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Competitive effect, but not competitive response, varies along a climatic gradient depending on tree species identity

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Forest Ecosystems 2024年第2期11卷 142-151页

作者： Teresa Valor Lluís Coll David I.Forrester Hans Pretzsch Miren del Río Kamil Bielak Bogdan Brzeziecki franz binder Torben Hilmers Zuzana Sitková Roberto Tognetti Aitor Ameztegui Department of Agricultural and Forest Sciences and Engineering(DCEFA) University of LleidaAv.Alcalde Rovira Roure 191E25198 LleidaSpain Joint Research Unit CTFC-AGROTECNIO-CERCA Ctra.Sant LlorençKm.225280SolsonaSpain Swiss Federal Institute of Forest Snow and Landscape Research WSLZürcherstrasse 1118903BirmensdorfSwitzerland CSIRO Land and Water GPO Box 1700CanberraACT2601Australia Chair of Forest Growth and Yield Science School of Life Sciences WeihenstephanTechnical University of MunichHans-Carl-Von-Carlowitz-Platz 285354FreisingGermany Forest Research Center INIA-CSICCtra.A Coruña Km 7.528040MadridSpain IuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIASpain Department of Silviculture Institute of Forest SciencesWarsaw University of Life SciencesNowoursynowska 159/3402776WarsawPoland Bavarian State Institute of Forestry(LWF) Hans-Carl-von-Carlowitz-Platz 1D-85354FreisingGermany National Forest Centre Forest Research InstituteT.G.Masaryka 2296001ZvolenSlovakia Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-Bolzano Piazza Università1 I-39100Bolzano

Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic ***: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to *** methods and information theory were used to select the best ***: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their ***: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of th

关键词： Competition coefficient Competition reduction Interspecific competition Intraspecific competition Mixing effects Mixed species forest Neighbourhood models Plant-plant interactions

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Tribologically induced nanostructural evolution of carbon materials: A new perspective

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Friction 2024年第1期12卷 144-163页

作者： Guilherme Oliveira NEVES Nicolás ARAYA Diego Berti SALVARO Thiago de Souza LAMIM Renan Oss GIACOMELLI Cristiano binder Aloisio Nelmo KLEIN JoséDaniel Biasoli de MELLO Laboratório de Materiais Universidade Federal de Santa CatarinaSanta Catarina 88040-900Brazil Departamento de Ingeniería Mecánica Facultad de IngenieríaUniversidad del Bío-BíoConcepcion 4070-386Chile Universidad de Concepción Concepcion 4070-386Chile SENAI Innovation Institute for Laser Processing Santa Catarina 89218-153Brazil Universidade Federal de Uberlândia Minas Gerais 38408-100Brazil

Carbon-based solid lubricants are excellent options to reduce friction and wear,especially with the carbon capability to adopt different allotropes *** the macroscale,these materials are sheared on the contact along with debris and contaminants to form tribolayers that govern the tribosystem *** a recently developed advanced Raman analysis on the tribolayers,it was possible to quantify the contactinduced defects in the crystalline structure of a wide range of allotropes of carbon-based solid lubricants,from graphite and carbide-derived carbon particles to multi-layer graphene and carbon *** addition,these materials were tested under various dry sliding conditions,with different geometries,topographies,and solid-lubricant application *** of the initial tribosystem conditions and allotrope level of atomic ordering,there is a remarkable trend of increasing the point and line defects density until a specific saturation limit in the same order of magnitude for all the materials tested.

关键词： carbon nanostructures tribology Raman spectroscopy defects quantification tribolayer solid lubrication

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Curse and blessing:upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3150-3151页

作者： Juliane Grimm Mascha binder Department of Internal Medicine IN Oncology/HematologyUniversity Hospital Halle(Saale)Halle(Saale)Germany

In a recently published study in The New England Journal of Medicine,Liu and colleagues were able to demonstrate that-apart from the antileukemic effects previously reported for hypomethylating agents(HMAs)-treatment with these drugs can also lead to demethylation and subsequent upregulation of oncogenes resulting in shorter survival in patients with myelo-dysplastic syndrome(MDS).

