmental facts but to status functions, i.e., the institutional interpretation of environmental facts through constitutive rules. We present how this declarative and distinct SAI modelling succeeds in managing the crisis with a context-aware crisis regulation.

关键词： Situated artificial institutions(SAIs) Normative system Tangible interaction Crisis management