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Efficiency, Effectiveness:Knowledge Exchange within Modernising Asia

博鳌观察 2016年第4期 36-38,7页

作者： frank-jürgen richter Horasis

It is vital to promote the top down discussionsthrough forums like those of Boao and *** their participation government ministers,CEOs, and so on will better identify with top-levelbroad issues and will be able to ins... 详细信息

关键词： Effectiveness Efficiency will

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Treatment of critical bone defects using calcium phosphate cement and mesoporous bioactive glass providing spatiotemporal drug delivery

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Bioactive Materials 2023年第10期28卷 402-419页

作者： Richard frank richter Corina Vater Margarete Korn Tilman Ahlfeld Martina Rauner Winnie Pradel Bernd Stadlinger Michael Gelinsky Anja Lode Paula Korn Centre for Translational Bone Joint and Soft Tissue ResearchUniversity Hospital Carl Gustav Carus and Faculty of MedicineTechnische Universitat DresdenDresdenGermany Department of Oral and Maxillofacial Surgery University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Department of Medicine III and Center for Healthy Aging University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Clinic of Cranio-Maxillofacial and Oral Surgery Center of Dental MedicineUniversity of ZurichSwitzerland

Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.

关键词： Drug delivery 3D plotting Alveolar cleft defect Calcium phosphate cement Mesoporous bioactive glass

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From basic properties to the Mott design of correlated delafossites

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npj Computational Materials 2021年第1期7卷 1084-1100页

作者： frank Lechermann European XFEL SchenefeldGermany Center for Computational Quantum Physics Flatiron InstituteNew YorkNYUSA

The natural-heterostructure concept realized in delafossites highlights these layered *** metallic,band-or Mott-insulating character may be associated with individual layers,inter-layer coupling still plays a decisive *** review the correlated electronic structure of PdCoO_(2),PdCrO_(2),and AgCrO_(2),showing that layer-entangled electronic states can deviate from standard classifications of interacting *** finding opens up possibilities for materials design in a subtle Mott-critical *** Hidden-Mott physics,correlation-induced semimetallicity,or Dirac/flat-band dispersions in a Mott background are emerging *** with achievements in the experimental preparation,this inaugurates an exciting research field in the arena of correlated materials.

关键词： materials metallic showing

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阻塞性睡眠呼吸暂停低通气综合征患者随访期经鼻持续气道正压通气治疗压力需求变化

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中华结核和呼吸杂志 2004年第8期27卷 560-561页

作者：肖永龙 frank richter Fulk Brunner Birgid Lerche 张德平郑培德南京大学医学院附属鼓楼医院呼吸科 210008 德国莱比锡罗伯特科赫医院睡眠中心

经鼻持续气道正压通气(nCPAP)是治疗中、重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)最有效的方法之一,我们的研究通过对随访期的nCPAP压力再滴定,以探讨随访期治疗压力需求变化趋势.

关键词：阻塞性睡眠呼吸暂停低通气综合征经鼻持续气道正压通气治疗压力缺氧

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经鼻持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者睡眠结构近远期的影响

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中华内科杂志 2004年第9期43卷 651-653页

作者：肖永龙 frank richter Fulk Brunner Birgid Lerche 张德平郑培德南京大学医学院附属鼓楼医院呼吸科 210008 德国莱比锡罗伯特科赫医院睡眠中心

目的　观察经鼻持续气道正压 (nCPAP)通气对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠结构近远期的影响。方法　 17例对照者行多导睡眠图 (PSG)监测 ,对 30例经PSG诊断的OSAHS患者行nCPAP治疗 ,治疗第 1夜行PSG监测 ,连续家庭nCPA... 详细信息

目的　观察经鼻持续气道正压 (nCPAP)通气对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠结构近远期的影响。方法　 17例对照者行多导睡眠图 (PSG)监测 ,对 30例经PSG诊断的OSAHS患者行nCPAP治疗 ,治疗第 1夜行PSG监测 ,连续家庭nCPAP治疗 6个月后行第 2次PSG监测 ,分析比较睡眠结构的变化。结果　OSAHS患者治疗前睡眠转换次数、1期、2期睡眠比例较对照组增加 (P 0 0 5 ) ,而REM期比例较治疗第 1夜降低 (P <0 0 5 )。结论　OSAHS患者睡眠转换次数明显增多 ,1期睡眠增加而REM期睡眠减少 ,睡眠结构紊乱。nCPAP治疗第 1夜及6个月后睡眠结构得到有效纠正 ,是OSAHS长期有效的治疗方法之一。

关键词：治疗前 CPAP 睡眠结构患者 OSAHS PSG 阻塞性睡眠呼吸暂停低通气综合征比例次数诊断

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