关键词： drugs myelo treatment

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Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis:the case of GFP

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Signal Transduction and Targeted Therapy 2022年第4期7卷 949-950页

作者： Christoph Schultheiß Mascha binder Department of Internal Medicine IV Oncology/HematologyMartin-Luther-University Halle-Wittenberg06120 HalleSaaleGermany

The applicability of immune-competent mice to model metastatic tumor progression is limited by the immunogenicity of exogenous proteins like GFP and firefly(ff)luciferase commonly used to track metastatic cells.A recent work published in Cancer Cell by Grzelak and colleagues now shows that development of mouse models that have been centrally tolerized to GFP can overcome this obstacle in transplantation models of metastasis.

关键词： metastasis metastatic immunogenicity

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On the added value of multi-scale modeling of concrete

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Frontiers of Structural and Civil Engineering 2022年第1期16卷 1-23页

作者： Jiaolong ZHANG Eva binder Hui WANG Mehdi AMINBAGHAI Bernhard LA PICHLER Yong YUAN Herbert A MANG College of Civil Engineering Tongji UniversityShanghai 200092China Department of Building Technology Linnaeus UniversityVaxjo 35195Sweden School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Institute for Mechanics of Materials and Structures TU WienVienna 1040Austria

This review of the added value of multi-scale modeling of concrete is based on three representative *** first one is concerned with the analysis of experimental data,taken from four high-dynamic *** structural nature of the high-dynamic strength increase can be explained by using a multi-scale *** accounts for the microstructure of the *** second example refers to multi-scale thermoelastic analysis of concrete pavements,subjected to solar heating.A sensitivity analysis with respect to the internal relative humidity(RH)of concrete has underlined the great importance of the RH for an assessment of the risk of microcracking of *** third example deals with multi-scale structural analysis of a real-scale test of a segmental tunnel *** has turned out that multi-scale modeling of concrete enables more reliable predictions of crack opening displacements in tunnel segments than macroscopic models taken from codes of ***,it is concluded that multi-scale models have indeed a significant added ***,its degree varies with these *** any case,it can be assessed by means of a comparison of the results from three sources,namely,multi-scale structural analysis,conventional structural analysis,and experiments.

关键词： experiments multi-scale analysis conventional structural analysis concrete reinforced concrete

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Single-cell trajectories of melanoma cell resistance to targeted treatment

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Cancer Biology & Medicine 2022年第1期19卷 56-73页

作者： Maria Schmidt Lena Sünke Mortensen Henry Loeffler-Wirth Corinna Kosnopfel Knut Krohn Hans binder Manfred Kunz Interdisciplinary Centre for Bioinformatics University of LeipzigLeipzig 04107Germany Department of Dermatology Venereology and AllergologyUniversity of WürzburgWürzburg 97074Germany Core Unit DNA Technologies Medical FacultyUniversity of LeipzigLeipzig 04103Germany Department of Dermatology Venereology and AllergologyUniversity of Leipzig Medical CenterLeipzig 04103Germany

Objective:Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant *** developments in single-cell sequencing technology have provided deeper insights into these ***:Here,we analyzed a BRAFV600 E-mutant melanoma cell line by single-cell RNA-seq under various conditions:cells sensitive to BRAF inhibition with BRAF inhibitor vemurafenib and cells resistant to BRAF inhibition with vemurafenib alone or vemurafenib in combination with the MEK1/2 inhibitors cobimetinib or *** reduction by t-distributed stochastic neighbor embedding and self-organizing maps identified distinct trajectories of resistance development clearly separating the 4 treatment conditions in cell and gene state ***:Trajectories associated with resistance to single-agent treatment involved cell cycle,extracellular matrix,and de-differentiation *** contrast,shifts detected in double-resistant cells primarily affected translation and mitogen-activated protein kinase pathway reactivation,with a small subpopulation showing markers of *** findings were validated in pseudotime analyses and RNA velocity ***:The single-cell transcriptomic analyses reported here employed a spectrum of bioinformatics methods to identify mechanisms of melanoma resistance to single-and double-agent *** study deepens our understanding of treatmentinduced cellular reprogramming and plasticity in melanoma cells and identifies targets of potential relevance to the management of treatment resistance.

关键词： Melanoma single-cell transcriptome sequencing treatment response

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Performance Back-deduction from a Loading to Flow Coefficient Map:Application to Radial Turbine

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Journal of Thermal Science 2012年第6期21卷 509-517页

作者： Xavier CARBONNEAU Nicolas binder Université de Toulouse Institut Supérieur de l'Aéronautique et de l'Espace(ISAE)10avenue Edouard Belin BP 54032 31400 ToulouseFrance

Radial turbine stages are often used for applications requiring off-design operation,as turbocharging for *** off-design ability of such stages is commonly analyzed through the traditional turbine map,plotting the reduced mass-flow against the pressure-ratio,for reduced-speed ***,some alternatives are possible,such as the flow-coefficient(Ψ)to loading-coefficient(φ)diagram where the pressure-ratio lines are actually straight lines,very convenient property to perform prediction.A robust method re-creating this map from a predicted Ψ-φ diagram is *** work has shown that this back-deduction quality,without the use of any loss models,depends on the knowledge of an intermediate pressure-ratio.A modelization of this parameter is then *** comparison with both experimental and CFD results is presented,with quite good agreement for mass flow rate and rotational speed,and for the intermediate pressure *** last part of the paper is dedicated to the application of the intermediate pressure-ratio knowledge to the improvement of the deduction of the pressure ratio lines in the Ψ-φ *** this improvement,the back-deduction method of the classical map is structured,applied and evaluated.

关键词：径流式涡轮应用程序流量系数装载系数涡轮机地图返回性能

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Tribological behaviour of sintered iron based self-lubricating composites

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Friction 2017年第3期5卷 285-307页

作者： Jose Daniel Biasoli DE MELLO Cristiano binder Gisele HAMMES Roberto binder Aloisio Nelmo KLEIN Laboratorio de Materiais(LabMat) Universidade Federal de Santa Catarina Florianópolis 88.040-900 SC BrazilLaboratorio de Tribologia e Materiais Universidade Federal de Uberl(a)ndia Uberl(a)ndia 38.400-902 MG Brazil Laboratorio de Materiais(LabMat) Universidade Federal de Santa Catarina Florianópolis 88.040-900 SC Brazil Whirlpool Embraco Unit Joinville 89.219-900 SC Brazil

This work is a review of previous works, presenting and discussing the most important results obtained by an ongoing research program towards the development of innovative, low-cost, self-lubricating composites with a low friction coefficient and high mechanical strength and wear resistance. Special emphasis is given to uniaxial die pressing of solid lubricant particles mixed with matrix powders and to metal injection moulding associated with in situ generation of solid lubricant particles. Initially, a microstructural model/processing route (powder injection moulding followed by plasma-assisted debinding and sintering) produced a homogeneous dispersion of in situ generated solid lubricant particles. Micrometric nodules of graphite with diameter smaller than 20 μm were formed, constituting a nanostructured stacking of graphite foils with nanometric thickness. Micro Raman analysis indicated that the graphite nodules were composed of turbostratic 2D graphite having highly misaligned graphene planes separated by large interlamellae distance. Large interplanar distance between the graphene foils and misalignment of these foils were confirmed by transmission electron microscopy and were, probably, the origin of the outstandingly low dry friction coefficient (0.04). The effect of sintering temperature, precursor content, metallic matrix composition and surface finish is also reported. Furthermore, the influence of a double-pressing/double-sintering (DPDS) technique on the tribological performance of self-lubricating uniaxially die-pressed hBN + graphite-Fe-Si-C-Mo composite is also investigated. Moreover, the tribological behaviour of die-pressed Fe-Si-C matrix composites containing 5, 7.5 and 10 wt% solid lubricants (hBN and graphite) added during the mixing step is analysed in terms of mechanical properties and wear mechanisms. Finally, the synergy between solid lubricant particles dispersed in a metallic matrix and fluid lubricants in a cooperative mixed lubrication re

关键词： tribological behaviour powder metallurgy iron based self-lubricating composites turbostratic graphite

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Obesity and its influence on liver dysfunction,morbidity and mortality after liver resection

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 704-714,I0018页

作者： Stephanie Kampf Michael Sponder Fabian Fitschek Daniel Laxar Martin Bodingbauer Carina binder Stefan Stremitzer Klaus Kaczirek Christoph Schwarz Division of Visceral Surgery Department of General SurgeryMedical University of ViennaViennaAustria Division of Cardiology Department of Internal Medicine IIMedical University of ViennaViennaAustria Clinical Institute of Pathology Medical University of ViennaViennaAustria

Background:Obesity and associated steatosis is an increasing health problem *** influence on post-hepatectomy liver failure(PHLF)and after liver resection(LR)is still ***:Patients who underwent LR were investigated and divided into three groups[normal weight:body mass index(BMI)18.5-24.9 kg/m2,overweight:BMI 25.0-29.9 kg/m2,obese:BMI≥30 kg/m2]in this retrospective *** aim of this study was to assess the influence of BMI and nonalcoholic steatohepatitis(NASH)on PHLF and ***:Of 888 included patients,361(40.7%)had normal weight,360(40.5%)were overweight,167(18.8%)were *** age was 62.5 years(IQR,54-69 years).The primary indication for LR was colorectal liver metastases(CLM)(n=366,41.2%).NASH was present in 58(16.1%)of normal weight,84(23.3%)of overweight and 69(41.3%)of obese patients(P<0.001).PHLF occurred in 16.3%in normal weight,15.3%in overweight and 11.4%in obese patients(P=0.32).NASH was not associated with *** was no association between patients’weight and the occurrence of postoperative complications(P=0.45).At multivariable analysis,solely major LR[odds ratio(OR):2.7,95%confidence interval(CI):1.83-4.04;P<0.001]remained a significant predictor for ***:Postoperative complications and PHLF are comparable in normal weight,overweight and obese patients and LRs using modern techniques can be safely performed in these patients.

关键词： Obesity liver resection(LR) post-hepatectomy liver failure(PHLF) morbidity

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Kinetically Controlled Supramolecular Block Copolymer Self-Assembly:Multicolor Photonic Crystal Patterns from a Single Formulation

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CCS Chemistry 2023年第10期5卷 2301-2311页

作者： Shuai Deng Renhua Deng Xi Mao Bijin Xiong Mian Wang Senbin Chen Wolfgang H.binder Jintao Zhu Zhenzhong Yang State Key Laboratory of Materials Processing and Die&Mould Technology Key Laboratory of Materials Chemistry for Energy Conversion and Storage(Ministry of Education)School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074 Chair of Macromolecular Chemistry Faculty of Natural Science II(ChemistryPhysicsand Mathematics)Martin Luther University Halle-WittenbergHalle(Saale) Department of Chemical Engineering Tsinghua UniversityBeijing 100084

Photonic crystal(PC)patterns with tunable and changeable nonvolatile structural colors printed from a single ink are of great interest for optical products but have rarely been reported because most inks can only output one respective structural ***,we propose a facile yet effective kinetically controlled self-assembly strategy to address this *** ink formulation containing supramolecular block copolymers(SBCPs)is *** patterns were printed by direct-ink-writing followed by solvent annealing to generate different structural colors by simply controlling the annealing *** self-assembly kinetic regime suggests that different colors result from various kinetically trapped metastable *** turn,the variation in structural color enables“visualization”of the self-assembly ***,we demonstrate that these kinetically trapped structures exhibit different responsive color-change *** addition,this kinetic control strategy can be synergistic with thermodynamic control to extend the color *** study provides a facile yet effective solution for well-designed PC patterns with tunable,responsive,and unfading colors printed from the simplest single-nozzle printer with a single colorless ink,presenting great potential in broad applications,including information storage,encryption,and anti-fake.

关键词： block copolymers self-assembly supramolecules photonic crystals direct write printing kinetics

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